ARTESUNATE

作品数：73被引量：225H指数：8
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相关领域：医药卫生更多>>
相关作者：姚丽谢红靳秋月陈立军王静更多>>
相关机构：武警医学院太原市第三人民医院山西医科大学山西省肿瘤医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金广西壮族自治区自然科学基金中国博士后科学基金更多>>
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  • 学科=医药卫生—药学x
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Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis被引量：2
《Journal of Pharmaceutical Analysis》2023年第7期817-829,共13页Jiayun Chen Xueling He Yunmeng Bai Jing Liu Yin Kwan Wong Lulin Xie Qian Zhang Piao Luo Peng Gao Liwei Gu Qiuyan Guo Guangqing Cheng Chen Wang Jigang Wang 
support by the Establishment of Sino-Austria“Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research,China(Grant No.:2020YFE0205100);the National Key Research and Development Program of China(Grant Nos.:2020YFA0908000,2022YFC2303600);the Distinguished Expert Project of Sichuan Province Tianfu Scholar(Grant No.:CW202002);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine,China(Grant No.:ZYYCXTD-C-202002);the National Natural Science Foundation of China(Grant Nos.:82141001,82274182,82074098,82173914);the China Academy of Chinese Medical Sciences(CACMS)Innovation Fund,China(Grant Nos.:CI2021A05101,CI2021A05104);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(Grant No.:CI2021B014);the Science and Technology Foundation of Shenzhen,China(Grant No.:JCYJ20210324115800001);the Science and Technology Foundation of Shenzhen,China(Shenzhen Clinical Medical Research Center for Geriatric Diseases),the National Key R&D Program of China Key Projects for International Cooperation on Science,Technology and Innovation(Grant No.:2020YFE0205100);the Fundamental Research Funds for the Central Public Welfare Research Institutes,China(Grant Nos.:ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-ND-010,ZZ15-ND-10),Shenzhen Governmental Sustainable Development Fund,China(Grant No.:KCXFZ20201221173612034);Shenzhen key Laboratory of Kidney Diseases,China(Grant No.:ZDSYS201504301616234);Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties,China(Grant No.:SZGSP001).
Sepsis is characterized by a severe and life-threatening host immune response to polymicrobial infection accompanied by organ dysfunction.Studies on the therapeutic effect and mechanism of immunomodulatory drugs on th...
关键词：ARTESUNATE SEPSIS Single-cell RNA sequencing Immunomodulatory activity 
Tumor microenvironment-responsive artesunate loaded Z-scheme heterostructures for synergistic photo-chemodynamic therapy of hypoxic tumor被引量：1
《Asian Journal of Pharmaceutical Sciences》2023年第3期37-48,共12页Jie Lv Xiaoyu Wang Xue Zhang Runpei Xu Shuyang Hu Shuangling Wang Meng Li 
Financial support was provided by the National Natural Science Foundation of China(grant no.21807024);the Youth Top-notch Talents Supporting Plan of Hebei Province(QNBJ19004);Scientific Research Foundation of Hebei Province for the Returned Overseas Chinese Scholars(C20220508);the Science and Technology Project of Hebei Education Department(no.ZD2021072);the Central Guidance on Local Science and Technology Development Fund of Hebei Province(226Z2601G);Science Fun for Creative Research Groups of Natural Science Foundation of Hebei Province(no.H2020206474);supported by the Postdoctoral Fund of Hebei Medical University.
Tumor microenvironment(TME)with the particular features of severe hypoxia,insufficient endogenous H2O2,and overexpression of glutathione(GSH)markedly reduced the antitumor efficacy of monotherapy.Herein,a TME-responsi...
关键词：Hypoxia Z-scheme heterostructure ARTESUNATE Tumor microenvironment Glutathione peroxidase 4 Synergistic therapy 
Artesunate synergizes with sorafenib to induce ferroptosis in hepatocellular carcinoma被引量：54
《Acta Pharmacologica Sinica》2021年第2期301-310,共10页Zhong-jie Li Hui-qi Dai Xiao-wei Huang Ji Feng Jing-huan Deng Zi-xuan Wang Xiao-mei Yang Yu-jia Liu Yong Wu Pan-hong Chen Huan Shi Ji-gang Wang Jing Zhou Guo-dong Lu 
supported by the National Natural Science Foundation of China(81672370 and 81972291);the Guangxi Natural Science Foundation Key Grant(2018GXNSFDA050006),the Hundred-Talent Program(2016),the Guangxi Medical University Training Program for Distinguished Young Scholars(2017),the OpenGrant from Key Laboratory of High-Incidence Tumor Prevention&Treatment(Guangxi Medical University,GKE2018-02)(all awarded to GDL);the Guangxi Natural Science Foundation Key Grant(2017GXNSFDA198020)awarded to JZ,and the Guangxi Specially Appointed Professor Grant awarded to JW.
