DEFENSINS

作品数：20被引量：64H指数：5
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相关领域：医药卫生更多>>
相关作者：冯云祝秉东夏明明王英李萌更多>>
相关机构：四川大学东南大学第三军医大学上海医科大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Signal Transduction and Targeted Therapy》《World Journal of Diabetes》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划江苏省自然科学基金更多>>
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Mechanisms and regulation of defensins in host defense被引量：7
《Signal Transduction and Targeted Therapy》2023年第9期3985-4014,共30页Jie Fu Xin Zong Mingliang Jin Junxia Min Fudi Wang Yizhen Wang 
We gratefully acknowledge the financial support provided by the Zhejiang Provincial Key R&D Program of China(2021C02008);the China Agriculture Research System of MOF and MARA(CARS-35);the National Natural Science Foundation of China(Grant Nos.32002185,31930057 and U21A20249);the National Key R&D Program(2018YFA0507802);Taishan Industrial Leading Talents Project;Program from National Center of Technology Innovation for Pigs for this study。
As a family of cationic host defense peptides,defensins are mainly synthesized by Paneth cells,neutrophils,and epithelial cells,contributing to host defense.Their biological functions in innate immunity,as well as the...
关键词：IMMUNITY HOMEOSTASIS LUNG 
Role of defensins in diabetic wound healing
《World Journal of Diabetes》2022年第11期962-971,共10页Zhi-Xiang Tan Rui Tao Si-Cheng Li Bing-Zheng Shen Lan-Xia Meng Zhan-Yong Zhu 
Supported by the Scientific Research Project of Hubei Health Committee,No.WJ2021F106.
The adverse consequences resulting from diabetes are often presented as severe complications.Diabetic wounds are one of the most commonly occurring complications in diabetes,and the control and treatment of this is co...
关键词：DEFENSIN Diabetic wound Wound healing INFLAMMATION RE-EPITHELIALIZATION Tissue regeneration 
Defensins as a promising class of tick antimicrobial peptides: a scoping review被引量：1
《Infectious Diseases of Poverty》2022年第3期84-84,共1页Jiahui Wu Xia Zhou Qiaoqiao Chen Zhiqiang Chen Jinyu Zhang Lele Yang Yuxuan Sun Guohui Wang Jianfeng Dai Tingting Feng 
This work was supported by the Priority Academic Program Development of Jiangsu Higher Education Institutions,National Natural Science Foundation of China(81971917,32170142 and 81271792);Jiangsu Natural Science Foundation(BK20211310);Open Project Fund from State Key Laboratory of Genetic Engineering,Fudan University(SKLGE1903);the Jiangsu Undergraduate Training Program for Innovation and Entrepreneurship,Soochow University(202010285133Y);the 23rd Undergraduates Extracurricular Academic Research Fund,Soochow University(KY20210120A).
Background: Ticks are hematophagous parasites that transmit an extensive range of pathogens to their vertebrate hosts.Ticks can destroy invading microorganisms or alleviate infection via their rudimentary but orchestr...
关键词：TICK Antimicrobial peptide DEFENSIN Antimicrobial activity 
The alteration of gut microbiota by bioactive peptides:a review被引量：1
《Systems Microbiology and Biomanufacturing》2021年第4期363-377,共15页Zitao Guo Dalong Yi Bo Hu Yi Shi Yu Xin Zhenghua Gu Huaigao Liu Liang Zhang 
This present work was funded by the National First-Class Discipline Program of Light Industry Technology and Engineering(LITE2018-22);the National Key Research&Developmental Program of China(2018YFA0900304).
Evidences suggest that the homeostasis of gut microbiota is among the most important factors for maintaining the physical and mental health of the host.Among the multiple factors affecting the homeostasis of gut micro...
关键词：Bioactive peptides Gut microbiota FOOD DEFENSINS BACTERIOCINS 
DICER1 regulates antibacterial function of epididymis by modulating transcription of p-defensins被引量：4
《Journal of Molecular Cell Biology》2019年第5期408-420,共13页Chunhua Tang Minjie Ni Shengsong Xie Yao Zhang Chaobao Zhang Zimei Ni Chen Chu Ligang Wu Yuchuan Zhou Yonglian Zhang 
the National Basic Research Program of China(973 Program;2014CB943103);the National Natural Science Foundation of China(31471104,31671203,and 31571192).
DICER1 is a key enzyme responsible for the maturation of microRNAs. Recent evidences suggested that DICER1 and microRNAs expressed in epididymis were involved in the control of male fertility. However, the exact mecha...
关键词：EPIDIDYMIS ANTIBACTERIAL PROPERTY DICER1 Β-DEFENSIN 
Human Beta Defensins 1,2 and 3 Produced by Amniochorion Membranes Is Similar in Term and Preterm Delivery
《Open Journal of Obstetrics and Gynecology》2017年第8期846-857,共12页Nathália Mayumi Noda-Nicolau Jossimara Polettini Camila Marconi José Carlos Peracoli Hélio Amante Miot Márcia Guimaraes da Silva 
Amniochorion membranes were collected from 25 pregnant women at preterm labor, in the presence or not of Preterm Premature Rupture of Membranes (PPROM) and 27 pregnant women at term in the presence at labor, in order ...
关键词：Preterm Birth Amniochorion Membranes Human Beta Defensins 
Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes被引量：4
《World Journal of Gastroenterology》2014年第27期9128-9137,共10页Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi 
Supported by TáMOP-4.2.2.A-11-1-KONV-2012-0035 Research Grant
AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.
关键词：α-defensins HNP1-3 β-defensin 1 DIABETES Copy number polymorphism Single nucleotide polymorphism 
Fungal defensins, an emerging source of anti-infective drugs
《Chinese Science Bulletin》2014年第10期931-935,共5页Yucheng Wu Bin Gao Shunyi Zhu 
supported by the National Basic Research Program of China(2010CB945300);the National Natural Science Foundation of China(31221091)
With the rapid increase of antibiotic-resistant pathogens and the decline of discovery and development of new antibiotics,there is an urgent need to exploit alternative anti-infective drugs.Fungal defensin-like peptid...
关键词：ANTIBIOTIC-RESISTANCE Micasin FUNGUS 
Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome被引量：4
《World Journal of Gastroenterology》2014年第2期363-375,共13页Jan Dabritz Jason Musci Dirk Foell 
A research fellowship awarded to Dabritz J by the German Research Foundation;No.DFG DA1161/5-1
Irritable bowel syndrome(IBS)is a common functional gastrointestinal(GI)disorder characterized by unspecific symptoms.In clinical practice it is crucial to distinguish between non-inflammatory functional problems and ...
关键词：S100A12 CALPROTECTIN LACTOFERRIN M2-pyruvate kinase Polymorphonuclear elastase DEFENSINS Granins Irritable bowel syndrome 
Natural Antimicrobial Peptides: Pleiotropic Molecules in Host Defense被引量：1
《CellBio》2013年第4期200-210,共11页Mercedes Leonor Sánchez Melina María Belén Martínez Paulo César Maffia 
Natural antimicrobial peptides (AMPs) are small cationic molecules that display antimicrobial activity against a wide range of bacteria, fungi and viruses. AMPs are multifunctional molecules that have an essential act...
关键词：ANTIMICROBIAL PEPTIDES Immune Response CATHELICIDINS DEFENSINS SLPI 
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