云南高校图书馆联盟文献共享服务平台- BICYCLOL

BICYCLOL: 作品数：12被引量：54H指数：5; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李燕陆宏张兰张健张祥建更多>>; 相关机构：河北医科大学第二医院中国医学科学院中国协和医科大学中国医学科学院北京协和医学院北京协和医学院更多>>; 相关期刊：《中国药理通讯》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家科技部专项基金更多>>

Clinical effect of microecological preparation combined with bicyclol on non-alcoholic fatty liver and its effect on liver fibrosis, blood lipid levels, serum inflammatory factors and TGF-β1: 《Journal of Hainan Medical University》2020年第12期39-43,共5页Hai-Ling Zhang Bo Tong Yan-Min Zhang Jie Zhang Xiao-Zhong Jiang Bin Liu; China Hepatitis Prevention Fund Project(tqgb20170015);Hebei medical science research key project(20170933);Hebei medical science research key project(20150842);Hebei Science and Technology Department funded project(162777133); Objective:To investigate the clinical effect of microecological preparation combined with bicyclol on nonalcoholic fatty liver (NAFLD) and its effect on liver fibrosis, serum inflammatory factors and transforming grow...; 关键词：Microecoloical agents BICYCLOL Nonalcoholic fatty liver TGF-Β1 Clinical efficacy

Genotoxicity and Embryotoxicity Study of Bicyclol Methyl Ether, Main Impurity in Bicyclol被引量：4: 《Chinese Journal of Integrative Medicine》2019年第10期743-749,共7页ZHANG Qian-qian LI Qiang DONG Lin LI Wan-fang LI Chao WANG Ai-ping WEI Jin-feng JIN Hong-tao; Objective: To assess the genotoxicity and embryotoxicity of bicyclol methyl ether(BME), the main impurity in bicyclol. Methods: Five concentrations of BME(0.5, 5, 50, 500 and 5000 μg/plate) were used in the Ames test...; 关键词：BICYCLOL methyl ether GENOTOXICITY EMBRYOTOXICITY AMES TEST chromosome aberration TEST zebrafish

Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication被引量：4: 《Acta Pharmaceutica Sinica B》2019年第4期769-781,共13页Meng-Hao Huang Hu Li Rong Xue Jianrui Li Lihua Wang Junjun Cheng Zhouyi Wu Wenjing Li Jinhua Chen Xiaoqin Lv Qiang Li Pei Lan Limin Zhao Yongfeng Yang Zonggen Peng Jiandong Jiang; supported by the National Natural Science Foundation of China(81321004,81621064,Jiandong Jiang;81322050,Zonggen Peng);National Mega-Project for “R&D for Innovative drugs”,Ministry of Science and Technology,China(2012ZX09301-002-001,Jiandong Jiang,2018ZX09711001-003-010,Zonggen Peng);Ministry of Education,China(NCET-12-0072,Zonggen Peng);CAMS Innovation Fund for Medical Sciences,China(CIFMS)(2017-I2M-3-012,Zonggen Peng); Bicyclol is a synthetic drug for hepatoprotection in clinic since 2004. Preliminary clinical observations suggest that bicyclol might be active against hepatitis C virus(HCV) with unknown mechanism. Here, we showed th...; 关键词：BICYCLOL Hepatitis C virus GLYCOLIPID transfer PROTEIN Host RESTRICTIVE factor PROTEIN interaction

Protective effect of bicyclol against bile duct ligation-induced hepatic fibrosis in rats被引量：5: 《World Journal of Gastroenterology》2015年第23期7155-7164,共10页Yong-Zhan Zhen Na-Ren Li Hong-Wei He Shuang-Shuang Zhao Guang-Ling Zhang Xiao-Fang Hao Rong-Guang Shao; Supported by the National Natural Science Foundation of China,No.81170409,No.81201281;the National S&T Major Special Project on Major New Drug Innovation,No.2012ZX09301002-001;the Wang Bao En Liver Fibrosis Foundation,No.20110026; AIM: To evaluate the protective effect of bicyclol against bile duct ligation(BDL)-induced hepatic fibrosis in rats.METHODS: Sprague-Dawley male rats underwent BDL and sham-operated animals were used as healthy contro...; 关键词：BICYCLOL Rat BILE DUCT LIGATION Liver FIBROSIS Gene expression profile

