DYSREGULATION

作品数：170被引量：528H指数：10
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相关领域：医药卫生生物学更多>>
相关作者：杨燕青李亮廉哲雄姚远王菲菲更多>>
相关机构：中国科学技术大学山东中医药大学附属眼科医院第二军医大学徐州医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金泰国研究基金更多>>
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Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases被引量：1
《Translational Neurodegeneration》2023年第1期604-637,共34页Sina Shadfar Sonam Parakh Md Shafi Jamali Julie D.Atkin 
supported by an Australian National Health and Medical Research Council(NHMRC)Dementia Teams Research Grant(1095215);Macquarie University MQCRF fellowship,Fight MND Foundation,and Motor Neuron Disease Research Australia.
Redox homeostasis refers to the balance between the production of reactive oxygen species(ROS)as well as reactive nitrogen species(RNS),and their elimination by antioxidants.It is linked to all important cellular acti...
关键词：Redox dysregulation DNA damage NEURODEGENERATION Reactive oxygen species Oxidative stress 
TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis被引量：1
《Translational Neurodegeneration》2022年第1期46-69,共24页Sarah Lépine Maria José Castellanos-Montiel Thomas Martin Durcan 
the Faculty of Medicine and Health Sciences of McGill University(to SL),a Canadian Mitacs Accelerate fellowship and ALS Canada trainee award(to MJCM).TMD acknowledges support from the Canada First Research Excellence Fund,awarded through the Healthy Brains,Healthy Lives initiative at McGill University,the CQDM FACs program,a US Department of Defense-ALS Discovery research grant and a project grant from CIHR(PJT-169095).
Amyotrophic lateral sclerosis(ALS)is a disease characterized by upper and lower motor neuron(MN)loss with a signature feature of cytoplasmic aggregates containing TDP-43,which are detected in nearly all patients.Mutat...
关键词：Amyotrophic lateral sclerosis DENERVATION Neuromuscular junction TDP-43 Dying-back Dying-forward 
Deciphering lipid dysregulation in ALS:from mechanisms to translational medicine
《Translational Neurodegeneration》2022年第1期192-218,共27页Ira Agrawal Yong Shan Lim Shi-Yan Ng Shuo-Chien Ling 
National Medical Research Council(NMRC/OFIRG/0042/2017);National Research Foundation(NRF2019-NRF-ISF003-3221);Ministry of Education(MOE-T2EP30220-0029),Singapore to S.-C.L.
Lipids,defined by low solubility in water and high solubility in nonpolar solvents,can be classified into fatty acids,glycerolipids,glycerophospholipids,sphingolipids,and sterols.Lipids not only regulate integrity and...
关键词：Amyotrophic lateral sclerosis SPHINGOLIPIDS TRIGLYCERIDES Phospholipids Cholesterol esters Fatty acids CERAMIDES Arachidonic acid LYSOPHOSPHATIDYLCHOLINE EICOSANOIDS 
New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis被引量：2
《Translational Neurodegeneration》2021年第4期595-610,共16页Frances Theunissen Phillip K.West Samuel Brennan Bojan Petrovic Kosar Hooshmand P.Anthony Akkari Matt Keon Boris Guennewig 
supported through the Australian National Health&Medical Research Council(NHMRC APP1163249).
Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by selective,early degeneration of motor neurons in the brain and spinal cord.Motor neurons have long axonal projections,which...
关键词：CYTOSKELETON NEUROFILAMENT Mitochondria Amyotrophic lateral sclerosis NEURODEGENERATION Axonal transport Gut microbiome 
Dysregulation of autophagy and mitochondrial function in Parkinson’s disease被引量：7
《Translational Neurodegeneration》2016年第1期152-160,共9页Bao Wang Neeta Abraham Guodong Gao Qian Yang 
The works were supported by National Natural Science Foundation of China(Grant No.31371400)(Q.Y)and(Grant No.31671060)(Q.Y).
Parkinson’s disease(PD)is the second most common neurodegenerative disease.Increasing evidence supports that dysregulation of autophagy and mitochondrial function are closely related with PD pathogenesis.In this revi...
关键词：Parkinson’s disease AUTOPHAGY MACROAUTOPHAGY MITOPHAGY Chaperone-mediated autophagy Mitochondria α-synuclein PINK/Parkin LRRK2 DJ-1 
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