云南高校图书馆联盟文献共享服务平台- SIGNAL

SIGNAL_TRANSDUCTION: 作品数：482被引量：3037H指数：28; 导出分析报告; 相关作者：张春翌沈万华袁莉张光毅陈伟更多>>; 相关机构：徐州医学院中国农业大学华中科技大学上海中医药大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPMIH被引量：1: 《Cell Research》2014年第6期727-741,共15页Tao Shen Chuang Sun Zhengmao Zhang Ningyi Xu Xueyan Duan Xin-Hua Feng Xia Lin; Bone morphogenetic proteins （BMPs） belong to the TGF-β superfamily of structurally related signaling pro teins that regulate a wide array of cellular functions. The key step in BMP signal transduction is the BMP re...; 关键词：PHOSPHORYLATION protein phosphatases signal transduction TGF-β

Reelin induces EphB activation被引量：5: 《Cell Research》2013年第4期473-490,共18页Elisabeth Bouche Mario I Romero-Ortega Mark Henkemeyer Timothy Catchpole Jost Leemhuis Michael Frotscher Petra May Joachim Herz Hans H Bock; The integration of newborn neurons into functional neuronal networks requires migration of cells to their final position in the developing brain, the growth and arborization of neuronal processes and the formation of ...; 关键词：signal transduction signaling crosstalk tyrosine kinase EPHRIN lipoprotein receptor HIPPOCAMPUS neural development

Decoding the phosphorylation code in Hedgehog signal transduction被引量：9: 《Cell Research》2013年第2期186-200,共15页Yongbin Chen Jin Jiang; We apologize to those whose work we could not cite due to space limitations. Y Chen is supported by grams from the National Natural Science Foundation of China （31271579）, National Key Basic Research Program of China （2013CB910900）, American Heart Association postdoctoral fellowship （10POST3640046）, Kunming Institute of Zoology startup foundation and Chinese Academy of Sciences. J Jiang is supported by grants from NIH （GM067045 and GM061269）, CPRIT （RPI00561） and Welch foundation 0-1603）, and is a Eugene McDermott Endowed Schol-ar of Biomedical Science at UTSW.; Hedgehog （Hh） signaling plays pivotal roles in embryonic development and adult tissue homeostasis, and its de-regulation leads to numerous human disorders including cancer. Binding of Hh to Patched （Ptc）, a twelve...; 关键词：HEDGEHOG SMO GLI signal transduction PHOSPHORYLATION development cancer

PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus被引量：7: 《Cell Research》2012年第4期661-676,共16页Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen; Acknowledgments We thank Drs Natlie G Ahn （University of Colorado）, Piero Crespo （Consejo Superior de Investigaciones CientFficas）, Xos6 R Bustelo （University of Salamanca）, Robert J Kay （University of British Columbia） and Juan S Bonifacino （National Institute of Child Health and Human Development） for generously providing the plasmids. This work was supported by research grants from Ministry of Science and Technology of China （2007CB947100 to YC and 2010CB529506 to YP and ZW）, National Natural Science Foundation of China （30830037 and 81021002 to YC and 30971660 to YP）, Chinese Academy of Sciences （KSCX2- EW-R-08 to YC.）, and Shanghai Institutes for Biological Sciences （2009KIP207 to YP）.; Ras plays a pivotal role in many cellular activities, and its subcellular compartmentalization provides spatial and temporal selectivity. Here we report a mode of spatial regulation of Ras signaling in the Golgi appar...; 关键词：RAS Signal transduction Golgi apparatus COMPARTMENTALIZATION ERK

Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels被引量：6: 《Cell Research》2011年第9期1343-1357,共15页Gang Ma Jiang Yu Yue Xiao Danny Chan Bo Gao Jianxin Hu Yongxing He Shengzhen Guo Jian Zhou Lingling Zhang Linghan Gao Wenjuan Zhang Yan Kang Kathryn SE Cheah Guoyin Feng Xizhi Guo Yujiong Wang Cong-zhao Zhou Lin He; This work was supported by the National Natural Science Foundation of China （30800613）, the 973 Program （2010CB529600, 2007CB947300）, the 863 Program （2009AA022701）, the Shanghai Municipal Commission of Science and Technology Program （09DJ1400601）, the Natural Science Foundation of Shanghai, China （Grant No. 08ZR1411000）, the National Key Project for the Investigation of New Drugs （2008ZX09312-003）, the Shanghai Leading Academic Discipline Project （B205）, and the General Research Fund of Hong Kong （HKU760608M）. The coauthor, Xizhi Guo, was supported by the ＂Pujiang Talent＂ Project （08PJ1407200）.; Brachydactyly type A1 （BDAI）, the first recorded Mendelian autosomal dominant disorder in humans, is characterized by a shortening or absence of the middle phalanges. Heterozygous missense mutations in the Indian He...; 关键词：Indian hedgehog BDA1 diffusion HEPARIN crystal structure degradation

Calcium-dependent modulation and plasma membrane targeting of the AKT2 potassium channel by the CBL4/ ClPK6 calcium sensor/protein kinase complex被引量：27: 《Cell Research》2011年第7期1116-1130,共15页Katrin Held Franqois Pascaud Christian Eckert Pawel Gajdanowicz Kenji Hashimoto Claire Corratge-Faillie Jan Niklas Offenborn Benoit Lacombe Ingo Dreyer Jean-Baptiste Thibaud Jorg Kudla; Potassium （K^＋） channel function is fundamental to many physiological processes. However, components and mech- anisms regulating the activity of plant K^＋channels remain poorly understood. Here, we show that the c...; 关键词：calcium sensor protein kinase potassium channel signal transduction

NF-kB in the regulation of epithelial homeostasis and inflammation被引量：34: 《Cell Research》2011年第1期146-158,共13页; The IKB kinase/NF-kB signaling pathway has been diseases. Increased activation of NF-kB is often detected implicated in the pathogenesis of several inflammatory in both immune and non-immune cells in tissues affected ...; 关键词：NF-KB signal transduction INFLAMMATION mouse models of human disease epithelial homeostasis

Chemical probing reveals insights into the signaling mechanism of inflammasome activation被引量：5: 《Cell Research》2010年第12期1289-1305,共17页Yi-Nan Gong Xiaoming Wang Jiayi Wang Zhenxiao Yang Shan Li Jieling Yang Liping Liu Xiaoguang Lei Feng Shao; Caspase-1-mediated IL-1β production is generally controlled by two pathways. Toll-like receptors （TLRs） recognize pathogen-derived products and induce NF-KB-dependent pro-IL-1β transcription; NOD-like receptors （...; 关键词：innate immunity INFLAMMASOME NOD-like receptors chemical biology signal transduction

EphA3 functions are regulated by collaborating phosphotyrosine residues: 《Cell Research》2010年第11期1263-1275,共13页Guanfang Shi Gang Yue Renping Zhou; Ephrin ligands interact with Eph receptors to regulate a wide variety of biological and pathological processes. Recent studies have identified several downstream pathways that mediate the functions of these receptors....; 关键词：tyrosine phosphorylation signal transduction cell migration growth cone collapse

PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site被引量：4: 《Cell Research》2009年第9期1062-1078,共17页Cathryn L Haigh Victoria A Lewis Laura J Vella Colin L Masters Andrew F Hill Victoria A Lawson Steven J Collins; The copper-binding, membrane-anchored, cellular prion protein （PrP~） has two constitutive cleavage sites producing distinct N- and C-terminal fragments （N1/C1 and N2/C2）. Using RK13 cells expressing either human P...; 关键词：PRION COPPER endoproteolytic cleavage signal transduction lipid raft

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

SIGNAL_TRANSDUCTION

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

SIGNAL_TRANSDUCTION

检索结果分析

下载全文

用户登录

高级检索检索式检索