QUADRUPLEX

作品数：16被引量：14H指数：2
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相关领域：生物学理学更多>>
相关作者：陈懿更多>>
相关机构：北京化工大学浙江中医药大学中国科学院杭州市第一人民医院更多>>
相关期刊：《Science China Chemistry》《有机化学》《Journal of Integrative Agriculture》《Science Bulletin》更多>>
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A quadruplex immunochromatographic assay for the ultrasensitive detection of 11 anesthetics被引量：4
《Nano Research》2023年第8期11269-11277,共9页Xianlu Lei Xinxin Xu Li Wang Wei Zhou Liqiang Liu Liguang Xu Hua Kuang Chuanlai Xu 
This work is financially supported by the National Key Research and Development Program of China(No.2022YFF1101002);Jiangsu Association for Science and Technology Youth Science and Technology Talent Support Project(No.TJ-2021-049).
Anesthetic residues in fish represent a potential risk to human health.Therefore,it is important to develop a sensitive and broad-specific method for the detection of anesthetics.In this study,we developed a colloidal...
关键词：BUPIVACAINE colloidal gold EUGENOL PROCAINE tricaine(TMS) 
Discovery of novel triple targeting G–quadruplex and topoisomerase 1/2 ligands from natural products evodiamine and rutaecarpine
《Chinese Chemical Letters》2023年第4期203-210,共8页Haibo Wang Xuexin Bai Yahui Huang Yueru Chen Guoqiang Dong Tianmiao Ou Shanchao Wu Defeng Xu Chunquan Sheng 
supported by the National Natural Science Foundation of China (Nos. 22077138 to S. Wu, 81725020 to C. Sheng;81872742 to G. Dong);the National Key Research and Development Program of China (No. 2020YFA0509200 to C. Sheng);Shanghai Rising-Star Program (No. 22QA1411300 to S. Wu)。
Inspired by the indolopyridoquinazoline scaffold of natural products evodiamine and rutaecarpine, novel triple G4 and Top1/2 ligands were rationally designed and synthesized. Systematic structure–activity relationshi...
关键词：Indolopyridoquinazoline G-QUADRUPLEX TOPOISOMERASE Structure-activity relationship Antitumor activity 
DNA/RNA helicase DHX36 is required for late stages of spermatogenesis
《Journal of Molecular Cell Biology》2022年第11期50-61,共12页Kejia Zhang Tianxin Zhang Yujie Zhang Jinyu Yuan Xinzhe Tang Chaobao Zhang Qianqian Yin Yonglian Zhang Ming-Han Tong 
supported by grants from the National Key R&D Program of China(2021YFC2700200 and 2022YFC2702602);the National Natural Science Foundation of China(31930034);the Science and Technology Commission of Shanghai Municipality(19JC1415800 to M.-H.T.).
Spermatogenesis is a highly complex developmental process that typically consists of mitosis, meiosis, and spermiogenesis. DNA/RNA helicase DHX36, a unique guanine-quadruplex (G4) resolvase, plays crucial roles in a v...
关键词：Dhx36 MEIOSIS guanine-quadruplex(G4) Spo11 SYNAPSIS meiotic recombination crossover 
Clinical Observation of Bifidobacterium Combined with Pediatric Diarrhea
《外文科技期刊数据库(文摘版)医药卫生》2022年第2期051-054,共4页CHENGJing 
Objective: to analyze the effect of bifidobacteria in treating diarrhea in children. Methods: into our hospital in October 2019 to September 2021 for children with diarrhea 80 cases, random digital table is divided in...
关键词：pediatric diarrhea bifidobacteria lactobacillus quadruplex tablets temoronization immune function 
Biological and molecular characterization of tomato brown rugose fruit virus and development of quadruplex RT-PCR detection被引量：7
《Journal of Integrative Agriculture》2021年第7期1871-1879,共9页YAN Zhi-yong ZHAO Mei-sheng MA Hua-yu LIU Ling-zhi YANG Guang-ling GENG Chao TIAN Yan-ping LI Xiang-dong 
supported by the grants from the National Natural Science Foundation of China (31720103912 and 31801704);the ’Taishan Scholar’ Construction Project, China (TS201712023)。
Tomato brown rugose fruit virus(ToBRFV) is a novel tobamovirus firstly reported in 2015 and poses a severe threat to the tomato industry. So far, it has spread to 10 countries in America, Asia, and Europe. In 2019, To...
