HYPOXIA-ISCHEMIA

作品数：41被引量：201H指数：9
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相关领域：医药卫生更多>>
相关作者：张玲妹张研孙凤艳马正良于常州更多>>
相关机构：江苏省麻醉医学研究所上海医科大学南京大学医学院附属鼓楼医院巴斯克大学更多>>
相关期刊：《Chinese Journal of Traumatology》《Cellular & Molecular Immunology》《Acta Pharmacologica Sinica》《International Journal of Ophthalmology(English edition)》更多>>
相关基金：国家自然科学基金广东省自然科学基金江苏省卫生厅科研基金更多>>
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PHLDA1 contributes to hypoxic ischemic brain injury in neonatal rats via inhibiting FUNDC1-mediated mitophagy
《Acta Pharmacologica Sinica》2024年第9期1809-1820,共12页Xiao-lu Jiang Zu-bin Zhang Chen-xi Feng Chen-jie Lin Hui Yang Lan-lan Tan Xin Ding Li-xiao Xu Gen Li Tao Pan Zheng-hong Qin Bin Sun Xing Feng Mei Li 
National Natural Science Foundation of China(82271405,82071379,82171703,82371719);Interdisciplinary Basic Frontier Innovation Program of Suzhou Medical College of Soochow University(YXY2304072);The Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB320021);Training Program Foundation for health talents of Gusu(GSWS2020052,GSWS2019049);Project of Suzhou Science and Technology Development Plan(SKY2021008,SYS2020154).
Hypoxia-ischemia(HI)is one of the main causes of neonatal brain injury.Mitophagy has been implicated in the degradation of damaged mitochondria and cell survival following neonatal brain HI injury.Pleckstrin homology-...
关键词：neonatal brain injury HYPOXIA-ISCHEMIA PHLDA1 MITOPHAGY FUNDC1 Mdivi-1 
Reperfusion after hypoxia-ischemia exacerbates brain injury with compensatory activation of the antiferroptosis system:based on a novel rat model被引量：3
《Neural Regeneration Research》2023年第10期2229-2236,共8页Tian-Lei Zhang Zhi-Wei Zhang Wei Lin Xin-Ru Lin Ke-Xin Lin Ming-Chu Fang Jiang-Hu Zhu Xiao-Ling Guo Zhen-Lang Lin 
supported by the National Natural Science Foundation of China,No.82271747(to ZLL);Medical and Health Science and Technology Program of Zhejiang Province of China,No.2023RC048(to WL)。
Hypoxic-ischemic encephalopathy,which predisposes to neonatal death and neurological sequelae,has a high morbidity,but there is still a lack of effective prevention and treatment in clinical practice.To better underst...
关键词：ferroptosis hypoxic-ischemic brain injury hypoxic-ischemic encephalopathy hypoxic-ischemic reperfusion brain injury mitochondria model proteomic analysis REPERFUSION Rice-Vannucci transmission electron microscopy 
Role of apoptosis-inducing factor in perinatal hypoxic-ischemic brain injury被引量：18
《Neural Regeneration Research》2021年第2期205-213,共9页Juan Rodriguez Tao Li Yiran Xu Yanyan Sun Changlian Zhu 
the Swedish Research Council(2018-02667);the National Natural Science Foundation of China(31761133015,U1704281,81901335);the Swedish Childhood Cancer Foundation(PR2018-0082);Swedish Governmental Grants to Scientists Working in Health Care(ALFGBG-717791);the Swedish Brain Foundation(FO2018-0034);the Chinese Scholarship Council to TL(201707040025)and to YX(201507040082)。
Perinatal complications,such as asphyxia,can cause brain injuries that are often associated with subsequent neurological deficits,such as cerebral palsy or mental retardation.The mechanisms of perinatal brain injury a...
关键词：apoptosis apoptosis inducing factor ASPHYXIA cell death free radical HYPOXIA-ISCHEMIA mitochondria NEONATES oxidative stress 
Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?被引量：24
《Neural Regeneration Research》2019年第10期1678-1683,共6页Anthony Davies Guido Wassink Laura Bennet Alistair J.Gunn Joanne O.Davidson 
supported by The Health Research Council of New Zealand(grant No.16/003,17/601);the Marsden Fund(grant No.17-UOA232);a Sir Charles Hercus Fellowship from the Health Research Council of New Zealand(grant No.16/003)
Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability.Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;ho...
关键词：HYPOXIA-ISCHEMIA hypoxic-ischemic ENCEPHALOPATHY THERAPEUTIC HYPOTHERMIA neuroprotection THERAPEUTIC strategies randomized controlled trials animal models fetal sheep PIGLETS 
Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats被引量：7
《Neuroscience Bulletin》2013年第3期287-294,共8页Xinjuan Li Hua Han Ruanling Hou Linyu Wei Guohong Wang Chaokun Li Dongliang Li 
supported by the National Natural Science Foundation of China (81100912);the Science Foundation of Xinxiang Medical University, China (CL and ZD 2009-63);the Science and Technology Project of Henan Province, China (092102310098)
Progesterone is an efficient candidate for treating stroke and traumatic brain damage. The current study was designed to investigate the effects of pro gesterone on glucose transporter proteins （GLUT1 and GLUT3） dur...
关键词：hypoxic-ischemic injury PROGESTERONE GLUT1 GLUT3 stroke 
Expression of neuroglobin in ocular hypertension induced acute hypoxic-ischemic retinal injury in rats被引量：2
《International Journal of Ophthalmology(English edition)》2011年第4期393-395,共3页Shao-Yang Shi Xue-Mei Feng You Li Xun Li and Xiao-Long Chen 
AIM: To investigate the Expression of neuroglobin (Ngb) in the retina of rats with ocular hypertension induced acute retinal hypoxic-ischemic injury. METHODS: Seventy Wistar rats were divided into 7 groups randomly. T...
关键词：NEUROGLOBIN HYPOXIA-ISCHEMIA RETINA 
Cannabinoid as a neuroprotective strategy in perinatal hypoxic-ischemic injury
《Neuroscience Bulletin》2011年第4期275-285,共11页Daniel Alonso-Alconada Antonia Alvarez Enrique Hilario 
supported by grants from Fondo de Investigación Sanitaria of Spanish Ministry of Health(PS09/02326);the Basque Government(GCI-07/79,IT-287-07)
Perinatal hypoxia-ischemia remains the single most important cause of brain injury in the newborn, leading to death or lifelong sequelae. Because of the fact that there is still no specific treatment for perinatal bra...
关键词：perinatal hypoxia-ischemia brain injury neuroprotective strategies endocannabinoid system 
The regulatory effect of memantine on expression and synthesis of heat shock protein 70 gene in neonatal rat models with cerebral hypoxic ischemia被引量：19
《Chinese Medical Journal》2003年第4期558-564,共7页陈惠金 刘志伟 周泽汉 蒋明华 钱龙华 吴圣楣 
ThestudywassupportedbyagrantfromtheNationalNaturalScienceFoundationofChina (No 39670 758)
To evaluate the neuroprotective effect of memantine, a non-competitive antagonist at the N-methyl-D-aspartate receptor, against hypoxic ischemia (HI) by exploring its regulation on the expression and synthesis of heat...
关键词：MEMANTINE heat shock protein 70 gene brain HYPOXIA-ISCHEMIA neonatal rat 
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