国家重点基础研究发展计划(2013CB932500)

作品数：13被引量：81H指数：5
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相关作者：彭春梅陆伟跃沈洁更多>>
相关机构：复旦大学更多>>
相关期刊：《Nano-Micro Letters》《Acta Pharmacologica Sinica》《Journal of Innovative Optical Health Sciences》《Science China Materials》更多>>
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AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage被引量：1
《Acta Pharmacologica Sinica》2023年第6期1290-1303,共14页Jin-peng Pei Yue Wang Lan-ping Ma Xin Wang Liang Liu Yu Zhang Rui Jin Zhi-qiang Ren Yan Deng Jing-kang Shen Tao Meng Ker Yu 
supported by Fudan University(EZF301002);The National Natural Science Foundation of China(81373442);NST Major Project of China(2018ZX09711002-008);NBR 973 Program of China(2013CB932500).
The receptor tyrosine kinase AXL is an emerging driver of cancer recurrence,while its molecular mechanism remains unclear.In this study we investigated how AXL regulated the disease progression and poor prognosis in n...
关键词：AXL NSCLC TNBC M2-macrophage antibody-drug conjugate 
Therapeutic efficacy and mechanism of CD73-TGFβ dual-blockade in a mouse model of triple-negative breast cancer被引量：2
《Acta Pharmacologica Sinica》2022年第9期2410-2418,共9页Yun Xing Zhi-qiang Ren Rui Jin Liang Liu Jin-peng Pei Ker Yu 
This work was funded by Fudan University(EZF301002);NSF of China(81373442);NST Major Project of China(2018ZX09711002-008);NBR 973 Program of China(2013CB932500).
Although chemotherapy and recently approved immunotherapies have improved treatment of triple-negative breast cancer (TNBC), the clinical outcome for this deadly disease remains unsatisfactory. We found that both clus...
关键词：CD73 NT5E TGFΒ TNBC antitumor immunity 
A pentapeptide enabled AL3810 liposome-based glioma-targeted therapy with immune opsonic effect attenuated被引量：1
《Acta Pharmaceutica Sinica B》2021年第1期283-299,共17页Jinyang Li Jiasheng Lu Haiyan Guo Jianfen Zhou Songli Wang Kuan Jiang Zhilan Chai Shengyu Yao Xiaoyi Wang Linwei Lu Cao Xie Yi Chen Weiyue Lu 
supported by the National Natural Science Foundation of China(Nos.81773657,and 81690263);Innovation Program of Shanghai Municipal Education Commission(2017-0107-00-07E00052,China);National Basic Research Program of China(973 Program,No.2013CB932500,China)
AL3810,a molecular dual inhibitor of the vascular endothelial growth factor receptor(VEGFR)and fibroblast growth factor receptor(FGFR),has earned the permission of phase II clinical trial for tumor treatment by China ...
关键词：LIPOSOME mn c(RGDyK) Immune opsonization IMMUNOGENICITY Anti-glioma efficacy 
Small interfering RNA delivery to the neurons near the amyloid plaques for improved treatment of Alzheimer’s disease被引量：3
《Acta Pharmaceutica Sinica B》2019年第3期590-603,共14页Qian Guo Xiaoyao Zheng Peng Yang Xiaoying Pang Kang Qian Pengzhen Wang Shuting Xu Dongyu Sheng Liuchang Wang Jinxu Cao Wei Lu Qizhi Zhang Xinguo Jiang 
supported by the National Natural Science Foundation of China (Nos. 81473150 and 81273461);Major Program of National Natural Science Foundation of China (No. 81690263);the National Basic Research Program of China (No. 2013CB932500)
Gene therapy represents a promising treatment for the Alzheimer’s disease(AD). However,gene delivery specific to brain lesions through systemic administration remains big challenge. In our previous work, we have deve...
关键词：siRNA delivery NEURONS AMYLOID PLAQUES BACE1 gene Alzheimer’s disease 
Liposomes and lipid disks traverse the BBB and BBTB as intact forms as revealed by two-step F?rster resonance energy transfer imaging被引量：9
《Acta Pharmaceutica Sinica B》2018年第2期261-271,共11页Tongcheng Dai Kuan Jiang Weiyue Lu 
supported by China Postdoctoral Science Foundation Grant (No.2017M611464);National Basic Research Program of China (973 Program, No. 2013CB932500);National Natural Science Foundation of China (Nos. 81773657, 81690263 and 81473149);Shanghai Education Commission Major Project (2017-01-07-00-07E00052);Shanghai International Science and Technology Cooperation Project (No. 16430723800)
The blood–brain barrier(BBB) and the blood–brain tumor barrier(BBTB) prevent drug and nano-drug delivery systems from entering the brain. However, ligand-mediated nano-drug delivery systems have significantly enhanc...
