POLYDATIN

作品数：14被引量：100H指数：7
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相关作者：王跃忠张佩文余传林骆苏芳陈考坛更多>>
相关机构：南方医科大学南方医院中国人民解放军第一军医大学广州中医药大学湖南师范大学更多>>
相关期刊：《Chinese Journal of Traumatology》《Medicinal Plant》《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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Polydatin ameliorates hepatic ischemia-reperfusion injury by modulating macrophage polarization
《Hepatobiliary & Pancreatic Diseases International》2024年第1期25-34,共10页Hai-Li Bao Chuan-Zhi Chen Chang-Zhen Ren Ke-Yan Sun Hao Liu Shao-Hua Song Zhi-Ren Fu 
This study was supported by grants from the National Natural Science Foundation of China(No.81970563);the Medical Health Science and Technology Project of Health Commission of Zhejiang Province(2019RC055).
Background:Polydatin,a glucoside of resveratrol,has shown protective effects against various diseases.However,little is known about its effect on hepatic ischemia-reperfusion(I/R)injury.This study aimed to elucidate w...
关键词：Hepatic ischemia-reperfusion injury POLYDATIN MACROPHAGE POLARIZATION INFLAMMATION 
Determination of Polydatin in Rat Serum and Its Changes by UPLC Method
《Medicinal Plant》2021年第2期63-64,69,共3页Haisheng ZENG Zhiqiang WANG Meiyuan LU Chao ZENG Mengxia YANG Guilin YANG 
Project of Traditional Chinese Medicine Administration of Guangxi Zhuang Autonomous Region(GZZC2019147);Project for Improving Basic Research Ability of Middle Aged and Young Teachers in Colleges and Universities of Guangxi in 2020(2020KY13034);The First Batch High-level Talent Scientific Research Project of The Affiliated Hospital of Youjiang Medical University for Nationalities in 2019(Y20196311);National Traditional Chinese Medicine Characteristic Technology Heritage Talent Training Program(2015481601003);Program of Youjiang Medical University for Nationalities(yy2018ky018).
[Objectives]To establish a UPLC-UV method for the determination of polydatin in the serum of Wistar rats.[Methods]Acquity UPLC BEH shield RP18 column(1.7μm,2.1 mm×100 mm,Waters Corporation,USA)was used as the analyt...
关键词：POLYDATIN Drug concentration in serum Content determination Ultra Performance Liquid Chromatography(UPLC) 
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway被引量：10
《Acta Pharmacologica Sinica》2020年第12期1587-1596,共10页Zhi-quan Chen Xiao-hong Sun Xue-juan Li Zhan-chi Xu Yan Yang Ze-yuan Lin Hai-ming Xiao Meng Zhang Shi-jian Quan He-qing Huang 
This work was supported by research grants from the National Natural Science Foundation of China(grant number 81770816 and 81973375);the Key Project of Natural Science Foundation of Guangdong Province,China(grant number 2017AO3O311036);and the Youth Science Foundation of Guangxi Medical University,China(grant number GXMUYSF201903).
We previously found that polydatin could attenuate renal oxidative stress in diabetic mice and improve renal fibrosis.Recent evidence shows that NADPH oxidase 4(Nox4)-derived reactive oxygen species(ROS)contribute to ...
关键词：POLYDATIN diabetic nephropathy renal fibrosis NOX4 CX32 oxidative stress 
Effects of polydatin on the proliferation,migration,and invasion of ovarian cancer被引量：2
《BIOCELL》2019年第4期313-319,共7页XIUCHUN ZHANG 
To investigate the effects of polydatin on the proliferation,migration,and invasion of ovarian cancer,the change of proliferative ability,migration ability,and invasive ability of human ovarian cancer cell OVCAR-3,A27...
关键词：POLYDATIN Ovarian cancer PROLIFERATION MIGRATION INVASION 
Polydatin prevents the induction of secondary brain injury after traumatic brain injury by protecting neuronal mitochondria被引量：15
《Neural Regeneration Research》2019年第9期1573-1582,共10页Li Li Hong-Ping Tan Cheng-Yong Liu Lin-Tao Yu Da-Nian Wei Zi-Chen Zhang Kui Lu Ke-Sen Zhao Marc Maegele Dao-Zhang Cai Zheng-Tao Gu 
supported by the National Natural Science Foundation of China,No.81501690(to ZTG);the Scientific Research Staring Foundation for Talent Introduction for Southern Medical University(to MM)
Polydatin is thought to protect mitochondria in different cell types in various diseases.Mitochondrial dysfunction is a major contributing factor in secondary brain injury resulting from traumatic brain injury.To inve...
