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DEPENDENT: 作品数：1277被引量：2392H指数：17; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：徐兴忠马建军黄莹蒋伶活陈柏林更多>>; 相关机构：中国科学院东南大学清华大学浙江大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>

MRE11 mobilizes CGAS and drives ZBP1-dependent necroptosis: 《Cell Research》2024年第7期477-478,共2页Manuel Beltrán-Visiedo Siddharth Balachandran Lorenzo Galluzzi; Recent data from Cho et al.demonstrate that the DNA repair protein MRE11 liberates CGAS from nucleosomes to license type I interferon secretion upon oncogenic stress and ionizing radiation.MRE11-mediated CGAS activati...; 关键词：INTERFERON HOMEOSTASIS ENDOGENOUS

CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation被引量：4: 《Cell Research》2022年第8期744-760,共17页Chao Wei Lumeng Jia Xiaona Huang Jin Tan Mulan Wang Jing Niu Yingping Hou Jun Sun Pengguihang Zeng Jia Wang Li Qing Lin Ma Xinyi Liu Xiuxiao Tang Fenjie Li Shaoshuai Jiang Jingxin Liu Tingting Li Lili Fan Yujie Sun Juntao Gao Cheng Li Junjun Ding; funded by grants from the National Key R&D Program(2017YFA0102800);the National Natural Science Foundation of China(31970811,31771639 and 32170798);the Guangdong Regenerative Medicine and Health of Guangdong Laboratory Frontier Exploration Project(2018GZR110105007);the Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06S029);Guangdong Basic and Applied Basic Research Foundation(2021B1515120063)to J.D.;the National Natural Science Foundation of China(32100497);Post-doctoral Program(2021M703760)to C.W.;the Fundamental Research Funds for the Central Universities of Jinan University(Natural Science)(116210004);China Postdoctoral Science Foundation(55350600);the Natural Science Foundation of Guangdong Province,China(2021A1515010938)to J.S.;the National Natural Science Foundation of China(31900519)to F.L.;the Natural Science Foundation of China(32025006,31871266);National Key R&D Program of China(2021YFA1100300,2016YFA0100103)to L.J.and C.L.;Part of the data analysis was performed on the High Performance Computing Platform of the Center for Life Sciences,Peking University.This work was also supported in part by the State Key R&D Program of China(2017YFA0505503);the National Natural Science Foundation of China(81890991);CAS Interdisciplinary Innovation Team(JCTD-2020-04);Beijing Municipal Natural Science Foundation(Z200021)to J.G.For FISH experiment。; Chromatin is spatially organized into three-dimensional structures at different levels including A/B compartments, topologically associating domains and loops. The canonical CTCF-mediated loop extrusion model can expl...; 关键词：CTCF RYBP SEPARATION

m^6A-dependent biogenesis of circular RNAs in male germ cells被引量：20: 《Cell Research》2020年第3期211-228,共18页Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan; supported by grants from the NIH(HD071736 and HD085506 to W.Y.);the Templeton Foundation(PID:61174 to W.Y.);RNA-seq was conducted in the Single Cell Genomics Core of the University of Nevada,Reno School of Medicine,which was supported,in part,by the NIH COBRE Grant(P30GM110767 to W.Y.);Bioinformatics and RPAD-seq were,in part,carried out in the BGI Co.Ltd,with the support of a grant from the Science,Technology and Innovation Commission of Shenzhen Municipality(JSGG20170824152728492 to C.T.);supported by grants from the Natural Science Foundation of Guangdong Province(2015A030313884 and 2018A030313528 to Y.T.and W.Q.);the Science and Technology Projects of Guangzhou(201607010137 and 201804010431 to W.Q.and Y.T.);the Family Planning Research Institute of Guangdong Province(S2014001 to Y.T.).; The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing...; 关键词：CIRCULAR mostly FRAMES

Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS被引量：9: 《Cell Research》2019年第1期67-79,共13页Tianzi Liuyu Keying Yu Liya Ye Zhidong Zhang Man Zhang Yujie Ren Zeng Cai Qiyun Zhu Dandan Lin Bo Zhong; the Ministry of Science and Technology of China (2014CB542601);Natural Science Foundation of China (31521091,31601131,31671454 and 31622036);National Natural Science Foundation of Hubei Province (2018CFA016);Wuhan University (2042017kf0199 and 2042017kf0242);State Key Laboratory of Veterinary Etiological Biology (SKLVEB2017KFKT004).; The activity and stability of the adapter protein MAVS (also known as VISA, Cardif and IPS-1), which critically mediates cellular antiviral responses, are extensively regulated by ubiquitination. However, the process ...; 关键词：MAVS the IRF3/7-dependent

