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JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells被引量：2
《Acta Pharmacologica Sinica》2015年第9期1099-1106,共8页Yuan LIU Xia ZHANG Juan WANG Jun YANG Wen-fu TAN 
This work was financially supported by National Natural Science Foundation of China （81173077）.
Aim： Many studies reveal an association between the acquired chemoresistant phenotype of cancer cells and tumor-initiating cell- like properties. The aim of this study was to determine the impact of c-Jun N-terminal ...
关键词：drug therapy JNK mitogen-activated protein kinases K562 cells KB cells HEDGEHOG tumor-initiating cell-like properties 
Mixture of five herbal extracts ameliorates pioglitazone-induced aggravation of hepatic steatosis via activating the adiponectin receptor 2/AMP-activated protein kinase signal pathway in diabetic KKAy mice被引量：1
《Journal of Traditional Chinese Medicine》2017年第5期588-598,共11页Wang Haiyan Li Linyi Qin Lingling Wang Dongchao Jiang Yueying Wu Xinli Xu Tunhai Liu Tonghua 
Supported by the Science and Technology Support Program of China(No.2014BAI10B04)
OBJECTIVE: To assess the effect of a mixture of five herbal extracts(FT-5) on insulin resistance, glucose/lipid metabolism, hepatic steatosis, and to investigate whether the combination of FT-5 and pioglitazone would ...
关键词：Pioglitazone Insulin resistance Hepatic steatosis AMP-activated protein kinases FT-5 KKAy mice 
Evolutionary dynamics of leucine‐rich repeat receptor‐like kinases and related genes in plants:A phylogenomic approach被引量：2
《Journal of Integrative Plant Biology》2014年第7期648-662,共15页Tao Shi Hongwen Huang Michael J.Sanderson Frans E.Tax 
supported by the United States National Science Foundation(DEB 1026200 to M.J.S.and IOS 1257316 to F.E.T.)
Leucine-rich repeat （LRR） receptor-like kinases （RLKs）, evolutionarily related LRR receptor-like proteins （RLPs） and receptor-like cytoplasmic kinases （RLCKs） have important roles in plant signaling, and their...
关键词：Domain architecture evolution gene duplication and loss leucine-rich repeat receptor-like kinases leucine-rich repeat receptor-like proteins receptor-like cytoplasmic kinases 
Bornyl acetate extracted from Sharen(Fructus Amomi)inhibits proliferation,invasion and induces apoptosis by suppressing phosphatidylinositol-3-kinase/protein kinase B signaling in colorectal cancer被引量：2
《Journal of Traditional Chinese Medicine》2023年第6期1081-1091,共11页LI Xiaohua DUAN Zhihang YUE Jianjun ZHANG Yongyu LI Yihang LIU Shifang NIE Qu YANG Depo ZHANG Lixia 
National Key R&D Program of China:Underground Ecological Planting Technology and Base Establishment of Sharen (Fructus Amomi) in the forest (2017YFC1701102);West Yunnan University of Applied Sciences University-level Engineering Research Center projects:Characteristic Dai-Medicine Resource ERC of West Yunnan University of Apllied Science (2022KYPT0004);National Natural Science Foundation of China:Study on the symbiotic system of Sharen (Fructus Amomi);weevil pollination and its "push-pull" pollination mechanism (82260736);Yunnan key labotatory of southern medicine utilization:Major Science and Technology Special Plan of Yunnan Province (202102AA100020);Scientific and Technological Talents and Platform Plan of Yunnan Province (202105AG070011)
OBJECTIVE:To investigate the antitumor effects of bornyl acetate(BA)isolated from Sharen(Fructus Amomi)in colorectal cancer(CRC)and the underlying mechanisms.METHODS:SW480 and HT29 cells were treated with increasing d...
关键词：bornyl acetate colorectal neoplasms phosphatidylinositol 3-kinase protein kinases B signal transduction 
Electroacupuncture stimulating Zusanli(ST36),Sanyinjiao(SP6)in mice with collagen-induced arthritis leads to adenosine A2A receptor-mediated alteration of p38αmitogen-activated protein kinase signaling and inhibition of osteoclastogenesis
《Journal of Traditional Chinese Medicine》2023年第6期1103-1109,共7页DU Zhongheng CONG Wenjie TANG Kejing ZHENG Qiqi SONG Zhiwei CHEN Yong YANG Su ZHANG Chunwu YE Tianshen 
National Natural Science Foundation of China:the Mechanism of Adenosine A2A Receptor Modulate Electroacupuncture Inhibiting Osteoclast Formation in Mice with Collagen-Induced Arthritis (No.81674053);Zhejiang Basic Public Welfare Research Project:the Role of P38 MAPK Pathway in the Inhibition of CIA Osteoclast Differentiation by Electroacupuncture via Adenosine Pathway (No.LY20H270015);Basic Medical and Health Technology Project of Wenzhou Science and Technology Bureau:Electroacupuncture of Mice with CIA Mitigate Joint Damage by the p38MAPK Pathway (No.Y20190198);Scientific Research Incubation Project of the First Affiliated Hospital of Wenzhou Medical University:Electroacupuncture of Mice with CIA Mitigate Joint Damage by the p38MAPK Pathway (No.FHY2019021)
OBJECTIVE:To observe the effect of electroacupuncture(EA)stimulating Zusanli(ST36),Sanyinjiao(SP6)on inhibition of osteoclastogenesis and the role of the adenosine A2A receptor(A2AR)and the p38αMitogen-Activated Prot...
