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Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1
《Bio-Design and Manufacturing》2025年第2期288-309,I0005-I0011,共29页Qing Zhang Chengxun He Juan Guo Dandan Tang Die Qian Chuan Zheng Chunjie Wu Wei Peng 
supported by the Natural Science Foundation of Sichuan Province(No.2022NSFSC0720);Research Center for the Development of the Comprehensive Health Industry and Rural Revitalization of Sichuan TCM(No.DJKYB202306);State Administration of Traditional Chinese Medicine of Sichuan Province of China(No.2020HJZX001).
Obesity has become a global threat to health;however,the available drugs for treating obesity are limited.We investigated the anti-obesity effect of hydroxy-α-sanshool(HAS),an amide derived from the fruit of Zanthoxy...
关键词：Hydroxy-α-sanshool Adipocyte targetability Mesoporous silica nanoparticles White adipose tissue browning OBESITY 
Transition metal sulfides in alkaline hydrogen evolution electrocatalysis:Re-exploring their structure and composition evolution and its correlation with activity
《Nano Research》2025年第3期153-168,共16页Chengqi Wu Jiaqi Liu Yiwei Tan 
financially supported by the Six Talent Peaks Project in Jiangsu Province(No.JNHB-043);the Research Fund of State Key Laboratory of Materials-Oriented Chemical Engineering(No.ZK201713);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX21_1174).
Herein,the activity and stability evolution of transition metal sulfides used as electrocatalysts for alkaline hydrogen evolution reaction(HER)are studied during a prolonged HER period.We have thoroughly characterized...
关键词：hydrogen evolution reaction transition metal sulfides alkaline water electrolysis amorphous structures metal hydroxy salts Pourbaix diagrams 
Ustusolate E and 11α-Hydroxy-Ustusolate E induce apoptosis in cancer cell lines by regulating the PI3K/AKT/mTOR and p-53 pathways
《Chinese Journal of Natural Medicines》2025年第3期346-353,共8页Mewlude Rehmutulla Sitian Zhang Jie Yin Jianzheng Huang Yang Xiao Zhengxi Hu Qingyi Tong Yonghui Zhang 
supported by the Program for Changjiang Scholars of the Ministry of Education of the People's Republic of China(No.T2016088);the National Natural Science Foundation for Distinguished Young Scholars(No.81725021);the National Key R&D Program of China(No.2021YFA0910500);the Science and Technology Major Project of Hubei Province(No.2021ACA012);the Innovative Research Groups of the National Natural Science Foundation of China(No.81721005);the Academic Frontier Youth Team of HUST(No.2017QYTD19);the Fundamental Research Funds for the Central Universities(No.2172019kfyXJS166).
Cancer represents a significant disease that profoundly impacts human health and longevity.Projections indicate a 47%increase in the global cancer burden by 2040 compared to 2020,accompanied by a further rise in the a...
关键词：Ustusolate E 11α-Hydroxy-ustusolate E Cancer PI3K/AKT/mTOR pathway p-53 Pathway 
地胆草中1个新的三萜
《中国中药杂志》2025年第5期1224-1230,共7页丁祖霄 谢红茜 陈林 郝俊杰 罗艳秋 江志勇 徐士奎 
云南省市场监管科学研究计划项目(2022YSJK08);兴滇英才支持计划项目;云南省科技计划项目重大科技专项生物医药专项(202402AA310030);云南省中医药联合专项重点项目(202101AZ070001-164);云南省教育厅高原特色民族药用植物研究科技创新团队项目;国家中医药管理局高水平中医药重点学科建设项目(Zyyzdxk-2023192)。
采用硅胶柱色谱、C18柱色谱、MCI柱色谱以及半制备型高效液相色谱等色谱手段对地胆草90%乙醇提取物的石油醚萃取部分进行化学成分研究,从中分离鉴定了10个化合物。通过1D NMR、2D NMR、MS、IR等波谱数据及理化性质分别鉴定为3β-hydrox...
关键词：地胆草 三萜 3β-hydroxy-6β 7β-epoxytaraxeran-14-ene 
Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia
《Nano Research》2025年第1期195-207,共13页Chun Zhu Yifei Yang Yike Jing Zhen Zeng Xuesong Yi Wei Sun Fei Yang 
supported by Hainan Province Science and Technology Special Fund(No.ZDYF2023GXJS165);National Natural Science Foundation of China(No.22102042);Hainan Province Key Scientific Research Project(No.ZDYF2021GXJS026)。
Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low conce...
