AUTOPHAGOSOMES

作品数：9被引量：30H指数：2
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相关领域：医药卫生生物学更多>>
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相关基金：国家自然科学基金北京市自然科学基金更多>>
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Ultrasound-activated in situ click chemistry to trigger autophagosome tracking for enhanced autophagy blockade and synergistic cancer therapy
《Aggregate》2024年第4期386-398,共13页Weixi Jiang Jingxue Wang Li Chen Xiaoling Qiu Chier Du Hongjin An Xun Guo Xiaoting Wang Junrui Wang Pan Li Zhigang Wang Haitao Ran Zhiyi Zhou Xiaoyuan Chen Jingjing Zhang Jianli Ren 
China Postdoctoral Science Foundation,Grant/Award Numbers:2022TQ0396,2023MD744153;National Natural Science Foundation of China,Grant/Award Numbers:82302218,82171946;CQMU Program for Youth Innovation in Future Medicine,Grant/Award Number:W0026;Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University,Grant/Award Number:KR2023Y044;Chongqing Science and Health Joint Medical Research Project-Young and Middle-Aged High-Level Talent Project,Grant/Award Number:2020GDRC011。
The blockade of cytoprotective autophagy has been demonstrated to effectively enhance the efficacy of sonodynamic therapy(SDT).However,the limited recognition of antiautophagy agents for autophagosomes impedes the cli...
关键词：autophagosomes tracking autophagy blockade click reaction sonodynamic therapy synergy 
A High-Contrast Autolysosome Probe for Detecting Interaction between Autophagosomes and Autolysosomes in Mitophagy
《Chinese Journal of Chemistry》2024年第8期858-866,共9页Weihua Wang Chu Han Shengjie Xie Zisong Cong Zixuan Yang Yuxin Feng Limin Xiang Heng Song 
the National Key Research and Development Program of China(2019YFA0210500)for H.S.;the National Natural Science Foundation of China(No.31900033 to H.s.)forfinancial support.
Comprehensive Summary,Autophagy is a multi-step cell metabolism process in which cells remove damaged and unwanted materials.During autophagy,autophagosomes fuse with lysosomes to form autophagosomes.Autophagosomal me...
关键词：MITOPHAGY Autolysosomes BIOIMAGING Biosensors Fluorescence imaging 
Protective effect of Liangxue Huayu decoction on human retinal pigment epithelial cell(ARPE-19)injury induced by hypoxia through autophagy pathway
《Pharmacology Discovery》2024年第1期44-50,共7页Han-Ran Zheng Yi-Tong Lin Sheng Chen Zi-Yang Chen Jun-Chang Cao Zhao-Da Ye Yan-Hong Hu 
support of the foundation projects:Fujian Province Traditional Chinese Medicine Research Project Plan(No.2021ZYJC08).
Background:Exploring the protective mechanism of the Liangxue Huayu(LXHY)decoction on human retinal pigment epithelial(RPE)cells induced by hypoxia through the autophagy pathway.Methods:The appropriate LXHY decoction ...
关键词：Liangxue Huayu decoction age-related macular degeneration AUTOPHAGY LYSOSOME AUTOPHAGOSOMES 
Corrigendum to“Biogenesis of autophagosomes from the ERGIC membrane system”[Journal of Genetics and Genomics (2023) 50,3-6]
《Journal of Genetics and Genomics》2023年第4期293-293,共1页Yaping Han Shulin Li Liang Ge 
This corrigendum clarifies statement in the article"Biogenesis of autophagosomes from the ERGIC membrane system"by Han et al.(2023).In the"The role of ERGIC-equivalents and COPll vesicles in autophagy in yeast"section...
