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作品数：326被引量：803H指数：13
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Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach
《Chinese Medical Journal》2025年第1期68-78,共11页Yujia Wang Yan Di Yongqi Li Jing Lu Bofan Ji Yuxia Zhang Zhiqing Chen Sijie Chen Bicheng Liu Rining Tang 
funded by the National Natural Science Foundation of China(No.82370742);the Key Program of Jiangsu Health and Health Committee(No.ZD2022045).
Background:Renal osteodystrophy(ROD)is a skeletal pathology associated with chronic kidney disease-mineral and bone disorder(CKD-MBD)that is characterized by aberrant bone mineralization and remodeling.ROD increases t...
关键词：Chronic kidney disease-mineral and bone disorder Renal osteodystrophy ADENINE PHOSPHATE TRANSCRIPTOMICS SPHINGOLIPIDS 
A novel mouse model of hyperuricemia and gouty nephropathy被引量：7
《Chinese Medical Journal》2020年第16期2012-2014,共3页Jin Guan Xiao-Qi Huang Jia-Le Dong Hui-Min Lu Yue-Wei Lin Mei Liu Zhi-Biao Yi Li-Min Wu Yong-Ming Huang Tian Lan 
Supported by grants from the Science and Technology Planning Project of Guangdong Province(No.2017A020211007),China;the Key Project of Natural Science Foundation of Guangdong Province(No.2016A030311014),China;the National Natural Science Foundation of China(No.81870420);Special Project on the Integration of Industry,Education and Research of Guangdong Province(No.2014B090902002);Science and Technological Program for Dongguan’s Social Development(No.2016108101043).
To the Editor:Hyperuricemia,the second most common metabolic disease after diabetes mellitus in China,is characterized by the elevated serum uric concentration which is due to the overactive uric acid production or un...
关键词：NEPHROPATHY ELEVATED DRUGS 
Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy被引量：4
《Chinese Medical Journal》2019年第21期2628-2635,共8页Zhi-Sheng Wu Wen-Li Huang Shu-Jie Gong 
Background:Epilepsy is a chronic and severe neurological disorder.Phosphatase and tensin homolog deleted on chromosome ten(PTEN)-deficient mice exhibit learning and memory deficits and spontaneous epilepsy.The aim of ...
关键词：EPILEPSY Status epilepticus BRAIN injuries Oxidative stress Neurons Inflammation 
Establishment of a Novel Mouse Model of Coronary Microembolization
《Chinese Medical Journal》2016年第24期2951-2957,共7页Yuan-Yuan Cao Zhang-Wei Chen Jian-Guo Jia Ao Chen You Zhou Yong Ye Yan-Hua Gao Yan Xia Shu-Fu Chang Jian-Ying Ma Ju-Ying Qian Jun-Bo Ge 
Background： Coronary microembolization （CME） has been frequently seen in acute coronary syndromes and percutaneous coronary intervention. Small animal models are required for further studies of CME related to sever...
关键词：Animal Model EMBOLIZATION Mice MICROSPHERES 
Adenovirus-mediated and tumor-specific transgene expression of the sodium-iodide symporter from the human telomerase reverse transcriptase promoter enhances killing of lung cancer cell line in vitro被引量：7
《Chinese Medical Journal》2010年第15期2070-2076,共7页SHI Yi-zhen ZHANG Jun LIU Zeng-li DU Shou-ying SHEN Yong-mei 
This work was supported by Project of Natural Science Foundation of Jiangsu Province （NO. BK2008164）.
Background The sodium-iodide symporter （NIS） protein can mediate the active radioiodine uptake.The human telomerase reverse transcriptase （hTERT） promoter is known to be selectively reactivated in majority of tumo...
关键词：sodium-iodide symporter INFECTION ADENOVIRIDAE iodine radioisotopes colony-forming units assay 
Synergistic antitumor effects of in vivo production of human endostatin and tissue inhibitor of metalloproteinase-1 in mice after subcutaneous implantation of primary fibroblasts transfected by adenovirus-mediated gene delivery被引量：1
《Chinese Medical Journal》2010年第7期922-928,共7页SHEN Wei-gan ZHU Jun ZHANG Yu SU Qing 
Background Tissue inhibitor of metalloproteinase （TIMP）-1 is a multifunctional protein. The aim of the study was to examine the feasibility of using a combination of adenovirus-mediated gene delivery of TIMP-1 plus ...
关键词：tissue inhibitor of metalloproteinase-1 ENDOSTATIN MELANOMA metastasis primary fibroblasts 
A novel mouse model of human breast cancer stem-like cells with high CD44^＋CD24^–/lower phenotype metastasis to human bone被引量：10
《Chinese Medical Journal》2008年第20期1980-1986,共7页LING Li-jun WANG Shui LIU Xiao-an SHEN En-chao DING Qiang LU Chao XU Jian CAO Qin-hong ZHU Hai-qing WANG Feng 
This work was supported by grants from National Natural Science Foundation of China （No. 300740076）, Jiangsu Six Kinds of Outstanding Talents Foundation （No. 2006B070）, Jiangsu Science and Education for Health Foundation （No. RC2007054） and Jiangsu Province Post-doctor Foundation （No. 0601048B）.
Background A satisfactory animal model of breast cancer metastasizing to bone is unavailable. In this study, we used human breast cancer stem-like cells and human bone to build a novel “human-source” model of human ...
关键词：breast cancer cancer stem-like cells human source bone metastasis animal model 
Suppression of experimental osteoarthritis by adenovirus-mediated double gene transfer被引量：20
《Chinese Medical Journal》2006年第16期1365-1373,共9页WANG Hai-jun YU Chang-long Kishi Hiroyuki Motoki Kazumi MAO Ze-bin Muraguchi Atsushi 
Background Osteoarthritis （OA） is a chronic and incurable disease, lacking effective treatment. Gene therapy offers a radical different approach to the treatment of arthritis. Even though the etiology of OA remains ...
关键词：OSTEOARTHRITIS receptors  interleukin- 1 tumor necrosis factor-alpha gene therapy 
Adenovirus-mediated overexpression of novel mutated IκBα inhibits nuclear factor κB activation in endothelial cells被引量：10
《Chinese Medical Journal》2005年第17期1422-1428,共7页ZHOU Lin-fu YIN Kai-sheng ZHU Zi-lu ZHU Yi YAO Xin MAO Hui XIE Wei-ping HUANG Mao 
This study was supported by grants from the National Youth NaturalScience Foundation of China(No.30400191)and the Key Subjectof’135’Project of Jiangsu Province(No.20013102).
Nuclear factor κB （NF-κB） overactivation, requiring phosphorylation and degradation of its inhibitor IκBα, is the basis for chronicity of airway inflammation in asthma. Based on our previous plasmid pShuttle-Iκ...
关键词：IκBα mutant nuclear factor κB recombinant adenovirus gene therapy asthma 
Inhibition of tumor growth in xenografted nude mice with adenovirus-mediated endostatin gene comparison with recombinant endostatin protein被引量：10
《Chinese Medical Journal》2004年第12期1809-1814,共6页梁志慧 吴沛宏 李立 薛刚 曾益新 黄文林 
Hi-TechResearchandDevelopmentProgramofChina(863Program)(No2003AA216061);andCMBSUMSScholarProgram(No.98677)
Background Inhibition of tumor growth by endostatin has been shown to be an effective strategy in cancer therapy in mice However, its widespread application has been hampered by difficulties in a large scale productio...
关键词：ANTIANGIOGENESIS ENDOSTATIN ADENOVIRUS gene therapy 
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