HOMEOSTASIS

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  • 期刊=Signal Transduction and Targeted Therapyx
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Advances in calcium-sensing receptor modulation: biased signaling and therapeutic potential
《Signal Transduction and Targeted Therapy》2025年第1期10-12,共3页Luisa Uhlmann Ulf Wagner 
support from the German Research Foundation(grant number WA 2765/9-2).
In a recent study published in Science,Liu and colleagues used computational ultra-large library docking to discover new chemotypes acting as positive allosteric modulators(PAM)of the Calcium-Sensing Receptor(CaSR),1 ...
关键词：HOMEOSTASIS THERAPEUTIC POTENTIAL 
Iron homeostasis and ferroptosis in human diseases:mechanisms and therapeutic prospects被引量：1
《Signal Transduction and Targeted Therapy》2024年第11期5015-5078,共64页Qin Ru Yusheng Li Lin Chen Yuxiang Wu Junxia Min Fudi Wang 
supported in part by the National Natural Science Foundation of China(31970689 to J.M.,32330047 and 31930057 to F.W.,82071970 to Y.W.and 82072506 to Y.L.);the Science Fund for Distinguished Young Scholars of Hubei Province(2023AFA109 to Y.W.);Hubei Provincial Natural Science Foundation of China(2024AFB971 to Q.R.).
Iron,an essential mineral in the body,is involved in numerous physiological processes,making the maintenance of iron homeostasis crucial for overall health.Both iron overload and deficiency can cause various disorders...
关键词：DISEASES HOMEOSTASIS THERAPEUTIC 
Neutrophil extracellular traps in homeostasis and disease
《Signal Transduction and Targeted Therapy》2024年第10期4408-4447,共40页Han Wang Susan JKim Yu Lei Shuhui Wang Hui Wang Hai Huang Hongji Zhang Allan Tsung 
National Institute of Health grants R01-CA214865 to A.T.State funding within the UVA Comprehensive Cancer Center“IDEA-Cancer pilot award”,“Cancer Therapeutics(CRX)pilot award”to H.Z.National Natural Science Foundation of China Grant Number 82200588 to H.W.
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen ...
关键词：HOMEOSTASIS INVOLVEMENT INFLAMMATION 
Adhesion G protein-coupled receptor latrophilin 1(ADGRL1):a novel regulator of glucose and energy homeostasis
《Signal Transduction and Targeted Therapy》2024年第8期3143-3144,共2页Kavaljit H.Chhabra 
This work was supported by the National Institutes of Health grant DK124619 to K.H.C.
Recently,I read with interest the research article entitled'Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity published in Signal Transduction and Targeted...
关键词：HOMEOSTASIS OBESITY HYPOTHALAMUS 
Linking IL-10 signaling with lipid metabolic programs in macrophages:dysregulated ceramide homeostasis drives colitis被引量：1
《Signal Transduction and Targeted Therapy》2024年第7期2835-2836,共2页Imke Atreya Markus F.Neurath 
supported by the following grants from the DFG;German Research Foundation:TRR241(project number 375876048);AT 122/2-1(project number 511510453);supported by the Interdisciplinary Center for Clinical Research Erlangen:IZKF D37.
In a recent study published in Nature,York and coworkers identified the immunometabolic regulation of mono-unsaturated fatty acid(MUFA)pools and the subsequent increase in sphingolipid biosynthesis in TLR2-activated m...
关键词：HOMEOSTASIS IMPAIRED INTESTINE 
2-APQC,a small-molecule activator of Sirtuin-3(SIRT3),alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis被引量：2
《Signal Transduction and Targeted Therapy》2024年第6期2748-2764,共17页Fu Peng Minru Liao Wenke Jin Wei Liu Zixiang Li Zhichao Fan Ling Zou Siwei Chen Lingjuan Zhu Qian Zhao Gu Zhan Liang Ouyang Cheng Peng Bo Han Jin Zhang Leilei Fu 
supported in part by National Natural Science Foundation of China(Grant No.82173666,Grant No.82374020,Grant No.82073998 and Grant No.22107015);Shenzhen science and technology research and development funds(Grant No.JCYJ20210324094612035);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.ZYYCXTD-D-202209);Natural Science Foundation of Liaoning Province(Grant No.2022-MS-251).
Sirtuin 3(SIRT3)is well known as a conserved nicotinamide adenine dinucleotide^(+)(NAD^(+))-dependent deacetylase located in the mitochondria that may regulate oxidative stress,catabolism and ATP production.Accumulati...
