DYSFUNCTIONAL

作品数：49被引量：153H指数：8
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相关领域：医药卫生更多>>
相关作者：高淑芳肖云平艳艳刘霞王丽华更多>>
相关机构：暨南大学信息科学与技术学院哈尔滨医科大学中国医科大学更多>>
相关期刊：《Genes & Diseases》《Eye and Vision》《Neural Regeneration Research》《World Journal of Nephrology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Dysfunctional glucose metabolism triggers oxidative stress to induce kidney injury in diabetes
《World Journal of Diabetes》2025年第4期19-24,共6页Meng Gao Meng-Ting Dai Guo-Hua Gong 
Supported by The Basic Research Project of Wenzhou Municipal Science and Technology Bureau,No.Y20240008;The Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2024KY138;The Key Laboratory of School of Laboratory Medicine and Life Sciences,Wenzhou Medical University of China,No.JS2023003。
In this editorial,we discussed the article published in the recent issue of the World Journal of Diabetes.To understand the effect of mizagliflozin on kidney injury induced by diabetes,we focused on the mechanisms by ...
关键词：Glucose metabolism Sodium-D-glucose cotransporter 1 Glucose reabsorption Mitochondrial dysfunction Reactive oxygen species Inflammation 
Halt aging? — functional HSCs lead the way
《Cell Research》2025年第3期157-158,共2页Rebecca T.Chu Adam B.Schroer Saul A.Villeda 
The aged immune system contributes to systemic aging,serving as a driver of morbidity and mortality in the elderly.In a recent Cell Research paper,Wang et al.identified both resilient and dysfunctional subsets of old ...
关键词：hematopoietic stem cells hscs dysfunctional hscs immune system cell research aging phenotypes functional hscs therapeutic targets systemic aging hematopoietic stem cells 
Specificity and Sensitivity of the iTrace Dysfunctional Lens Index in Early Diagnosis of Cataract
《Open Journal of Ophthalmology》2025年第1期7-10,共4页Yasser Rifay 
The iTrace Dysfunctional Lens Index (DLI) offers a quantitative approach to lens assessment, potentially facilitating the early detection of cataracts. Globally, the prevalence of cataracts has increased due to aging ...
关键词：KERATOCONUS Anterior Segment OCT Early Detection 
Nanoengineered mitochondria enable ocular mitochondrial disease therapy via the replacement of dysfunctional mitochondria
《Acta Pharmaceutica Sinica B》2024年第12期5435-5450,共16页Yi Wang Nahui Liu Lifan Hu Jingsong Yang Mengmeng Han Tianjiao Zhou Lei Xing Hulin Jiang 
supported by the National Natural Science Foundation of China(82020108029,82304416,82073398,82302367,China);supported by the Natural Science Foundation of Jiangsu Province(BK20231016,BK20231019,China);the China Postdoctoral Science Foundation(grant Number:2022M720173,China);Jiangsu Funding Program for Excellent Postdoctoral Talent(2023,China);the Fundamental Research Funds for the Central Universities(2632023GR20,China);State Key Laboratory of Natural Medicines China Pharmaceutical University(SKLNMZZ202021,China);Double First-class University Projects(CPU2018GY06,China);Double First-Rate construction plan of China Pharmaceutical University(CPU2022QZ18,China)。
Leber’s hereditary optic neuropathy(LHON)is an ocular mitochondrial disease that involves the impairment of mitochondrial complex I,which is an important contributor to blindness among young adults across the globe.H...
关键词：Engineered mitochondria Mitochondrial transfer Mitochondrial disease Leber’s hereditary optic neuropathy Nanoparticle Complex I defect Mitochondrial function IDEBENONE 
Functional biomaterials for modulating the dysfunctional pathological microenvironment of spinal cord injury被引量：1
《Bioactive Materials》2024年第9期521-543,共23页Dezun Ma Changlong Fu Fenglu Li Renjie Ruan Yanming Lin Xihai Li Min Li Jin Zhang 
supported by the National Key R&D Program of China(Grant No.2022YFB3808000/2022YFB3808001);the National Natural Science Foundation of China(Grant Nos.82301554,51903050 and 82104888);Scientific Research Foundation for the High-level Talents Fujian University of Traditional Chinese Medicine(X2021007talents,X2019011talents);School management project of Fujian University of traditional Chinese Medicine(X2023019).
Spinal cord injury(SCI)often results in irreversible loss of sensory and motor functions,and most SCIs are incurable with current medical practice.One of the hardest challenges in treating SCI is the development of a ...
