云南高校图书馆联盟文献共享服务平台- EPITOPES

EPITOPES: 作品数：96被引量：141H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：郭礼和费俭夏国宏邢力叶欣更多>>; 相关机构：中国科学院上海生命科学研究院郑州大学南昌大学广州血液中心更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金World Health Organization国家重点基础研究发展计划中国博士后科学基金更多>>

Localization Analysis of Heterophilic Antigen Epitopes of H1N1 Influenza Virus Hemagglutinin被引量：1: 《Virologica Sinica》2019年第3期306-314,共9页Chun-Yan Guo Hai-Xiang Zhang Jun-Jun Zhang Li-Jun Sun Hui-Jin Li Dao-Yan Liang Qing Feng Yan Li Yang-Meng Feng Xin Xie Jun Hu; supported by The National Key Research and Development Program of China (Grant No. 2016YFD0500700);The Natural Science Basic Research Program of Shaanxi Province (Grant No. 2016JM8065);Shaanxi Provincial People’s Hospital Incubation Fund Program (Grant No. 2015YX-4); Previous studies have indicated that two monoclonal antibodies(mAbs;A1-10 and H1-84)of the hemagglutinin(HA)antigen on the H1N1 influenza virus cross-react with human brain tissue.It has been proposed that there are h...; 关键词：H1N1 influenza virus HA ANTIGEN MONOCLONAL antibody LOCALIZATION Heterophilic EPITOPE

Elimination of murine and human T-cell epitopes in recombinant immunotoxin eliminates neutralizing and anti-drug antibodies in vivo被引量：1: 《Cellular & Molecular Immunology》2017年第5期432-442,共11页Ronit Mazor Devorah Crown Selamawit Addissie Youjin Jang Gilad Kaplan Ira Pastan; Antibodies against the toxin portion of recombinant immunotoxins （RIT） reduce their efficacy and pose a potential safety risk. To overcome this problem we mutated the very immunogenic immunotoxin SSIP to produce LMB...; 关键词：anti-drug antibodies deimmunization IMMUNOGENICITY mouse epitopes T-cell epitopes

Chimerically fused antigen rich of overlapped epitopes from latent membrane protein 2 （LMP2） of Epstein-Barr virus as a potential vaccine and diagnostic agent被引量：2: 《Cellular & Molecular Immunology》2016年第4期492-501,共10页Xiaoyun Lin Shao Chen Xiangyang Xue Lijun Lu Shanli Zhu Wenshu Li Xiangmin Chen Xiaozhi Zhong Pengfei Jiang Torsoo Sophia Sename Yi Zheng Lifang Zhang; This work was supported by a grant from the National Natural Science Foundation of China （No： 81372447）.; Epstein-Barr virus （EBV） is prevalent throughout the world and is associated with several malignant diseases in humans. Latent membrane protein 2 （LMP2） of EBV plays a crucial role in the pathogenesis of EBV-assoc...; 关键词：Epstein-Barr virus （EBV） EPITOPE latent membrane protein 2 （LMP2） VACCINE

Computational prediction of cleavage using proteasomal in vitro digestion and MHC I ligand data被引量：2: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2013年第9期816-828,共13页Yu-feng LU Hao SHENG Yi ZHANG Zhi-yang LI; Project(No.11271059)supported by the National Natural Science Foundation of China; Proteasomes are responsible for the production of the majority of cytotoxic T lymphocyte(CTL) epitopes.Hence,it is important to identify correctly which peptides will be generated by proteasomes from an unknown protei...; 关键词：Cytotoxic T lymphocyte epitopes Kernel function PROTEASOME Stabilized matrix method

Identification of novel HLA-A 0201-restricted epitopes from anterior gradient-2 as a tumor-associated antigen against colorectal cancer被引量：1: 《Cellular & Molecular Immunology》2012年第2期175-183,共9页Hyun Ju Lee Cheol Yi Hong Chun-Ji Jin Mi-Hyun Kim Youn-Kyung Lee Thanh-Nhan Nguyen-Pham Hyunah Lee Byoung Chul Park Ik-Joo Chung Hyeoung-Joon Kim Je-Jung Lee; Anterior gradient-2 （AGR2） promotes tumor growth, cell migration and cellular transformation and its enhanced expression is almost completely restricted to malignant tissues, thus making AGR2 an interesting target f...; 关键词：AGR2 colorectal cancer dendritic cell tumor-associated antigen