关键词：STATEMENT system REMOVE 
Biogenesis of autophagosomes from the ERGIC membrane system被引量：1
《Journal of Genetics and Genomics》2023年第1期3-6,共4页Yaping Han Shulin Li Liang Ge 
funded by Beijing Natural Science Foundation(JQ20028);the National Natural Science Foundation of China(32130023,91854114,32061143009);Ministry of Science and Technology of the People’s Republic of China(2019YFA0508602,2021YFA0804802)。
Introduction Macroautophagy(hereafter referred as autophagy)is a process of cellular self-degradation.In response to nutrient deprivation or other stimuli,a nascent double-membrane autophagosome,encapsulating intracel...
关键词：ERGIC COPII vesicle Autophagosome biogenesis Autophagy ERES 
Schwann cells differentiated from skin-derived precursors provide neuroprotection via autophagy inhibition in a cellular model of Parkinson’s disease被引量：3
《Neural Regeneration Research》2022年第6期1357-1363,共7页Jia-Nan Yan Hai-Ying Zhang Jun-Rui Li Ying Chen Yong-Cheng Jiang Jia-Bing Shen Kai-Fu Ke Xiao-Su Gu 
Technology Project of Nantong of China,Nos.JC2020052(to XSG),JCZ19087(to XSG);the National Natural Science Foundation of China,Nos.81873742(to KFK),81901195(to JBS),81502867(to TX),82073627(to TX).
Autophagy has been shown to play an important role in Parkinson’s disease.We hypothesized that skin-derived precursor cells exhibit neuroprotective effects in Parkinson’s disease through affecting autophagy.In this ...
关键词：alpha-synuclein AUTOPHAGOSOMES AUTOPHAGY neural regeneration NEUROPROTECTION Parkinson’s disease PI3K/AKT/mTOR pathway skin-derived precursor Schwann cells 
Retromer localizes to autophagosomes during HCV replication被引量：1
《Virologica Sinica》2017年第3期245-248,共4页Peiqi Yin Zhi Hong Leiliang Zhang Youyang Ke 
supported by grants from the National Natural Science Foundation of China(81471955,81672035,81301438);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-3-020);the National Key Plan for Research and Development of China(2016YFD0500300);the Program for Changjiang Scholars and Innovative Research Team in University(IRT13007);the Fundamental Research Funds for the Central Universities,the PUMC Youth Fund(3332016085)
Dear Editor,Hepatitis C virus（HCV）is a positive-strand RNA virus that belongs to the genus Hepacivirus within the Flaviviridae family.HCV causes chronic liver diseases,and185 million people are infected（Messina et ...
关键词：Flaviviridae replication belongs approved autophagy vaccine infected strand RNA cargo 
Autophagy activation aggravates neuronal injury in the hippocampus of vascular dementia rats被引量：25
《Neural Regeneration Research》2014年第13期1288-1296,共9页Bin Liu Jing Tang Jinxia Zhang Shiying Li Min Yuan Ruimin Wang 
supported by the Scientific Technology Research Project of Hebei Provincial Higher Learning Schools in China,No.ZH2012046;the Major Medical Research Program of Hebei Province in China,No.ZD2013087
It remains unclear whether autophagy affects hippocampal neuronal injury in vascular dementia. In the present study, we investigated the effects of autophagy blockade on hippocampal neuro- nal injury in a rat model of...
关键词：nerve regeneration vascular dementia AUTOPHAGY beclin-l cathepsin B microtbule-associated protein 1 light chain 3 AUTOPHAGOSOMES LYSOSOMES WORTMANNIN neural regeneration 
Homeostatic cell cycle and the origin of autophagosomal vesicles
《Advances in Biological Chemistry》2013年第3期275-287,共13页Amalia Slomiany Bronislaw L. Slomiany 
The autophagosomes were identified in the viable cycloheximide (CHX)-treated cells which had an incapacitated translational process and thus disabled synthesis of endoplasmic reticulum (ER)-derived vesicular transport...
关键词：AUTOPHAGOSOMES ER-Transport Vesicles CELL ORGANELLE Repair LYSOSOMAL CELL DEBRIDEMENT Homeostatic CELL Cycle 
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