《Journal of Molecular Cell Biology》

作品数：860被引量：1994H指数：20
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《Journal of Molecular Cell Biology》
主办单位：中国细胞生物学学会;中国科学院上海生命科学研究院；生物化学与细胞生物学研究所
最新期次：2024年8期更多>>
发文主题：P53CANCERSIGNALINGSARS-COVPROMOTES更多>>
发文领域：医药卫生生物学农业科学理学更多>>
发文作者：洪建中周东坡平文祥方永强王龙更多>>
发文机构：中国科学院上海生命科学研究院杜伦大学齐齐哈尔师范学院西北农林科技大学更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金上海市自然科学基金更多>>
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Hypoxia signaling in the adipose tissue
《Journal of Molecular Cell Biology》2024年第8期1-18,共18页Phu M.Huynh Fenfen Wang Yu A.An 
supported by National Institutes of Health(NIH)grants K01-DK125447,R03-DK135783,and P30-DK056338(Pilot Award)to Y.A.A;the American Diabetes Association(ADA)Postdoctoral Fellowship Award 11-23-PDF-23 to F.W.
Obesity per se is rapidly emerging all over the planet and further accounts for many other life-threatening conditions,such as diabetes,cardiovascular diseases,and cancers.Decreased oxygen supply or increased relative...
关键词：HYPOXIA OBESITY adipose tissue hypoxia-inducible factor 
A polarized multicomponent foundation upholds ciliary central microtubules
《Journal of Molecular Cell Biology》2024年第8期19-32,共14页Qingxia Chen Huijie Zhao Xinwen Pan Chuyu Fang Benhua Qiu Jingting Guo Xiumin Yan Xueliang Zhu 
supported by the National Natural Science Foundation of China(31991192,32230027,32270725,32100551,and 32270807);Shandong Natural Science Foundation(2022HWYQ-075).
Cilia’s back-and-forth beat pattern requires a central pair(CP)of microtubules.However,the mechanism by which the CP is upheld above the transition zone(TZ)remains unclear.Here,we showed that a rod-like substructure ...
关键词：basal plate central pair ciliary motility ependyma HYDROCEPHALUS motile cilia 
Temsirolimus inhibits FSP1 enzyme activity to induce ferroptosis and restrain liver cancer progression
《Journal of Molecular Cell Biology》2024年第8期33-45,共13页Rui-Lin Tian Tian-Xiang Wang Zi-Xuan Huang Zhen Yang Kun-Liang Guan Yue Xiong Pu Wang Dan Ye 
funded by grants from the National Key R&D Program of China(2020YFA0803202 to D.Y.);the National Natural Science Foundation of China(82225036 and 31821002 to D.Y.,32101011 to P.W.).
Ferroptosis is a non-apoptotic mode of cell death characterized by iron-dependent accumulation of lipid peroxidation.While lipid radical elimination reaction catalyzed by glutathione peroxidase 4(GPX4)is a major anti-...
关键词：TEMSIROLIMUS FSP1 ferroptosis liver cancer 
ATP promotes protein coacervation through conformational compaction
《Journal of Molecular Cell Biology》2024年第8期46-57,共12页Yueling Zhu Shiyan Lin Lingshen Meng Min Sun Maili Liu Jingyuan Li Chun Tang Zhou Gong 
supported by grants from the National Natural Science Foundation of China(92353304,31971155,and 21991081);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(2020329).
Adenosine triphosphate(ATP)has been recognized as a hydrotrope in the phase separation process of intrinsically disordered proteins(IDPs).Surprisingly,when using the disordered Arg-Gly/Arg-Gly-Gly(RG/RGG)rich motif fr...
关键词：intrinsically disordered protein phase separation ATP conformational compaction HNRNPG 
Correction to:Mitochondrial aldehyde dehydrogenase rescues against diabetic cardiomyopathy through GSK3β-mediated preservation of mitochondrial integrity and Parkin-mediated mitophagy
《Journal of Molecular Cell Biology》2024年第8期58-58,共1页
This is a correction to:Yingmei Zhang,Rongjun Zou,Miyesaier Abudureyimu,Qiong Liu,Jipeng Ma,Haixia Xu,Wei Yu,Jian Yang,Jianguo Jia,Sanli Qian,Haichang Wang,Yang Yang,Xin Wang,Xiaoping Fan,Jun Ren,Mitochondrial aldehyd...
