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作品数：591被引量：894H指数：11
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相关机构：兰州大学中国药科大学北京大学中国科学院更多>>
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Hydroxy-α-sanshool-loaded adipose-targeted mesoporous silica nanoparticles induce white adipose browning and reduce obesity by activating TRPV1
《Bio-Design and Manufacturing》2025年第2期288-309,I0005-I0011,共29页Qing Zhang Chengxun He Juan Guo Dandan Tang Die Qian Chuan Zheng Chunjie Wu Wei Peng 
supported by the Natural Science Foundation of Sichuan Province(No.2022NSFSC0720);Research Center for the Development of the Comprehensive Health Industry and Rural Revitalization of Sichuan TCM(No.DJKYB202306);State Administration of Traditional Chinese Medicine of Sichuan Province of China(No.2020HJZX001).
Obesity has become a global threat to health;however,the available drugs for treating obesity are limited.We investigated the anti-obesity effect of hydroxy-α-sanshool(HAS),an amide derived from the fruit of Zanthoxy...
关键词：Hydroxy-α-sanshool Adipocyte targetability Mesoporous silica nanoparticles White adipose tissue browning OBESITY 
Transition metal sulfides in alkaline hydrogen evolution electrocatalysis:Re-exploring their structure and composition evolution and its correlation with activity
《Nano Research》2025年第3期153-168,共16页Chengqi Wu Jiaqi Liu Yiwei Tan 
financially supported by the Six Talent Peaks Project in Jiangsu Province(No.JNHB-043);the Research Fund of State Key Laboratory of Materials-Oriented Chemical Engineering(No.ZK201713);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX21_1174).
Herein,the activity and stability evolution of transition metal sulfides used as electrocatalysts for alkaline hydrogen evolution reaction(HER)are studied during a prolonged HER period.We have thoroughly characterized...
关键词：hydrogen evolution reaction transition metal sulfides alkaline water electrolysis amorphous structures metal hydroxy salts Pourbaix diagrams 
Surface embedded binary Co-Cu hydroxy phosphate over surface of oxy/hydroxides for efficient nitrate reduction to ammonia
《Nano Research》2025年第1期195-207,共13页Chun Zhu Yifei Yang Yike Jing Zhen Zeng Xuesong Yi Wei Sun Fei Yang 
supported by Hainan Province Science and Technology Special Fund(No.ZDYF2023GXJS165);National Natural Science Foundation of China(No.22102042);Hainan Province Key Scientific Research Project(No.ZDYF2021GXJS026)。
Electrochemical nitrate reduction reaction(NO3RR)to ammonia is a promising approach to address excess Ncontamination in aqueous environment but suffers from a limited ammonia yield and selectivity due to the low conce...
关键词：nitrate reduction hydroxy phosphate surface embedded water dissociation active hydroxy adsorbed 
Controllable synthesis of hydrogen-bonded organic framework encapsulated enzyme for continuous production of chiral hydroxybutyric acid in a two-stage cascade microreactor
《Chinese Journal of Chemical Engineering》2025年第1期175-184,共10页Danyang Zhao Qiangqiang Xue Yujun Wang Guangsheng Luo 
supported by the National Key Research and Development Program of China(2019YFA0905100);the National Natural Science Foundation of China(21991102,22378227).
Constructing a framework carrier to stabilize protein conformation,induce high embedding efficiency,and acquire low mass-transfer resistance is an urgent issue in the development of immobilized enzymes.Hydrogen-bonded...
关键词：Hydrogen-bonded organic framework Immobilized enzyme Synthesis Chiral hydroxycarboxylic acid BIOCATALYSIS Nanostructure 
Vitamin D 1,25-Dihydroxyvitamin D_(3) reduces lipid accumulation in hepatocytes by inhibiting M1 macrophage polarization被引量：1
《World Journal of Gastrointestinal Oncology》2024年第12期4685-4699,共15页Wen-Jing Luo Xian-Wen Dong Hua Ye Qiao-Su Zhao Qiu-Bo Zhang Wen-Ying Guo Hui-Wei Liu Feng Xu 
Supported by the Natural Science Foundation of Ningbo,No.202003N4234;and Medical and Health Research Project of Zhejiang Province,No.2024KY1477.
BACKGROUND Non-alcoholic fatty liver disease(NAFLD),which is a significant liver condition associated with metabolic syndrome,is the leading cause of liver diseases globally and its prevalence is on the rise in most n...
