《Journal of Molecular Cell Biology》

作品数：855被引量：1983H指数：20
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《Journal of Molecular Cell Biology》
主办单位：中国细胞生物学学会;中国科学院上海生命科学研究院；生物化学与细胞生物学研究所
最新期次：2024年7期更多>>
发文主题：P53CANCERSIGNALINGSARS-COVPROMOTES更多>>
发文领域：医药卫生生物学农业科学理学更多>>
发文作者：洪建中周东坡平文祥方永强王龙更多>>
发文机构：中国科学院上海生命科学研究院杜伦大学齐齐哈尔师范学院西北农林科技大学更多>>
发文基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金上海市自然科学基金更多>>
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ZW10:an emerging orchestrator of organelle dynamics during the cell division cycle
《Journal of Molecular Cell Biology》2024年第7期1-11,共11页Sm Faysal Bellah Fengrui Yang Fangyuan Xiong Zhen Dou Xuebiao Yao Xing Liu 
supported by grants from the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,W2411017,32450537,91953000,92153302,32170733,and 22177106);Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003);the Ministry of Education(IRT_17R102);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);the Fundamental Research Funds for the Central Universities(KB9100000007,KB9100000006,and KB9100000013).
Zeste white 10(ZW10)was first identified as a centromere/kinetochore protein encoded by the ZW10 gene in Drosophila.ZW10 guides the spindle assembly checkpoint signaling during mitotic chromosome segregation in metazo...
关键词：ZW10 KINETOCHORE membrane-bound organelle membraneless organelle MITOSIS 
Sterile activation of RNA-sensing pathways in autoimmunity
《Journal of Molecular Cell Biology》2024年第7期12-29,共18页Jiaxin Li Junyan Zhu Hui Yang Fajian Hou 
supported by grants from Chinese Academy of Sciences Pilot Strategic Science and Technology Project B(XDB0570100);the National Key Research and Development Program of China(2020YFA0804200 and 2023YFC3404800);the National Natural Science Foundation of China(32070902,82073166,and 82273203).
RNA-sensing pathways play a pivotal role in host defense against pathogenic infections to maintain cellular homeostasis.However,in the absence of infection,certain endogenous RNAs can serve as the activators of RNA-se...
关键词：innate immune responses RNA sensors endogenous RNAs AUTOIMMUNITY 
Single-cell landscape of alternative polyadenylation in human lymphoid hematopoiesis
《Journal of Molecular Cell Biology》2024年第7期30-45,共16页Jiaqi Qiang Shan Yu Jun Li Yu Rong Xiaoshuang Wang Yong Zhu Fang Wang 
supported by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-040 to F.W.);the National Key Research and Development Program of China(2021YFA1102400 to F.W.,2019YFA0111700 to X.W.);the National Natural Science Foundation of China(82022001 and 81970103 to F.W.,82070111 to Y.Z.).
Alternative polyadenylation(APA)is an essential post-transcriptional process that produces mature mRNA isoforms by regulating the usage of polyadenylation sites(PASs).APA is involved in lymphocyte activation;however,i...
关键词：alternative polyadenylation HEMATOPOIESIS lymphoid differentiation post-transcription SINGLE-CELL 
Modeling gastric intestinal metaplasia in 3D organoids using nitrosoguanidine
《Journal of Molecular Cell Biology》2024年第7期46-59,共14页Yuan Li Jiena Chen Tao Li Jie Lin Haocheng Zheng Nadia Johnson Xuebiao Yao Xia Ding 
supported by grants from the National Natural Science Foundation of China(82205095,82374292,92059102,32090040,82204894,and 82305179);the China Postdoctoral Science Foundation(2022M720520);the Anhui TCM Synergism Project(202303a0702003).
Gastric intestinal metaplasia(GIM)represents a precancerous stage characterized by morphological and pathophysiological changes in the gastric mucosa,where gastric epithelial cells transform into a phenotype resemblin...
关键词：gastric organoids MNNG intestinal metaplasia TRANS-DIFFERENTIATION precancerous lesion 
PHLDA2 is critical for p53-mediated ferroptosis and tumor suppression
《Journal of Molecular Cell Biology》2024年第7期60-62,共3页Xin Yang Wei Gu 
Dear Editor,Inactivation of the tumor suppressor p53 is a pivotal event in the formation of most human cancers.Dissecting the precise mechanism of p53 in tumor suppression contributes to the development of a better st...
