CHROMATIN

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Chromatin compartments at DNA double-stranded breaks
《Cell Research》2024年第5期337-338,共2页Jaewon Min Jean Gautier 
In a recent article published in Nature,Arnould and colleagues reveal that DNA double-stranded breaks(DSBs)strengthen chromatin compartmentalization near the breaks.They show that"D"compartments arise from clustering ...
关键词：DOUBLE thereby BREAKS 
scNanoATAC-seq:a long-read single-cell ATAC sequencing method to detect chromatin accessibility and genetic variants simultaneously within an individual cell被引量：3
《Cell Research》2023年第1期83-86,共4页Yuqiong Hu Zhenhuan Jiang Kexuan Chen Zhangxian Zhou Xin Zhou Yan Wang Jingwei Yang Bo Zhang Lu Wen Fuchou Tang 
This project was supported by the Beijing Advanced Innovation Center for Genomics and grants from the National Key R&D Program of China(2018YFA0107601).
Dear Editor,The accessible chromatin regions were enriched in regulatory elements in human genome and many genetic variations associated with human diseases were identified within them.1 Single-cell assay for transpos...
关键词：METHOD INSERTION CHROMATIN 
Single-cell epigenome analysis reveals age-associated decay of heterochromatin domains in excitatory neurons in the mouse brain被引量：2
《Cell Research》2022年第11期1008-1021,共14页Yanxiao Zhang Maria Luisa Amaral Chenxu Zhu Steven Francis Grieco Xiaomeng Hou Lin Lin Justin Buchanan Liqi Tong Sebastian Preissl Xiangmin Xu Bing Ren 
supported by funding from Ludwig Institute for Cancer Research(to B.R.);NIH grants 1R01AG067153(to X.X,B.R.),R01AG066018(to B.R.);supported in part by NIH K99CA252020;supported by an NIH training grant(T32GM008806-18);in part by NIH K99HG011483.
Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-associated decline in organ functions in mammals;however,the specific cell types and gene loci affected by this type of epigenetic cha...
关键词：EXCITATORY assessed CHROMATIN 
Rett syndrome-causing mutations compromise MeCP2- mediated liquid—liquid phase separation of chromatin被引量：5
《Cell Research》2020年第5期393-407,共15页Liang Wang Mingli Hu Mei-Qing Zuo Jicheng Zhao Di Wu Li Huang Yongxin Wen Yunfan Li Ping Chen Xinhua Bao Meng-Qiu Dong Guohong Li Pilong Li 
This work was supported by grants from the Ministry of Science and Technology of China(2017YFA0504202 to G.L.,2019YFA0508403 to P.L,2018YFE0203302 to P.C.);the National Natural Science Foundation of China(31525013,31630041 and 31521002 to G.L.,31871443 to P.L.,31871290 to P.C.);The work was also supported by the Chinese Academy of Sciences(CAS)Strategic Priority Research Program(XDB19040202);the CAS Key Research Program on Frontier Science(QYZDY-SSW-SMC020);an HHMI International Research Scholar grant(55008737)to G.L.
Rett syndrome(RTT),a severe postnatal neurodevelopmental disorder,is caused by mutations in the X-linked gene encoding methyl-CpG-binding protein 2(MeCP2).MeCP2 is a chromatin organizer regulating gene expression.RTT-...
关键词：MECP2 separation LIQUID 
Altered chromatin recruitment by FOXA1 mutations promotes androgen independence and prostate cancer progression被引量：4
《Cell Research》2019年第9期773-775,共3页Bohan Xu Bing Song Xiaodong Lu Jung Kim Ming Hu Jonathan C.Zhao Jindan Yu 
Dear Editor,F0XA1,a forkhead(FKHD)family transcription factor,is highly expressed in the epithelium of endoderm-derived organs, including the prostate gland.1 Transgenic mouse studies have shown that F0XA1 expression ...
关键词：FOXA1 FKHD DNA 
Integrative single-cell analysis of transcriptome,DNA methylome and chromatin accessibility in mouse oocytes被引量：22
《Cell Research》2019年第2期110-123,共14页Chan Gu Shanling Liu Qihong Wu Lin Zhang Fan Guo 
grants from the Ministry of Science and Technology of China (2018YFA0107701);the National Natural Science Foundation of China (31771590 and 31822035);the Science and Technology Department of Sichuan Province (2018JZ0025);the Fundamental Research Funds for the Central Universities.
Oocyte growth is a key step in forming mature eggs that are ready to be fertilized.The states and modifications of chromatin represent critical sources of information for this process.However,the dynamics and interrel...
