STIMULATION

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MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB
《Signal Transduction and Targeted Therapy》2024年第11期5267-5285,共19页Xiujian Wang Xiao Tao Pengjie Chen Penglei Jiang Wenxiao Li Hefeng Chang Cong Wei Xinyi Lai Hao Zhang Yihan Pan Lijuan Ding Zuyu Liang Jiazhen Cui Mi Shao Xinyi Teng Tianning Gu Jieping Wei Delin Kong Xiaohui Si Yingli Han Huarui Fu Yu Lin Jian Yu Xia Li Dongrui Wang Yongxian Hu Pengxu Qian He Huang 
supported by the National Key Research and Development Program of China(2022YFA1103500 to P.Q.);the National Key Nature Science Foundation of China(82130003 to H.H.);the Key Project of Science and Technology Department of Zhejiang Province(2019C03016 and 2020C03G2013586 to H.H.,Z24H080001 to P.Q.);the National Natural Science Foundation of China(82200248 and 82000194 to H.H.,82222003 and 82161138028 to P.Q.);the Key R&D Program of Zhejiang(2024SSYS0023 to H.H.,2024SSYS0024 to P.Q.,2024SSYS0025 to Y.H.);the Fundamental Research Funds for the Central Universities(226-2024-00007 to P.Q.).
Clinical evidence supports the notion that T cell exhaustion and terminal differentiation pose challenges to the persistence and effectiveness of chimeric antigen receptor-T(CAR-T)cells.MEK1/2 inhibitors(MEKIs),widely...
关键词：JUNB metabolism STIMULATION 
Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss被引量：1
《Signal Transduction and Targeted Therapy》2024年第2期751-765,共15页Xudong Xie Peng Cheng Liangcong Hu Wu Zhou Detai Zhang Samuel Knoedler Guodong Liu Yuan Xiong Hang Xue Yiqiang Hu Barbara Kern Doha Obed Adriana CPanayi Lang Chen Chenchen Yan Ze Lin Guandong Dai Bobin Mi Yingze Zhang Guohui Liu 
supported by the National Key Research&Development Program of China(2021YFA1101500);National Science Foundation of China(No.82002313,No.82072444);Department of Science and Technology of Hubei Province(2021CFB425);Wuhan Science and Technology Bureau(2022020801020464)。
The clinical role and underlying mechanisms of valproic acid(VPA)on bone homeostasis remain controversial.Herein,we confirmed that VPA treatment was associated with decreased bone mass and bone mineral density(BMD)in ...
关键词：MIR protective STIMULATION 
Cellular mechanotransduction in health and diseases:from molecular mechanism to therapeutic targets被引量：9
《Signal Transduction and Targeted Therapy》2023年第8期3705-3736,共32页Xingpeng Di Xiaoshuai Gao Liao Peng Jianzhong Ai Xi Jin Shiqian Qi Hong Li Kunjie Wang Deyi Luo 
This work was supported by the National Science Fund of China(Grant Number:82270720);National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(Grant Number:Y2021LC005);1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(Grant Number:ZYGD18011);The National Science Fund of China(Grant Number:81873601).Many thanks to ClinicalTrials.gov(https://clinicaltrials.gov/ct2/home),which is maintained by the National Library of Medicine(NLM)at the National Institutes of Health(NIH),for the support of clinical trials collection.We appreciate the support from Biorender(https://www.biorender.com)for helping us create some of the figures.We thank Xintong Bao for her kind and excellent help in this study。
Cellular mechanotransduction,a critical regulator of numerous biological processes,is the conversion from mechanical signals to biochemical signals regarding cell activities and metabolism.Typical mechanical cues in o...
关键词：DISEASES STIMULATION THERAPEUTIC 
T cells in health and disease被引量：24
《Signal Transduction and Targeted Therapy》2023年第7期3296-3345,共50页Lina Sun Yanhong Su Anjun Jiao Xin Wang Baojun Zhang 
This work was supported by the National Key Research and Development Program of China grants 2021YFA1100702(to B.Z.);Major International(Regional)Joint Research Project grants 81820108017(to B.Z.);National Natural Science Foundation of China grants 82271792(to L.S.);32200727(to L.S.);Innovation Capability Support Program of Shaanxi 2021TD-38(to B.Z.).
T cells are crucial for immune functions to maintain health and prevent disease.T cell development occurs in a stepwise process in the thymus and mainly generates CD4^(+)and CD8^(+)T cell subsets.Upon antigen stimulat...
