MODIFYING

作品数：196被引量：391H指数：9
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Modifying the progression of Parkinson's disease through movement interventions:multimodal quantification of underlying mechanisms
《Neural Regeneration Research》2024年第8期1651-1652,共2页Manuel Bange Damian Marc Herz Dumitru Ciolac Gabriel Gonzalez-Escamilla Sergiu Groppa 
Introduction:Parkinson’s disease(PD)is the most common neurodegenerative movement disorder.The pathological hallmark is the progressive loss of dopaminergic neurons of the substantia nigra pars compacta,which is acco...
关键词：alterations MOVEMENT 
Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis
《Neural Regeneration Research》2024年第8期1768-1771,共4页Federica Azzolini Ettore Dolcetti Antonio Bruno Valentina Rovella Diego Centonze Fabio Buttari 
In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying therapies.Howeve r,in recent years,several data from pre-clinical and clinical studies suggested a possible ...
关键词：disease-modifying behaviour endocannabinoid system long-term potentiation multiple sclerosis NEUROPLASTICITY NEUROPROTECTION physical exercise synaptopathy 
Are ATXN2 variants modifying our understanding about neural pathogenesis,phenotypes,and diagnostic?
《Neural Regeneration Research》2022年第11期2445-2447,共3页Jose Miguel Laffita-Mesa Martin Paucar Per Svenningsson 
ATXN2 one gene with multiple phenotype effects:ATXN2 gene encodes a cytosolic protein(ataxin-2)with pleiotropic functions(see below).This gene contains a number of exonic Cytosine-Adenine-Guanine(CAG)-repeats which en...
关键词：PATHOGENESIS NEURAL interrupted 
From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?被引量：3
《Neural Regeneration Research》2022年第5期933-936,共4页Rita Caridade Silva Helena Sofia Domingues António J.Salgado Fábio G.Teixeira 
the financial support from Prémios Santa Casa Neurociências Prize Mantero Belard for Neurodegenerative Diseases Research(MB-28-2019);supported by the European Regional Development Fund(FEDER);through the Competitiveness Internationalization Operational Programme(POCI);by National funds;through the Foundation for Science and Technology(FCT);under the scope of projects UIDB/50026/2020;UIDP/50026/2020 and POCI-01-0145-FEDER-029751;developed under the scope of the project NORTE-01-0145-FEDER-000023;supported by the Northern Portugal Regional Operational Programme(NORTE 2020);under the Portugal 2020 Partnership Agreement,through the European Regional Development Fund(FEDER);funded by ICVS Scientific Microscopy Platform,member of the national infrastructure PPBI-Portuguese Platform of Bioimaging(PPBI-POCI-01-0145-FEDER-022122)(to FGT)。
Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.Clinically,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons.Current tre...
关键词：disease-modifying strategies mesenchymal stem cells N-ACETYLCYSTEINE neuroprotection Parkinson's disease stem cells secretome 
Alpha-synuclein preformed fibrils:a tool to understand Parkinson’s disease and develop disease modifying therapy
《Neural Regeneration Research》2021年第11期2219-2221,共3页Piotr Chmielarz Andrii Domanskyi 
supported by grants from the Academy of Finland#293392,#319195;Päivikki and Sakari Sohlberg Foundation(to AD);Polish National Science Centre grant 2019/35/D/NZ7/03200-Sonata 15(to PC).
Parkinson’s disease(PD)is the second most common neurodegenerative disorder characterized by multiple motor and nonmotor symptoms,which include,among others,constipation,sleep disturbance,bradykinesia,gait and balanc...
关键词：degeneration Alpha driving 
Targeting transglutaminase 2 as a potential disease modifying therapeutic strategy for synucleinopathies
《Neural Regeneration Research》2021年第8期1560-1561,共2页Jie Zhang Hilary Grosso Jasutkar M.Maral Mouradian 
supported by grants from the Michael J. Fox Foundation for Parkinson’s Research (ID 12350);the American Parkinson Disease Association, the New Jersey Health Foundation, and by NIH grants NS101134, NS096032, and NS116921。
Synucleinopathies are a group of progressive neurodegenerative disorders characterized by the accumulation of α-synuclein(α-Syn) aggregates in Lewy bodies(LBs) and Lewy neurites(LNs) in Parkinson's disease(PD) and d...
关键词：ATROPHY THERAPEUTIC AGGREGATION 
Promises and pitfalls of immune-based strategies for Huntington's disease被引量：1
《Neural Regeneration Research》2017年第9期1422-1425,共4页Gabriela Delevati Colpo Erin Furr Stimming Natalia Pessoa Rocha Antonio Lucio Teixeira 
Huntington＇s disease （HD） is an autosomal-dominant neurodegenerative disease characterized by the selec- tive loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline ...
关键词：Huntington＇s disease treatment disease modifying therapy INFLAMMATION 
Genetically modifying transcription factors to promote CNS axon regeneration
《Neural Regeneration Research》2017年第5期737-738,共2页Saloni T.Mehta John L.Bixby Vance P.Lemmon 
supported by NIH HD057632 to VPL and JLB.VPL holds the Walter G.Ross Distinguished Chair in Developmental Neuroscience
Following injury to the central nervous system（CNS）,severed axons fail to regenerate and re-form functional connections.Accordingly,CNS neurons appear to lack the intrinsic ability to modify their gene expression pa...
关键词：CNS gene JUN VP 
Amyotrophic lateral sclerosis disease modifying therapeutics:a cell biological perspective
《Neural Regeneration Research》2017年第3期407-408,共2页Bor Luen Tang 
supported by the NUS Graduate School for Integrative Sciences and Engineering
Amyotrophic lateral sclerosis（ALS）is a progressively fatal neuromuscular disorder classically characterized by loss of upper and lower motor neurons from the cortex to the spinal cord Diagnosed patients have a media...
关键词：Amyotrophic lateral sclerosis disease modifying therapeutics:a cell biological perspective ALS CELL 
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