关键词：OOCYTE growth TRANSCRIPTOME mouse OOCYTES 
Accurate annotation of accessible chromatin in mouse and human primordial germ cells被引量：2
《Cell Research》2018年第11期1077-1089,共13页Jingyi Li Shijun Shen Jiayu Chen Wenqiang Liu Xiaocui Li Qianshu Zhu Beiying Wang Xiaolong Chen Li Wu Mingzhu Wang Liang Gu Hong Wang Jiqing Yin Cizhong Jiang Shaorong Gao 
Extensive and accurate chromatin remodeling is essential during primordial germ cell （PGC） development for the perpetuation of genetic information across generations. Here, we report that distal c/s-regulatory eleme...
关键词：Embryonic germ cells 
Histone H3 lysine 4 monomethylation modulates long- range chromatin interactions at enhancers被引量：3
《Cell Research》2018年第2期204-220,共17页Jian Yan Shi-An A Chen Andrea Local Tristin Liu Yunjiang Qiu Kristel M Dorighi Sebastian Preissl Chloe M Rivera Chaochen Wang Zhen Ye Kai Ge Ming Hu Joanna Wysocka Bing Ren 
Long-range chromatin interactions between enhancers and promoters are essential for transcription of many developmentally controlled genes in mammals and other metazoans. Currently, the exact mechanisms that connect d...
关键词：ENHANCER H3K4mel MLL3 MLL4 chromatin loop 
Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening被引量：4
《Cell Research》2017年第5期642-656,共15页Shuyi Ji Linying Zhu Yimeng Gao Xiaoran Zhang Yupeng Yan Jin Cen Rongxia Li Rong Zeng Lujian Liao Chunhui Hou Yawei Gao Shaorong Gao Gang Wei Lijian Hui 
Lineage conversion by expression of lineage-specific transcription factors is a process of epigenetic remodeling that has low efficiency. The mechanism by which a cell resists lineage conversion is largely unknown. Us...
关键词：Baf60b ATM P53 chromatin remodeling lineage conversion hepatic conversion 
Visualization of aging-associated chromatin alterations with an engineered TALE system被引量：5
《Cell Research》2017年第4期483-504,共22页Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu 
We thank Drs Lusheng Gu and Wei Ji and the Center for Bio- logical Instrument Development （CBID）, Institute of Biophysics, Chinese Academy of Sciences （CAS）, for their help in analyzing CLEM images, as well as Shuoguo Li and Center for Biological Imaging （CBI）, Institute of Biophysics, CAS, for technical as- sistance in SIM imaging. We are grateful to Yang Zhao and Lei Bai for administrative assistance. This work was supported by the National Basic Research Program of China （973 Program; 2015CB964800, 2014CB910503 and 2014CB964600）, the Nation- al High Technology Research and Development Program of China （2015AA020307）, CAS （XDA01020312, KJZDEW-TZ-L05, and CXJJ-16M271）, the National Natural Science Foundation of China （NSFC; 81625009, 81330008, 31222039, 81371342, 81300261, 81300677, 81271266, 81471414, 81422017, 81401159, 31671429, 81601233, 81671377, 31601109, and 31601158）, Beijing Natural Science Foundation （7141005 and 5142016）, Pro- gram of Beijing Municipal Science and Technology Commission （Z 151100003915072）, Key Research Program of the Chinese Academy of Sciences （KJZDEW-TZ-L05）, the Thousand Young Talents Program of China, and the State Key Laboratory of Stem Cell and Reproductive Biology （2016SRLabKF13）. TX was sup- ported by NSFC （31127901, 31421002, 81427802, and 31130065） and the Instrument Developing Project of the Chinese Acade- my of Sciences （YZ201443）. ZYJ was supported by the NSFC （81420108017 and 81525010） and the National Basic Research Program of China （973 Program; 2016YFA0100600）. WZ was supported by Youth Innovation Promotion Association of CAS and Early Career Fellowship of Chinese Society of Cell Biology. JQ was supported by the NSFC （31230047） and the National Ba- sic Research Program of China （973 Program; 2014CB943203）. LS was supported by NSFC （81571385）. YY was supported by the Key Special Fund （2016YFC1000601）, the National Basic Research Program of China （973 Program; 2014CB943203） and Beijing Nova
Visualization of specific genomic loci in live cells is a prerequisite for the investigation of dynamic changes in chro- matin architecture during diverse biological processes, such as cellular aging. However, current...
关键词：thioredoxin-fused TALE aging ribosomal DNA repeat TELOMERE CENTROMERE 
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