NEUROTRAUMA

作品数：22被引量：46H指数：4
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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury
《Neural Regeneration Research》2025年第11期3063-3075,共13页Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles W.Plant 
supported by Ohio State Start Up Fund;National Institutes of Health(NIH);Department of Defense(DoD);Wings for Life Spinal Cord Research Foundation,Wings for Life Spinal Cord Research Foundation(Austria);California Institute of Regenerative Medicine(CIRM);International Spinal Research Trust(United Kingdom);Stanford University Bio-X Program Interdisciplinary Initiatives Seed Grant IIP-7;Dennis Chan Foundation;Klein Family Fund;Lucile Packard Foundation for Children's Health;Stanford Institute for Neuro-Innovation and Translational Neurosciences(SINTN);Saunders Family Neuroscience Fund;James Doty Neurosurgery Fund;Hearst Neuroscience Fund;Eileen Bond Research Fund(to GP)。
In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative medicine.Considering the non-regenerative nature of the mature central nervous system,the c...
关键词：axon regeneration central nervous system regeneration induced pluripotent stem cells NEUROTRAUMA regenerative medicine spinal cord injury stem cell therapy 
Neurogenic potential of NG2 in neurotrauma:a systematic review
《Neural Regeneration Research》2024年第12期2673-2683,共11页Yuri R.Rigo Radharani Benvenutti Luis V.Portela Nathan R.Strogulski 
supported by funding from FAPERGS under Grant No.1010267;FAPERGS/PPSUS;No.17/2551-0001;FAPERGS/PRONEX;No.16/2551-0000499-4;FAPERGS/CAPES under Grant No.19/25510000717-5;Conselho Nacional de Desenvolvimento Científico e Tecnologico under Grants Nos.4011645/2012-6 and#5465346/2014-6;Irish Research Council Government of Ireland Postdoctoral Fellowship;No.GOIPD/2022/792;Irish Research Council Enterprise Postdoctoral Fellowship;No.EPSPD/2022/112。
Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of research.This is reflected in a large d...
关键词：neural-glial antigen 2 neural-glial factor 2 neuron differentiation NG2 cell regeneration spinal cord injury(SCI) traumatic brain injury(TBI) 
Neutrophil extracellular traps mediate neuro-immunothrombosis被引量：2
《Neural Regeneration Research》2024年第8期1734-1740,共7页Jianbo Lou Jianning Zhang Quanjun Deng Xin Chen 
supported by the National Natural Science Foundation of China,No.82271399(to XC);the Project of Tianjin Applied Basic and Multiple Support Research,No.21JCZDJC00910(to XC);the Scientific Research Program of Tianjin Education Commission(Natural Science)of China,No.2019ZD034(to QD);the Science&Technology Program of Tianjin for Cultivation of Innovative Talents,No.22JRRCRC00020(to QD);the Tianjin Medical University"Clinical Talent Training 123 Climbing Plan"(to XC);the Tianjin Health Care Elite Prominent Young Doctor Development Program(to XC);the Young and Middle-aged Backbone Innovative Talent Program(to XC)。
Neutrophil extracellular traps are primarily composed of DNA and histones and are released by neutrophils to promote inflammation and thrombosis when stimulated by various inflammato ry reactions.Neutrophil extracellu...
关键词：inflammation neuro-immunothrombosis neurologic diseases NEUROTRAUMA neutrophil extracellular traps PLATELET THROMBOSIS traumatic brain injury 
Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury被引量：2
《Neural Regeneration Research》2022年第7期1505-1511,共7页Seth A.Herr Liangqin Shi Thomas Gianaris Yucheng Jiao Siyuan Sun Nick Race Scott Shapiro Riyi Shi 
supported by a grant from National Institute of Neurological Disorders and Stroke R21(No.1R21NS115094-01)。
Lipid peroxidation-derived aldehydes,such as acrolein,the most reactive aldehyde,have emerged as key culprits in sustaining post-spinal cord injury(SCI)secondary pathologies leading to functional loss.Strong evidence ...
关键词：ACROLEIN acrolein-lysine adduct alda-1 enzymatic catalyst lipid peroxidation mitochondrial aldehyde dehydrogenase-2 NEUROTRAUMA oxidative stress reactive aldehydes spinal cord contusion 
Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury被引量：3
《Neural Regeneration Research》2022年第2期378-385,共8页Mawj Mandwie Jordan A.Piper Catherine A.Gorrie Kevin A.Keay Giuseppe Musumeci Ghaith Al-Badri Alessandro Castorina 
The University of Technology Sydney(UTS)Start-up Research Grant 2018 funded this study(to AC)。
Evidence suggests that rapid changes to supporting glia may predispose individuals with spinal cord injury(SCI) to such comorbidities. Here, we interrogated the expression of astrocyte-and microglial-specific markers ...
