GENE_TRANSFER

作品数：204被引量：510H指数：11
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相关作者：王晶江洪黄从新李庚山李建军更多>>
相关机构：武汉大学中国医学科学院阜外心血管医院大连民族大学青岛大学医学院附属医院更多>>
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Non-integrating lentiviral vectors based on the minimal S/MAR sequence retain transgene expression in dividing cells被引量：1
《Science China(Life Sciences)》2016年第10期1024-1033,共10页Zhen Xu Feng Chen Lingling Zhang Jing Lu Peng Xu Guang Liu Xuemin Xie Wenli Mu Yajun Wang Depei Liu 
supported by the Major State Basic Research Development Program of China(2011CB965203)
Safe and efficient gene transfer systems are the basis of gene therapy applications. Non-integrating lentiviral(NIL) vectors are among the most promising candidates for gene transfer tools, because they exhibit high t...
关键词：gene transfer non-integrating lentivirus scaffold/matrix attachment region （S/MAR） episomal vectors 
Membrane immunoglobulin expressed by retroviral vector gene transfer mimics partial function of the B-cell receptor in vivo被引量：1
《Science China(Life Sciences)》2016年第1期49-58,共10页Jing Lu Feng Chen Zhen Xu Lingling Zhang Peng Xu Depei Liu Chihchuan Liang 
supported by the National Basic Research Program of China(2011CB965203)to Yue Huang
Activation of B-cells is initiated by the ligation of B-cell receptors by its cognate antigen, inducing a series of signal cascades. Understanding the molecular mechanisms of these important events is a crucial goal f...
关键词：BCR membrane immunoglobuUn retroviral vector 
Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma被引量：6
《Science China(Life Sciences)》2010年第10期1215-1220,共6页WANG GuiLan LU JiRong 
This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on airway inflammation and airway responsiveness in asthmatic mice. The retrovirus-mediated delivery ...
关键词：asthma model retrovirus vector IL-4RA gene transfer 
Treatment of chronical myocardial ischemia by adenovirus-mediated hepatocyte growth factor gene transfer in minipigs被引量：1
《Science China(Life Sciences)》2008年第6期537-543,共7页YUAN Biao ZHANG YouRong ZHAO Zhong WU DanLi YUAN LiZhen WU Bin WANG LiSheng HUANG Jun 
National "863" Programme (Grant Nos. 2003AA216080 and 2007AA021007)
Growth factor gene transfer-induced therapeutic angiogenesis has become a novel approach for the treatment of myocardial ischemia. In order to provide a basis for the clinical application of an adeno- virus with hepat...
关键词：gene therapy hepatocyte growth factor ADENOVIRUS chronical ischemic myocardium therapeutic angiogenesis 
A study of gene transfer and expression of human clotting factor IX in Hemophilia B mice mediated by mini-adenoviral vector被引量：1
《Science China(Life Sciences)》2003年第6期631-640,共10页高啸波 叶晨波 侍鼎 陈立 邱信芳 薛京伦 
supported by the State High Technology Development Program(863).
Vector GtiIX containing human clotting factor IX cDNA with intron 1 (hFIX mini-gene or Fi’IX) driven by CMV promoter was constructed based on the mini-adenoviral vector GT2073 (mini-Ad vector) with all viral protein ...
关键词：HEMOPHILIA B  mini-adenovirus  HUMAN CLOTTING factor IX mini-gene  gene therapy  HEMOPHILIA B mouse. 
Skeletal muscle-specific expression of human blood coagulation factor Ⅸ rescues factor Ⅸ deficiency mouse by AAV-mediated gene transfer被引量：5
《Science China(Life Sciences)》1999年第6期628-634,共7页赖立辉 陈立 卢大儒 王琪 高啸波 邱信芳 Jerry L.Hsueh 薛京伦 王健民 周虹 
Project supported by the State High Technology Development Program (863-Z20-02-01);Shanghai Postdoctoral Foundation and National Natural Science Foundation of China (Grant No. 39880019).
The efficacy of recombinant adeno-associated virus (AAV) vector to deliver and express human blood clotting factor DC (hFIX) gene in skeletal muscle of coagulation factor IX deficiency mouse strain (FactorIX-knockout)...
关键词：AAV hFIX FACTOR IX DEFICIENCY MOUSE direct-muscular gene therapy. 
Asialoglycoprotein receptor and liposome synergistically mediate the gene transfer into primary rat hepatocytes
《Science China(Life Sciences)》1999年第4期435-440,共6页李崇辉 温守明 翟海峰 孙曼霁 
Gene transfer into primary rat hepatocytes was performed by employing cationic liposome as DNA carrier and the specific ligand of hepatic asialoglycoprotein receptor (ASGPR), asialofetuin, as liver-targeting ligand. T...
关键词：asialoglycoprotein receptor CATIONIC LIPOSOME RECEPTOR-MEDIATED gene transfer primary hepatocyte. 
Baculovirus-mediated gene transfer into mammalian cells
《Science China(Life Sciences)》1998年第5期473-478,共6页朱应 齐义鹏 刘子夜 肖庚富 
A kind of cytotoxinic gene barnase was cloned downstream of immediate early promoter from cytomegalovirus (CMV). Recombinant virus vAcCMVBar was constructed using Bac\|to\|Bac system by insertion of the expression cas...
关键词：ACNPV BARNASE gene MAMMALIAN cells. 
Electro-acupuncture-mediated gene transfer
《Science China(Life Sciences)》1998年第5期555-560,共6页张继峰 秦阳君 付爱华 汤健 陈光慧 蔡东 韩济生 
Gene transfer is one of the key techniques in gene therapy application. Unfortunately, it seems that by now, there still exists no approach with simplicity, easiness, efficiency and safety. A novel method for gene del...
关键词：electro\|acupuncture gene transfer. 
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