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EPITOPES: 作品数：96被引量：141H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：郭礼和费俭夏国宏邢力叶欣更多>>; 相关机构：中国科学院上海生命科学研究院郑州大学南昌大学广州血液中心更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金World Health Organization国家重点基础研究发展计划中国博士后科学基金更多>>

Structural insights into the distinct protective mechanisms of human antibodies targeting ZIKV NS1: 《hLife》2024年第10期527-541,共15页Qi Pan Xiaomin Xing Jianhai Yu Qiang Chen Haizhan Jiao Wanqin Zhang Yingfen Wen Ming Gao Wei Zhao Lei Yu Hongli Hu; supported by grants from the National Natural Science Foundation of China(81971924 to L.Y.and 32370146 to W.Z.);Guangzhou Municipal Science and Technology Bureau(2023A03J0791 to L.Y.);Guangdong Science and Technology Program(2021B1212030014 to W.Z.);Guangdong Basic and Applied Basic Research Fund Enterprise Joint Fund(2021A1515220017 to W.Z.);Medical Scientific Research Foundation of Guangdong Province(B2022112 to J.Y.),Shenzhen Science and Technology Innovation Committee(JCYJ20210324131802008 to H.H.);Ganghong Young Scholar Development Fund(to H.H.);the Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation(HZQB-KCZYB-2020056 to H.H.);the Kobilka Institute of Innovative Drug Discovery and Presidential Fellowship and University Development Fund at the Chinese University of Hong Kong,Shenzhen(to H.H.,H.J.,and Q.C.);Presidential Fellowship at the Chinese University of Hong Kong,Shenzhen(to Q.P.and W.Z.)。; Antibodies targeting non-structural protein 1(NS1)confer protection against Zika virus(ZIKV).Although monoclonal an-tibodies(MAbs)3G2 and 4B8 are more potent than MAb 4F10 in suppressing ZIKV infection in neonatal mic...; 关键词：Zika virus(ZIKV) non-structural protein 1(NS1) monoclonal antibodies(MAbs) EPITOPES

Neutralization of SARS-CoV-2 infection by antibodies targeting diverse epitopes: 《Genes & Diseases》2024年第4期134-137,共4页Shusheng Wang Yunji Liao Kaiyong Yang Hang Ma Zhangyi Song Haiqiu Huang Li Zhang Ailing Wang Lei Han Jiawei Zhang Hui Chen Haiyang Yin Yantin Bian Hua Jiang Xiaodong Xiao Yueqing Xie Yunsheng Yuan Jianwei Zhu; the National Natural Science Foundation of China(No.81773621,82073751 to JZ);the National Science and Technology Major Project"Key New Drug Creation and Manufacturing Program"of China(No.2019ZX09732001-019 to JZ);the Key R&D Supporting Program(Special support for developing medicine for infectious diseases)from the Administration of Chinese and Singapore Tianjin Eco-city to Jecho Biopharmaceuticals Ltd.Co.,Zhejiang University special CoVID-19 grant 2020XGZX099;Shanghai Jiao Tong University"Crossing Medical and Engineering"grant 20X190020003 to JZ.; The CoVID-19 pandemic that started in late 2019 is sweeping through the world,posing historic challenges to global health,and disrupting social and economic lives.Previous and recent studies indicate that monoclonal a...; 关键词：ANTIBODIES inhibited MONOCLONAL

Generation and application of two monoclonal antibodies targeting conserved linear epitopes in the NP protein of influenza A virus被引量：2: 《Journal of Integrative Agriculture》2022年第7期2095-2105,共11页ZHAO Yu-hui WEN Xia LI Qi-bing JIANG Li WANG Guang-wen LIANG Li-bin WANG Xiu-rong CHEN Hua-lan LI Cheng-jun; supported by the Natural Science Foundation of Heilongjiang Province,China(JQ2019C005);the National Natural Science Foundation of China(31702265 and 32172847)。; Monoclonal antibodies(mAbs) are widely used in virus research and disease diagnosis. The nucleoprotein(NP) of influenza A virus(IAV) plays important roles in multiple stages of the virus life cycle. Therefore, generat...; 关键词：influenza A virus NUCLEOPROTEIN monoclonal antibody application

