云南高校图书馆联盟文献共享服务平台- BAICALEIN

BAICALEIN: 作品数：71被引量：390H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张黎胡燕华王琼李惠勉杨琳更多>>; 相关机构：中国药科大学华中科技大学郑州大学第二附属医院北京大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金河南省科技攻关计划国家杰出青年科学基金广东省自然科学基金更多>>

A comprehensive overview on antiviral effects of baicalein and its glucuronide derivative baicalin: 《Journal of Integrative Medicine》2024年第6期621-636,共16页Xin-yang Liu Wei Xie He-yang Zhou Hui-qing Zhang Yong-sheng Jin; supported by National Natural Science Foundation of China(No.81573585);the Innovative Practice of Undergraduate Project of Naval Medical University(No.FH2021104)。; Natural product-based antiviral candidates have received significant attention.However,there is a lack of sufficient research in the field of antivirals to effectively combat patterns of drug resistance.Baicalein and ...; 关键词：BAICALIN BAICALEIN Antiviral effects Influenza virus FLAVIVIRUS Hepatitis B virus Mechanism

Inhibition of Cancer Cell Growth by Baicalein via ESR1 Based on Molecular Dynamics Simulations: 《Proceedings of Anticancer Research》2024年第6期150-156,共7页Chao Kang Mengke Wang Yongsong Zhang; This study investigates the mechanism by which baicalin inhibits cancer cell growth through estrogen receptor 1 (ESR1) using molecular dynamics simulations. The results show that baicalin primarily binds to the ligand...; 关键词：BAICALIN ESR1 Molecular dynamics simulation Cancer cell growth Estrogen signaling pathway

Herbal combinations against COVID-19:A network pharmacology,molecular docking and dynamics study: 《Journal of Integrative Medicine》2023年第6期593-604,共12页Jian-bo Song Li-qin Zhao Hong-ping Wen Yuan-ping Li; supported by the Wu Jieping Medical Foundation(No.320.6750.2021–08-11).; Objective:The aim of this study is to identify molecules from traditional Chinese medicine(TCM)with potential activity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants.Methods:We app...; 关键词：Herbal medicine Molecular docking BAICALEIN Severe acute respiratory syndrome coronavirus 2 Coronavirus disease 2019

Enhancement of CREC sensitivity to fosfomycin by baicalein through increasing outer membrane permeability: 《Infectious Diseases Research》2022年第4期15-19,共5页Hai-Yang Xing Ding Ding Ling-Na Qu Cheng-Yu Li; This work was supported by Wenling Science and Technology Bureau for Youth Scholars(No.2021S00058).; Background:To confirm whether baicalein improves the sensitivity of carbapenem-resistant Escherichia coli(CREC)to fosfomycin by increasing the permeability of bacterial outer membrane in vitro experiments.Methods:The ...; 关键词：BAICALEIN FOSFOMYCIN CREC SYNERGY outer membrane permeability

Baicalein Attenuates Severe Polymicrobial Sepsis via Alleviating Immune Dysfunction of T Lymphocytes and Inflammation被引量：1: 《Chinese Journal of Integrative Medicine》2022年第8期711-718,共8页CHEN Hai-yan ZHANG Shu LI Jun HUANG Na SUN Jin LI Bao-hua YANG Jun LI Zong-fang; Supported by Program for Changjiang Scholars and Innovative Research Team in University,China(No.IRT1171)。; Objective:To investigate the effect of baicalein on polymicrobial sepsis-induced immune dysfunction and organ injury.Methods:A sepsis model was induced in Sprague-Dawley rats via caecal ligation and puncture(CLP).Spec...; 关键词：BAICALEIN Chinese medicine SEPSIS SPLEEN INFLAMMATION LYMPHOCYTES

Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR/IL-22 pathway in ILC3s被引量：39: 《Acta Pharmacologica Sinica》2022年第6期1495-1507,共13页Yan-yang Li Xiao-jing Wang Yu-lin Su Qing Wang Shao-wei Huang Zeng-feng Pan Yan-ping Chen Jun-jie Liang Mei-ling Zhang Xue-qian Xie Zhi-yun Wu Jin-yan Chen Lian Zhou Xia Luo; This work was supported by the National Natural Science Foundation of China(Grant No.82074092);Characteristic Innovation Project of Guangdong Provincial Universities(Grant No.2020KTSCX026);“Double First-class”and High-level University Discipline Collaborative Innovation Team Project of Guangzhou University of Chinese Medicine(Grant No.2021xk81);Natural Science Foundation of Guangdong Province(Grant no.2021A1515012219);Guangdong Provincial Bureau of Traditional Chinese Medicine(Grant no.20181076).; Ulcerative colitis(UC)is a chronic inflammatory disease of the gastrointestinal tract,which is closely related to gut barrier dysfunction.Emerging evidence shows that interleukin-22(IL-22)derived from group 3 innate l...; 关键词：ulcerative colitis BAICALEIN epithelial barrier group 3 innate lymphoid cells INTERLEUKIN-22 aryl hydrocarbon receptor CH223191 FICZ

Flavonoids from traditional Chinese herbs for diabetes in rats:a network Meta-analysis被引量：2: 《Journal of Traditional Chinese Medicine》2022年第1期1-8,共8页WU You HU Yuli LIU Wei SUN Boju ZHANG Chengfei WU Lili LIU Tonghua; Supported by the International Cooperation Base for the Prevention and Treatment of Chronic Diseases by Traditional Chinese Medicine(No.GZYYGJ2019034);National Center for International Research(No.2015B01022)。; OBJECTIVE:In this Meta-analysis,we evaluated the hypoglycemic effect of 5 flavonoids found in traditional Chinese herbs(naringenin,kaempferol,puerarin,baicalein,and luteolin)on diabetic rats.METHODS:Four databases inc...; 关键词：diabetes mellitus NARINGENIN KAEMPFEROL PUERARIN BAICALEIN LUTEOLIN Meta-analysis

Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo被引量：2: 《Journal of Traditional Chinese Medical Sciences》2021年第3期238-247,共10页Yang Liu Jing Sun Linying Zhong Yu Li A Na Er Tong Li Le Yang Ling Dong; supported by the National Natural Science Foundation of China (81473362)。; Objective: To determine the in vitro and in vivo absorption properties of active ingredients of the Chinese medicine, baicalein, to enrich mechanistic understanding of oral drug absorption.Methods: The Biopharmaceutic...; 关键词：Biopharmaceutical classification system BAICALEIN Intrinsic dissolution rate In situ intestinal perfusion Physiologically based pharmacokinetics Absorption properties

Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes被引量：18: 《Acta Pharmacologica Sinica》2021年第5期701-714,共14页Bing-yan Liu Ling Li Gao-li Liu Wei Ding Wen-guang Chang Tao Xu Xiao-yu Ji Xian-xin Zheng Jing Zhang Jian-xun Wang; This work was supported by the Natural Science Foundation of Shandong Province(No.JQ201815);the National Natural Science Foundation of China(No.81770232);grants from FuWai Hospital(No.2019kf-03).; Baicalein is a natural flavonoid extracted from the root of Scutellaria baicalensis that exhibits a variety of pharmacological activities.In this study,we investigated the molecular mechanisms underlying the protectiv...; 关键词：BAICALEIN cardiac hypertrophy ISOPROTERENOL ROS CATALASE FUNDC1

Potential Action Mechanism of Baicalin on COVID-19 Based on Network Pharmacology: 《Medicinal Plant》2021年第1期87-90,共4页Kun FANG Zhengjie XU Suxiao JIANG Ping ZHANG Lijuan DUAN; Supported by Special Key R&D Project for COVID-19 Epidemic Prevention and Control of Ningxia Hui Autonomous Region(2020XGFY0013).; [Objectives]To collect the main active components and targets of baicalein,and to explore the relationship between their targets and COVID-19 and the treatment mechanism of potential unknown targets.[Methods]The 2D an...; 关键词：Network pharmacology BAICALEIN COVID-19 Action mechanism

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