SPERMATOGENESIS

作品数：359被引量：1218H指数：16
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RpL38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis
《Science China(Life Sciences)》2024年第11期2411-2425,共15页Yang Fang Fengchao Zhang Fangzhen Zhao Jiajia Wang Xinkai Cheng Fei Ye Jiayu He Long Zhao Ying Su 
supported by the Laoshan Laboratory(LSKJ202203204);the National Natural Science Foundation of China(32170832,32170541);the Fundamental Research Funds for Central Universities,China(202012004).
Switching from mitotic spermatogonia to meiotic spermatocytes is critical to producing haploid sperms during male germ cell differentiation.However,the underlying mechanisms of this switch remain largely unexplored.In...
关键词：Drosophila melanogaster SPERMATOGENESIS RpL38 SPERMATOGONIA BAM 
DEtail-seq is an ultra-efficient and convenient method for meiotic DNA break profiling in multiple organisms被引量：2
《Science China(Life Sciences)》2023年第6期1392-1407,共16页Wei Xu Chao Liu Zhe Zhang Changbin Sun Qin Li Kuan Li Hui Jiang Wei Li Qianwen Sun 
supported by the National Natural Science Foundation of China (91740105,31822028,32071437,31900302);Central Public-interest Scientific Institution Basal Research Fund (Y2022QC33)。
Programmed DNA double-strand break(DSB)formation is a crucial step in meiotic recombination,yet techniques for highefficiency and precise mapping of the 3’ends of DSBs are still in their infancy.Here,we report a nove...
关键词：MEIOSIS DSB DNA break fragile site ENHANCER SPERMATOGENESIS 
Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal被引量：4
《Science China(Life Sciences)》2023年第5期1151-1169,共19页Hong-Yan Wang Xiang Liu Jian-Yang Chen Yingyi Huang Yifang Lu Fujian Tan Qun Liu Mingming Yang Shuo Li Xianghui Zhang Yating Qin Wenxiu Ma Yingming Yang Liang Meng Kaiqiang Liu Qian Wang Guangyi Fan Rafael H.Nóbrega Shanshan Liu Francesc Piferrer Changwei Shao 
supported by the National Key R&D Program of China(2018YFD0900301);the National Nature Science Foundation of China(31722058,31802275,31472269);the AoShan Talents Cultivation Program Supported by Qingdao National Laboratory for Marine Science and Technology(2017ASTCP-ES06);the Taishan Scholar Project Fund of Shandong of China to C.S.;the National Ten-Thousands Talents Special Support Program to C.S.;the Central Public-interest Scientific Institution Basal Research Fund,CAFS(2020TD19);the China Agriculture Research System(CARS-47-G03)。
Female-to-male sex reversals(pseudomales)are common in lower vertebrates and have been found in natural populations,which is a concern under rapid changes in environmental conditions.Pseudomales can exhibit altered sp...
关键词：Cynoglossus semilaevis SPERMATOGENESIS single-cell transcriptome sex reversal SPERMATOGONIA 
Recent advances in mammalian reproductive biology被引量：9
《Science China(Life Sciences)》2020年第1期18-58,共41页Lu Wen Qiang Liu Jingjing Xu Xixi Liu Chaoyi Shi Zuwei Yang Yili Zhang Hong Xu Jiang Liu Hui Yang Hefeng Huang Jie Qiao Fuchou Tang Zi-Jiang Chen 
Reproductive biology is a uniquely important topic since it is about germ cells, which are central for transmitting genetic information from generation to generation. In this review, we discuss recent advances in mamm...
关键词：PREIMPLANTATION fetal germ cell OOGENESIS SPERMATOGENESIS female infertility male infertility gene editing single-cell sequencing 
Micro RNA profiles and potential regulatory pattern during the early stage of spermatogenesis in mice被引量：6
《Science China(Life Sciences)》2015年第5期442-450,共9页LUO MengMeng HAO LiLi HU Fen DONG YaNan GOU LiXia ZHANG WenDian WANG Xin ZHAO YuHui JIA MengChun HU SongNian ZHANG XiuJun 
supported by the National Natural Science Foundation of China(81170616,81072093,30671092,81302323,31100915);the Natural Science Foundation of Hebei Province(C2014209140,C2009001260,C2012401039,H2013209194,C2013209024);the Scientific and Technical Supporting Programs of Hebei Province(10276109D)
Spermatogenesis is a complicated and poorly understood process that relies on the precise regulation of the self-renewal and differentiation of spermatogonia. In many organisms, micro RNAs(mi RNAs) are involved in mul...
关键词：SPERMATOGENESIS miRNA profiling post-transcriptional regulation focal adhesion cytoskeleton dynamic Wnt signaling pathway 
Lipid metabolism and Drosophila sperm development被引量：4
《Science China(Life Sciences)》2012年第1期35-40,共6页WANG Chao HUANG Xun 
supported by the National Natural Science Foundation of China (Grant Nos. 30771060 and 31071253)
Lipids are essential membrane structural components and important signal carriers. The major enzymatic metabolisms of various lipids (phospholipid, sphingolipid, cholesterol) are well studied. The developmental functi...
关键词：Drosophila spermatogenesis phosphatidylinositol lipids fatty acids CHOLESTEROL 
Molecular basis of cryptorchidism-induced infertility被引量：9
《Science China(Life Sciences)》2010年第11期1274-1283,共10页LIU YiXun & LI XiXia State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 
supported by the National Basic Research Program of China (Grant No. 2006CB944000);the National Key Basic Research Program (Grant Nos.G199055901,2006CB504001 and 2007CB947502);the National Natural Science Foundation of China (Grant Nos. 31071018,30618005, 30600311 and 30230190);the CAS Knowledge Innovation Program (Grant Nos.KSCX-2-SW-201 and KSCA2-YWR-55);the Beijing Natural Science Foundation (Grant No.5073032)
Artificial cryptorchidism or local testicular heat treatment can induce reversible oligospermia or azoospermia in monkeys and rats via germ cell apoptosis. Local warming of monkey testes in water at 43°C for 2 consec...
关键词：CRYPTORCHIDISM SPERMATOGENESIS apoptosis heat stress SERTOLI cells blood-testis barrier TIGHT JUNCTION 
Cloning and identification of a novel RNF6 transcrip-tional splice variant Spg2 in human development被引量：3
《Science China(Life Sciences)》2008年第4期302-307,共6页ZHU Li TONG GuoQin CHEN Jie WANG Yun WANG SaiQun ZHAO MuZhi LI JianMin MA JianHua 
the National Basic Research Program(973 Program)of China(Grant No.G1999055901);National Natural Science Foundation of China(Grant No.30000088)
RING finger proteins are zinc finger proteins containing the RING motifs. They act mainly as E3 ubiq-uitin ligases, bind the ubiquitin E2 conjugating enzyme and promote degradation of targeted proteins, Many novel gen...
关键词：alternative splice RING domain UBIQUITINATION SPERMATOGENESIS 
The cloning and expression characterization of the centrosome protein genes family (centrin genes) in rat testis被引量：1
《Science China(Life Sciences)》2002年第6期655-662,共8页孙晓冬 俞作仁 薛社普 葛晔华 李赛 韩代书 马静 王永潮 
This work was supported by the Special Funds for Major State Basic Research Project (Grant No. G1999055901)
Centrins are members of the centrosome protein family, which is highly conserved during revolution. The homologous genes of centrin in many organisms had been cloned, but the sequences of the rat centrin genes were no...
关键词：centrin  centrosome  spermatogenesis. 
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