关键词：Spinal cord injury Dysfunctional pathological microenvironment Functional biomaterials Axon regeneration Functional recovery 
GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease被引量：1
《Neuroscience Bulletin》2024年第4期451-465,共15页Huiqin Li Xiang Cao Xinya Gu Mengqi Dong Lili Huang Chenglu Mao Shengnan Xia Haiyan Yang Xinyu Bao Yongbo Yang Yun Xu 
supported by the National Natural Science Foundation of China(82271334,82130036,81920108017,82171310);the National Science and Technology Innovation 2030--Major Program of"Brain Science and Brain-Like Research"(2022ZD0211800);Jiangsu Provincial‘333’High-level Talent Training Project Funding,the Key Research and Development Program of Jiangsu Province of China(BE2020620);Jiangsu Province Key Medical Discipline(ZDXK202216).
Moyamoya disease(MMD)is a chronic occlusive cerebrovascular disease with the development of a network of abnormal vessels.Immune inflammation is associated with the occurrence and development of MMD.However,the mechan...
关键词：Moyamoya disease Vascular endothelial cells GM-CSF VEGF 
The dysfunctional Wnt pathway down-regulates MLH1/SET expression and promotes microsatellite instability and immunotherapy response in colorectal cancer
《Genes & Diseases》2024年第2期542-545,共4页Jiyan Wang Tao He Qingle Gao Hongkai Chang Xintong Dai Juze Yang Shuangping Liu Shuai Zhang Changliang Shan Chunze Zhang 
supported by grants from National Nature Science Foundation of China(No.81973356,81902826 and 82273963);Natural Science Foundation of Tianjin(No.21JCZDJC00060 and 21JCYBJC00180);the Fundamental Research Funds for the Central Universities of Nankai University(No.ZB22010404,3206054,91923101,63213082,and 92122017).
The tumor heterogeneity results in different clinical characteristics of tumor patients,so precise therapy is a popular treatment strategy clinically.Microsatellite instability(MSI)is found in 10%-15%of colorectal can...
关键词：IMMUNOTHERAPY COLORECTAL clinical 
CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells
《Cellular & Molecular Immunology》2024年第4期349-361,共13页Ye Seon Kim Yu Sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu Lee Brian A.Zabel Yoe-Sik Bae 
supported by Basic Science Research Program(NRF-2020M3A9D3038435,NRF-2017R1A5A1014560);the Korea Initiative for Fostering the University of Research and Innovation Program(NRF-2020M3H1A1077095);through the National Research Foundation of Korea(NRF)funded by the Ministry of Science,ICT and Future Planning and by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute(KHIDI);funded by the Ministry of Health&Welfare,Republic of Korea(grant number:HI22C2004).
Distinct neutrophil populations arise during certain pathological conditions.The generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain un...
关键词：SEPSIS NEUTROPHILS CD200R AUTOPHAGY IGF-1 Regulatory T cells 
Endosomal traffic disorders:a driving force behind neurodegenerative diseases
《Translational Neurodegeneration》2024年第1期42-70,共29页Jianru Dong Weiwei Tong Mingyan Liu Mengyu Liu Jinyue Liu Xin Jin Ju Chen Huachao Jia Menglin Gao Minjie Wei Ying Duan Xin Zhong 
supported by the National Natural Science Foundation of China(81901309);the Science and Technology Funding Project to Support the High-Quality Development of China Medical University(2023JH2/20200039);the Basic Scientific Research Project of Institutions of Higher Learning of Liaoning Province(LJKZ0775);the Joint Plan of Science and Technology of Liaoning Province(2023-MSLH-369)the Science and Technology Innovation Team Project of China Medical University(CXTD2022007).
Endosomes are crucial sites for intracellular material sorting and transportation.Endosomal transport is a critical process involved in the selective uptake,processing,and intracellular transport of substances.The equ...
关键词：Endosomal traffic disorders Glycolipid metabolism Autophagy Immunity Neurodegenerative disease Pathological protein aggregation NEUROINFLAMMATION Dysfunctional synapses and neural network DNA and RNA defects Therapeutic drugs 
Repair of dysfunctional bone marrow endothelial cells alleviates aplastic anemia被引量：4
《Science China(Life Sciences)》2023年第11期2553-2570,共18页Shu-Qian Tang Tong Xing Zhong-Shi Lyu Li-Ping Guo Mi Liang Chen-Yuan Li Yuan-Yuan Zhang Yu Wang Lan-Ping Xu Xiao-Hui Zhang Xiao-Jun Huang Yuan Kong 
supported by the National Key Research and Development Program of China(2021YFA1100900,2022YFA1103300);the National Natural Science Foundation of China(82070188,82270229,81930004);Beijing Natural Science Foundation(7232181);Peking University People's Hospital Scientific Research Development Funds(RDGS2022-04).
Aplastic anemia(AA)is a life-threatening disease characterized by bone marrow(BM)failure and pancytopenia.As an important component of the BM microenvironment,endothelial cells(ECs)play a crucial role in supporting he...
关键词：aplastic anemia endothelial cell N-ACETYL-L-CYSTEINE hematopoietic stem cell T cell 
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