关键词：mitochondrial integrity parkin mediated mitophagy diabetic cardiomyopathy aldehyde dehydrogenase GSK mitochondrial aldehyde dehydrogenase 
ZW10:an emerging orchestrator of organelle dynamics during the cell division cycle
《Journal of Molecular Cell Biology》2024年第7期1-11,共11页Sm Faysal Bellah Fengrui Yang Fangyuan Xiong Zhen Dou Xuebiao Yao Xing Liu 
supported by grants from the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,W2411017,32450537,91953000,92153302,32170733,and 22177106);Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003);the Ministry of Education(IRT_17R102);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);the Fundamental Research Funds for the Central Universities(KB9100000007,KB9100000006,and KB9100000013).
Zeste white 10(ZW10)was first identified as a centromere/kinetochore protein encoded by the ZW10 gene in Drosophila.ZW10 guides the spindle assembly checkpoint signaling during mitotic chromosome segregation in metazo...
关键词：ZW10 KINETOCHORE membrane-bound organelle membraneless organelle MITOSIS 
Sterile activation of RNA-sensing pathways in autoimmunity
《Journal of Molecular Cell Biology》2024年第7期12-29,共18页Jiaxin Li Junyan Zhu Hui Yang Fajian Hou 
supported by grants from Chinese Academy of Sciences Pilot Strategic Science and Technology Project B(XDB0570100);the National Key Research and Development Program of China(2020YFA0804200 and 2023YFC3404800);the National Natural Science Foundation of China(32070902,82073166,and 82273203).
RNA-sensing pathways play a pivotal role in host defense against pathogenic infections to maintain cellular homeostasis.However,in the absence of infection,certain endogenous RNAs can serve as the activators of RNA-se...
关键词：innate immune responses RNA sensors endogenous RNAs AUTOIMMUNITY 
Single-cell landscape of alternative polyadenylation in human lymphoid hematopoiesis
《Journal of Molecular Cell Biology》2024年第7期30-45,共16页Jiaqi Qiang Shan Yu Jun Li Yu Rong Xiaoshuang Wang Yong Zhu Fang Wang 
supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-040 to F.W.);the National Key Research and Development Program of China(2021YFA1102400 to F.W.,2019YFA0111700 to X.W.);the National Natural Science Foundation of China(82022001 and 81970103 to F.W.,82070111 to Y.Z.).
Alternative polyadenylation(APA)is an essential post-transcriptional process that produces mature mRNA isoforms by regulating the usage of polyadenylation sites(PASs).APA is involved in lymphocyte activation;however,i...
关键词：alternative polyadenylation HEMATOPOIESIS lymphoid differentiation post-transcription SINGLE-CELL 
Modeling gastric intestinal metaplasia in 3D organoids using nitrosoguanidine
《Journal of Molecular Cell Biology》2024年第7期46-59,共14页Yuan Li Jiena Chen Tao Li Jie Lin Haocheng Zheng Nadia Johnson Xuebiao Yao Xia Ding 
supported by grants from the National Natural Science Foundation of China(82205095,82374292,92059102,32090040,82204894,and 82305179);the China Postdoctoral Science Foundation(2022M720520);the Anhui TCM Synergism Project(202303a0702003).
Gastric intestinal metaplasia(GIM)represents a precancerous stage characterized by morphological and pathophysiological changes in the gastric mucosa,where gastric epithelial cells transform into a phenotype resemblin...
关键词：gastric organoids MNNG intestinal metaplasia TRANS-DIFFERENTIATION precancerous lesion 
PHLDA2 is critical for p53-mediated ferroptosis and tumor suppression
《Journal of Molecular Cell Biology》2024年第7期60-62,共3页Xin Yang Wei Gu 
Dear Editor,Inactivation of the tumor suppressor p53 is a pivotal event in the formation of most human cancers.Dissecting the precise mechanism of p53 in tumor suppression contributes to the development of a better st...
关键词：P53 SUPPRESSOR PRECISE 
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