Sorafenib is the first-line medication for advanced hepatocellular carcinoma(HCC),but it can only extend limited survival.It is imperative to find a combination strategy to increase sorafenib efficacy.Artesunate is su...
关键词：SORAFENIB ARTESUNATE HCC Ferroptosis MITOCHONDRIA LYSOSOME 
Artesunate attenuates LPS-induced osteoclastogenesis by suppressing TLR4/TRAF6 and PLCγ1-Ca^(2+)-NFATc1 signaling pathway被引量：21
《Acta Pharmacologica Sinica》2020年第2期229-236,共8页Xiang-zhou Zeng Yue-yang Zhang Qin Yang Song Wang Bin-hua Zou Yan-hui Tan Min Zou Shu-wen Liu Xiao-juan Li 
the National Natural Science Foundation of China(81773740,81073119,and 81611130078);the Natural Science Foundation of Guangdong Province,China(2015A030313287);the Natural Science Foundation of Hainan Province,China(817129).
In chronic infectious diseases caused by gram-negative bacteria,such as osteomyelitis,septic arthritis,and periodontitis,osteoclastic activity is enhanced with elevated inflammation,which disturbs the bone homeostasis...
关键词：ARTESUNATE OSTEOCLAST LPS PP2B-Aα CA^(2+) NFATc1 TLR4 RAW264.7 cells chronic INFECTIOUS diseases 
Poly(D,L-lactic-co-glycolic acid)-based artesunate nanoparticles:formulation,antimalarial and toxicity assessments被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2017年第11期977-985,共9页Kabiru DAUDA Zulaikha BUSARI Olajumoke MORENIKEJI Funmilayo AFOLAYAN Oyetunde OYEYEMI Jairam MEENA Debasis SAHU Amulya PAND A 
Objective： The aim of this study was to formulate polymer-based artesunate nanoparticles for malaria treatment. Methods： Artesunate was loaded with poly（D,L-lactic-co-glycolic acid） （PLGA） by solvent evaporation...
关键词：Poly（D L-lacUc-co-glycolic acid） （PLGA） Artesunate-PLGA delivery system ANTIPLASMODIAL Toxicity 
Artemisinin anti-malarial drugs in China被引量：13
《Acta Pharmaceutica Sinica B》2016年第2期115-124,共10页Zongru Guo 
Discovered by Youyou Tu, one of the 2015 Nobel Prize winners in Physiology or Medicine, together with many other Chinese scientists, artemisinin, artemether and artesunate, as well as other artemisinins, have brought ...
关键词：ANTIMALARIAL ARTEMISININ ARTEMETHER ARTESUNATE DIHYDROARTEMISININ 
Anti-malaria drug artesunate protects bronchial epithelium from DNA damage induced by asthma被引量：1
《中国药理学与毒理学杂志》2015年第S1期25-26,共2页TzeKheeCHAN WNFeliciaTAN BevinPENGELWARD WSFredWONG 
The project supported by a NMRC grant NMRC/CBRG/0027/2012from the National Medical Research Council of Singapore,with additional support from the Singapore-MIT Alliance for Research and Technology
OBJECTIVE To investigate the genome protective effects of anti-malaria drug,artesunate in an experimental allergic asthma model.METHODS Mice were sensitized on day 0 and 7 and challenged on day 14 with 100μg house du...
关键词：ARTESUNATE HDM ASTHMA DNA damage cell death COMET 
In vitro and in vivo effect of artesunate against prostate cancer:Targetting STAT3 pathway to combat disease progression
《中国药理学与毒理学杂志》2015年第S1期81-82,共2页NachiyappanALAMELU KwangSeokAHN KodappullySivaramanSIVEEN AlanPremKUMAR GautamSETHI 
OBJECTIVE In prostate cancer(PCa),signal transducer and activator of transcription factor3(STAT3)has been strongly associated with tumor progression,through numerous means.Hence this allows STAT3 to be an important ta...
关键词：ANTITUMOR DU145 JAK SHP-1 
Anti-malarial drug,artesunate,as a novel therapeutic drug target for airway wall remodeling in asthma
《中国药理学与毒理学杂志》2015年第S1期54-55,共2页SherylTAN BenjaminONG ChangCHENG WanxingEugeneHO JohnK.CTAM AlastairG.STEWART TrudiHARRIS Wai-ShiuFredWONG ThaiTRAN 
OBJECTIVE Airway wall remodeling(AWR),which refers to structural changes in the airway,is a key characteristic of asthma.Airway smooth muscle(ASM)cell hypertrophy and hyperplasia contributes to AWR.Glucocorticoids,whi...
关键词：ASTHMA AIRWAY WALL REMODELING PI3K cyclin D1 
Artesunate and its emerging anti-neoplastic effects:beyond its role in attenuating tumor growth in osteosarcomas
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2012年第12期1029-1030,共2页Shailendra KAPOOR 
I read with great interest the recent article "Artesunate inhibits growth and induces apoptosis inhuman osteosarcoma HOS cell
关键词：药理学 性质 药物 实验 
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