SCAVENGING

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Self-assembled carbon monoxide nanogenerators managing sepsis through scavenging multiple inflammatory mediators被引量：1
《Bioactive Materials》2024年第9期595-611,共17页Yang Wu Xia Chen Zhaolin Zeng Bei Chen Zhenxing Wang Zhiyong Song Hui Xie 
supported by National Natural Science Foundation of China(Grant No.82302720 to Y.Wu,82125023,82072504 to H.Xie,82272562 to Z-X Wang),Natural Science Foundation of Hunan Province(Grant No.2023JJ40997 to Y.Wu);China Postdoctoral Science Foundation(Grant No.2023M733964 to Y.Wu,2023M733946 to X.Chen).
Sepsis,a life-threatening syndrome of organ damage resulting from dysregulated inflammatory response,is distinguished by overexpression of inflammatory cytokines,excessive generation of reactive oxygen/nitrogen specie...
关键词：SEPSIS Carbon monoxide nanogenerator Heme oxygenase-1 Scavenging inflammatory storm 
Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect
《Bioactive Materials》2024年第8期137-153,共17页Xiaoqing Lu Shimin Dai Benzhao Huang Shishuo Li Peng Wang Zhibo Zhao Xiao Li Ningbo Li Jie Wen Yunhan Sun Zhentao Man Bing Liu Wei Li 
supported by National Natural Science Foundation of China(Nos.52002223,81672185 and 81702152);Key Technology Research and Development Program of Shandong(Major Science and Technology Innovation Project)(2020CXGC010502);Taishan Scholar Foundation of Shandong Province(No.tsqn202211348);the Shandong Province Natural Science Foundation(Grant Nos.ZR2022MH222 and ZR2023MH209).
Enhancing the regeneration of cartilage defects remains challenging owing to limited innate self-healing as well as acute inflammation arising from the overexpression of reactive oxygen species(ROS)in post-traumatic m...
关键词：EXOSOMES Hydrogels CARTILAGE Reactive oxygen species MACROPHAGE Inflammation 
ROS-responsive&scavenging NO nanomedicine for vascular diseases treatment by inhibiting endoplasmic reticulum stress and improving NO bioavailability
《Bioactive Materials》2024年第7期239-252,共14页Jian Li Jvhong Zhang Pengcheng Yu Han Xu Meihui Wang Zhebin Chen Bo Yu Jing Gao Qiao Jin Fan Jia Jian Ji Guosheng Fu 
supported by the National Key Research and Development Program of China (2022YFB3807300);the National Natural Science Foundation of China (51933009,82370427,22305219);the Fundamental Research Funds for the Central Universities,China (26-2023-00074);the Natural Science Foundation of Zhejiang Province,China (No.LY20H020005);The Zhejiang Provincial Traditional Chinese Medicine Science and Technology Plan,China (2022ZX012);The Province and Central Administration-Zhejiang Provincial Health Commission,China (WKJ-ZJ-2209).
Vascular diseases seriously threaten human life and health.Exogenous delivery of nitric oxide(NO)represents an effective approach for maintaining vascular homeostasis during pathological events.However,the overproduct...
关键词：Cardiovascular diseases Nitric oxide Reactive oxygen species Endoplasmic reticulum stress NANOMEDICINE 
Nano oxygen chamber by cascade reaction for hypoxia mitigation and reactive oxygen species scavenging in wound healing
《Bioactive Materials》2024年第5期67-81,共15页Xiaoxue Han Leah Ju Chai Saengow Wen Ren Randy Ewoldt Timothy Fan Joseph Irudayaraj 
Hypoxia,excessive reactive oxygen species(ROS),and impaired angiogenesis are prominent obstacles to wound healing following trauma and surgical procedures,often leading to the development of keloids and hypertrophic s...
关键词：HYPOXIA ROS scavenging ANTI-INFLAMMATION Oxygen nanobubble Scarless wound healing 
A tough,antibacterial and antioxidant hydrogel dressing accelerates wound healing and suppresses hypertrophic scar formation in infected wounds被引量：5
《Bioactive Materials》2024年第4期269-281,共13页Xiaoqing Liu Yiming Sun Jie Wang Yongyuan Kang Zhaolong Wang Wangbei Cao Juan Ye Changyou Gao 
supported by the Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering(2021SZ-TD004);the Natural Science Foundation of Zhejiang Province(LD21E030001);the Joint Fund of National Natural Science Foundation of China(U22A20155);the Lingyan Program of Zhejiang Province(2022C01106).
Wound management is an important issue that places enormous pressure on the physical and mental health of patients,especially in cases of infection,where the increased inflammatory response could lead to severe hypert...
关键词：Hydrogel dressing Hypertrophic scars Wound healing Bacterial infection ROS-scavenging 
A shear-thinning,ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis被引量：7
《Bioactive Materials》2023年第4期274-290,共17页Yibo Ying Zhiyang Huang Yurong Tu Qiuji Wu Zhaoyu Li Yifan Zhang Huilei Yu Annian Zeng Hanzhi Huang Jiahui Ye Weiyang Ying Min Chen Zhiyi Feng Ziyue Xiang Qingsong Ye Sipin Zhu Zhouguang Wang 
This study was partly funded by grants from the National Natural Science Funding of China(82172424,82271629);Outstanding Youth Fund of Zhejiang Province(LR22H060002);Zhejiang Medical and Health Science and Technology Plan Project(2022RC210,2021KY212);Wenzhou Basic Science Research Plan Project(Y20210045);CAMS Innovation Fund for Medical Sciences(2019-I2M-5-028).
Spinal cord injury(SCI)is a serious clinical disease.Due to the deformability and fragility of the spinal cord,overly rigid hydrogels cannot be used to treat SCI.Hence,we used TPA and Laponite to develop a hydrogel wi...
关键词：Shear-thinning hydrogel Dental pulp stem cells Ferroptosis ROS-Scavenging Synaptic regulation 
Sustained delivery of rhMG53 promotes diabetic wound healing and hair follicle development被引量：3
《Bioactive Materials》2022年第12期104-115,共12页Hong Niu Haichang Li Ya Guan Xin Zhou Zhongguang Li Serana Li Zhao Peng Chen Tao Tan Hua Zhu Valerie Bergdall Xuehong Xu Jianjie Ma Jianjun Guan 
National Institutes of Health (R01AG056919).
MG53 is an essential component of the cell membrane repair machinery,participating in the healing of dermal wounds.Here we develop a novel delivery system using recombinant human MG53(rhMG53)protein and a reactive oxy...
关键词：Diabetic wound healing hair follicle stem cell MG53 ROS-Scavenging hydrogel Controlled drug delivery 
The protein corona modulates the inflammation inhibition by cationic nanoparticles via cell-free DNA scavenging被引量：1
《Bioactive Materials》2022年第7期249-259,共11页Xingliang Liu Huiyi Liang Yanzi Yan Jingjiao Wu Massimo Bottini Lixin Liu Yongming Chen 
The financial support from the National Natural Science Foundation of China(21875290);the key Areas Research and Development Program of Guangzhou(202007020006);support of Sun Yat-sen University(19lgjc01)was acknowledged for support。
A central paradigm in nanomedicine is that when synthetic nanoparticles(NPs)enter the body,they are immediately cloaked by a corona of macromolecules(mostly proteins)that mediates the role of the physico-chemical prop...
关键词：Cationic nanoparticles Cell-free DNA Inflammation inhibition Protein corona Rheumatoid arthritis 
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