关键词：SIRT3 HOMEOSTASIS metabolism 
DEAD-box helicase 17(DDX17)protects cardiac function by promoting mitochondrial homeostasis in heart failure
《Signal Transduction and Targeted Therapy》2024年第6期2774-2790,共17页Mingjing Yan Junpeng Gao Ming Lan Que Wang Yuan Cao Yuxuan Zheng Yao Yang Wenlin Li Xiaoxue Yu Xiuqing Huang Lin Dou Bing Liu Junmeng Liu Hongqiang Cheng Kunfu Ouyang Kun Xu Shenghui Sun Jin Liu Weiqing Tang Xiyue Zhang Yong Man Liang Sun Jianping Cai Qing He Fuchou Tang Jian Li Tao Shen 
supported by grants from the National Key R&D Program of China(2021YFE0114200,2018YFC2000100);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2021-I2M-1-050);the Project funded by China Postdoctoral Science Foundation(2023M732704);the National Natural Science Foundation of China(81770228,82370584,81470427 and U23A20470);the Beijing Natural Science Foundation(7232141,7212086);the Beijing Hospital Clinical Research 121 Project(121-2016004);the National High Level Hospital Clinical Research Funding(BJ-2021-199,BJ-2023-156,BJ-2019-159).
DEAD-box helicase 17(DDX17)is a typical member of the DEAD-box family with transcriptional cofactor activity.Although DDX17 is abundantly expressed in the myocardium,its role in heart is not fully understood.We genera...
关键词：DDX17 HOMEOSTASIS cardiac 
PBX/Knotted 1 homeobox-2(PKNOX2)is a novel regulator of myocardial fibrosis
《Signal Transduction and Targeted Therapy》2024年第5期2231-2249,共19页Liang Chen Haotong Li Xiaorui Liu Ningning Zhang Kui Wang Anteng Shi Hang Gao Deniz Akdis Ardan MSaguner Xinjie Xu Elena Osto Willem Van de Veen Guangyu Li Antoni Bayés-Genís Firat Duru Jiangping Song Xiangjie Li Shengshou Hu 
supported by the National Natural Science Foundation of China(82100377);National High Level Hospital Clinical Research Funding(2023-GSP-RC-01,2023-GSP-ZD-2);the Beijing Nova Program(Z211100002121046,20220484205).Figure 10 was created with BioRender.com.
Much effort has been made to uncover the cellular heterogeneities of human hearts by single-nucleus RNA sequencing.However,the cardiac transcriptional regulation networks have not been systematically described because...
关键词：NOX2 HOMEOSTASIS FIBROSIS 
Unraveling the role of METTL14 in metabolic dysfunction-associated fatty liver disease:insights and therapeutic implications
《Signal Transduction and Targeted Therapy》2024年第5期1781-1783,共3页So Jung Kim Jeongeun Hyun 
This study was supported by the National Research Foundation of Korea(grant number 2021R1C1C1003904 to J.H.)。
The recent article published in Signal Transduction and Targeted Therapy sheds light on the significance of N6-methyladenosine(m6A)methyltransferase-like protein METTL14 in mitigating the progression of metabolic dysf...
关键词：liver HOMEOSTASIS al. 
Infection with SARS-CoV-2 can cause pancreatic impairment被引量：1
《Signal Transduction and Targeted Therapy》2024年第5期2143-2160,共18页Wei Deng Linlin Bao Zhiqi Song Ling Zhang Pin Yu Yanfeng Xu Jue Wang Wenjie Zhao Xiuqin Zhang Yunlin Han Yanhong Li Jiangning Liu Qi Lv Xujian Liang Fengdi Li Feifei Qi Ran Deng Siyuan Wang Yibai Xiong Ruiping Xiao Hongyang Wang Chuan Qin 
supported by the Institute of Basic Medical Sciences,the Chinese Academy of Medical Sciences,the Neuroscience Center,the China Human Brain Banking Consortium,the ALS Brain Bank Initiative in China,and Home for Heal and Help for their assistance in this paper.This work was supported by the National Natural Science Foundation of China(82141204,82061138007,82221004,82041008);the National Key Research and Development Project of China(2020YFA0707803);the CAMS Innovation Fund for Medical Sciences(CIFMS)grant(2021-1-I2M-035,2021-1-I2M-034 and 2021-CAMS-JZ002);Bill&Melinda Gates Foundation(INV-006371);Key-Area Research and Development Program of Guangdong Province(2022B1111020005).
Evidence suggests associations between COVID-19 patients or vaccines and glycometabolic dysfunction and an even higher risk of the occurrence of diabetes.Herein,we retrospectively analyzed pancreatic lesions in autops...
关键词：INFECTED ELEVATED HOMEOSTASIS 
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