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A morphologically transformable hypoxia-induced radical anion for tumor-specific photothermal therapy: 《Acta Pharmaceutica Sinica B》2024年第12期5407-5417,共11页Hongyu Wang Dengyuan Hao Qihang Wu Tingting Sun Zhigang Xie; supported by the National Natural Science Foundation of China(52003267 and 51973214);the Natural Science Foundation of Jilin Province(YDZJ202101ZYTS027,China).; Tumor microenvironment activatable therapeutic agents and their effective tumor accumula-tion are significant for selective tumor treatment.Herein,we provide an unadulterated nanomaterial combining the above advantage...; 关键词：Perylene diimide Morphological transformation Radical anion HYPOXIA TUMOR-SPECIFIC Photothermal therapy NANOFIBER Amino acid

Decreased Amino Acid Transporter LAT2 Is the Main Determinant of Impaired Protein Utilization During Aging: 《Engineering》2024年第11期88-98,共11页Rui Song Guang Li Liang Zhao Lili Qiu Xiyu Qin Xiaoxu Zhang Xiaoxue Liu Jun Zhou Mengxiao Hu Liwei Zhang Jiaqi Su Xinjuan Liu Xiaoyu Wang; funded by the National Key Research and Development Program of China(2023YFF1104502);the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(2022QNRC001).; As the global demographic shifts toward an aging population,understanding the efficiency of protein uti-lization in older adults becomes crucial.Our study explores the intricate relationship between protein intake and...; 关键词：AGING Protein utilization PEPTIDE Amino acid Large neutral amino acid transporter 2

Methylmalonic Acidemia: An Unusual Cause of Chronic Renal Disease in Adults: 《Open Journal of Nephrology》2024年第3期334-339,共6页Kamel El Reshaid Abdulrahman Al Kanderi; Background: Methylmalonic aciduria (MMA) is a genetic disorder of aminoacid metabolism, due to mutations in methylmalonyl-CoA mutase, which leads to the accumulation of methylmalonic acid in body fluids. Patients typi...; 关键词：Methylmalonic Acidemia Kidney Failure Metabolic Acidosis Autosomal Recessive Amino Acid Disorder Kreps Cycle Hyperammonia Vitamin 12 CARNITINE

氨基酸基防污可注射自融合水凝胶的制备及其在术后防粘连中的应用被引量：1: 《Science China Materials》2024年第5期1521-1532,共12页李萌张梦园刘正谢瑞琳杨宇轩申锴翔杨爱民成一龙; financially supported by the National Natural Science Foundation of China(52322309 and 52173139);the"Young Talent Support Plan"of Xi’an Jiaotong University;the Fundamental Research Funds for the Central Universities(xzy022022015 and xzy022023018)。; 设计和制备具有优异防污能力的可注射防粘连材料对预防手术后组织和器官的粘连具有重要的意义.在此,我们将含有羟基的氨基酸衍生物引入水凝胶的制备中,通过N-丙烯酰丝氨酸(ASer)的自由基聚合制备了一种新型的氢键交联水凝胶(PASer).结...; 关键词：HYDROGEL INJECTABILITY ANTIFOULING amino acid abdominal adhesion

Edaravone-loaded poly(amino acid) nanogel inhibits ferroptosis for neuroprotection in cerebral ischemia injury被引量：1: 《Asian Journal of Pharmaceutical Sciences》2024年第2期89-101,共13页Yunhan Zhang Zhulin Zou Shuang Liu Fangfang Chen Minglu Li Haoyang Zou Haiyan Liu Jianxun Ding; supported by the National Natural Science Foundation of China(Grant No.U23A20591,52203201,52173149,and 81971174);the Youth Talents Promotion Project of Jilin Province(Grant No.202019);the Science and Technology Development Program of Jilin Province(Grant No.20210101114JC);Research Cooperation Platform Project of Sino-Japanese Friendship Hospital of Jilin University and Basic Medical School of Jilin University(Grant No.KYXZ2022JC04).; Neurological injury caused by ischemic stroke is a major cause of permanent disability and death. The currently available neuroprotective drugs fail to achieve desired therapeutic efficacy mainly due to short circulat...; 关键词：Poly(amino acid)nanogel Controlled drug delivery Inhibition of ferroptosis NEUROPROTECTION Cerebral ischenia injury therapy

