TARGETED

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Targeted tilianin lipid nanoparticles for the treatment of atherosclerosis through remodeling lesional macrophage phenotype
《Nano Research》2025年第2期571-585,共15页Yaoyao Luo Zhongshan He Mengran Guo Xinchun Wang Zhaohui Jin Min Sun Huiling Yang Wanqin Zeng Shengbin Liu Yupei Zhang Guohong Li Xiaoling Yin Shugang Qin Xing Duan Yong'an Hu Xiangrong Song 
This research was supported by the Science and Technology Project of Xinjiang Production and Construction Corps(No.2022AB020);the Youth Fund of National Natural Science Foundation of China(Nos.82104081 and 82400537);the Sichuan Province Science and Technology Support Program(No.2023NSFSC1682,and No.2024NSFSC0714,Zhongshan He);the Postdoctoral Fellowship Program of CPSF under Grant(No.GZC20241133,Zhongshan He);the Sichuan University Postdoctoral Research and Development Fund(No.2024SCU12014);the West China Hospital Postdoctoral Research and Development Fund(No.2024HXBH058);the Sichuan University Postdoctoral Interdisciplinary Innovation Fund(No.JCXK2203).
Remodeling of the lesional macrophages in atherosclerotic plaques from pro-inflammatory M1 to pro-resolving M2 phenotype is emerging as a promising approach to atherosclerosis treatment.Tilianin(Til),as a natural plan...
关键词：ATHEROSCLEROSIS tilianin lipid nanoparticles M1 to M2 remodeling lesional macrophage-targeted 
Targeted nanostrategies eliminate pre-metastatic niche of cancer
《Nano Research》2024年第6期5358-5373,共16页Juan Wang Ning Zhang Xiuping Ding Chengrui Fu Xiaodong Li Baosheng Li Jianxun Ding Tianmeng Sun 
the National Natural Science Foundation of China(Nos.82325029,U23A20591,U22A20156,52273158,82102845,52173149,and 52022095);the Shandong Province Innovation Platform Projects(No.2021LCZX04);the Academic Promotion Program of Shandong First Medical University(No.2019LJ004);the Shandong Natural Science Foundation Major Basic Research Project(No.ZR2022ZD31);the Shandong Province Traditional Chinese Medicine Science and Technology Program(No.Z-2022075);the Shandong Province Natural Science Foundation(No.ZR2020MH090).
Establishing a pre-metastatic niche(PMN)in secondary organs is a prerequisite for cancer metastases.Despite advances in cancer therapy,the efficient inhibition of PMN formation remains a clinical challenge.Recent adva...
关键词：nanoparticle controlled drug delivery pre-metastatic niche elimination metastasis suppression cancer therapy 
Therapeutic sponge prevents postoperative breast cancer recurrence by sustainably dissociating into CD44-targeted nanoplatform
《Nano Research》2024年第3期1792-1803,共12页Junhui Sui Mingda Zhao Zhihao Guo Jiafeng Li Jie Chen Hongli Chen Jie Liang Yong Sun Xingdong Zhang Yujiang Fan 
sponsored by the National Natural Science Foundation of China(Nos.51973136 and 32071352);the Open Project Program of the Third Affiliated Hospital of Xinxiang Medical University(No.KFKTZD202102).
Locoregional recurrence and distant metastasis of breast cancer still pose a significant risk for patients’survival.To address the clinical challenge,functional absorbable sponges(HA-SH/PP-Dox/Lap/COL I(HCNPs))were c...
关键词：therapeutic sponge scattered tumor cells recurrence and metastasis CD44-targeted nanoparticles breast cancer 
EGFR-targeted and gemcitabine-incorporated chemogene for combinatorial pancreatic cancer treatment被引量：1
《Nano Research》2024年第2期848-857,共10页Miao Xie Qiushuang Zhang Yuanyuan Guo Lijuan Zhu Xinyuan Zhu Chuan Zhang 
supported by the National Key Research and Development Program of China(No.2018YFA0902601);the National Natural Science Foundation of China(Nos.52225302,52103265,and 22175116);the Shanghai Sailing Program(No.21YF1434300);the Natural Science Foundation of Shanghai(No.23ZR1448000);the Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(No.21TQ1400219).
Pancreatic cancer stands out as a recognized intractable tumor due to its high malignancy and mortality rates,which are largely attributed to the insensitivity of current clinical chemotherapies or multidrug-resistanc...
关键词：antisense oligonucleotide chemogene NANOBODY drug delivery system pancreatic cancer 
Microwave triggered multifunctional nanoplatform for targeted photothermal-chemotherapy in castration-resistant prostate cancer被引量：2
《Nano Research》2023年第7期9688-9700,共13页Pengyuan Liu Yajun Wu Xiaogang Xu Xudong Fan Chuan Sun Xiaojie Chen Jindan Xia Shiting Bai Li Qu Huasong Lu Jing Wu Jun Chen Ji-Gang Piao Zhibing Wu 
This study was supported by the National Natural Science Foundation of China(Nos.82172679 and 82104405);Zhejiang Provincial Medicine and Health Science Foundation(No:2021KY010).
Lacking a precise targeting strategy,castration-resistant prostate cancer(CRPC)is still hard to be treat effectively.Exploring treatment options that can accurately target CPRC is an important issue with urgent need.I...
