TOPIRAMATE

作品数:27被引量:62H指数:5
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相关领域:医药卫生更多>>
相关作者:赵传胜楼东东吴逊王薇薇谭岩更多>>
相关机构:中国医科大学附属第一医院牡丹江医学院北京医科大学第一医院山西省儿童医院更多>>
相关期刊:《国外新药介绍》《World Journal of Pediatrics》《Acta Epileptologica》《World Journal of Clinical Cases》更多>>
相关基金:国家教育部博士点基金吉林省杰出青年科学基金国家自然科学基金更多>>
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Successful medical treatment of west syndrome with a KCNA2 variant: a case report
《Acta Epileptologica》2022年第1期62-70,共9页Han Wang Yanwei Zhu Dezhi Cao Hong Chen Xin Ding Qi Zeng Huafang Zou Jianxiang Liao 
This study was sponsored by the Sanming Project of Medicine in Shenzhen(SZSM 201812005);Shenzhen Key Medical Discipline Construction Fund(SZXK033);Epilepsy Research Fund of China Association Against Epilepsy(CU-C-2021-02);Support Project for Clinical Research of Young and Middle-aged Doctors in South of the Ten Ridges Neurology(Z20210308).
Background:West syndrome is a devastating disorder characterized by a triad of epileptic spasms,abnormal electroencephalography(EEG),and developmental arrest or psychomotor delay.In addition to early diagnosis,knowing...
关键词:EPILEPSY Gene variation KCNA2 West syndrome TOPIRAMATE 
Clinical characteristics of two cohorts of infantile spasms: response to pyridoxine or topiramate monotherapy被引量:7
《World Journal of Pediatrics》2018年第3期290-297,共8页Jiao Xue Ping Qian Hui Li Ye Wu Hui Xiong Yue-Hua Zhang Zhi-Xian Yang 
Background Infantile spasms (IS) was an epileptic disease with varied treatment widely among clinicians. Here, we aimed to compare and analyze the clinical characteristics of IS response to pyridoxine or topiramate mo...
关键词:INFANTILE SPASMS PYRIDOXINE TOPIRAMATE 
Topiramate as a neuroprotective agent in a rat model of spinal cord injury被引量:1
《Neural Regeneration Research》2017年第12期2071-2076,共6页Firat Narin Sahin Hanalioglu Huseyin Ustun Kamer Kilinc Burcak Bilginer 
partly supported by Turkish Neurosurgical Society
Topiramate(TPM) is a widely used antiepileptic and antimigraine agent which has been shown to exert neuroprotective effects in various experimental traumatic brain injury and stroke models. However, its utility in s...
关键词:nerve regeneration spinal cord injury TOPIRAMATE NEUROPROTECTION oxidative damage NITRICOXIDE motor function neural regeneration 
Topiramate induced peripheral neuropathy:A case report and review of literature被引量:1
《World Journal of Clinical Cases》2017年第12期446-452,共7页Sherifa Ahmed Hamed 
Drug-induced peripheral neuropathy had been rarely reported as an adverse effect of some antiepileptic drugs(AEDs) at high cumulative doses or even within the therapeutic drug doses or levels.We describe clinical and ...
关键词:TOPIRAMATE PERIPHERAL NEUROPATHY Sodium channel BLOCKADE ANTIEPILEPTIC DRUGS 
Paroxysmal kinesigenic dyskinesia presenting with transient involuntary twitching movements involving right leg in a 24-year-old man responding well to topiramate
《医学争鸣》2017年第1期62-64,共3页YU Yong-Peng SUN Ren-Tao REN Wei-Feng TAN Lan 
the National Natural Science Foundation of China(81400957)
Paroxysmal kinesigenic dyskinesia(PKD)is presented as a short paroxysmal attack of focal or generalized involuntary movement.The most common treatments for PKD are carbamazepine and phenytoin.Though the cases of clini...
关键词:paroxysmal kinesigenic dyskinesia TOPIRAMATE CARBAMAZEPINE 
Protective effect of topiramate on hypoxic-ischemic brain injury in neonatal rat被引量:4
《Asian Pacific Journal of Tropical Medicine》2014年第6期496-500,共5页Hong Jiang Juan-Juan Lei Yi-He Zhang 
supported by Social Development Science and Technology Research Projects of Shanxi Province(2011 ks-30)
Objective:To explore protective effeet of topiramate(TPM) on hypoxic—ischemic brain injury.Methods:A total of 360 neonatal rats were seleeted then randomly divided into sham operation group,ischemia and hypoxia group...
关键词:TPM Brain Injury NSE GABA 
An effective initial polytherapy for children with West syndrome被引量:1
《Neural Regeneration Research》2013年第17期1623-1630,共8页Feiyong Jia Huiyi Jiang Lin Du Ning Li Ji Sun Chunbo Niu 
Adrenocorticotropic hormone is recommended worldwide as an initial therapy for infantile spasms. However, infantile spasms in about 50% of children cannot be fully controlled by adrenocorticotropic hormone monotherapy...
关键词:neural regeneration brain injury West syndrome SPASM etiology POLYTHERAPY adrenocorticotropichormone TOPIRAMATE vitamin B6 intravenous immunoglobulin seizure-free ELECTROENCEPHALOGRAPH NEUROREGENERATION 
Development and Validation of LC-MS/MS Method for the Quantification of Chiral Separated R-Bicalutamide in Human Plasma
《American Journal of Analytical Chemistry》2013年第2期63-76,共14页N. T. Ramarao S. Vidyadhara R. L. C. Sasidhar B. Deepti R. Surendra Yadav 
A simple, rapid, specific and precise liquid chromatography—tandem mass spectrophotometric (LC-MS/MS) method was developed and validated for the quantification of chiral separated R-bicalutamide from S-bicalutamide, ...
关键词:LC-MS/MS R-Bicalutamide TOPIRAMATE VALIDATION Human Plasma 
Meta-analysis of efficacy of topiramate in migraine prophylaxis
《Neural Regeneration Research》2012年第23期1806-1811,共6页Yiyi Guo Ximei Han Tingmin Yu Gang Yao 
OBJECTIVE:To evaluate the treatment effects and safety of topiramate in migraine prophylaxis. DATA RETRIEVAL:We searched the Medline database,EMbase,Cochrane Library and China National Knowledge Infrastructure datab...
关键词:TOPIRAMATE MIGRAINE PROPHYLAXIS EFFICACY META-ANALYSIS neural regeneration 
Topiramate: An <i>in Vitro</i>and <i>in Vivo</i>Comparison between the Pharmacokinetic Properties of a Generic (Sincronil) and the Reference (Topamax) Formulation
《Pharmacology & Pharmacy》2012年第2期124-128,共5页Marco Prosdocimi Fethi Trabelsi Flavio Moroni 
The use of generic formulation of therapeutic agents may allow a significant reduction of costs for patients and the National Health Services. This is particularly true for drugs used in prolonged therapies such as to...
关键词:TOPIRAMATE MIGRAINE PHARMACOKINETICS 
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