Correction to:Amino acid-based enteral nutrition is effective for pediatric Crohn’s disease:a multicenter prospective study: 《Gastroenterology Report》2024年第1期872-872,共1页; This is a correction to:Qingfan Yang,Ting Zhang,Na Diao,Kang Chao,Huijun Shu,Jie Wu,Dexiu Guan,Li Wang,Xiwei Xu,Zhenghong Li,Xiang Gao,Amino acid-based enteral nutrition is effective for pediatric Crohn’s disease:a m...; 关键词：PEDIATRIC PROSPECTIVE CROHN

Taurine: a promising nutraceutic in the prevention of retinal degeneration被引量：2: 《Neural Regeneration Research》2024年第3期606-610,共5页Diego García-Ayuso Johnny Di Pierdomenico Ana Martínez-Vacas Manuel Vidal-Sanz Serge Picaud María PVillegas-Pérez; supported by Instituto de Salud CarlosⅢ(ISCⅢ):PI19/00203;cofunded by ERDF;"A way to make Europe"to MPVP and DGA;P122/00900;RD16/0008/0026 co-funded by ERDF;"A way to make Europe"to MPVP and RD21/0002/0014;financiado porla Unión Europea-NextGenerationEU;Fundación Robles Chillida to DGA;RED2018-102499-T;PID201 9-106498GB-I00;funded by MCIN/AEI/10.13039/501100011 033 to MVS;IHU FOReSIGHT[ANR-18-IAHU-0001] to SP; Taurine is considered a non-essential amino acid because it is synthesized by most mammals.However,dietary intake of taurine may be necessary to achieve the physiological levels required for the development,maintenanc...; 关键词：amino acid ANTI-INFLAMMATORY ANTIOXIDANT gamma-aminobutyric acid NUTRACEUTICAL photoreceptor degeneration RETINA retinitis pigmentosa TAURINE

Amino acid-based enteral nutrition is effective for pediatric Crohn’s disease:a multicenter prospective study被引量：1: 《Gastroenterology Report》2024年第1期3-10,共8页Qingfan Yang Ting Zhang Na Diao Kang Chao Huijun Shu Jie Wu Dexiu Guan Li Wang Xiwei Xu Zhenghong Li Xiang Gao; supported by the Guangdong Provincial Key Laboratory of Microecological Preparations[grant number 2022B1212020004];the Medical Scientific Research Foundation of Guangdong Province of China[grant number A2022099];the program of Guangdong Provincial Clinical Research Center for Digestive Diseases[grant number 2020B1111170004].; Background:Exclusive enteral nutrition(EEN)therapy effectively induces remission in pediatric Crohn’s disease(CD).However,this may depend on the type of enteral formula used.Moreover,data on the efficacy of amino aci...; 关键词：pediatric Crohn’s disease exclusive enteral nutrition amino acid-based enteral formula prospective study effectiveness nutrition improvement

New paradigm of oral rehydration in patients affected by irritable bowel syndrome with chronic diarrhea: 《World Journal of Gastrointestinal Pharmacology and Therapeutics》2024年第1期1-4,共4页Marco Chiarelli Matilde De Simone Gerardo Cioffi Ugo Cioffi; Irritable bowel syndrome with diarrhea is a very frequent clinical condition characterized by disabling intestinal symptoms.This disease presents with daily abdominal pain for at least 3 months related to defecation a...; 关键词：DIARRHEA Irritable bowel syndrome Diarrhea-predominant irritable bowel syndrome Medical food Amino acid beverage formulation

Dual Functional Diblock Amino Acid Copolymer Displaying Synergistic Effect with Curcumin against MRSA and Encapsulation of Curcumin被引量：1: 《Chinese Journal of Chemistry》2023年第23期3333-3338,共6页Yueming Wu Yuan Chen Haowen Yu Alideertu Dong Runhui Liu; supported by the National Key Research and Development Program of China(2022YFC2303100);the National Natural Science Foundation of China(Nos.52203162,22075078);Program of Shanghai Academic/Technology Research Leader(20xD1421400);China National Postdoctoral Program for Innovative Talents(Bx20220108);the China Postdoctoral Science Foundation(2021M701198);Open Research Fund of State Key Laboratory of Polymer Physics and Chemistry(Changchun Institute of Applied Chemistry,Chinese Academy of Sciences),the Open Project of Engineering Research Center of Dairy Quality and Safety Control Technology(Ministry of Education,R202201);Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission);Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization in this manuscript.; The intensive use of antibiotics intensifies the development of bacterial resistance,which has become a serious problem globally.Methicillin-resistant Staphylococcus aureus(MRSA)has resulted in significant morbidity a...; 关键词：Amino acid polymer Antimicrobial Synergy ENCAPSULATION MRSA

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