MONOPHOSPHATE

作品数：92被引量：261H指数：8
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相关领域：医药卫生更多>>
相关作者：肖明芳应汉杰杨晓亮吕浩何明芳更多>>
相关机构：南京工业大学南京大学福建中医药大学中国人民解放军第一军医大学更多>>
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相关基金：国家自然科学基金福建省自然科学基金国家重点基础研究发展计划广东省自然科学基金更多>>
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Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1a axis to alleviate ferroptosis in metabolic-associated fatty liver disease
《Acta Pharmaceutica Sinica B》2025年第1期151-167,共17页Aoxiang Zhuge Shengjie Li Shengyi Han Yin Yuan Jian Shen Wenrui Wu Kaicen Wang Jiafeng Xia Qiangqiang Wang Yifeng Gu Enguo Chen Lanjuan Li 
supported by the National Natural Science Foundation of China(81790631,81874142,and 82073041);the National Key Research and Development Program of China(2018YFC2000500,2021YFA1301104,and 2021YFC2301804);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-045,China);the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(JNL-2022001A,China);the China Postdoctoral Science Foundation(2023M743125).
Emerging evidences have indicated the role of ferroptosis in the progression of metabolicassociated fatty liver disease(MAFLD);thus,inhibiting ferroptosis is a promising strategy for the development of MAFLD therapeut...
关键词：Metabolic-associated fatty liver disease Ferroptosis Lipid peroxidation Akkermansia muciniphila ACETATE Adenosine 50-monophosphate 
Peptide nanotube loaded with a STING agonist,c-di-GMP,enhance cancer immunotherapy against melanoma被引量：1
《Nano Research》2023年第4期5206-5215,共10页Ziyuan Zhang Juan Liu Min Xiao Quanfeng Zhang Zhonghua Liu Meiyan Liu Peng Zhang Youlin Zeng 
supported by the National Natural Science Foundation of China(Nos.21877036 and 32201044);the Key Project of Developmental Biology and Breeding from Hunan Province(No.2022XKQ0205);the Hunan Natural Science Foundation(No.2021JJ40335);the Science and Technology Planning Project of Hunan Province(No.2018TP1017).
The activation of the stimulating factor of the interferon gene(STING)pathway can enhance the immune response within the tumor.Cyclic diguanylate monophosphate(c-di-GMP)is a negatively charged,hydrophilic STING agonis...
关键词：cyclic diguanylate monophosphate stimulating factor of the interferon gene(STING) peptide nanotubes in situ immunity tumor immunotherapy 
Molecular Similarity within Carcinogen and Guanine Cyclic Nucleotide Structures
《Journal of Biosciences and Medicines》2022年第5期86-94,共9页Wynford Robert Williams 
Tumor promoters, apoptosis and autophagy modulators, chemotherapy drugs, and endogenous steroids demonstrate molecular similarity relative to cyclic nucleotide structure. This study explores relative molecular similar...
关键词：ANESTHETICS Cancer CARCINOGENS Guanosine Cyclic Monophosphate Molecular Similarity 
Cyclic Nucleotide Structural Differentiation of Compounds Modulating Apoptosis and Drug Resistance被引量：2
《Journal of Biosciences and Medicines》2021年第8期10-28,共19页Wynford Robert Williams 
Carcinogenesis is associated with malfunction in the cGMP-mediated regulation of cytosolic Ca2+ and reactive oxygen species. Chemotherapy resistant cancer cells are re-sensitised to apoptosis by the action ...
关键词：Cancer CHEMOTHERAPY Guanosine Cyclic Monophosphate Molecular Similarity Multidrug Resistance 
Liraglutide suppresses the proliferation of endometrial cancer cells through the adenosine 5'-monophosphate(AMP)-activated protein kinase signaling pathway被引量：2
《Chinese Medical Journal》2021年第5期576-578,共3页Xin-Xin Zhu Zong-Hao Feng Lin-Zhi Liu Yan Zhang 
This work was supported by a grant from the National Natural Science Foundation of China(No.81272870).
