PHOSPHATASE

作品数：255被引量：886H指数：14
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相关领域：医药卫生生物学更多>>
相关作者：储成才司丽珍曹守云于晓王洪梅更多>>
相关机构：中国科学院遗传与发育生物学研究所山东大学湖北中医药大学安徽中医学院第一附属医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家教育部博士点基金瑞士科学基金更多>>
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Suberoylanilide hydroxamic acid overcomes erlotinib-acquired resistance via phosphatase and tensin homolog deleted on chromosome 10-mediated apoptosis in non-small cell lung cancer被引量：7
《Chinese Medical Journal》2020年第11期1304-1311,共8页Peng-Fei Wu Wei-Wei Gao Cui-Lan Sun Tai Ma Ji-Qing Hao 
Background::Epidermal growth factor receptor(EGFR)tyrosine kinase inhibitors(TKIs),such as erlotinib and gefitinib,are widely used to treat non-small cell lung cancer(NSCLC).However,acquired resistance is unavoidable,...
关键词：Acquired resistance ERLOTINIB Histone deacetylase Lung cancer SAHA 
Involvement of phosphatase and tensin homolog-induced putative kinase 1–Parkin-mediated mitophagy in septic acute kidney injury被引量：12
《Chinese Medical Journal》2019年第19期2340-2347,共8页Xin-Gui Dai Wei Xu Tao Li Jia-Ying Lu Yang Yang Qiong Li Zhen-Hua Zeng Yu-Hang Ai 
This work was supported by grants from the National Natural Science Foundation of China(Nos.81601708,81671960);the Natural Science Foundation of Hunan Province,China(No.2018JJ2014).
Background:Studies have reported mitophagy activation in renal tubular epithelial cells(RTECs)in acute kidney injury(AKI).Phosphatase and tensin homolog-induced putative kinase 1(PINK1)and E3 ubiquitin-protein ligase ...
关键词：Sepsis Acute kidney injury Autophagy MITOPHAGY PHOSPHATASE and TENSIN homolog-induced putative KINASE 1 E3 ubiquitin-protein ligase Parkin 
Age differences in associations of serum alkaline phosphatase and mortality among peritoneal dialysis patients被引量：1
《Chinese Medical Journal》2019年第2期232-236,共5页Juan Wu Xin-Hui Liu Rong Huang Hai-Shan Wu Qun-Ying GUO Chun-Yan Yi Xue-Qing YU Xiao Yang 
grants from the Natural Science Foundation of China (Nos.81774069,81570614, 81600.516,81603437);National Key Research and Development Program (No.2016YFC0906101);Program of the Ministry of Health of China (No.201502023), the Guangdong Science Foundation of China (Nos. 2014B020212020,2017A050503003,2017B020227006);Foundation of Guangdong Key Laboratory of Nephrology (No.2017B030314019);the Guangzhou Committee of Science and Technology,China (No.201704020167);and the Medical and Health Program of Zhejiang Province, China (No.2016KYB018).
To the Editor:Serum alkaline phosphatase (ALP) is an important bone turnover marker in chronic kidney disease (CKD) patients, with studies indicating that higher serum ALP levels are associated with increased mortalit...
关键词：Serum ALKALINE PHOSPHATASE TURNOVER chronic KIDNEY 
Effects of Glucocorticoid?Induced Transcript 1 Gene Deficiency on Glucocorticoid Activation in Asthmatic Mice被引量：5
《Chinese Medical Journal》2018年第23期2817-2826,共10页Cheng-Ping Hu Qiu-Fen Xun Xiao-Zhao Li Xin-Yue Hu Ling Qin Ruo-Xi He Jun-Tao Feng 
grants from the National Natural Science Foundation of China (No.81270080and No.81670027).
Background: Glucocorticoid (GC) is the first?line therapy for asthma, but some asthmatics are insensitive to it. Glucocorticoid?induced transcript 1 gene (GLCCI1) is reported to be associated with GCs efficiency in as...