关键词：Liposomes DISKS Intact form BBB BBTB FRET 
Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma被引量：21
《Acta Pharmaceutica Sinica B》2018年第1期85-96,共12页Chunhui Ruan Lisha Liu Yifei Lu Yu Zhang Xi He Xinli Chen Yujie Zhang Qinjun Chen Qin Guo Tao Sun Chen Jiang 
supported by the National Natural Science Funds of China (21602030 and 81172993);National Basic Research Program of China (973 Program, 2013CB932500), Shanghai Sailing Program (16YF1400900);Scientific Research Foundation of Fudan University for Talent Introduction (JJF301103);National Science Fund for Distinguished Young Scholars (81425023)
The blood–brain barrier(BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme(GBM). The present study exploits albumin as drug deliver...
关键词：Human serum albumin PACLITAXEL Drug delivery Substance P Blood–brain barrier GLIOMA 
Enhanced glioma-targeting and stability of ~LGICP peptide coupled with stabilized peptide ~DA7R被引量：5
《Acta Pharmaceutica Sinica B》2018年第1期106-115,共10页Mingfei Zhang Weiyue Lu 
supported by National Basic Research Program of China (973 Program, No. 2013CB932500);National Natural Science Foundation of China (Nos. 81773657, 81690263 and 81473149);Shanghai Education Commission Major Project (No. 2017-01-07-00-07-E00052);Shanghai International Science and Technology Cooperation Project (No.16430723800)
Malignant glioma is usually accompanied by vigorous angiogenesis to provide essential nutrients. An effective glioma targeting moiety should include excellent tumor-cell homing ability as well as good neovasculature-t...
关键词：GLIOMA NEOVASCULATURE Target PEPTIDE Stabilization Blood–tumor barrier 
Cell membrane-coated nanoparticles for tumor-targeted drug delivery被引量：4
《Science China Materials》2017年第6期504-510,共7页柴芝兰 胡雪峰 陆伟跃 
supported by the National Basic Research Program of China (2013CB932500);the National Natural Science Foundation of China (81273458 and 81473149)
Nanoparticles can be enriched at tumor site and improve the therapeutic efficacy of many chemother- apy drugs with the well-known enhanced permeability and retention （EPR） effect. While conventional preparations of ...
关键词：cell membrane biomimetic nanoparticle tumor-tar geting drug delivery 
Enhancing sensitivity of SERRS nanoprobes by modifying heptamethine cyanine-based reporter molecules
《Journal of Innovative Optical Health Sciences》2016年第4期85-93,共9页Yunfei Zhang Danqi Li Xingyu Zhou Xihui Gao Shengyuan Zhao Cong Li 
supported by the National Basic Research Program of China(973 Program,2013CB932500);the National Natural Science Foundation of China(Nos 81371624,81571741);the Nanotechnology Program of Shanghai Science and Technology Committee(13NM1400400,15140901300);The innovation and entrepreneurship training program for college students in Huazhong University of Science&Technology(14A215).Yunfei Zhang and Danqi Li contributed equivalently to this work.
Surface enhanced resonance Raman scattering(SERRS)is a physical phenomenon that occurs when the energy of incident light is dose to that of electronic excitation of reporter molecules(RMs)attached on substrates.SERRS ...
关键词：Surface enhanced resonance Raman scattering gold nanoparticles reporter molecules heptamethine cyanine. 
A Review on Graphene-Based Gas/Vapor Sensors with Unique Properties and Potential Applications被引量：20
《Nano-Micro Letters》2016年第2期95-119,共25页Tao Wang Da Huang Zhi Yang Shusheng Xu Guili He Xiaolin Li Nantao Hu Guilin Yin Dannong He Liying Zhang 
financial supports provided by the National Basic Research Program of China(2013CB932500);the National Natural Science Foundation of China(21171117 and 61574091);the Program for New Century Excellent Talents in University(NCET-12-0356);the Program of Shanghai Academic/Technology Research Leader(15XD1525200);Shanghai Jiao Tong University Agri-X Funding(Agri-X2015007);the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning
Graphene-based gas/vapor sensors have attracted much attention in recent years due to their variety of structures, unique sensing performances, room-temperature working conditions, and tremendous application prospects...
关键词：GRAPHENE Gas/Vapor SENSOR CHEMIRESISTOR Detection mechanism 
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