关键词：nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed 
Controllable synthesis of hydrogen-bonded organic framework encapsulated enzyme for continuous production of chiral hydroxybutyric acid in a two-stage cascade microreactor
《Chinese Journal of Chemical Engineering》2025年第1期175-184,共10页Danyang Zhao Qiangqiang Xue Yujun Wang Guangsheng Luo 
supported by the National Key Research and Development Program of China(2019YFA0905100);the National Natural Science Foundation of China(21991102,22378227).
Constructing a framework carrier to stabilize protein conformation,induce high embedding efficiency,and acquire low mass-transfer resistance is an urgent issue in the development of immobilized enzymes.Hydrogen-bonded...
关键词：Hydrogen-bonded organic framework Immobilized enzyme Synthesis Chiral hydroxycarboxylic acid BIOCATALYSIS Nanostructure 
Vitamin D 1,25-Dihydroxyvitamin D_(3) reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization被引量：1
《World Journal of Gastrointestinal Oncology》2024年第12期4685-4699,共15页Wen-Jing Luo Xian-Wen Dong Hua Ye Qiao-Su Zhao Qiu-Bo Zhang Wen-Ying Guo Hui-Wei Liu Feng Xu 
Supported by the Natural Science Foundation of Ningbo,No.202003N4234;and Medical and Health Research Project of Zhejiang Province,No.2024KY1477.
BACKGROUND Non-alcoholic fatty liver disease(NAFLD),which is a significant liver condition associated with metabolic syndrome,is the leading cause of liver diseases globally and its prevalence is on the rise in most n...
关键词：Non-alcoholic fatty liver disease HEPATOCYTES MACROPHAGES Polarization Vitamin D receptor Peroxisome proliferator activated receptorγ 
^(t)BuOK/TMSOK-Mediated“Alkyl Halide to Alkyl Free Radical”Transformation for Transition-Metal-Free Benzoinα-C—H Alkylation
《Chinese Journal of Chemistry》2024年第23期3041-3046,共6页Zhouying Wang Lu Gan Zhibin Song Yunyun Liu Jie-Ping Wan 
financially supported by the National Natural Science Foundation of China(22161022,21861019).
The alkali tert-butoxide(^(t)BuOK or^(t)BuONa)mediated generation of aryl free radical from aryl iodide remarks a milestone discovery in the free radical chemistry.However,the equivalent“alkyl halide to alkyl free ra...
关键词：Alkyl halide Free radical α-Hydroxy ketone C-H bond ALKYLATION Transition metal-free 
Co-Catalyzed Dehydrogenation Claisen Condensation of Secondary Alcohols with Esters
《Chinese Journal of Chemistry》2024年第22期2818-2824,共7页Shuo Gao Wentao Hao Yuqi Ji Xiulin Li Chunyan Zhang Guoying Zhang 
supported by the National Natural Science Foundation of China(22002067,22202228);the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province(20220052);the Science and Technology Project of Shanxi Province(202103021223457,202303021221256);Research Project Supported by Shanxi Scholarship Council of China.
Catalytic dehydrogenation,with its exceptional atom economy and chemoselectivity,offers a highly desirable yet challenging approach for converting multiple environmentally friendly alcohols into crucial molecules.Furt...
关键词：Cobalt Pincer Ligand DEHYDROGENATION Claisen Condensation 3-Hydroxy-prop-2-en-1-one ALCOHOLS 3d transition metals ENOLS ENONES 
Research progress on the mechanism of exercise against depression被引量：1
《World Journal of Psychiatry》2024年第11期1611-1617,共7页Ya-Lin Zhao Shu-Ya Sun Hao-Cheng Qin Yu-Lian Zhu Zhi-Wen Luo Yuan Qian Shuo Chen 
Supported by Nanjing Municipal Sports Bureau Research Bureau Project-Building a Sports Hospital with Chinese Medicine Characteristics to Help Sports-Health Integration,No.NJTY2023-104;Exploring a New Model of“Integration of Sport and Health”,No.JSYGY-3-2023-506.
The substantial global health burden of depression encourages the development of innovative and broadly effective interventions.This paper aimed to examine recent advancements by which exercise works as an antidepress...
关键词：EXERCISE Depression Dose-response relationship Glucocorticoid cortisol 5-hydroxy tryptamine NOREPINEPHRINE 
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