SINGLE-STRAND

作品数：43被引量：116H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：徐彤伍东升温小恒陆星华钱家鸣更多>>
相关机构：北京协和医院复旦大学华中科技大学中南大学更多>>
相关期刊：《Science Bulletin》《Journal of Chinese Pharmaceutical Sciences》《Science China(Life Sciences)》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划安徽省自然科学基金上海市教育委员会重点学科基金更多>>
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Research progress on the non-coding region of single-stranded positive-sense RNA(+ssRNA)viruses
《Journal of Chinese Pharmaceutical Sciences》2025年第1期1-13,共13页Liangrong Guo Guoyue Liu Ju Sun Dengguo Wei 
National Key Research and Development Programs of China(Grant No.2021YFD1801102);the National Natural Science Foundation of China(Grant No.22077043,32473010);the Fundamental Research Funds for the Central Universities(2662023PY005 to DW);HZAU-AGIS Cooperation Fund(SZYJY2022016 to DW);Natural Science Foundation of Hubei Province(2021CFA061 to DW);the Funding from National Key Laboratory of Agricultural Microbiology(AML2023B05 to DW)。
Single-stranded positive-sense RNA(+ssRNA)viruses encompass a diverse range of species and exert profound effects on human and animal health,as well as agricultural economic productivity.The 5'and 3'untranslated regio...
关键词：+ssRNAvirus UTR Structure VACCINE 
Principles of amino-acid–ribonucleotide interaction revealed by binding affinities between homogeneous oligopeptides and singlestranded RNA molecules
《Nano Research》2023年第12期13294-13300,共7页Pengyu Wang Xiaocui Fang Ping Li Minxian Li Yanlian Yang Chen Wang 
supported by the National Natural Science Foundation of China(Nos.21721002,32101130,and 31971295);Financial support from the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)is also gratefully acknowledged.
We have determined the binding strengths between ribonucleotides of adenine(A),guanine(G),uracil(U),and cytosine(C)in homogeneous single-stranded ribonucleic acids(ssRNAs)and homo-decapeptides consisting of 20 common ...
关键词：PEPTIDES single-stranded ribonucleic acid(ssRNA) binding affinity flow cytometry 
Physical and numerical investigation on fluid flow and inclusion removal behavior in a single-strand tundish被引量：4
《Journal of Iron and Steel Research International》2023年第6期1182-1198,共17页Qi Quan Zhi-xiao Zhang Tian-peng Qu Xiang-long Li Jun Tian De-yong Wang 
financially supported by the National Natural Science Foundation of China(Nos.52174321,51874203 and 52074186).
Aiming at the problem that the existence of inclusions in the tundish continuous casting process can easily lead to quality defects of the slab,the stainless steel continuous casting tundish was taken as the research ...
关键词：Non-metallic inclusion Flow control device Residence time distribution curve Removal behavior Discrete particle model 
Prolonged control of insulin-dependent diabetes via intramuscular expression of plasmid-encoded single-strand insulin analogue被引量：1
《Genes & Diseases》2023年第3期1101-1113,共13页Lu Deng Ping Yang Caixia Li Lifang Xie Wanling Lu Yanhan Zhang Ming Liu Gang Wang 
supported by the National Natural Science Foundation of China(No.31971390);the International Cooperative Project of Sichuan Province on Science and Technology Innovation(China)(No.2021YFH0142).
Daily insulin injection is necessary for the treatment of the insulin-dependent diabetes. However, the process is painful and inconvenient. Accordingly, we have made exploratory efforts to establish an alternative met...
关键词：Diabetes Gene therapy Intramuscular injection PLASMID Single-strand insulin analogue(SIA) Synthetic promoter 
Oxidation degree dependent adsorption of ssDNA onto graphene-based surface
《Chinese Physics B》2021年第10期488-494,共7页Huishu Ma Jige Chen Haiping Fang Xiaoling Lei 
supported by the National Natural Science Foundation of China(Grant Nos.11305237 and 11974366);the Fundamental Research Funds for the Central Universities,China,the Natural Science Foundation of Shanghai,China(Grant No.19ZR1463200);the Key Research Program of Chinese Academy of Sciences(Grant No.QYZDJ-SSW-SLH053).
DNA/GO composite plays a significant role in the research field of biotechnology and nanotechnology,and attracts a great deal of interest.However,it is still unclear how the oxidation degree of the graphene-based surf...
