SPERMATOGENESIS

作品数：359被引量：1218H指数：16
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Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis被引量：78
《Cell Research》2017年第10期1216-1230,共15页Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong 
M-HT was supported by the Strategic Priority Research Pro- gram of the Chinese Academy of Sciences （XDB19000000）, the Ministry of Science and Technology of China （2014CB943101）, the National Key Research and Development Program of China （2016YFC1000600）, SIBS foundation, the National Natural Science Foundation of China （31471401 and 31671553）, the Science and Technology Commission of Shanghai Municipality （14140901502 and 14JC1407100）. This work was also supported by NIH HG008688 （CH）. CH is an investigator of the Howard Hughes Medical Institute. XY was supported by the National Natural Science Foundation of China （81472855 and 91540109）, the Ministry of Science and Technology of China Grant （2016YFC0906001）. We thank the Histology, Flow Cytometry and Vivarium services at SIBCB, and the Genome Sequencing and High-performance Computing services from the National Protein Science Facility （Beijing） at Tsinghua University.
Spermatogenesis is a differentiation process during which diploid spermatogonial stem cells （SSCs） produce hap- loid spermatozoa. This highly specialized process is precisely controlled at the transcriptional, postt...
关键词：m6A RNA modification Mettl3 Mettll4 spermatogonial stem cell SPERMIOGENESIS 
Mettl3-mediated m ^6A regulates spermatogonial differentia- tion and meiosis initiation被引量：65
《Cell Research》2017年第9期1100-1114,共15页Kai Xu Ying- Yang Gui-Hai Feng Bao-Fa Sun Jun-Qing Chen Yu-Fei Li Yu-Sheng Chen Xin-Xin Zhang Chen-Xin Wang Li-Yuan Jiang Chao Liu Ze-Yu Zhang Xiu-Jie Wang Qi Zhou Yun-Gui Yang Wei Li 
We thank Dr Y-L Zhao from Beijing Institute of Genomics,Chinese Academy of Sciences for scientific suggestion. This work was supported by the National Natural Science Foundation of China （31422038, 31471395, 31625016 and 31670824）, the National Basic Research Program of China （2014CB964800, 2016YFC0900300）, CAS Strategic Priority Research Program （XDB14030300, QYZDY-SSW-SMC027/002, QYZDB-SSW- SMC022）. We thank BIG sequencing core facility for sequencing.
METTL3 catalyzes the formation of N%methyl-adenosine （m6A） which has important roles in regulating various biological processes. However, the in vivo function of Mettl3 remains largely unknown in mammals. Here we ge...
关键词：Mettt3 m6A SPERMATOGENESIS spermatogonial differentiation MEIOSIS alternative splicing 
Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis被引量：140
《Cell Research》2017年第9期1115-1127,共13页Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He 
We thank Prof Tao Pan （The University of Chicago） for kind- ly providing the polysome profiling instrument. We thank Peter Chen and Phil Xie for technical assistance. We also thank the Institutes of Biomedical Sciences at Fudan University for the protein mass spectrometry experiments. This work was support- ed by the National Science Fund for Excellent Young Scholars （31622039 to BS）, the National Key Research and Development Program of China （2016YFC1000600 to BS, 2016YFA0500902 to ML, 2017YFA0103803 to JS）, the Science Foundation for Distinguished Young Scholars of Jiangsu Province （BK20160045 to BS）, and National Institutes of Health grants HG008935 and GM113194 （to CH）. CH is an investigator of the Howard Hughes Medical Institute （HHMI）. HM is supported by the Postdoctoral International Exchange Program of the China Postdoctoral Coun- cil （CPC）. PH is supported by the University of Chicago Medical Scientist Training Program （MSTP; NIH MSTP training grant T32GM007281）.
N^6-methyladenosine （m^6A） is the most common internal modification in eukaryotic mRNA. It is dynamically in- stalled and removed, and acts as a new layer of mRNA metabolism, regulating biological processes includin...