关键词：Asthma GLUCOCORTICOID Receptor Glucocorticoid-Induced TRANSCRIPT 1 GLUCOCORTICOIDS MITOGEN-ACTIVATED Protein Kinase Phosphatase-1 
A Chinese Adult Patient with Fructose 1,6-bisphosphatase Deficiency被引量：1
《Chinese Medical Journal》2017年第16期2009-2010,共2页Jing-Ru Lu Cui Wang Le-Ping Shao 
To the Editor： Fructose 1,6-bisphosphatase （FBPase） deficiency is an autosomal recessive metabolic disease, which is characterized by episodic attacks of hypoglycemia, ketosis, and lactic acidosis triggered by long...
Wild-type p53-induced Phosphatase I Deficiency Exacerbates Myocardial Infarction-induced Ischemic Injury被引量：2
《Chinese Medical Journal》2017年第11期1333-1341,共9页Ke-Mei Liu Hai-Hong Zhang Ya-Nan Wang Lian-Mei Wang Hong-Yu Chen Cai-Feng Long Lian-Feng Zhang Hong-Bing Zhang Hong-Bing Yan 
Background： Myocardial infarction （MI） is a major disease burden. Wild-type p53-induced phosphatase 1 （Wipl） has been studied extensively in the context of cancer and the regulation of different types of stem cel...
关键词：lschemic Injury Myocardial Infarction Wild-type p53-induced Phosphatase 1 
Expression of PH Domain Leucine-rich Repeat Protein Phosphatase, Forkhead Homeobox Type 0 3a and RAD51, and their Relationships with Clinicopathologic Features and Prognosis in Ovarian Serous Adenocarcinoma
《Chinese Medical Journal》2017年第3期280-287,共8页Jun Zhang Jun-Chao Wang Yue-Hong Li Rui-Xue Wang Xiao-Mei Fan 
Background： Ovarian serous adenocarcinoma can be divided into low- and high-grade tumors, which exhibit substantial differences in pathogenesis, clinicopathology, and prognosis. This study aimed to investigate the d...
关键词：Forkhead Homeobox Type O 3a lnanlunohistochemistry Ovarian Serous Adenocarcinomas PH Domain Leucine-rich Repeat Protein Phosphatase PROGNOSIS RAD51 
MiR-106b-5p Inhibits Tumor Necrosis Factor-α-induced Apoptosis by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 in Vascular Endothelial Cells被引量：3
《Chinese Medical Journal》2016年第12期1406-1412,共7页Jing Zhang Su-Fang Li Hong Chen Jun-Xian Song 
This research was funded by the National Natural Science Foundation of China (NSFC)
Background： Apoptosis of endothelial cells （ECs） plays a key role in the development of atherosclerosis and there are also evidence indicated that phosphatase and tensin homolog deleted on chromosome 10 （PTEN） is...
关键词：Apoptosis ATHEROSCLEROSIS MicroRNAs Phosphatase and Tensin Homolog Deleted on Chromosome 10 
CDX2 Inhibits Invasion and Migration of Gastric Cancer Cells by Phosphatase and Tensin Homologue Deleted from Chromosome 10/Akt Signaling Pathway被引量：8
《Chinese Medical Journal》2015年第8期1065-1071,共7页Yong-Qiang Liu Zhi-Gang Bai Xue-Mei Ma Zhong-Tao Zhang 
This study was supported by grants from the Beijing Natural Science Foundation
Background： Gastric cancer （GC） is one of the most prevalent malignancies in the world today, with a high mortality rate. CDX2 is a Drosophila caudal-related homeobox transcription factor that plays an important ro...
关键词：CDX2 Epithelial-mesenchymal Transition Gastric Cancer PTEN 
Phosphatase and Tensin Homologue Genetic Polymorphisms and their Interactions with Viral Mutations on the Risk of Hepatocellular Carcinoma被引量：5
《Chinese Medical Journal》2015年第8期1005-1013,共9页Yan Du Yu-Wei Zhang Rui Pu Xue Han Jian-Ping Hu Hong-Wei Zhang Hong-Yang Wang Guang-Wen Cao 
the National Key Basic Research Program (973 Project)，the National Natural Science Foundation of China，the Science and Technology Commission of Shanghai Municipality No.12ZR1453600)
Background： Chronic hepatitis B virus （HBV） infection is the major cause of hepatocellular carcinoma （HCC）. Some HBV mutants and dysregulation of phosphatase and tensin homolog （PTEN） may promote the developmen...
关键词：Hepatitis B Virus Hepatocellular Carcinoma Polymorphism Phosphatase and Tensin Homolog Viral Mt  tation 
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