关键词：castration-resistant prostate cancer gold nanocage heat shock protein 70 targeted drug delivery photothermalchemotherapy 
LAT1 targeted brain delivery of temozolomide and sorafenib for effective glioma therapy
《Nano Research》2023年第7期9743-9751,共9页Yufei Zhang Qian Cheng Yuhao Xue Kai Yao Madiha Zahra Syeda Jian Xu Jianheng Wu Zhenjie Wang Longguang Tang Qingchun Mu 
This work was supported by the National High Technology Research and Development Program of China(No.2019YFC0121000);the National Natural Science Foundation of China(Nos.32201127 and 82270113);Medical Scientific Research Foundation of Guangdong Province,China(No.A2021298).
Glioma is the most common primary craniocerebral tumor caused by the cancerous growth of glial cells in the brain and spinal cord.Currently,standard treatment is the surgical resection followed by concurrent radiation...
关键词：L-type amino acid transporter 1(LAT1) GLIOMA blood-brain barrier(BBB) ferroptosis drug delivery 
Mesothelin targeted nano-system enhanced chemodynamic therapy and tirapazamine chemotherapy via lactate depletion被引量：1
《Nano Research》2023年第5期7108-7118,共11页Guodong Cao Wei Cao Jiawei Zhang Qing Chen Junjie Chen Qiang Chu Qiang Sun Maoming Xiong Bo Chen Xiang Li 
the mission book of promotion program of basic and clinical collaborative research of Anhui Medical University(No.2022xkjT028);Anhui Provincial Scientific Research Preparation Plan Project(No.2022AH051171);the Anhui Provincial Natural Science Foundation(No.2208085MH240);Postgraduates of Colleges and Universities in Anhui Province(No.YJS20210308);the National Natural Science Foundation of China(No.81602425);the Anhui Quality Engineering Project(Nos.2020jyxm0898,2020jyxm0910,and 2019kfkc334);the Anhui Medical University Clinical Research Project(No.2020xkj176);the Anhui Health Soft Science Research Project(No.2020WR01003);the Key Research and Development Program of Anhui Province(No.201904a07020045).
The enhanced permeability and retention(EPR)effect alone is not enough for nanoparticles to reach the target.Combination of active and passive targeting may be an effective drug delivery route.Hollow ferric-tannic aci...
关键词：MESOTHELIN lactate oxidase tumor metastasis synergetic cancer therapy chemodynamic therapy 
Targeted regulation of neuroinflammation via nanobiosignaler for repairing the central nerve system injuries被引量：1
《Nano Research》2023年第2期2938-2948,共11页Xiaoru Sun Huitong Ruan Qidong Liu Silu Cao Qi Jing Yaru Xu Lize Xiong Wenguo Cui Cheng Li 
supported by the Found of National Natural Science Foundation of China(Nos.82003658,82101261,81930051,and 82271223);Shanghai Fourth People’s Hospital,School of Medicine,Tongji University(Nos.sykyqd01901 and SYXKZT-2021-2001);Natural Science Foundation of Shanghai(No.16ZR1426400).
Neuroinflammation,commonly associated with various central nervous system(CNS)diseases such as postoperative cognitive dysfunction(POCD),is primarily mediated by the disruption of biological signals in microglia.Howev...
关键词：biosignal NANOPARTICLES MICROGLIA NEUROINFLAMMATION targeted delivery 
A novel hierarchical targeting and controllable smart nanoparticles for enhanced in situ nuclear photodynamic therapy
《Nano Research》2022年第5期4212-4223,共12页Gankun Yuan Qilu Wang Zifan You Xuening Chen Jinping Xue Xiao Jia Juanjuan Chen 
This study was supported by the National Natural Science Foundation of China(Nos.81703345 and 21974009);the Natural Science Foundation of Fujian Province(No.2021J01549);the National Health and Family Planning Commission Jointly established a scientific research fund(No.WKJ2016-2-14).
Photodynamic therapy(PDT)is a promising and non-invasive treatment for various cancers.Although nuclear PDT has considerable therapeutic prospects,it is still hindered by the non-specific recognition of tumor tissues ...
关键词：photodynamic therapy hierarchical targeted nuclear localization signal poly-β-cyclodextrin nuclear-targeted 
A pH-responsive biomimetic drug delivery nanosystem for targeted chemo-photothermal therapy of tumors被引量：2
《Nano Research》2022年第5期4274-4284,共11页Yanmin Ju Zhiyi Wang Zeeshan Ali Hongchen Zhang Yazhou Wang Nuo Xu Hui Yin Fugeng Sheng Yanglong Hou 
This work was financially supported by the National Natural Science Foundation of China(Nos.52027801,51631001,and 52002402);the National Key R&D Program of China(No.2017YFA0206301);the Natural Science Foundation of Beijing Municipality(No.2191001),and the China-German Collaboration Project(No.M-0199);the Natural Science Foundation of Jiangsu Province(No.BK20200574)。
Smart drug delivery nanosystem is significant for tumor treatments due to its possibility of temporally,spatially,and dose-controlled release.However,the therapeutic efficacy of drug delivery nanosystem is often compr...
关键词：drug delivery macrophage cell membrane pH stimuli synergistic therapy 
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