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EPILEPSY: 作品数：786被引量：1111H指数：13; 导出分析报告; 相关作者：熊志奇岳旺王蕾张芳陈迁更多>>; 相关机构：首都医科大学复旦大学中国科学院上海生命科学研究院青岛大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金北京市自然科学基金更多>>

Raising New Hope for Controlling Seizures in Focal Cortical Dysplasia with Gene Therapy: 《Neuroscience Bulletin》2024年第7期1028-1030,共3页Yuanzhi Yang Yang Zheng Zhong Chen Cenglin Xu; supported by grants from the National Natural Science Foundation of China(82330116 and 82374064);the Natural Science Foundation of Zhejiang Province(LD22H310003).; Focal cortical dysplasia(FCD)is characterized by abnormal cortical development and pharmacoresistant epilepsy,often accompanied by cognitive and behavioral malfunctions[1].According to the International League against...; 关键词：EPILEPSY al. THERAPY

Interleukins in Epilepsy:Friend or Foe被引量：2: 《Neuroscience Bulletin》2024年第5期635-657,共23页Yuan Dong Xia Zhang Ying Wang; supported by grants from the National Natural Science Foundation of China(82003729);the Natural Science Foundation of Shandong Province(ZR2022QH144 and ZR2020QH357).; Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures,affecting~65 million worldwide.Evidence in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epilep...; 关键词：EPILEPSY INTERLEUKINS NEUROINFLAMMATION

The Contributions of Thrombospondin-1 to Epilepsy Formation被引量：1: 《Neuroscience Bulletin》2024年第5期658-672,共15页Yao Cheng Yujie Zhai Yi Yuan Qiaoyun Wang Shucui Li Hongliu Sun; supported by the Natural Science Foundation of Shandong Province(ZR2021MH034 and ZR2022MH059);the National Natural Science Foundation of China(81573412).We’d like to thank Editage for English language editing.; Epilepsy is a neural network disorder caused by uncontrolled neuronal hyperexcitability induced by an imbalance between excitatory and inhibitory networks.Abnormal synaptogenesis plays a vital role in the formation of...; 关键词：Thrombospondin-1 EPILEPTOGENESIS SYNAPTOGENESIS HYPEREXCITABILITY

Stem Cell Transplantation Represents a New Strategy for the Treatment of Epilepsy被引量：1: 《Neuroscience Bulletin》2024年第5期673-676,共4页Yuan Zhou Yi Wang Lin Yang; supported by grants from the National Natural Science Foundation of China(82373859).; Epilepsy is a neurological disorder characterized by faulty neuronal synchronization and repeated seizures.The balance between glutamatergic excitatory neurons and gammaaminobutyric acid inhibitory neurons is critical...; 关键词：EPILEPSY TRANSPLANTATION STRATEGY

mTORC2:The“Ace in the Hole”for a Broader Control of Epileptic Seizures?被引量：1: 《Neuroscience Bulletin》2024年第5期677-679,共3页Shuo Zhang Xiongfeng Guo Wei Huang Cenglin Xu; supported by grants from the National Natural Science Foundation of China(82173796 and 82374064);the Medical and Health Research Project of Zhejiang Province,China(2021RC097).; Over 70 million people worldwide suffer from epilepsy-one of the most prevalent chronic neurological disorders[1].Despite the availability of over thirty anti-seizure drugs(ASDs)that mainly act on voltage-gated ion ch...; 关键词：DRUGS SPITE EPILEPSY

GABAergic Interneuron Cell Therapy for Drug-Resistant Epilepsy被引量：2: 《Neuroscience Bulletin》2024年第5期680-682,共3页Junzi Chen Zhongxia Li Yi Wang Liying Chen; supported by grants from the National Natural Science Foundation(82204350);the Natural Science Foundation of Zhejiang Province(Q22H309365 and LQ22H310007).; Epilepsy,one of the most common central nervous system disorders,affects about 70 million people of all ages worldwide[1].It is characterized by hyperactive neuronal networks,resulting from imbalanced excitatory and i...; 关键词：EPILEPSY THERAPY SEIZURE

Novel Mechanism,Drug Target and Therapy in Epilepsy: 《Neuroscience Bulletin》2024年第5期561-563,共3页Cenglin Xu Yi Wang Zhong Chen; supported by the National Natural Science Foundation of China(82330116);the Natural Science Foundation of Zhejiang Province(D24H310001).; Epilepsy,which is characterized by unprovoked seizures and has a prevalence of nearly 1%,is becoming one of the leading causes of disability and death globally[1].The exact mechanisms behind epilepsy are still unknown...; 关键词：EPILEPSY THERAPY DEATH

Development of SV2A Ligands for Epilepsy Treatment:A Review of Levetiracetam,Brivaracetam,and Padsevonil被引量：1: 《Neuroscience Bulletin》2024年第5期594-608,共15页Peng-Peng Wu Bi-Rong Cao Fu-Yun Tian Zhao-Bing Gao; supported by funding from the High-level New R&D Institute(2019B090904008);the High-level Innovative Research Institute(2021B0909050003)of the Department of Science and Technology of Guangdong Province;National Science and Technology Innovation 2030 Major Program(2021ZD0200900);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Zhongshan Municipal Bureau of Science and Technology(CXTD2022013);the National Science Fund for Distinguished Young Scholars(81825021);the funding from Zhongshan Municipal Bureau of Science and Technology(210724194041939).; Epilepsy is a common neurological disorder that is primarily treated with antiseizure medications(ASMs).Although dozens of ASMs are available in the clinic,approximately 30%of epileptic patients have medically refract...; 关键词：LEVETIRACETAM EPILEPSY Antiseizure medications Synaptic vesicle protein 2A BRIVARACETAM Padsevonil

Pathological and Physiological High-frequency Oscillations on Electroencephalography in Patients with Epilepsy被引量：1: 《Neuroscience Bulletin》2024年第5期609-620,共12页Hongyi Ye Cong Chen Shennan A.Weiss Shuang Wang; supported by the National Natural Science Foundation of China(82171437 and 81971207).; High-frequency oscillations(HFOs)encompass ripples(80 Hz–200 Hz)and fast ripples(200 Hz–600 Hz),serving as a promising biomarker for localizing the epileptogenic zone in epilepsy.Spontaneous fast ripples are always ...; 关键词：RIPPLES EPILEPSY Memory SLEEP Surgical outcome

Spatial Distribution of Parvalbumin-Positive Fibers in the Mouse Brain and Their Alterations in Mouse Models of Temporal Lobe Epilepsy and Parkinson’s Disease: 《Neuroscience Bulletin》2023年第11期1683-1702,共20页Changgeng Song Yan Zhao Jiajia Zhang Ziyi Dong Xin Kang Yuqi Pan Jinle Du Yiting Gao Haifeng Zhang Ye Xi Hui Ding Fang Kuang Wenting Wang Ceng Luo Zhengping Zhang Qinpeng Zhao Jiazhou Yang Wen Jiang Shengxi Wu Fang Gao; supported by the Ministry of Science and Technology of China(2021ZD0201005);the National Natural Science Foundation of China(82071529 and 81974204);the Key R&D Program of Shaanxi Province(2021SF-238).; Parvalbumin interneurons belong to the major types of GABAergic interneurons.Although the distribution and pathological alterations of parvalbumin interneuron somata have been widely studied,the distribution and vulne...; 关键词：alterations EPILEPSY fibers

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