HEXOKINASE

作品数：30被引量：85H指数：6
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相关领域：医药卫生更多>>
相关作者：李芬张申华贾敏蒋振黄金文更多>>
相关机构：川北医学院天门市第一人民医院河北医科大学锦州医科大学更多>>
相关期刊：《Cancer Biology & Medicine》《Acta Biochimica et Biophysica Sinica》《Animal Nutrition》《Journal of Ocean University of China》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金湖北省自然科学基金更多>>
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The Ca^(2+)/CaN/ACC and cAMP/PKA/HK signal pathways are required for PBAN-mediated sex pheromone biosynthesis in Conogethes punctiferalis
《Journal of Integrative Agriculture》2024年第8期2735-2751,共17页Yao Zhang Zelong She Ruolan He Shuangyan Yao Xiang Li Xiaoguang Liu Xinming Yin Jizhen Wei Mengfang Du Shiheng An 
supported by the National Natural Science Foundation of China(31970472,32272547);the National Science Fund of Henan Province for Distinguished Young Scholars,China(202300410191);the Basic Research Project of the Key Scientific Research Projects of Universities in Henan Province,China(21zx013);the Henan Agricultural Research System,China(HARS-2209-G3);the Henan Special Support for High-Level Talents Central Plains Science and Technology Innovation Leading Talents,China(224200510018);the earmarked fund for China Agricultural Research System(CARS-27)。
Conogethes punctiferalis is a crop and fruit pest that has caused serious economic losses to agricultural production.This pest relies heavily on its sex pheromone to ensure sexual encounters and subsequent mating succ...
关键词：Conogethes punctiferalis sex pheromone CAMP/PKA CALCINEURIN acetyl-CoA carboxylase HEXOKINASE 
Hexokinase 1 and 2 mediates glucose utilization to regulate the synthesis of kappa casein via ribosome protein subunit 6 kinase 1 in bovine mammary epithelial cells
《Animal Nutrition》2024年第1期338-349,共12页Tianyu Yang Jia Guo Han Song Osmond Datsomor Yuhang Chen Maocheng Jiang Kang Zhan Guoqi Zhao 
supported by the Development Project of China(2017YFD0502104-3);the China Agriculture Research System(CARS-36);the National Natural Science Foundation of China(No.31972589)
Glucose plays a vital part in milk protein synthesis through the mTOR signaling pathway in bovine mammary epithelial cells(BMEC).The objectives of this study were to determine how glucose affects hexokinase(HK)activit...
关键词：Glucose HEXOKINASE Milk protein Mechanistic target of rapamycin complex 1 signaling pathway Bovine mammary epithelial cell Kappa casein 
LncRP11-675F6.3 responds to rapamycin treatment and reduces triglyceride accumulation via interacting with HK1 in hepatocytes by regulating autophagy and VLDL-related proteins
《Acta Biochimica et Biophysica Sinica》2023年第10期1606-1617,共12页Lingling Wang Xiaojuan Fang Ziyou Yang Xueling Li Mengdi Cheng Liang Cheng Ganglin Wang Wei Li Lin Liu 
supported by the grants from the National Natural Science Foundation of China(No.81970753);the Wenzhou Science and Technology Bureau Foundation(No.ZY2021011).
Long noncoding RNAs(lncRNAs)have been widely proven to be involved in liver lipid homeostasis.Herein,we identify an upregulated lncRNA named lncRP11-675F6.3 in response to rapamycin treatment using a microarray in Hep...
关键词：lncRP11-675F6.3 TRIGLYCERIDES AUTOPHAGY LIPOPROTEIN hexokinase 1 nonalcoholic fatty liver disease 
Aerobic glycolysis promotes tumor immune evasion and tumor cell stemness through the noncanonical function of hexokinase 2被引量：1
《Cancer Communications》2023年第3期387-390,共4页Haiyan He Liwei Xiao Juhong Wang Dong Guo Zhimin Lu 
Ministry of Science and Technology of the People’s Republic of China,Grant/Award Number:2020YFA0803300;National Natural Science Foundation of China,Grant/Award Numbers:82188102,82030074,81902423;Zhejiang Natural Science Foundation Key Project,Grant/Award Number:LD21H160003;Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang,Grant/Award Number:2019R01001。
The Warburg effect is a key metabolic feature of cancer cells and manifests as substantially increased glycolysis regardless of the presence of oxygen[1].The initial step of glycolysis is catalyzed by hexokinase(HK),w...
关键词：GLYCOLYSIS METABOLISM ATTRACTIVE 
Regulatory effects of evodiamine on glucose metabolism-related factors in CT26 colorectal carcinoma-bearing mice
《Precision Medicine Research》2022年第4期12-17,共6页Jiang-Yue Yu Kui Chen Ruo-Qin Zhao Li-Qun Wang Chao Gong Shen-Zhou Huang Yun-Juan Zheng Pei-Wen Zhu Xin-Ran Song Fang-Hua Wu 
the Affiliated Fuzhou First Hospital of Fujian Medical University,the Fuzhou Science and Technology planning project(2020-WS-123).
Objective:To investigate the therapeutic effect of evodiamine(EVO)on the expression of hexokinase(HK),lactate dehydrogenase A(LDHA),and pyruvate kinase M(PKM),key enzymes of glycolysis,in the tumor-bearing mice after ...