关键词：STIMULATION MAINTAIN STEPWISE 
From tuberculosis bedside to bench:UBE2B splicing as a potential biomarker and its regulatory mechanism
《Signal Transduction and Targeted Therapy》2023年第3期1282-1295,共14页Mengyuan Lyu Jian Zhou Yanbing Zhou Weelic Chong Wei Xu Hongli Lai Lu Niu Yang Hai Xiaojun Yao Sheng Gong Qinglan Wang Yi Chen Yili Wang Liyu Chen Zengwanggema Jiongjiong Zeng Chengdi Wang Binwu Ying 
Thanks to Xuan Chen at West China Hospital of Stomatology,Sichuan University for providing THP-1 cell line.Thanks to Xiaohuan Su at Core Facilities of West China Hospital for cell line identification.Thanks to Sisi Wu,Jinkui Pi,and Yufei Cheng at Core Facilities of West China Hospital for their help on capturing fluorescence signal by using confocal laser scanning microscope(Leica).Thanks to Dr.Li Yu at Tsinghua University,and Chengqi Yi at Peking University for their advices on writing.This work was funded by the National Science&Technology Pillar Program during the 13th Five-year Plan Period[Grant number:2018ZX10715003];National Natural Science Foundation of China[Grant number:82272416,Grant number:U20A20394].
Alternative splicing(AS)is an important approach for pathogens and hosts to remodel transcriptome.However,tuberculosis(TB)-related AS has not been sufficiently explored.Here we presented the first landscape of TB-rela...
关键词：TUBERCULOSIS STIMULATION diagnosis 
Trends in insulin resistance:insights into mechanisms and therapeutic strategy被引量：34
《Signal Transduction and Targeted Therapy》2022年第8期2762-2786,共25页Mengwei Li Xiaowei Chi Ying Wang Sarra Setrerrahmane Wenwei Xie Hanmei Xu 
supported by NANJING ANJI BIOTECHNOLOGY Co.Ltd,the Project Program of State Key Laboratory of Natural Medicines(SKLNMZZ202028);National Natural Science Foundation of China(82103118)。
The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition.Insulin is a key peptide hormone and mediates the syste...
关键词：METABOLISM STIMULATION diagnosis 
Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone被引量：1
《Signal Transduction and Targeted Therapy》2022年第5期1783-1796,共14页Shan Su Duo Hua Jin-Peng Li Xia-Nan Zhang Lei Bai Li-Bo Cao Yi Guo Ming Zhang Jia-Zhen Dong Xiao-Wei Liang Ke Lan Ming-Ming Hu Hong-Bing Shu 
This work was supported by grants from the State Key R&D Program of China(2017YFA0505800 and 2021YFA1302400);the National Natural Science Foundation of China(31922021,32170713,31830042,and 31771555);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-071).
Whether and how innate antiviral response is regulated by humoral metabolism remains enigmatic.We show that viral infection induces progesterone via the hypothalamic-pituitary-adrenal axis in mice.Progesterone induces...
关键词：PROGESTERONE METABOLISM STIMULATION 
Greasy hair against obesity
《Signal Transduction and Targeted Therapy》2022年第1期11-12,共2页Sandra Nickel Bruno Christ 
B.C.is supported by the German Research Foundation(DFG)within the Research Unit Programme FOR 5151wQuaLiPerF(Quantifying Liver Perfusion-Function Relationship in Complex Resection-A Systems Medicine Approach)"by grant number 436883643;the Individual Research Grant"Experimental and clinical proof-of-concept to establish stem cell treatment of post-hepatectomy liver failure"by grant number CH 109/25.
In their article,Choa et al.open the perspective to loose fat by in creasing seboge nesis.Envisioning a T cell-depe ndent mechanism,they suggest that stimulation of sebum production by thymic stromal lymphopeietin(TSL...
关键词：OBESITY AL STIMULATION 
Persistent astrocytic IL-3 stimulation of microglia slows disease in Alzheimer’s:treatment perspectives for Alzheimer’s
《Signal Transduction and Targeted Therapy》2021年第12期3369-3370,共2页Natja Haag Hans Zempel 
This research was funded by the Else-Kröner-Fresenius Stiftung(2019_A41);the Jürgen-Manchot-Stiftung and was supported by the Koeln Fortune Program/Faculty of Medicine,University of Cologne(assigned to HZ);a START-grant from the RWTH/University Hospital Aachen assigned to NH.
In their new paper,McAlpine and colleagues provide compelling evidence that astrocyte dependent microglial stimulation is crucial for fighting off one of the most prominent Alzheimer disease(AD)pathological hallmarks,...
关键词：STIMULATION ALZHEIMER DEGENERATION 
PTEN suppresses tumorigenesis by directly dephosphorylating Akt被引量：3
《Signal Transduction and Targeted Therapy》2021年第8期2294-2296,共3页Lang Bu Huan Wang Ji-an Pan Lang Chen Fan Xing Junyu Wu Shun Li Deyin Guo 
This work is supported by the National Natural Science Foundation of China(#81620108020);Guangdong Zhujiang Talents Program,Shenzhen Science and Technology Program(#KQTD20180411143323605);National Ten-thousand Talents Program(all to D.G.).
Dear Editor,The serine-threonine kinase Akt plays a central role in regulating cell proliferation,migration,angiogenesis,transformation,energy metabolism,and death.1 The stimulation of growth factors recruits the PI3K...
关键词：METABOLISM STIMULATION DEATH 
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