Advances of Bioinformatics Tools Applied in Virus Epitopes Prediction被引量：7: 《Virologica Sinica》2011年第1期1-7,共7页Simon Rayner; The National Natural Science Foundations of China (30870131);the National Key Projects in the Infectious Fields (2008ZX10002-011, 2008ZX10004-004); In recent years,the in silico epitopes prediction tools have facilitated the progress of vaccines development significantly and many have been applied to predict epitopes in viruses successfully. Herein,a general over...; 关键词：EPITOPE BIOINFORMATICS Epitope prediction algorithms

Association of variations of NAb 2F5 and 4E10 epitopes and disease progression in Chinese antiretroviral treatment-na（i）ve patients infected with HIV-1 clade B＇被引量：1: 《Chinese Medical Journal》2010年第23期3406-3411,共6页ZHANG Xiao-li HAN Xiao-xu DAI Di BAO Ming-jia XU Dong-bing ZHANG Zi-ning WANG Ya-nan ZHAO Min Tristan Bice JIANG Yong-jun SHANG Hong; Background Studies on human immunodeficiency virus type 1 （HIV-1） vaccines have recently focused on targeting the conserved neutralizing epitopes 2F5 and 4E10, and hence it is important to understand the extent of m...; 关键词：GP41 neutralizing epitope 2F5 4E10 MUTATION

Complex positive selection pressures drive the evolution of HIV-1 with different co-receptor tropisms被引量：5: 《Science China(Life Sciences)》2010年第10期1204-1214,共11页ZHANG ChiYu DING Na CHEN KePing YANG RongGe; supported by the National Natural Science Foundation of China (Grant No. 30600352);the "Top-notch Personnel" Project of Ji-angsu University, the National Basic Research Program of China (Grant No. 2006CB504200);the Open Research Fund Program of the State Key Laboratory of Virology of China (Grant No. 2009008); HIV-1 co-receptor tropism is central for understanding the transmission and pathogenesis of HIV-1 infection. We performed a genome-wide comparison between the adaptive evolution of R5 and X4 variants from HIV-1 subtyp...; 关键词：HIV-1 co-receptor tropism adaptive evolution positively selected site R5 and X4 GP120 EPITOPES

Anti-epitope antibody, a novel site-directed antibody against human acetylcholinesterase: 《Acta Pharmacologica Sinica》2004年第4期431-435,共5页Xing-meiZHANG GangLIU Man-jiSUN; Project supported by the "9th Five-Year" Military Medicine Health Science Foundation (No 96Z017).; AIM: To construct synthetic antigens using the epitope of human brainacetylcholinesterase (hbAChE) for induction and detection of the specific antibody against theepitope, and to analyse the immunogenicity of the anti...; 关键词：ACETYLCHOLINESTERASE BUTYRYLCHOLINESTERASE EPITOPES antibodies enzyme-linked immunosorbent assay Western blotting

The expression and antigenicity identification of recombinant rat TGF-β1 in bacteria被引量：1: 《Cell Research》2001年第2期95-100,共6页GaoCF KongXT; Shanghai Medical Development grant No. ZD99001 and aGrant (SFB-542) from the Deutsche Forschungsgemeinschaft.; In order to study structure-function details of TGF-beta1, the recombinant mature form of rat TGF-beta1 was expressed in bacteria. Synthesis of the 112 amino-acid carboxyl-terminal part of TGF-beta1 (amino acid 279-39...; 关键词：Amino Acid Sequence Animals Base Sequence EPITOPES Escherichia coli Gene Expression Regulation Bacterial Genetic Vectors Molecular Sequence Data Plasmids Protein Structure Tertiary Rats Recombinant Proteins Research Support Non-U.S. Gov't Transformation Genetic Transforming Growth Factor beta

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