关键词：ELECTROACUPUNCTURE arthritis experimental receptor adenosine A2A mitogen-activated protein kinases signal transduction OSTEOCLASTS 
Protein kinase-based neural signaling pathways for ginsenosides:a retrospective review
《Journal of Traditional Chinese Medicine》2015年第3期349-354,共6页He Wenbin Zhang Junlong Chen Naihong 
National Natural Science Foundation of China(the Study of Electrochemical Mechanism on the Common Syndrome Factors Concerning Alzheimer's Disease and Parkinson's Disease,No.81273629);Prescription-syndrome Effect of Dihuang Yinzi Treating Alzheimer Disease and Parkinson Disease Based on the Theory of Syndrome Factor,No.81273898;Study on the Synergistic Mechanism of Polygala Tenuifolia and Acorus Gramineus Improving Memory Through Modulating Synaptic Plasticity Molecular Network,No.81473375;Shanxi Scholarship Council of China(the Study of Electrochemical Mechanism on the Common Syndrome Factors Concerning Brain Degenerative Diseases,No.2013-134);Shanxi Provincial Project of International Science Technology Cooperation(R&D of Screen System for Chinese Medicines of Anti-Neuronal Apoptosis Based on the Modulation Mechanism of Neuroglial Cells,No.2010081065)
Ginsenosides are the main active components of ginseng,which have been reported to target brain tissues and produce multiple neuroprotective effects.Ginsenosides have been shown to improve learning ability and memory ...
关键词：PANAX GINSENOSIDES Signal transduction Protein kinase C Calcium-calmodulin-dependent protein kinase type 2 JNK mitogen-activated protein kinases Protein-tyrosine kinases 
Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination
《Neural Regeneration Research》2025年第2期394-401,共8页Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza 
supported by Catalan Government,Nos.2014SGR344(to JT),2017SGR704(to JT),2021SGR01214(to MAL);MCIN/AEI/10.13039/501100011033/by“ERDF A way of making Europe,”Nos.SAF2015-67143(to JT),PID2019-106332GB-I00(to JT and MAL)and PID2022-141252NB-I00(to MAL).
During the development of the nervous system,there is an overproduction of neurons and synapses.Hebbian competition between neighboring nerve endings and synapses performing different activity levels leads to their el...
关键词：acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB 
The role of Src family kinases in mediating M-CSF receptor signaling and monocytic cell survival
《Advances in Bioscience and Biotechnology》2012年第5期592-602,共11页Yijie Wang Melissa G. Piper Clay B. Marsh 
Previously, we reported that M-CSF induced monocyte survival through the activation of Akt, p38MAPK and Erk1/2 kinases. Here, we found that Src family kinases were upstream of these kinases and played a central role i...
关键词：MONOCYTE/MACROPHAGE M-CSF RECEPTOR SRC Family KINASES Cell SURVIVAL 
The intracellular mechanism of alpha-fetoprotein promoting the proliferation of NIH 3T3 cells被引量：27
《Cell Research》2002年第2期151-156,共6页MENG SEN LI, PING FENG LI, FBI YI YANG, SHI PENG HE, Guo GUANG DU, GANG LI1 Department of Biochemistry and Molecular Biology, 2 Department of Biophysics, Health Science Center, Peking University, Beijing 100083, China 
This work was supported by National NaturalScience Fundation of China(No.39760077).
AIM: The existence and properties of alpha-fetoprotein (AFP) receptor on the surface of NIH 3T3 cells and the effects of AFP on cellular signal transduction pathway were investigated. METHODS: The effect of AFP on the...
关键词：3T3 Cells Animals Cell Division Cyclic AMP Cyclic AMP-Dependent Protein Kinases Dose-Response Relationship  Drug Humans Mice Receptors  Peptide Research Support  Non-U.S. Gov't Signal Transduction Time Factors ALPHA-FETOPROTEINS 
c-Jun N-terminal kinase 3 deficiency protects axotomized retinal ganglion cells via affecting mitochondria involved apoptosis pathway
《International Journal of Ophthalmology(English edition)》2019年第1期30-37,共8页Rong-Rong Wang Cheng-Fang Li De-Zu Wang Cheng-Wu Zhang Gui-Xiang Liu 
AIM: To illustrate the isoform-specific role and mechanism of c-Jun N-terminal kinases(JNKs) in mouse optic nerve axotomy induced neurotrauma. METHODS: We firstly investigated the expression of JNK1, JNK2, and JNK3 in...
关键词：retinal GANGLION cells c-Jun N-TERMINAL KINASES optic nerve MITOCHONDRIA NOXA NEUROTRAUMA 
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