国家自然科学基金(20372075)

作品数：9被引量：1H指数：1
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Synthesis of a 1,2,7,8-Tetraoxa-spiro[5.5]undecane被引量：1
《Chinese Journal of Chemistry》2007年第9期1304-1308,共5页张琦 李云 伍贻康 
Project supported by the National Natural Science Foundation 0f China （Nos. 20025207, 20272071, 20372075, 20321202, 20672129, and 20621062）, and the Chinese Academy of Sciences （Nos. NKGCX2-SW-209 and KJCX2.YW.H08）.
Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy lin...
关键词：PEROXIDE ANTIMALARIAL ARTEMISININ hydrogen peroxide spiro compound 
Synthesis of 15-Demethyl Brefeldin A and Its 7-epi Isomer
《Chinese Journal of Chemistry》2007年第6期802-807,共6页沈鑫 杨永青 胡祺 黄嘉慧 高剑 伍贻康 
Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202, 20672129, 20621062）, and the Chinese Academy of Sciences （Nos. NKGCX2-SW-209, KJCX2.YW.H08）.
Synthesis of 15-demethyl brefeldin A and its 7-epimer is detailed. X-ray crystallographic structure for 15-demethyl brefeldin A is also disclosed.
关键词：ANTIBIOTICS asymmetric synthesis ANALOGUE LACTONE 
Synthesis of 1,2-Dioxane Type Antimalarial Peroxides
《Chinese Journal of Chemistry》2006年第9期1180-1189,共10页刘鹤华 张琦 金红霞 沈鑫 伍贻康 
Project supported by the National Natural Science Foundation of China （Nos. 20025207. 20272071, 20372075 and 20321202） and the Chinese Academy of Sciences （No. KGCX2-SW-209）. Dedicated to Professor Xikui Jiang on the occasion of his 80th birthday.
Synthesis of five simple analogues of peroxyplakoric acid by using Kobayashi＇s method to construct the key 1,2-dioxane core is detailed.
关键词：PEROXIDE CYCLIZATION hemiketal ANTIMALARIAL 
Synthesis of a Nitro Analogue of Plakoric Acid
《Chinese Journal of Chemistry》2006年第9期1190-1195,共6页张琦 金红霞 刘鹤华 伍贻康 
Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202） and the Chinese Academy of Sciences （No. KGCX2-SW-209）. Dedicated to Professor Xikui Jiang on the occasion of his 80th birthday.
Synthesis of a nitro analogue of plakoric acid is presented. The peroxy bond was incorporated into the substrate structure through a boron trifluoride etherate catalyzed methoxy-hydroperoxy group partial exchange reac...
关键词：PEROXIDE CYCLIZATION hemiketal EXCHANGE ANTIMALARIAL 
Synthesis and in vino Antimalarial Activity of Several Simple Analogues of Peroxyplakoric Acid
《Chinese Journal of Chemistry》2005年第11期1469-1473,共5页LIU, He-Hua JIN, Hong-Xia ZHANG, Qi WU, Yi-Kang KIM, Hye-Sook WATAYA, Yusuke 
Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202）, the Chinese Academy ot Sciences （“Knowledge Innovation”project, KGCX2-SW-209）, and the Major State Basic Research Development Program （No. G2000077502） of China.
Several simple analogues of peroxyplakoric acid were synthesized by using Kobayashi＇s method to construct the key 1,2-dioxane core and tested in vitro for antimalarial activity. The scope and limitation of the method...
关键词：PEROXIDES SPIROKETALS CYCLIZATIONS hemiketals 
Conversion of N-Acyl-4-phenyl/benzyl-oxazolidine-2-thiones into Thiol Esters in the Presence of EtSH-K2CO3
《Chinese Journal of Chemistry》2005年第11期1561-1563,共3页HU, Qi SUN, Ya-Ping WU, Yi-Kang 
Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075 and 20321202）, the Kn6wledge Innovation Project of the Chinese Academy of Sciences （No. KGCX2-SW-209）, and the Major State Basic Research Development Program （No. G2000077502）.
N-Acyl-β-hydroxy-4-phenyl-oxazolidinethiones could be rapidly converted into their ethyl thiol esters in high yields by treatment with EtSH at 0 ℃ in CH3CN or 9 ： 1 （V ： V） THF-H2O in the presence of a catalytic...
关键词：chiral auxiliary cleavage thiol ester ALDOL 
An Efficient Enantioselective Synthesis of Blastmycinone
《Chinese Journal of Chemistry》2005年第11期1519-1522,共4页YANG, Yong-Qing wu, Yi-Kang 
Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202）, the Chinese Academy of Sciences （Knowledge Innovation Project, No. KGCX2-SW-209）, and the Major State Basic Research Development Program （No. G2000077502）.
Blastmycinone, a degradation product of the antibiotic antimycin A, was synthesized with a TiCl4-mediated asymmetric aldolization as the key step. Some unexpected yet interesting chemistry was also observed.
关键词：LACTONE asymmetric synthesis ALDOL ACYLATION chiral auxiliary 
Some Attempts to Employ the Singlet Oxygen Generated from H_2O_2
《Chinese Journal of Chemistry》2004年第9期999-1002,共4页金红霞 刘鹤华 伍贻康 
the National Natural Science Foundation of China (Nos. 20025207, 20272071, 20372075, 20321202), the Qinghaosu Science and Technology Foundation, the Chinese Academy of Sciences (No. KGCX2-SW-209) and the Major State Basic Resear
Some attempts to employ the singlet oxygen generated from molybdate-catalyzed decomposition of hydrogen peroxide are presented. Reduction of ascaridole with diimide is also described, along with the preliminary result...
关键词：PEROXIDE singlet oxygen free radical CLEAVAGE MECHANISM 
Synthesis and Cleavage Studies of a 1,2-Dioxolane-type Peroxide
《Chinese Journal of Chemistry》2004年第9期1029-1033,共5页刘鹤华 金红霞 伍贻康 
the National Natural Science Foundation (Nos. 20025207, 20272071, 20372075 and 20321202), the Qinghaosu Science and Technology Foundation, the Chinese Academy of Sciences (KGCX2-SW-209) and the Major State Basic Research Develop
A [1,2]dioxolane-type peroxide was synthesized and tested for its cleavage behavior with Fe2+-cysteinate as a simple model of biological redox species. No S-alkylation product was observed.
关键词：cyclic peroxide ARTEMISININ free radical CLEAVAGE mechanism 
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