关键词：nerve REGENERATION TRAUMATIC brain injury POLYDATIN MITOCHONDRIA endoplasmic reticulum stress SIRT1 reactive oxygen species p38 MITOCHONDRIAL membrane potential MITOCHONDRIAL permeability transition pore lateral fluid PERCUSSION neural REGENERATION 
Polydatin ameliorates Staphylococcus aureus- induced mastitis in mice via inhibiting TLR2- mediated activation of the p38 MAPK/NF-κB pathway被引量：15
《Acta Pharmacologica Sinica》2017年第2期211-222,共12页Kang-feng JIANG Gan ZHAO Gan-zhen DENG Hai-chong WU Nan-nan YIN Xiu-ying CHEN Chang-wei QIU Xiu-li PENG 
This study was supported by the National Natural Science Foundation of China （No 31272631 and 31472254）.
Recent studies show that Polydatin （PD） extracted from the roots of Polygonum cuspidatum Sieb, a widely used traditional Chinese remedies, possesses anti-inflammatory activity in several experimental models. In this...
关键词：MASTITIS Staphylococcus aureus POLYDATIN DEXAMETHASONE ANTI-INFLAMMATION cytokines TLR2 MYD88 p38 MAPK/NF-κBsignaling pathway 
Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip
《Science Foundation in China》2015年第1期35-35,共1页
support by the National Natural Science Foundation of China(Grant Nos.81273483,91227123 and 11161160552)
Prof.Qin Jianhua’s group at the Division of Biotechnology,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,reported the exploration of the anti-aging role of polydatin in Caenorhabditis elegans(C.eleg...
关键词：Biotechnology DALIAN unclear INVENTION RESVERATROL throughput attributed regula manipulation oxidative 
Polydatin attenuated food allergy via store-operated calcium channels in mast cell被引量：4
《World Journal of Gastroenterology》2013年第25期3980-3989,共10页Bo Yang Jian-Jie Li Ji-Juan Cao Cheng-Bin Yang Jie Liu Qiong-Mei Ji Zhi-Gang Liu 
Supported by The Natural Science Foundation of China,No.81271950,to Ji QM;Projects of International/HMT(Hong Kong,Macao,and Taiwan)Cooperation and Innovation Platform in Science and Technology of Guangdong Higher Education Institutions,No.2012gjhz0009,to Liu ZG;Key Laboratory Construction Program of Shenzhen,No.SW201110010,to Liu ZG;Basic Research Program of Shenzhen University,No.201101,to Liu ZG;Basic Research Foundation of Shenzhen,No.JC201005250059A,JCYJ20120613115535998
AIM: To investigate the effect of polydatin (PD), a resveratrol glucoside, on mast cell degranulation and antiallergic activity. METHODS: After the rats were orally sensitized with ovalbumin (OVA) for 48 d and underwe...
关键词：POLYDATIN Food ALLERGY MAST cells Store-operated calcium channels CA2+ 
The Progress of the Research on Cardio-Vascular Effects and Acting Mechanism of Polydatin被引量：8
《Chinese Journal of Integrative Medicine》2012年第9期714-719,共6页刘龙涛 郭刚 吴敏 张文高 
Supported by the National Natural Science Foundation of China(No.81102721);A Planned Technologic Item of State Administration of Traditional Chinese Medicine(No 04-05LP30);Chinese National Scientific Fund for Post-doctor(No 20070410622);Its Special Aid ltem(No.201003226);the Key Technologies R&D Program of Shandong Province(No 2010 GSF 10289)
Rhizoma Polygoni Cuspidati, a Chinese herbal drug, has actions of dispelling dampness, alleviating jaundice, clearing heat, subsiding toxin, activating blood, and removing stasis. Polydatin （PD）, one of its chief ac...
关键词：POLYDATIN cardio-vascular system pharmacological action mechanism study REVIEW 
Effect of polydatin on phospholipase A_2 in lung tissues in rats with endotoxic shock被引量：9
《Chinese Journal of Traumatology》2004年第4期239-243,共5页舒仕瑜 王兴勇 凌智瑜 卢仲毅 
This projectwassupportedbytheChineseMedicalAdministrationBureauofChongqingCity (No .2 0 0 2 4 2 2 1)
Objective: To study the effect of polydatin on p hospholipase A2 in lung tissues in rats with endotoxic shock. Methods: Thirty-two healthy male Wistar rats were employed in this study. A total of 8 rats received norma...
关键词：Shock septic Phospholipases A POLYDATIN 
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