Localization Analysis of Heterophilic Antigen Epitopes of H1N1 Influenza Virus Hemagglutinin被引量：1: 《Virologica Sinica》2019年第3期306-314,共9页Chun-Yan Guo Hai-Xiang Zhang Jun-Jun Zhang Li-Jun Sun Hui-Jin Li Dao-Yan Liang Qing Feng Yan Li Yang-Meng Feng Xin Xie Jun Hu; supported by The National Key Research and Development Program of China (Grant No. 2016YFD0500700);The Natural Science Basic Research Program of Shaanxi Province (Grant No. 2016JM8065);Shaanxi Provincial People’s Hospital Incubation Fund Program (Grant No. 2015YX-4); Previous studies have indicated that two monoclonal antibodies(mAbs;A1-10 and H1-84)of the hemagglutinin(HA)antigen on the H1N1 influenza virus cross-react with human brain tissue.It has been proposed that there are h...; 关键词：H1N1 influenza virus HA ANTIGEN MONOCLONAL antibody LOCALIZATION Heterophilic EPITOPE

Generation of Monoclonal Antibody to Porcine Reproductive and Respiratory Syndrome Virus GP4 Protein and Identification of Its Minic Epitopes: 《Journal of Northeast Agricultural University(English Edition)》2019年第2期49-59,共11页Liu Peng Yuan Qing Li Wei-qun Yin Xue-ting Ghulam Abbas Li Peng-chong Zhang Chao-fan Huang Xiao-dan Zhang Rui-li Li Guang-xing; Supported by the National Natural Science Foundation of China(31372438,31200122); Porcine reproductive and respiratory syndrome virus(PRRSV)GP4 protein was prokaryotically expressed,and used as an antigen to immunize six-week-old BALB/c female mice.With conventional cell fusion method,an anti-PRRSV...; 关键词：porcine REPRODUCTIVE and respiratory syndrome virus(PRRSV) GP4 protein MONOCLONAL antibody PHAGE display technique VIRAL infection

Identification of the Epitopes of Monoclonal Antibodies against P74 of Helicoverpa armigera Nucleopolyhedrovirus: 《Virologica Sinica》2013年第6期360-367,共8页Limin Liao Dianhai Hou Huachao Huang Manli Wang Fei Deng Hualin Wang Zhihong Hu Tao Zhang; supported by the National Science Foundation of China(31130058 to Z.H.).Monoclonal Antibodies against HearNPV P74; P74 is a per os infectivity factor of baculovirus.Here,we report the production of three monoclonal antibodies (mAbs),denoted as 20D9,20F9 and 21E1,raised against P74 of Helicoverpa armigera nucleopolyhedrovirus (Hear...; 关键词：HEARNPV P74 Linear epitope Monoclonal antibody

Generation and Characterization of a Panel of Monoclonal Antibodies Against Distinct Epitopes of Human CD146: 《生物物理学报》2009年第S1期231-232,共2页Ping Wang1, Xiyun Yan.National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China; CD146 (MUC18, Mel-CAM/MCAM) is a transmembrane protein, originally identified as a biomarker of melanoma, and plays an important role in cancer invasion and metastasis.; 关键词：HUMAN CD146 antibody different EPITOPES

Characterization of the neutralizing activity of three anti-human TNF monoclonal antibodies and prediction of their TNF epitopes by molecular modeling and mutant protein approach被引量：5: 《中国生物学文摘》2006年第1期52-52,共1页Cansheng Zhu Xuesong Liu Jiannan Feng Wei Zhang Beifen Shen Weiming Ou＇yang Yunxin Cao Boquan Jin; 关键词：瘤坏死因子单克隆抗体压制活性 TNF表位分子图形突变型蛋白质

Monoclonal Antibodies Against Human Brain Acetylcholinesterase and Properties of Epitopes Directed by the Antibodies: 《Chinese Science Bulletin》1994年第16期1392-1397,共6页朱美财孙曼霁辛颜彬方允中; Project supported by the National Natural Science Foundation of China.; Acetylcholinesterase (AChE, EC, 3, 1, 1, 7,) is distributed in human nervous system, and also in non-nervous systems such as erythrocytes and serum. It is a kind of secretory as well as membrane-combining protein. The...; 关键词：human brain ACETYLCHOLINESTERASE MONOCLONAL ANTIBODY epitope.

ANALYSIS ON EPITOPES OF IGM WITH MONOCLONAL ANTI-ISOTYPIC AND ANTI-IDIOTYPIC ANTIBODIES AGAINST IgM FROM B-CLL: 《Chinese Journal of Cancer Research》1992年第4期36-42,共7页沈关心苏娜王晓林朱慧芬张悦秦立轩; A double antibodies additivity ELISA test was employed to identify the epltopes which can be recognized by monoclonal antibodies (McAbs) against IgM from B chronic lymphocyte leukemia (B-CLL). The computer grouping pr...; 关键词：antigen epltope antibody monoclonal additivity ELISA test B chronic lymphocyte leukemia computer grouping programme analysis.

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