EPILEPSY

作品数：786被引量：1111H指数：13
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相关机构：首都医科大学复旦大学中国科学院上海生命科学研究院青岛大学更多>>
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Epilepsy therapy beyond neurons: Unveiling astrocytes as cellular targets
《Neural Regeneration Research》2026年第1期23-38,共16页Yuncan Chen Jiayi Hu Ying Zhang Lulu Peng Xiaoyu Li Cong Li Xunyi Wu Cong Wang 
supported by the National Key Research and Development Program of China,No. 2023YFF0714200 (to CW);the National Natural Science Foundation of China,Nos. 82472038 and 82202224 (both to CW);the Shanghai Rising-Star Program,No. 23QA1407700 (to CW);the Construction Project of Shanghai Key Laboratory of Molecular Imaging,No. 18DZ2260400 (to CW);the National Science Foundation for Distinguished Young Scholars,No. 82025019 (to CL);the Greater Bay Area Institute of Precision Medicine (Guangzhou)(to CW)。
Epilepsy is a leading cause of disability and mortality worldwide. However, despite the availability of more than 20 antiseizure medications, more than one-third of patients continue to experience seizures. Given the ...
关键词：ASTROCYTE cellular microenvironment drug resistance EPILEPSY EXCITABILITY homeostasis metabolism neural networks NEUROINFLAMMATION neuron 
Investigation of epilepsy-related genes in a Drosophila model
《Neural Regeneration Research》2026年第1期195-211,共17页Xiaochong Qu Xiaodan Lai Mingfeng He Jinyuan Zhang Binbin Xiang Chuqiao Liu Ruina Huang Yiwu Shi Jingda Qiao 
supported by the Guangdong Basic and Applied Basic Research Foundation,No.2022A1515111123(to JQ)。
Complex genetic architecture is the major cause of heterogeneity in epilepsy,which poses challenges for accurate diagnosis and precise treatment.A large number of epilepsy candidate genes have been identified from cli...
关键词：Drosophila melanogaster ELECTROPHYSIOLOGY EPILEPSY GENETICS morphology neurogenetic diseases POLYGENE precision medicine seizure behavior UAS/GAL4 system 
Context-dependency in medicine:how neuronal excitability influences the impact of dopamine on cognition
《Neural Regeneration Research》2025年第11期3225-3226,共2页Mahboubeh Ahmadi Nahid Rouhi Javad Mirnajafi-Zadeh Bechara J.Saab 
Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain processes.While dopamine is primarily associated with pleasure,reward,and motivation,its effect...
关键词：DOPAMINE EPILEPSY primarily 
The complex role of protocadherin-19 in brain function:a focus on the oxytocin system
《Neural Regeneration Research》2025年第11期3211-3212,共2页Sara Mazzoleni Marta Busnelli Silvia Bassani 
supported by a grant from Telethon Foundation(grant No.GGP20056 to SB);The generation of Pcdh19 floxed mouse model was funded by Cariplo Foundation(grant No.2014-0972 to SB)。
Mutations in the protocadherin-19(PCDH19)gene(Xq22.1)cause the X-linked syndrome known as developmental and epileptic encephalopathy 9(DEE9,OMIM#300088)(Dibbens et al.,2008).DEE9 is characterized by early-onset cluste...
关键词：EPILEPSY FUNCTION SYSTEM 
The role of axon guidance molecules in the pathogenesis of epilepsy
《Neural Regeneration Research》2025年第5期1244-1257,共14页Zheng Liu Chunhua Pan Hao Huang 
supported by the National Natural Science Foundation of China,Nos. 81760247, 82171450;the Scientific Research Foundation for Doctors of the Affiliated Hospital of Zunyi Medical University,No.(2016)14 (all to HH)。
Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target no...
关键词：axon guidance drug-resistant epilepsy EPILEPSY nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity NEURONS synaptic remodeling 
Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies被引量：2
《Neural Regeneration Research》2025年第4期917-935,共19页Dian Jiao Lai Xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu 
supported by the National Natural Science Foundation of China,No.32130060(to XG).
Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The ...
关键词：DIAGNOSIS drug treatment ELECTROENCEPHALOGRAPHY epilepsy monitoring EPILEPSY nerve regeneration NEUROSTIMULATION non-drug interventions PATHOGENESIS prediction 
Epileptic brain network mechanisms and neuroimaging techniques for the brain network被引量：1
《Neural Regeneration Research》2024年第12期2637-2648,共12页Yi Guo Zhonghua Lin Zhen Fan Xin Tian 
supported by the Natural Science Foundation of Sichuan Province of China,Nos.2022NSFSC1545 (to YG),2022NSFSC1387 (to ZF);the Natural Science Foundation of Chongqing of China,Nos.CSTB2022NSCQ-LZX0038,cstc2021ycjh-bgzxm0035 (both to XT);the National Natural Science Foundation of China,No.82001378 (to XT);the Joint Project of Chongqing Health Commission and Science and Technology Bureau,No.2023QNXM009 (to XT);the Science and Technology Research Program of Chongqing Education Commission of China,No.KJQN202200435 (to XT);the Chongqing Talents:Exceptional Young Talents Project,No.CQYC202005014 (to XT)。
Epilepsy can be defined as a dysfunction of the brain network,and each type of epilepsy involves different brain-network changes that are implicated diffe rently in the control and propagation of interictal or ictal d...
关键词：electrophysiological techniques EPILEPSY functional brain network functional magnetic resonance imaging functional near-infrared spectroscopy machine leaning molecular imaging neuroimaging techniques structural brain network virtual epileptic models 
Nrf2 as a potential target for the treatment of epilepsy被引量：1
《Neural Regeneration Research》2024年第9期1865-1866,共2页Prince Kumar Singh Tawfeeq Shekh-Ahmad 
supported by The Israel Science Foundation,No.1976/20(to TSA).
Epilepsy is a prevalent chronic brain disorder that is characterized by a persistent predisposition to recurrently generate epileptic seizures and is often associated with cognitive and psychological consequences.Epil...
关键词：EPILEPSY NRF2 
Astrocyte chloride,excitatory-inhibitory balance and epilepsy
《Neural Regeneration Research》2024年第9期1887-1887,共1页Verena Untiet Maiken Nedergaard Alexei Verkhratsky 
Excitation and inhibition are at the core of brain function and malfunction.To sustain the activity of neuronal networks over time and space,glutamatergic excitation is balanced by GABAergic inhibition.The equipoise o...
关键词：EPILEPSY EXCITATORY excitation 
Aberrant adult neurogenesis in intractable epilepsy:can GABAergic progenitor transplantation normalize this process?
《Neural Regeneration Research》2024年第7期1419-1420,共2页Muhammad N.Arshad Janice R.Naegele 
Temporal lobe epilepsy(TLE) is a common type of focal epilepsy characterized by seizure foci within the temporal lobes.While surgical resection of the foci is an established and effective approach for controlling seiz...
关键词：EPILEPSY PROGENITOR seizures 
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