Reducing the oxidative stress mediates the cardioprotection of bicyclol against ischemia-reperfusion injury in rats被引量：8: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2013年第6期487-495,共9页Jie CUI Zhi LI Ling-bo QIAN Qin GAO Jue WANG Meng XUE Xiao-e LOU Iain C.BRUCE Qiang XIA Hui-ping WANG; Project (Nos. 2011C23105 and 2012C33088) supported by the Department of Science and Technology of Zhejiang Province,China; Objective:To investigate the beneficial effect of bicyclol on rat hearts subjected to ischemia-reperfusion(IR) injuries and its possible mechanism.Methods:Male Sprague-Dawley rats were intragastrically administered wi...; 关键词：Ischemia-reperfusion injury CARDIOPROTECTION Oxidative stress Mitochondrial permeability transition pore BICYCLOL

Bicyclol protects HepG2 cells against D-galacto-samine-induced apoptosis through inducing heat shock protein 27 and mitochondria associated pathway被引量：6: 《Acta Pharmacologica Sinica》2010年第2期219-226,共8页Xiu-qi BAO Geng-tao LIU; Aim： To study the inducing effect of bicyclol on heat shock protein 27 （HSP27） and its role on anti-apoptosis in HepG2 cells intoxicated with D-galactosamine （D-GaIN）. Methods： HepG2 cells were treated with vari...; 关键词：BICYCLOL heat shock protein MITOCHONDRIA c-Jun N-terminal kinase apoptosis HepG2 cells cytochrome c D-GALACTOSAMINE

Enantioseparation of Racemic Anti-hepatitis New Drug Bicyclol with Crystallization被引量：2: 《Chinese Chemical Letters》2005年第11期1471-1473,共3页Wei HU Yan LI Chun Zhen ZHANG; The enantioseparation of anti-hepatitis new drug （±）-bicyclol was performed by optically active alkaloid. The alcoholic acid, the hydrolysate of bicyclol was reacted with optically active alkaloid, such as brucine,...; 关键词：（±）-Bicyclol 4 4＇-dimethoxy-2 3 2 3＇-bis（methylenedioxy）-6-hydroxymethyl-6＇-methoxy-carbonyl biphenyl anti-hepatitis resolution.

Toxicity of novel anti-hepatitis drug bicyclol: A preclinical study被引量：5: 《World Journal of Gastroenterology》2005年第5期665-671,共7页Geng-TaoLiu YanLi Huai-LingWei HongLu HuiZhang Yu-GuiGao Ling-ZhiWang; Supported by the Grant From Ministry of Sciences and Technology of China, No.96-901-01 -45; AIM: To study the toxicity of bicyclol to animals. METHODS: Acute toxicity test was performed in Kunming strain mice that were orally given bicyclol at the doses of 3 and 5 g/kg body weight, respectively. Wistar rats ...; 关键词：BICYCLOL Antiviral agents Toxicity test

Inhibition of Fas/FasL mRNA expression and TNF-a release in concanavalin A-induced liver injury in mice by bicyclol被引量：23: 《World Journal of Gastroenterology》2004年第12期1775-1779,共5页MinLi Geng-TaoLiu; Supported by the Grant from Ministry of Science and Technology of China,No.94-ZD-02; AIM: Bicyclol, 4,4'-dimethoxy-5,6,5',6'-dimethylene-dioxy-2-hydroxymethy1-2'-carbonyl biphenyl, is a new anti-hepatitis drug. The aim of the present study was to investigate the protective effect of bicyclol on concan...; 关键词：抑制剂 FAS/FASL mRNA 基因表达 TNF-α 伴刀豆蛋白 A-诱导肝损害老鼠免疫学

Pharmacology and clinical effect of Bicyclol——A new anti—hepatitis drug: 《中国药理通讯》2002年第4期18-18,共1页刘耕陶; 关键词：新型抗肝炎药物抗病毒药物 BicycLDL HBV-DNA 临床疗效药理学

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