ATHEROSCLEROTIC

作品数:163被引量:489H指数:12
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相关领域:医药卫生更多>>
相关作者:顾振纶陈可冀谢梅林杨涛徐霖更多>>
相关机构:中国中医科学院西苑医院北京大学苏州医学院内蒙古医科大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金高等学校学科创新引智计划更多>>
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Inhibition of the RXRA-PPARα-FABP4 signaling pathway alleviates vascular cellular aging by an SGLT2 inhibitor in an atherosclerotic mice model
《Science China(Life Sciences)》2024年第12期2678-2691,共14页Weiwei Zhang Linghuan Wang Yujia Wang Yan Fang Ruihua Cao Zhiyi Fang Dong Han Xu Huang Zhenghui Gu Yingjie Zhang Yan Zhu Yan Ma Feng Cao 
supported by the National Key Research and Development Projects (2022YFC3602400);the National Natural Science Foundation of China (92249301,82200496);Project of National Clinical Research Center for Geriatric Diseases (NCRCGPLAGH-2022001)。
Atherosclerosis is the pathological cause of atherosclerotic cardiovascular disease(ASCVD),which rapidly progresses during the cellular senescence.Sodium-glucose cotransporter 2 inhibitors(SGLT2is)reduce major cardiov...
关键词:ATHEROSCLEROSIS cellular senescence SGLT2 inhibitors PPARΑ 
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice
《Acta Pharmacologica Sinica》2024年第11期2277-2289,共13页Meng-yun Xu Jing-jing Xu Li-jing Kang Zheng-hong Liu Mei-ming Su Wen-qi Zhao Zhi-hua Wang Lu Sun Jian-bo Xiao Paul C.Evans Xiao-yu Tian Li Wang Yu Huang Xin-miao Liang Jian-ping Weng Suo-wen Xu 
supported by grants from the National Key R&D Program of China(Grant No.2021YFC2500500);the National Natural Science Foundation of China(Grant No.82370444,82070464,82003741);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB38010100);supported by the Program for Innovative Research Team of The First Affiliated Hospital of USTC(CXGG02);Anhui Provincial Key Research and Development Program(Grant No.202104j07020051);Anhui Provincial Natural Science Foundation(Grant No.2208085J08).
Urolithin A(UroA),a dietary phytochemical,is produced by gut bacteria from fruits rich in natural polyphenols ellagitannins(ETs).The efficiency of ETs metabolism to UroA in humans depends on gut microbiota.UroA has sh...
关键词:atherosclerosis urolithin A INFLAMMATION YAP/TAZ endothelial cells 
Improving a Patient’s CVD Risk Assessment—Updating the Interpretation of the Lipid Profile
《World Journal of Cardiovascular Diseases》2024年第9期515-520,共6页David S. Schade Allen Adolphe Robert Philip Eaton 
The lipid profile remains an important laboratory assessment to prevent cardiovascular disease. Interpretation of the non-fasting lipid profile has significantly changed based on new information concerning the pathoge...
关键词:Lipid Profile Atherosclerotic Risk Cardiovascular Disease High Density Lipoprotein Low Density Lipoprotein 
YKL40 potentially via activating the P38 pathway in decreasing atherosclerotic plaque stability
《Chinese Medical Journal》2024年第8期1003-1005,共3页Chao Wang Yandong Liu Wei Huan Jianjin Wu Jie Jin Sili Zou Yu Chen Lefeng Qu 
Specifically Invited Professor of Oriental Scholar of Shanghai Colleges and Universities Tracking Program(No.GZ2016008);National Natural Science Foundation of China(No.81870347)
To the Editor:Atherosclerosis is the main pathological feature of ischemic stroke,which remains a major cause of disability and death worldwide.[1]Vulnerable plaque,was characterized by ulceration,platelet activation,...
关键词:YKL40 markedly STABILITY 
Metabolite acetyl-L-carnitine participates in Bifidobacterium animalis F1-7 to ameliorate atherosclerotic inflammation by downregulating theTLR4/NF-κB pathway
《Food Science and Human Wellness》2024年第2期813-822,共10页Xi Liang Zhe Zhang Xiaoying Tian Qingyu Cui Haiyan Lu Maozhen Zhao Tongjie Liu Huaxi Yi Pimin Gong Lanwei Zhang 
supported by Shandong Taishan industry leading talent project(LJNY202101);the National Key R&D of China(2018YFC0311201)。
This study aimed to explore the effect of Bifidobacterium animalis F1-7 on the improvement of atherosclerotic inflammation.Arteriosclerosis model ApoE^(-/-)mice were orally administered with B.animalis F1-7 for 12 wee...