关键词：host range identity quadruplex RT-PCR detection phylogenetic tree SYMPTOM TOBAMOVIRUS tomato brown rugose fruit virus 
The catalytic properties of DNA G‐quadruplexes rely on their structural integrity
《Chinese Journal of Catalysis》2021年第7期1102-1107,共6页Jielin Chen Mingpan Cheng Jiawei Wang Dehui Qiu David Monchaud Jean‐Louis Mergny Huangxian Ju Jun Zhou 
国家自然科学基金(21977045,21635005);中央高校基本科研业务费(02051430210);南京大学高层次人才科研启动经费(020514912216).
The influence of the G‐quartet structural integrity on the catalytic activity of the G‐quadruplex(G4)was investigated by comparing the G4‐DNAzyme performances of a series of G4s with a G‐vacancy site and a G‐trip...
关键词：G‐quadruplex G‐quadruplex DNAzyme G‐vacancy G‐quartet integrity Guanine surrogate 
GMP-quadruplex-based hydrogels stabilized by lanthanide ions被引量：1
《Science China Chemistry》2018年第5期604-612,共9页Jin Zhang Xiaoyang Li Xiuping Sun Aixin Song Yebang Tan Jingcheng Hao 
supported by the National Natural Science Foundation of China(21573134,21420102006)
This work describes the gelation behaviors and properties of a biological molecule, guanosine 5′-monophosphate disodium salt(GMP), in the presence of trivalent lanthanide ions. Hydrogels composed of GMP-quadruplexes ...
关键词：G-quadruplex hydrogel hydrogen bonding electrostatic interaction ion-dipole interaction fluorescence enhancement 
Cytotoxicities, Telomerase and Topoisomerases I Inhibitory Activities and Interactions of Terpyridine Derivatives with DNAs
《Chemical Research in Chinese Universities》2015年第6期970-975,共6页WEI Chunying GAO Ning 
Supported by the National Natural Science Foundation of China（No.21171108）.
A novel compound 4-methyl-7-{[4-（2,2＇：6＇,2＂-terpyridin-4＇-yl）benzyl]amino}-2H-chromen-2-one（1） was synthesized, and its DNA-binding properties, cytotoxicity, and telomerase and Topo I inhibitory activities we...
关键词：TERPYRIDINE COUMARIN QUADRUPLEX TELOMERASE Topoisomerase I 
A single base permutation in any loop of a folded intramolecular quadruplex influences its structure and stability
《Journal of Biophysical Chemistry》2012年第4期341-347,共7页Dinesh Yadav Richard D. Sheardy 
The human telomere sequence (TTAGGG)4 folds into an unusual conformation possessing three G-tetrads linked by TTA loops. The first loop is a propeller loop while the second and third loops are transverse loops. Using ...
关键词：Cell DNA QUADRUPLEXES Sequence Context Circular DICHROISM Structure Stability 
A Study of Interaction between Flavonoids and the Parallel Quadruplex Structure [d（TGGGGT）]4 by Electrospray Ionization Mass Spectrometry被引量：1
《Chinese Journal of Chemistry》2012年第7期1433-1438,共6页徐牛生 杨洪梅 崔勐 宋凤瑞 刘志强 刘淑莹 
Acknowledgement This work was supported by the National Natural Science Foundation of China （No. 28073137）.
In this study, electrospray ionization mass spectrometry （ESI-MS） was used to investigate interaction of 21 flavonoids （10 aglycones and 11 glycosides） with the parallel quadruplex structure [d（TGGGGT）]4. Relati...
关键词：FLAVONOIDS G-quadruplex DNA INTERACTION ESI-MS 
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