This study investigated the effect of liraglutide(an analog of human glucagon-like peptide-1[GLP-1])on the proliferation of Ishikawa(IK)and human endometrial carcinoma(HEC)-IB endometrial cancer(EC)cell lines,identifi...
关键词：ENDOMETRIAL cancer PROGESTERONE 
Effect of endostatin overexpression on angiotensin Ⅱ-induced cardiac hypertrophy in rats
《Chinese Medical Journal》2019年第22期2716-2723,共8页You-Jin Dai Jue-Xiao Gong Rong Bian 
Background:Endostatin,a biologically active fragment of collagen XVIII,has been observed in patients w让h ischemic heart disease.The aim of the present study was to investigate whether endostatin overexpression could ...
关键词：ENDOSTATIN Cardiac HYPERTROPHY CARDIOMYOCYTES Cyclic ADENOSINE MONOPHOSPHATE Protein kinase A 
ADSL, AMPD1, and ATIC Expression Levels in Muscle and Their Correlations with Muscle Inosine Monophosphate Content in Dapulian and Hybridized Pig Species被引量：3
《Open Journal of Animal Sciences》2017年第4期393-404,共12页Rongsheng Zhu Yanping Wang Huaizhong Wang Song Lin Shouli Sun Baohua Huang Hongmei Hu 
We investigated the relationship between muscle inosine monophosphate (IMP) content and mRNA levels of ADSL, AMPD1, and ATIC in Dapulian (DPL), Landrace × Dapulian (LDPL), and Duroc × Landrace × Dapulian (DLDPL) hy...
关键词：PIGS ADSL GENE AMPD1 GENE ATIC GENE Correlation INOSINE MONOPHOSPHATE 
Guanylyl cyclase C signaling axis and colon cancer prevention被引量：2
《World Journal of Gastroenterology》2016年第36期8070-8077,共8页Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman 
Supported by NIH,No.R01CA170533,No.R01CA206026 and No.P30CA56036;Targeted Diagnostic and Therapeutics,Inc.;a Ruth L.Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH,No.CA180500(To Blomain ES);a Ruth L.Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows from the NIH,No.F30 DK103492(To Merlino DJ);a Predoctoral Fellowship in Pharmacology/Toxicology from the PhR MA Foundation
Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, a...
关键词：Colorectal cancer GUANYLIN UROGUANYLIN Chemoprevention Heat-stable ENTEROTOXINS Cyclic GUANOSINE MONOPHOSPHATE Guanylyl CYCLASE C 
Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin被引量：1
《Pain Studies and Treatment》2014年第1期6-10,共5页Marco Antonio Mibielli Carlos Pereira Nunes Ari Boulanger Scussel Jr. Mendel Suchmacher Neto Lisa Oliveira Mauro Geller 
Rationale: In a previously published trial on spinal acute non-traumatic pain, peripheral neuro- regenerative combination of UTP, CMP and hydroxocobalamin presented unexpected analgesicproperties. Objective: To corrob...
关键词：URIDINE TRIPHOSPHATE CYTIDINE MONOPHOSPHATE Hydroxocobalamin Analgesia 
EFFECT OF 3,4-DIHYDROXYACETOPHENONE ON RABBIT PLATELET PHOSPHODIESTERASE ACTIVITY被引量：1
《Chinese Science Bulletin》1987年第3期204-207,共4页徐海新 安岩 汪钟 
3,4-Dihydroxyacetophenone (DHAP) which is extracted from the leaves of a Ghinese medicinal herb of Ilex pubescens Hook. et Arn. var. glaber Chang, has been tried in the treatment of coronary heart disease. Clinical da...
关键词：relieve ADENOSINE medicinal VENOM MONOPHOSPHATE PLATELET inhibited hydrolysis snake RABBIT 
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