关键词:Bifidobacterium animalis F1-7 Atherosclerosis INFLAMMATION METABONOMICS ACETYL-L-CARNITINE 
Roles of the Apolipoprotein E Gene and Its Polymorphisms in the Etiopathophysiology of Type 2 Diabetes Mellitus and Its Atherosclerotic Complication in Senegalese Females
《Journal of Diabetes Mellitus》2023年第4期300-324,共25页Maïmouna Touré Fatou Diallo Agne Amadou Dieng Rokhaya Ndiaye Diallo Lamine Gueye Abdoulaye Samb 
Lipid metabolism disorders would be among the components responsible for the risk of the onset of T2DM and its vascular complications. Apolipoprotein E plays an important role in lipid metabolism. We studied the invol...
关键词:APOE Gene POLYMORPHISMS Type 2 diabetes Mellitus Vascular Dysfunctions 
Lipoprotein(a)and Atherosclerotic Cardiovascular Diseases:Evidence from Chinese Population
《Cardiology Discovery》2023年第1期40-47,共8页Jianjun Li 
the Capital Health Development Fund(201614035);CAMS Major Collaborative Innovation 517 Project(2016-12M-1-011)awarded to Dr.Jianjun Li.
Cardiovascular disease(CVD)is the leading cause of mortality worldwide.Multiple factors are involved in CVD,and emerging data indicate that lipoprotein(a)(Lp(a))may be associated with atherosclerotic cardiovascular di...
关键词:LIPOPROTEIN (a) EPIDEMIOLOGY ATHEROSCLEROTIC CARDIOVASCULAR DISEASES Chinese POPULATION 
Oral nanoparticles containing naringenin suppress atherosclerotic progression by targeting delivery to plaque macrophages被引量:3
《Nano Research》2023年第1期925-937,共13页Mengran Guo Zhongshan He Zhaohui Jin Lingjing Huang Jingmei Yuan Shugang Qin Xinchun Wang Lili Cao Xiangrong Song 
This study was supported by the Youth Fund of National Natural Science Foundation of China(No.82104081);Sichuan Province Science and Technology Support Program(No.2020JDRC0052);the 1.3.5 Project for Disciplines of excellence,West China Hospital,Sichuan University(No.ZYGD18020/ZYJC18006);Science and Technology Project of Xinjiang Production and Construction Corps(No.2022AB020).
Atherosclerosis is the main cause of ischemic stroke and myocardial infarction diseases.Nanoparticles have shown unique benefits for atherosclerosis treatment by targeting the lesional macrophages of plaques.However,m...
关键词:ATHEROSCLEROSIS MACROPHAGES Peyer’s patches oral delivery folic acid NARINGENIN 
Effects of Simvastatin on Endoplasmic Reticulum Stress-Mediated Apoptosis in Atherosclerotic Calcification
《Cardiology Discovery》2022年第4期209-217,共9页Jianhua Li Libo Zhao Zhe Zhou Lin Liu Xiao Zou Weihao Xu Li Fan Muyang Yan Shengqi Wang 
Objective:The effectiveness of statins in reducing atherosclerotic calcification remains controversial.The aim of this study was to confirm that simvastatin reduces atherosclerotic calcification and stabilizes plaque ...
关键词:Endoplasmic reticulum stress STATINS Atherosclerotic calcification APOPTOSIS 
Estimation of atherosclerotic cardiovascular disease risk in type 2 diabetes被引量:2
《Chinese Medical Journal》2022年第21期2605-2607,共3页Xiaoling Cai Chu Lin Linong Ji 
To the Editor:The global prevalence of diabetes is increasing dramatically.[1]To prevent and treat diabetes and its cardiovascular complications,clinical practice guidelines recommend to assess the prevalent nonmodifi...
关键词:CARDIOVASCULAR DIABETES CLINICAL 
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