国家重点基础研究发展计划(2010CB126100)

作品数：37被引量：113H指数：6
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相关作者：贺红武刘建超钱旭红彭浩李秀梅更多>>
相关机构：华中师范大学华东理工大学江苏省农业科学院南京农业大学更多>>
相关期刊：《安徽农业科学》《科学通报》《中国生物工程杂志》《化学与生物工程》更多>>
相关主题：杀菌活性SYNTHESISPHOSPHONATE生物活性杀虫活性更多>>
相关领域：化学工程理学医药卫生农业科学更多>>
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C11 , a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis被引量：3
《Acta Pharmacologica Sinica》2019年第6期823-832,共10页Zhuo Chen Lin-jiang Tong Bai-you Tang Hong-yan Liu Xin Wang Tao Zhang Xian-wen Cao Yi Chen Hong-lin Li Xu-hong Qian Yu-fang Xu Hua Xie Jian Ding 
National Natural Science Foundation of China (grants 81173080, 81321092, 21236002 and 21302054);National Basic Research Program of China (973 Program, 2010CB126100);National High Technology Research and Development Program of China (863 Program, 2011AA10A207);National Science & Technology Pillar Program (2009ZX09103-102);Shanghai Committee of Science and Technology (grant 13ZR1453100);Fundamental Research Funds for the Central Universities.
The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer intervention due to their roles in tumor metastasis and angiogenesis. Here, we identified a new sele...
关键词：C11 FGFR1 INHIBITOR ANTITUMOR BREAST cancer metastasis ANGIOGENESIS 
The discovery of new scaffold of plant activators：From salicylic acid to benzotriazole
《Chinese Chemical Letters》2017年第4期919-926,共8页Kang Chang Jian-Qin Chen Yan-Xia Shi Mei-Jian Sun Peng-Fei Li Zhen-Jiang Zhao Wei-Ping Zhu Hong-Lin Li Yu-Fang Xu Bao-Ju Li Xu-Hong Qian 
financially supported by the National Basic Research Program of China(973 Program,No.2010CB126100);the National High Technology Research and Development Program of China(863 Program,No.2011AA10A207);the Shanghai Leading Academic Discipline Project(B507);the Fundamental Research Funds for the Central Universities
Started from salicylic acid（SA） and related commercialized plant activators,based on molecular threedimensional shape and pharmacophore similarity comparison（SHAFTS）,a new lead compound benzotriazole was predicted...
关键词：Plant activator Systemic acquired resistance Salicylic acid Benzotriazole Virtual screening 
3-(2-氯-4-三氟甲基苯氧基)苯甲酰腙的合成与生物活性
《化学与生物工程》2017年第1期23-26,共4页彭浩 贺红武 
国家973计划资助项目(2010CB126100);国家自然科学基金资助项目(21002037)
以3-(2-氯-4-三氟甲基苯氧基)苯甲酸(Ⅰ)为起始原料,经酯化、肼解后得3-(2-氯-4-三氟甲基苯氧基)苯甲酰肼(Ⅲ),再与不同的芳香醛缩合,合成了4个未见文献报道的3-(2-氯-4-三氟甲基苯氧基)苯甲酰腙(Ⅳa~Ⅳd)。目标化合物经1 HNMR、IR、MS...
关键词：苯甲酰腙 抑制活性 白化活性 
O-[1-(2-甲基-4-氨基嘧啶-5-甲基)-1H-[1,2,3]-三唑-4-基]甲基取代苯甲酰氨基硫代甲酸酯的合成与生物活性被引量：1
《化学与生物工程》2016年第11期1-7,共7页谭效松 朱国中 贺红武 
国家973计划资助项目(2010CB126100);国家自然科学基金资助项目(20772042)
丙酮酸脱氢酶系（PDHc）属于焦磷酸硫胺素（TPP）依赖性酶,是一个具有重要农学意义的农药作用靶标。以微生物中的丙酮酸脱羧酶E1（PDHc E1）为靶标,设计合成TPP类似物有望发现新型的杀菌活性化合物。以三唑环代替TPP结构中的噻唑环,以...
关键词：丙酮酸脱羧酶 焦磷酸硫胺素 氨基硫代甲酸酯 生物活性 
4-取代苯甲酰氧基-2-取代苯甲酰氨基噻唑衍生物的合成与生物活性
《华中师范大学学报（自然科学版）》2015年第5期730-734,共5页刘勇军 张莎莎 刘建超 贺红武 
国家重点基础研究发展规划项目(2010CB126100);国家自然科学基金项目(21172090;31000867);教育部创新团队项目(IRT0953)
以商品化的杀菌剂噻唑菌胺和噻氟酰胺为先导,保持噻唑环活性结构,在噻唑环的4位引入酯基,设计合成了9个新型的4-取代苯甲酰氧基-2-取代苯甲酰氨基噻唑衍生物,中间体2-亚氨基-4-噻唑烷酮由简便易得的原料溴乙酸乙酯与硫脲一步合成.用IR、...