关键词：EVODIAMINE mouse colon cancer cells tumor-bearing mice GLYCOLYSIS HEXOKINASE lactate dehydrogenase A pyruvate kinase M 
A non-metabolic function of hexokinase 2 in small cell lung cancer:promotes cancer cell stemness by increasing USP11-mediated CD133 stability被引量：7
《Cancer Communications》2022年第10期1008-1027,共20页Juhong Wang Fei Shao Yannan Yang Wei Wang Xueying Yang Renda Li Hong Cheng Sijin Sun Xiaoli Feng Yibo Gao Jie He Zhimin Lu 
Ministry of Science and Technology of the People’s Republic of China,Grant/Award Number:2020YFA0803300;National Natural Science Foundation of China,Grant/Award Numbers:82188102,82030074,82122053,32100574;Beijing Municipal Science&Technology Commission,Grant/Award Number:Z191100006619115;R&D Program of Beijing Municipal Education commission,Grant/Award Number:KJZD20191002302;CAMS Innovation Fund for Medical Science,Grant/Award Numbers:2021-1-I2M-012,2021-I2M-1-067;Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences,Grant/Award Number:2021-PT310-001;Key-Area Research and Development Program of Guangdong Province,Grant/Award Number:2021B0101420005;Sanming Project of Medicine in Shenzhen,Grant/Award Numbers:SZSM201612097,SZSM201812062;Aiyou Foundation,Grant/Award Number:KY201701;Natural Science Foundation of Shandong Province,Grant/Award Number:ZR2020QH191;Zhejiang Natural Science Foundation-Key Project,Grant/Award Number:LD21H160003;Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang,Grant/Award Number:2019R01001;Zhimin Lu is the Kuancheng Wang Distinguished Chair。
Background:Maintenance of cancer stem-like cell(CSC)stemness supported by aberrantly regulated cancer cell metabolism is critical for CSC self-renewal and tumor progression.As a key glycolytic enzyme,hexokinase 2(HK2)...
关键词：HK2 metabolic enzyme non-metabolic function cancer stem-like cell CD133 USP11 UBIQUITYLATION SCLC 
长链非编码RNA-Hexokinase 2的生物信息学分析
《医学信息》2022年第19期1-5,10,共6页魏晨 蒋振 
南充市科技局项目(编号:20SXJCQN0004、18SXHZ0281)。
目的运用生物信息学分析方法,分析长链非编码RNA-Hexokinase 2(HK2)在细胞内的调控靶基因及信号通路,并对其进行生物学功能注释,阐述lncRNA-HK2在细胞内的功能作用。方法在miRDB数据库和Starbase3.0数据库中预测与lncRNA-HK2有miRNA-lnc...
关键词：长链非编码RNA-Hexokinase 2 信号通路 蛋白磷酸化 
Detection and surveillance of circulating tumor cells in osteosarcoma for predicting therapy response and prognosis被引量：1
《Cancer Biology & Medicine》2022年第9期1397-1409,共13页Haoran Mu Dongqing Zuo Jie Chen Zhigang Liu Zhuo Wang Liu Yang Qihui Shi Yingqi Hua 
supported by the National Natural Science Foundation of China(Grant No.21775103 to Q.S.,Grant No.82172366 to L.Y.,and Grant No.81802985 to D.Z.);Shanghai Science and Technology Committee(Grant No.20ZR1473000 to Q.S.).
Objective:Osteosarcoma(OS)is an aggressive,highly metastatic,relatively drug-resistant bone tumor with poor long-term survival rates.The presence and persistence of circulating tumor cells(CTCs)in the peripheral blood...
关键词：Circulating tumor cells OSTEOSARCOMA hexokinase 2 single-cell sequencing mesenchymal tumor 
IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation
《Cancer Biology & Medicine》2022年第7期1008-1028,共21页Tingting Feng Jing Wang Kai Cheng Qiqi Lu Ru Zhao Shiguan Wang Qingyun Zhang Luna Ge Jihong Pan Guanhua Song Lin Wang 
supported by the National Natural Science Foundation of China(Grant Nos.81772760 and 82072850);the Natural Science Foundation of Shandong Province(Grant Nos.ZR2020YQ55 and ZR2020QH327),the Shandong Taishan Scholarship(Grant No.tsqn20161076);the Innovation Project of Shandong Academy of Medical Sciences(2020);the program for Outstanding PhD candidate of Shandong University(2020)and Academic promotion programme of Shandong First Medical University(LJ001).
Objective:Androgen deprivation therapy(ADT)is still the principal treatment option for prostate cancer(PCa).In addition to reactivation of androgen receptor signaling,the resistance of PCa to apoptosis during ADT also...
关键词：Prostate cancer castration resistance IL13Rα1 apoptosis GLYCOLYSIS 
Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma被引量：1
《Biomedical and Environmental Sciences》2022年第7期622-632,共11页JIAO Ning JI Wan Sheng ZHANG Biao SHANG Yu Kui ZHANG Yu Chen YU Wei Qun JIN Hai Long LI Chao ZHANG Cheng Ying YAN Cheng YUE Wen ZHANG Qing 
supported by National Natural Science Foundation of China [81372595]
Objective To investigate the regulatory relationship of Protein Phosphatase 2 Regulatory Subunit B"Alpha(PPP2R3A)and hexokinase 1(HK1)in glycolysis of hepatocellular carcinoma(HCC).Methods In HepG2 and Huh7 cells,PPP2...
关键词：Hepatocellular carcinoma PPP2R3A Hexokinase 1 GLYCOLYSIS 
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