关键词：single-strand DNA(ssDNA) molecular dynamics simulation oxidation degrees graphene-based surfaces 
Pathways and assays for DNA double-strand break repair by homologous recombination被引量：7
《Acta Biochimica et Biophysica Sinica》2019年第9期879-889,共11页Jinbao Li Huize Sun Yulin Huang Yali Wang Yuyan Liu Xuefeng Chen 
This work is supported by the grants from the National Natural Science Foundation of China(Nos.31671294 and 31872808);the National Basic Key Research Program of China(No.2015CB910602);National Thousand Young Talents Program to X.C.;We thank Dr Xiangwei He(Zhejiang University,Hangzhou,China)for critical reading of the manuscript.
Double strand breaks(DSBs)are the most detrimental type of DNA damage that must be repaired to ensure genome integrity and cell survival.Unrepaired or improperly repaired DSBs can potentially cause tumorigenesis or ce...
关键词：double-strand break HOMOLOGOUS recombination synthesis-dependent STRAND ANNEALING break-induced REPLICATION SINGLE-STRAND ANNEALING 
Orthogonal assays for the identification of inhibitors of the single-stranded nucleic acid binding protein YB-1
《Acta Pharmaceutica Sinica B》2019年第5期997-1007,共11页Alexander J.Trevarton Yan Zhou Dehua Yang Gordon W.Rewcastle Jack U.Flanagan Antony Braithwaite Peter R.Shepherd Cristin G.Print Ming-Wei Wang Annette Lasham 
supported by grants from Health Research Council of New Zealand(IRF213-China,13-1019 to PS,CP,AL and AB);the Ministry of Science and Technology of China(2014DFG32200 to M-WW);Shanghai Science and Technology Development Fund(15DZ2291600 to M-WW,China);the Thousand Talents Program in China([2011]166 to M-WW)
We have previously shown that high expression of the nucleic acid binding factor YB-1 is strongly associated with poor prognosis in a variety of cancer types. The 3-dimensional protein structure of YB-1 has yet to be ...
关键词：Cancer YB-1 LUCIFERASE Alpha Screen TRANSCRIPTION factor Single-stranded DNA 
Effect of a Single Repeat Sequence of the Human Telomere d（TTAGGG）on Structure of Single-Stranded Telomeric DNA d[AGGG（TTAGGG）6]
《Chinese Journal of Chemical Physics》2018年第5期635-640,735,共7页Tian-lei Guang Ya-ting Gao Xiao-dong Ye 
supported by the National Natural Scientific Foundation of China (No.21674107);the Fundamental Research Funds for the Central Universities (No.WK2340000066)
The structures of human telomeric DNA have received much attention due to its significant biological importance.Most studies have focused on G-quadruplex structure formed by short telomeric DNA sequence,but little is ...
关键词：Circular dichroism spectroscopy G-guadruplex Sedimentation velocity experiments 
Synergistic and non-specific nucleic acid production by T7 RNA polymerase and Bsu DNA polymerase catalyzed by single-stranded polynucleotides
《Synthetic and Systems Biotechnology》2018年第2期130-134,共5页Nicholas J.Emery Sagardip Majumder Allen P.Liu 
This work is supported by a generous gift from Kendall and Susan Warren and the NIH Director's New Innovator Award DP2 HL117748-01 to A.P.L.The authors wish to thank Maxwell DeNies,Lili Tian,and Jennifer Knister for helpful discussion.
Point-of-care molecular diagnostic tests show great promise for providing accurate,timely results in lowinfrastructure healthcare settings and at home.The design space for these tests is limited by a variety of possib...
关键词：CATALYZED utilizing rational 
Supramolecular Polymerization Driven by the Dimerization of Single-stranded Helix to Double-stranded Helix被引量：2
《Chinese Journal of Polymer Science》2018年第3期261-261,262-265,共5页Chao Zeng Chen-Yang Zhang Jun-Yan Zhu Ze-Yuan Dong 
financially supported by the National Natural Science Foundation of China(Nos.21574054,21722403,and 21420102007)
We reported a type of strong and highly directional non-covalent interactions based on the dimerization of single-stranded helix to double-stranded helix that can achieve supramolecular polymerization, giving rise to ...
关键词：HELIX Double-stranded helix Supramolecular polymers Supramolecular polymerization DIMERIZATION 
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