关键词：YTHDC2 N^6-methyladenosine m^6A SPERMATOGENESIS TRANSLATION 
Atg7 is required for acrosome biogenesis during spermatogenesis in mice被引量：28
《Cell Research》2014年第7期852-869,共18页Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li 
The acrosome is a specialized organelle that covers the anterior part of the sperm nucleus and plays an essential role in the process of fertilization. The molecular mechanism underlying the biogenesis of this lysosom...
关键词：acrosome biogenesis autolysosome AUTOPHAGY GLOBOZOOSPERMIA Atg7 
piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism被引量：7
《Cell Research》2012年第10期1429-1439,共11页Ergin Beyret Na Liu Haifan Lin 
piRNAs, a class of small non-coding RNAs associated with PIWI proteins, have broad functions in germline development, transposon silencing, and epigenetic regulation. In diverse organisms, a subset of piRNAs derived f...
关键词：MIWI MILL PIRNA ping-pong mechanism SPERMATOGENESIS MEIOSIS 
-pigenetic modifications and self-renewal regulation of ~ouse germline stem cells被引量：2
《Cell Research》2011年第8期1164-1171,共8页Jiyoung Lee 
Germline stem （GS） cells were established from gonocytes and spermatogonia of postnatal mouse testes. GS cells proliferate in the presence of several kinds of cytokines, and a small percentage of GS cells also show ...
关键词：germline stem cells spermatogonial stem cells SPERMATOGENESIS SELF-RENEWAL genomic imprinting 
Identification of differentially expressed genes of primary spermatocyte against round spermatid isolated from human testis using the laser capture microdissection technique被引量：3
《Cell Research》2004年第6期507-512,共6页GangLIANG XiaoDongZHANG LuJingWANG YuShenSHA JianChaoZHANG ShiYingMIAO ShuDongZONG LinFangWANG S.S.KOIDE 
The method of laser capture microdissection (LCM) combined with suppressive subtractive hybridization (SSH) was developed to isolate specific germ cells from human testis sections and to identify the genes expressed d...
关键词：laser capture microdissection suppressive subtractive hybridization SPERMATOGENESIS cytochrome c oxidase Ⅱ humanin. 
Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis被引量：4
《Cell Research》2003年第3期171-177,共7页SHENGWEIZOU JIANCHAOZHANG XIAODONGZHANG SHIYINGMIAO SHUDONGZONG QISHENG LINFANGWANG 
supported by grants from the Special Fund for Major State Basic Research Project(No.G1999055901);National Natural Sciences Foundation of China(No.30240019);National High Technology Research and Technology of China(No.2001AA221131);State Ministry of Science and Technology Program(No.2002BA711A011.
Variable Charge X/Y (VCX/Y) is a human testis-specific gene family that localized on X and Y chromosomes. In this study, VCY protein was expressed in E. coli in the form of glutathione-S-transferase (GST) fusion prote...
关键词：VCX/Y protein SPERMATOGENESIS nucleoli colocnlization. 
Temperature dependent expression of cdc2 and cyclin B1 in spermatogenic cells during spermatogenesis被引量：12
《Cell Research》2000年第4期289-302,共14页KONG WEI HUA ZHENG GU JI NING LU JIA KE TSO Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China College of Life Science, Shandong University, Jinan 250100, China 
National Natural Science FOundation of China.Grant! Nos: 39770370, 39630160;We are grateful to Dr. A. Koff and Dr. J. Pines f
p34cdc2 and Cyclin B1 are key components of cell cycle controlling machine and are believed to play a fundamental role in gametogenesis. It is also well known that, in scrotal mammals, spermatogenesis depends greatly ...
关键词：TEMPERATURE SPERMATOGENESIS CDC2 cyclin B8 
Identification and expression of epidermal growth factor gene in mouse testis被引量：3
《Cell Research》1997年第1期51-59,共9页ZHANGMEILAN YUANCHANGYAN 等 
Epidermal growth factor (EGF) is produced primarily by Leydig cells of human testis. Expression of the EGF gene was assessed in mouse testis during the course of sexual maturation by the application of the RT-PCR meth...
关键词：Epidermal growth factor TESTIS gene expression SPERMATOGENESIS sexual  maturation 
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