关键词：P53 SUPPRESSOR PRECISE 
HSD17B13 liquid–liquid phase separation promotes leukocyte adhesion in chronic liver inflammation
《Journal of Molecular Cell Biology》2024年第6期1-13,共13页Jing Ye Xiyu Huang Manman Yuan Jinglin Wang Ru Jia Tianyi Wang Yang Tan Shun Zhu Qiang Xu Xingxin Wu 
National Natural Science Foundation of China(82273989,2193005,81722047,and 81874317);Fundamental Research Funds for the Central Universities(020814380161).
The rs72613567:TA polymorphism in 17-beta hydroxysteroid dehydrogenase 13(HSD17B13)has been found to reduce the progression from steatosis to metabolic dysfunction-associated steatohepatitis(MASH).In this study,we sou...
关键词：17-beta hydroxysteroid dehydrogenase 13 liquid–liquid phase separation non-alcoholic steatohepatitis liver inflammation platelet activating factor fibrinogen synthesis 
Single-cell analysis defines LGALS1+fibroblasts that promote proliferation and migration of intrahepatic cholangiocarcinoma
《Journal of Molecular Cell Biology》2024年第6期14-27,共14页Qiqi Cao Jinxian Yang Lixuan Jiang Zhao Yang Zhecai Fan Shuzhen Chen Sibo Zhu Lei Yin Hongyang Wang Wen Wen 
National Natural Science Foundation of China(82072600,82173146,81830054,81988101,and 91859205);Plan of the Shanghai Municipal Health Commission(2022XD036).
The incidence rate of intrahepatic cholangiocarcinoma(ICC),which has a poor prognosis,is rapidly increasing.To investigate the intratumor heterogeneity in ICC,we analyzed single-cell RNA sequencing data from the prima...
关键词：single-cell RNA sequencing(scRNA-seq) intrahepatic cholangiocarcinoma(ICC) LGALS1 FIBROBLAST 
Phase separation of SPIN1 through its IDR facilitates histone methylation readout and tumorigenesis
《Journal of Molecular Cell Biology》2024年第6期28-42,共15页Yukun Wang Yuhan Chen Mengyao Li Jiayue Wang Yuhan Jiang Rong Xie Yifeng Zhang Zhihua Li Zhenzhen Yan Chen Wu 
National Natural Science Foundation of China(32071277);Science and Technology Program of Hebei Province(216Z2602G);Natural Science Foundation of Hebei Province(C2021201012);Interdisciplinary Research Program of Natural Science of Hebei University(DXK202006).
Spindlin1(SPIN1)is a unique multivalent histone modification reader that plays a role in ribosomal RNA transcription,chromosome segregation,and tumorigenesis.However,the function of the extended N-terminal region of S...
关键词：SPIN1 IDR phase separation histone methylation reader TUMORIGENESIS 
Blockade of TNF-α/TNFR2 signalling suppresses colorectal cancer and enhances the efficacy of anti-PD1 immunotherapy by decreasing CCR8+T regulatory cells
《Journal of Molecular Cell Biology》2024年第6期43-58,共16页Yixian Guo Feng Xie Xu Liu Shouyu Ke Jieqiong Chen Yi Zhao Ning Li Zeyu Wang Gang Yi Yanying Shen Dan Li Chunchao Zhu Zizhen Zhang Gang Zhao Hong Lu Bin Li Wenyi Zhao 
National Natural Science Foundation of China(31872740,31961133011,32070878,and 81830051);Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20210601).
The enrichment of regulatory T cells(Tregs)in the tumour microenvironment(TME)has been recognized as one of the major factors in the initiation and development of resistance to immune checkpoint inhibitors.C–C motif ...
关键词：TNFR2 CCR8 regulatory T cells colorectal cancer 
Unleashing the power of antigen-presenting neutrophils
《Journal of Molecular Cell Biology》2024年第6期59-60,共2页Yingcheng Wu Jiaqiang Ma Qiang Gao 
Neutrophils,the most abundant white blood cells in the human body,have long been recognized for their critical role in innate immunity(Quail et al.,2022).They serve as the first line of defense against invading pathog...
关键词：NEUTROPHILS IMMUNITY POWER 
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