关键词：affective disorders ASTROCYTES glial fibrillary acidic protein ionized calcium binding adaptor molecule 1 memory MICROGLIA NEUROTRAUMA spinal cord injury 
Regulation of neuroimmune processes by damage-and resolution-associated molecular patterns被引量：5
《Neural Regeneration Research》2021年第3期423-429,共7页Andis Klegeris 
supported by grants from the Natural Sciences and Engineering Research Council of Canada and the Jack Brown and Family Alzheimer's Disease Research Foundation。
Sterile inflammatory processes are essential for the maintenance of central nervous system homeostasis,but they also contribute to various neurological disorders,including neurotrauma,stroke,and demyelinating or neuro...
关键词：Alzheimer's disease ASTROCYTES DAMPS HMGB1 microglia neurodegeneration neuroimmune responses neuroinflammation NEUROTRAUMA OLIGODENDROCYTES pattern-recognition receptors RAMPS 
Altered physiology of gastrointestinal vagal afferents following neurotrauma被引量：3
《Neural Regeneration Research》2021年第2期254-263,共10页Emily N.Blanke Gregory M.Holmes Emily M.Besecker 
the National Institutes of Health(NINDS 49177;NINDS 105987);Craig H.Neilsen Foundation Senior Research award(295319)to GMH;a grant from the National Institutes of Health(NINDS F31 NS 087834)to EMB。
The adaptability of the central nervous system has been revealed in several model systems.Of particular interest to central nervous system-injured individuals is the ability for neural components to be modified for re...
关键词：gastrointestinal functions MICROBIOME NEUROTRAUMA nodose ganglia sensory neuropathy spinal cord injury traumatic brain injury vagal afferents visceral reflexes 
Fast-tracking regenerative medicine for traumatic brain injury被引量：6
《Neural Regeneration Research》2020年第7期1179-1190,共12页Brooke Bonsack Matt Heyck Chase Kingsbury Blaise Cozene Nadia Sadanandan Jea-Young Lee Cesar V. Borlongan 
CVB was funded by National Institutes of Health(NIH)R01NS071956,NIH R01NS090962,NIH R21NS089851,NIH R21NS094087;Veterans Affairs Merit Review I01 BX001407
Traumatic brain injury remains a global health crisis that spans all demographics,yet there exist limited treatment options that may effectively curtail its lingering symptoms.Traumatic brain injury pathology entails ...
关键词：clinical trials combined therapy inflammatory cascade NEUROINFLAMMATION neuroprotection NEUROTRAUMA PHARMACOTHERAPY preclinical studies secondary cell death stem cells 
Delayed treatment of secondary degeneration following acute optic nerve transection using a combination of ion channel inhibitors
《Neural Regeneration Research》2017年第2期307-316,共10页Nathanael J.Yates Marcus K.Giacci Ryan L. O'Hare Doig Wissam Chiha Bethany E. Ashworth Jade Kenna Carole A. Bartlett Melinda Fitzgerald 
financial support from the National Health and Medical Research Council(NHMRC),Australia(APP1061791);an NHMRC Career Development Fellowship(APP1087114)
Studies have shown that a combined application of several ion channel inhibitors immediately after central nervous system injury can inhibit secondary degeneration. However, for clinical use, it is necessary to determ...
关键词：nerve regeneration optic nerve injury neurotrauma secondary degeneration seromas calcium channel inhibitor node of Ranvier Tau phosphorylation lipid peroxidation oxidative stress neural regeneration 
Restoring nervous system structure and function using tissue engineered living scaffolds被引量：5
《Neural Regeneration Research》2015年第5期679-685,共7页Laura A.Struzyna James P.Harris Kritika S.Katiyar H.Isaac Chen D.Kacy Cullen 
support provided by the U.S.Army Medical Research and Materiel Command through the Joint Warfighter Medical Research Program(#W81XWH-13-13207004);Axonia Medical,Inc.;Department of Veterans Affairs(RR&D Merit Review#B1097-I);National Institutes of Health(NINDS T32-NS043126);Penn Medicine Neuroscience Center;the National Science Foundation(Graduate Research Fellowship DGE-1321851)
Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following ner- vous system injury...
关键词：living scaffolds neural tissue engineering cell transplant BIOMATERIALS regeneration NEUROTRAUMA NEURODEGENERATION axon pathfinding cell migration 
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