关键词：噻氟酰胺 噻唑菌胺 苯甲酰氧基 噻唑化合物 杀菌 抗肿瘤 
6-烷氨(氧)基-3-甲硫基-1H-吡唑并[3,4-d]嘧啶-4(5H)-酮衍生物的合成与生物活性被引量：1
《应用化学》2014年第8期922-927,共6页刘建超 梁英 贺红武 
国家重点基础研究发展规划项目(973计划)(2010CB126100);国家自然科学基金资助项目(21172090;31000867);教育部创新团队资助项目(IRT0953);国家科技支撑计划(2011BAE06B04)~~
用六氯乙烷、三苯基膦和5-氨基吡唑衍生物一锅法合成关键中间体膦亚胺。再利用串联aza-Wittig反应,加入对氯苯基异氰酸酯,进一步和烷基胺或取代酚反应合成了11个未见文献报道的6-烷氨(氧)基-3-甲硫基-1H-吡唑并[3,4-d]嘧啶-4(5H)-酮衍...
关键词：AZA-WITTIG反应 吡唑并[3 4-d]嘧啶 杀菌活性 除草活性 
DDQ/TFA： an Efficient Nonmetallic Reagent System for the Oxidative Coupling to Construct Phenanthrene Rings被引量：1
《Chemical Research in Chinese Universities》2014年第4期619-623,共5页LI Ling HU Yanna WANG Kailiang WANG Qingmin 
Supported by the National Key Project for Basic Research of China（No.2010CB126100）, the National Natural Science Foundation of China（Nos.21132003, 21121002, 21372131） and the Specialized Research Fund for the Doctoral Program of Higher Education of China（No.20120031110010）.
A mild synthetic method of a series of phenanthrenes with different substituents on the phenanthrene ring is described.The method involves intramolecular oxidative coupling with 2,3-dichloro-5,6-dicyanobenzoquinone （...
关键词：Intramolecular oxidative coupling 2 3-Dichloro-5 6-dicyanobenzoquinone（DDQ） 1 2-Diarylethylene Phenanthrene ring ALKALOID 
Synthesis,Characterization and X-ray Crystal Structure of 2-Methylpropan-2-aminium Methyl ((4-Fluorobenzamido)(4-fluorophenyl)methyl) phosphonate·H_2O被引量：1
《Chinese Journal of Structural Chemistry》2014年第7期985-989,共5页高玉焦 邓小艳 彭浩 贺红武 
supported by the National Basic Research Program of China(2010CB126100);the National Natural Science Foundation of China(21002037 and 21172090);The research was supported in part by the PCSIRT(No.IRT0953)
A new crystal of 2-methylpropan-2-aminium methyl （（4-fluorobenzamido）（4- fluorophenyl）methyl）phosphonate has been prepared at room temperature and characterized by ZH- NMR, 13C NMR, IR, MS, elemental analysis an...
关键词：X-ray crystallography BENZAMIDE PHOSPHONATE 
QAAR exploration on pesticides with high solubility:An investigation on sulfonylurea herbicide dimers formed through π–π stacking interactions被引量：10
《Chinese Chemical Letters》2014年第7期973-977,962,共5页Shuang Xia Yue Feng Jia-Gao Cheng Hai-Bin Luo Zhong Li Zheng-Ming Li 
National Key Technology R&D Program of China(No.2011BAE06B05);National Natural Science Foundation of China(No.21172070);National High Technology Research Development Program of China(No.2011AA10A207);National Basic Research Program of China(No.2010CB126100);the Fundamental Research Funds for the Central Universities
Bioactive compounds could form aggregates that influence the bio-interactive processes. In this letter, based on π-π stacking models, quantitative aggregation-activity relationship （QAAR） studies were carried out ...
关键词：Aggregate QAAR/QSAR π-π Interaction SULFONYLUREA 
Synthesis, Characterization and X-ray Crystal Structure of 4-Fluoro-N-(2-methyl-5-((2-(p-tolyloxy)acetamido)- methyl)pyrimidin-4-yl)benzamide被引量：1
《Chinese Journal of Structural Chemistry》2014年第2期223-227,共5页邓小艳 彭浩 贺红武 
supported by the National Basic Research Program of China(2010CB126100);the National Natural Science Foundation of China(21002037 and 21172090);supported in part by the PCSIRT(No.IRT0953)
A new crystal of 4-fluoro-N-（2-methyl-5-（（2-（p-tolyloxy）acetamido）methyl）pyrimi- din-4-yl）benzamide has been prepared at room temperature and characterized by 1H NMR, 13C- NMR, IR, MS, elemental analysis and X...
关键词：X-ray crystallography acetamido BENZAMIDE pyrimidin 
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