Cdhl regulates craniofacial development via APC- dependent ubiquitination and activation of Goosecoid被引量：2: 《Cell Research》2016年第6期699-712,共14页Rui Shao Jia Liu Guang Yan Jinfang Zhang Yujiao Han Jianfeng Guo Zhan Xu Zhu Yuan Jiankang Liu Marcos Malumbres Lixin Wan Wenyi Wei Weiguo Zou; Acknowledgments We thank Brian North, Shavali Shaik, Aletn W. Lau, Matthew B. Greenblatt, Hiroyuki Inuzuka and Pengda Liu for critical reading of the manuscript, and members of the Zou and Wei labs for useful discussions. This work was supported by the Chinese Ministry of Science and Technology （MOST, 973 Program; 2014CB964704 and 2015CB964503）, the National Natural Science Foundation of China （NSFC; 31371463） and NIH （GM089763, GM094777 and CA177910 to WW）. WZ is a scholar of the ＇National I000 Young Talents Program of China＇ and ＇the National Science Fund for Excellent Young Scholars＇（NSFC; 81322027）. WW is a Leukemia and Lymphoma Society Scholar and ACS Research Scholar.; Craniofacial anomalies （CFAs） characterized by birth defects of skull and facial bones are the most frequent congenital disease. Genomic analysis has identified multiple genes responsible for CFAs; however, the unde...; 关键词：APC Cdhl Wwp2 GOOSECOID Sox6 craniofacial development craniofacial anomalies

Park7 interacts with p47phox to direct NADPH oxidase- dependent ROS production and protect against sepsis被引量：5: 《Cell Research》2015年第6期691-706,共16页Wenjun Liu Hailong Wu Lili Chen Yankai Wen Xiaoni Kong Wei-Qiang Gao; Inappropriate inflammation responses contribute to mortality during sepsis. Through Toll-like receptors （TLRs）, reactive oxygen species （ROS） produced by NADPH oxidase could modulate the inflammation responses. Pa...; 关键词：Park7 INFLAMMATION SEPSIS NADPH oxidase

Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics被引量：22: 《Cell Research》2015年第6期707-725,共19页Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim; Receptor-interacting protein kinase-3 （RIP3 or RIPK3） is an essential part of the cellular machinery that executes ＂programmed＂ or ＂regulated＂ necrosis. Here we show that programmed necrosis is activated in resp...; 关键词：RIP3 （RIPK3） MLKL programmed necrosis CHEMOTHERAPY hypomethylating agents

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis被引量：132: 《Cell Research》2014年第12期1403-1419,共17页Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang; The role of Fat Mass and Obesity-associated protein （FTO） and its substrate N6-methyladenosine （m6A） in mRNA processing and adipogenesis remains largely unknown. We show that FTO expression and m6A levels are inve...; 关键词：N6-methyladenosine （m6A） METTL3 FTO mRNA splicing ADIPOGENESIS

Phosphorylation-dependent interaction between tumor suppressors Dig and Lgl: 《Cell Research》2014年第4期451-463,共13页Jinwei Zhu Yuan Shang Qingwen Wan Yitian Xia Jia Chen Quansheng Du Mingjie Zhang; The tumor suppressors Discs Large （Dig）, Lethal giant larvae （Lgl） and Scribble are essential for the establishment and maintenance of epithelial cell polarity in metazoan. Dig, Lgl and Scribble are known to inter...; 关键词：DIG Lgl cell polarity tumor suppressor phosphorylation-dependent interaction crystal structure

S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance被引量：12: 《Cell Research》2011年第12期1723-1739,共17页Jiqin Zhang Qinqin Gao Pishun Li Xiaoli Liu Yuanhui Jia Weicheng Wu Jiwen Li Shuo Dong Haruhiko Koseki Jiemin Wong; Recent studies demonstrate that UHRF1 is required for DNA methylation maintenance by targeting DNMT1 to DNA replication foci, presumably through its unique hemi-methylated DNA-binding activity and interaction with DNM...; 关键词：UHRF2 UHRF 1 DNA methylation histone methylation DNMT1

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