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SIGNAL_TRANSDUCTION: 作品数：482被引量：3037H指数：28; 导出分析报告; 相关作者：张春翌沈万华袁莉张光毅陈伟更多>>; 相关机构：徐州医学院中国农业大学华中科技大学上海中医药大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

RON in hepatobiliary and pancreatic cancers:Pathogenesis and potential therapeutic targets: 《World Journal of Gastroenterology》2021年第20期2507-2520,共14页Shao-Long Chen Guo-Ping Wang Dan-Rong Shi Shu-Hao Yao Ke-Da Chen Hang-Ping Yao; National Natural Sciences Foundation of China,No.81872883;Zhejiang Major Medical Health&Sciences Technology Foundation Projects,No.WKJ-ZJ-13.; The receptor protein tyrosine kinase RON belongs to the c-MET proto-oncogene family.Research has shown that RON has a role in cancer pathogenesis,which places RON on the frontline of the development of novel cancer th...; 关键词：RON Signal transduction HEPATOBILIARY Pancreatic neoplasms Molecular targeted therapy

Emerging role of the KRAS-PDK1 axis in pancreatic cancer被引量：3: 《World Journal of Gastroenterology》2014年第31期10752-10757,共6页Riccardo Ferro Marco Falasca; Supported by Pancreatic Cancer Research Fund; Pancreatic cancer is a highly aggressive tumour that is very resistant to treatments and it is rarely diagnosed early because of absence of specific symptoms. Therefore, the prognosis for this disease is very poor and...; 关键词：Pancreatic cancer Signal transduction KRAS Phosphoinositide 3-kinase 3-phosphoinositide-dependent protein kinase 1

Insights into erlotinib action in pancreatic cancer cells using a combined experimental and mathematical approach被引量：1: 《World Journal of Gastroenterology》2012年第43期6226-6234,共9页Falko Lange Katja Rateitschak Christina Kossow Olaf Wolkenhauer Robert Jaster; Supported by A grant of the Bundesministerium für Bildung und Forschung through the FORSYS partner program, No.0315255;the Helmholtz Society as part of the Systems Biology Network; AIM:To gain insights into the molecular action of erlotinib in pancreatic cancer (PC) cells. METHODS:Two PC cell lines, BxPC-3 and Capan-1, were treated with various concentrations of erlotinib, the specific mitogen-a...; 关键词：ERLOTINIB Pancreatic cancer Epidermal growth factor receptor Signal transduction Mathematical modeling

Effects of CpG-ODNs on phenotype and function of monocyte-derived dendritic cells in chronic hepatitis B被引量：1: 《World Journal of Gastroenterology》2011年第43期4825-4830,共6页Xiao-Xing Xiang Xia-Qiu Zhou Jun-Xue Wang Qing Xie Xiong Cai Hong Yu Hui-Juan Zhou; Supported by Grants From Shanghai Committee of Scienceand Technology,Shanghai,China,No.044119624; AIM:To study the effects of synthetic nonmethylated CpG-containing oligodeoxynucleotides(CpG-ODNs) ,either alone or combined with recombinant Hepatitis B surface antigen(HBsAg) polypeptide,on the phenotype,function,an...; 关键词：Chronic hepatitis B Dendritic cell CpG oligodeoxynucleotides Hepatitis B surface antigen Signal transduction

Late SV40 factor:A key mediator of Notch signaling in human hepatocarcinogenesis被引量：16: 《World Journal of Gastroenterology》2011年第29期3420-3430,共11页Ren-Hua Fan Jing Li Nan Wu Ping-Sheng Chen; Supported by The National Natural Science Foundation of China,No.30470780; AIM:To investigate the relationship between late SV40 factor(LSF)and Notch signaling in the development and progress of hepatocellular carcinoma(HCC).METHODS:Liver cancer tissue specimens from 25 patients were analyze...; 关键词：Notch receptor Late SV40 factor Signal transduction Hepatocellular carcinoma

Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth被引量：6: 《World Journal of Gastroenterology》2011年第25期2992-3001,共10页Chen Huang Guang Yang Tao Jiang Jun Cao Ke-Jian Huang Zheng-Jun Qiu; Supported by A Grant from the Science and Technology Commission of Shanghai Municipality,No. 09QA1404600;a grant from the Affiliated First People’s Hospital of ShanghaiJiao Tong University,No. 0801; AIM:To evaluate the effect of RNA interference (RNAi) mediated silence of signal transduction and activation of transcription (STAT)3 on the growth of human pancreatic cancer cells both in vitro and in vivo.METHODS:ST...; 关键词：Signal transduction and activation of tran-scription 3 RNA interference Pancreatic cancer GROWTH

Signal transduction mechanism of TRB3 in rats with non-alcoholic fatty liver disease被引量：5: 《World Journal of Gastroenterology》2009年第19期2329-2335,共7页Yu-Gang Wang Min Shi Ting Wang Ting Shi Jue Wei Na Wang Xi-Mei Chen; AIM： To evaluate the possible role of Tribble 3 （TRB3） in a rat model of non-alcoholic fatty liver disease （NAFLD） and its signal transduction mechanism.METHODS： Thirty Sprague-Dawley rats were randomized into t...; 关键词：Non-alcoholic fatty liver disease Rat Tribble 3 Protein Kinase B Insulin resistance

Reactive oxygen species: A double-edged sword in oncogenesis被引量：14: 《World Journal of Gastroenterology》2009年第14期1702-1707,共6页Jin-Shui Pan Mei-Zhu Hong Jian-Lin Ren; Supported by National Natural Science Foundation of China, No. 30750013 ;Key Science Research Project Natural Science Foundation of Xiamen, No. WKZ0501; Reactive oxygen species (ROS) are molecules or ions formed by the incomplete one-electron reduction of oxygen. Ofinterest, it seems that ROS manifest dual roles, cancer promoting or cancer suppressing, in tumorigenesi...; 关键词：p38 mitogen-activated protein kinases Reactive oxygen species Signal transduction TUMORIGENESIS

Autophagy and ethanol-induced liver injury被引量：12: 《World Journal of Gastroenterology》2009年第10期1178-1185,共8页Terrence M Donohue Jr; Supported by Development funds from the Section of Gastroenterology/Hepatology, University of Nebraska Medical Center;Bridge Research Grant from the University of Nebraska Medical Center;Medical Research Funds from the Department of Veterans Affairs, United States of America; The majority of ethanol metabolism occurs in the liver. Consequently, this organ sustains the greatest damage from ethanol abuse. Ethanol consumption disturbs the delicate balance of protein homeostasis in the liver, ...; 关键词：AUTOPHAGY AUTOPHAGOSOME Ethanolmetabolism HEPATOMEGALY LYSOSOMES Signal transduction

Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells被引量：8: 《World Journal of Gastroenterology》2008年第36期5570-5583,共14页Sinikka Latvala Taija E Pietil Ville Veckman Riina A Kekkonen Soile Tynkkynen Riitta Korpela Ilkka Julkunen; The Medical Research Council of the Academy of Finland and the Sigrid Juselius Foundation; AIM： To analyze the ability of nine different potentially probiotic bacteria to induce maturation and cytokine production in human monocyte-derived dendritic cells （moDCs）. METHODS： Cytokine production and maturat...; 关键词：Probiotic bacteria Immune response Cytokine CHEMOKINE Dendritic cell HUMAN Gene expression Signal transduction

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