关键词：Non-alcoholic fatty liver disease HEPATOCYTES MACROPHAGES Polarization Vitamin D receptor Peroxisome proliferator activated receptorγ 
^(t)BuOK/TMSOK-Mediated“Alkyl Halide to Alkyl Free Radical”Transformation for Transition-Metal-Free Benzoinα-C—H Alkylation
《Chinese Journal of Chemistry》2024年第23期3041-3046,共6页Zhouying Wang Lu Gan Zhibin Song Yunyun Liu Jie-Ping Wan 
financially supported by the National Natural Science Foundation of China(22161022,21861019).
The alkali tert-butoxide(^(t)BuOK or^(t)BuONa)mediated generation of aryl free radical from aryl iodide remarks a milestone discovery in the free radical chemistry.However,the equivalent“alkyl halide to alkyl free ra...
关键词：Alkyl halide Free radical α-Hydroxy ketone C-H bond ALKYLATION Transition metal-free 
Co-Catalyzed Dehydrogenation Claisen Condensation of Secondary Alcohols with Esters
《Chinese Journal of Chemistry》2024年第22期2818-2824,共7页Shuo Gao Wentao Hao Yuqi Ji Xiulin Li Chunyan Zhang Guoying Zhang 
supported by the National Natural Science Foundation of China(22002067,22202228);the Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province(20220052);the Science and Technology Project of Shanxi Province(202103021223457,202303021221256);Research Project Supported by Shanxi Scholarship Council of China.
Catalytic dehydrogenation,with its exceptional atom economy and chemoselectivity,offers a highly desirable yet challenging approach for converting multiple environmentally friendly alcohols into crucial molecules.Furt...
关键词：Cobalt Pincer Ligand DEHYDROGENATION Claisen Condensation 3-Hydroxy-prop-2-en-1-one ALCOHOLS 3d transition metals ENOLS ENONES 
Synergistic solvent extraction of boric acid by trioctylamine and 2-hydroxydodecanoic acid
《Chinese Journal of Chemical Engineering》2024年第10期117-126,共10页Zhuojun Jiang Yufeng Liang Shuyao Xiong Guo Li Qian Zhang Benzheng Xia Liangrong Yang Zheng Li 
supported by the National Natural Science Foundation of China(22278407,21922814,22138012,22178349);CAS Project for Young Scientists in Basic Research(YSBR-038);National Key Research and Development Program of China(2021YFC2901500,2022YFC2105302);Shandong Energy Institute(SEI U202306).
A synergistic solvent extraction system comprising trioctylamine(TOA)and ligands with hydroxyl and carboxyl groups can efficiently recover boric acid(H_(3)BO_(3))and separate boron isotopes.However,the structure of li...
关键词：Boric acid 2-Hydroxydodecanoic acid Synergistic extraction Coordination mechanism Boron isotope separation 
8-Hydroxy-2'-Deoxyguanosine (8-OH-2dG) as a Biomarker of Oxidative Stress (OS) in the Acute Exacerbation of Spontaneous Preterm Birth (SPTB)
《Open Journal of Obstetrics and Gynecology》2024年第10期1548-1555,共8页Salma Abdi Mahmoud 
Spontaneous preterm birth (SPTB) is characterized by the delivery of a baby before 37 completed weeks of gestation, and this condition is associated with significant health challenges for the newborn. Emerging evidenc...
关键词：Preterm Birth 8-Hydroxy-2'-Deoxyguanosine Oxidative Stress DNA Damage 
Allosteric regulation of Keap1 by 8β-hydroxy-acyclocostunolide for the treatment of acute lung injury
《Acta Pharmaceutica Sinica B》2024年第9期4174-4178,共5页Juan Zhang Min Zhang Qi-Meng Zhu Xin-Rong Xu Yan-Li Feng Sheng Lin Feng Qiu Cheng-Peng Sun 
National Natural Science Foundation of China(No.82274069,82030116,and 82141212);China Postdoctoral Science Foundation(No.2022M720095 and 2023T160434);Young Elite Scientists Sponsorship Programby China Association of Chinese Medicine(No.2022-QNRC2-B09).
To the Editor:Acute lung injury(ALI)is a debilitating lung disease characterized by pulmonary edema,diffuse alveolar damage,and uncontrolled neutrophil infiltration^(1).Severe cases of ALI can potentially lead to the ...
关键词：Macrophage overactivation KEAP1 8β-Hydroxy-a-cyclocostunolide Nrf2 Acute lung injury 
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