This study was sponsored by the Sanming Project of Medicine in Shenzhen(SZSM 201812005);Shenzhen Key Medical Discipline Construction Fund(SZXK033);Epilepsy Research Fund of China Association Against Epilepsy(CU-C-2021-02);Support Project for Clinical Research of Young and Middle-aged Doctors in South of the Ten Ridges Neurology(Z20210308).
Background:West syndrome is a devastating disorder characterized by a triad of epileptic spasms,abnormal electroencephalography(EEG),and developmental arrest or psychomotor delay.In addition to early diagnosis,knowing...
Background Infantile spasms (IS) was an epileptic disease with varied treatment widely among clinicians. Here, we aimed to compare and analyze the clinical characteristics of IS response to pyridoxine or topiramate mo...
Topiramate(TPM) is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in s...
Drug-induced peripheral neuropathy had been rarely reported as an adverse effect of some antiepileptic drugs(AEDs) at high cumulative doses or even within the therapeutic drug doses or levels.We describe clinical and ...
the National Natural Science Foundation of China(81400957)
Paroxysmal kinesigenic dyskinesia(PKD)is presented as a short paroxysmal attack of focal or generalized involuntary movement.The most common treatments for PKD are carbamazepine and phenytoin.Though the cases of clini...
supported by Social Development Science and Technology Research Projects of Shanxi Province(2011 ks-30)
Objective:To explore protective effeet of topiramate(TPM) on hypoxic—ischemic brain injury.Methods:A total of 360 neonatal rats were seleeted then randomly divided into sham operation group,ischemia and hypoxia group...
Adrenocorticotropic hormone is recommended worldwide as an initial therapy for infantile spasms. However, infantile spasms in about 50% of children cannot be fully controlled by adrenocorticotropic hormone monotherapy...
A simple, rapid, specific and precise liquid chromatography—tandem mass spectrophotometric (LC-MS/MS) method was developed and validated for the quantification of chiral separated R-bicalutamide from S-bicalutamide, ...
OBJECTIVE:To evaluate the treatment effects and safety of topiramate in migraine prophylaxis. DATA RETRIEVAL:We searched the Medline database,EMbase,Cochrane Library and China National Knowledge Infrastructure datab...
The use of generic formulation of therapeutic agents may allow a significant reduction of costs for patients and the National Health Services. This is particularly true for drugs used in prolonged therapies such as to...