云南高校图书馆联盟文献共享服务平台- SOLAMARGINE

SOLAMARGINE: 作品数：17被引量：19H指数：3; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：赵雪淞邹莲华丁丹丁辉更多>>; 相关机构：华东理工大学东北师范大学河南省人民医院郑州大学更多>>; 相关期刊：《Modern Chemotherapy》《Molecular Plant》《Journal of Cancer Therapy》《Science China Chemistry》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划更多>>

Steroidal scaffold decorations in Solanum alkaloid biosynthesis被引量：1: 《Molecular Plant》2024年第8期1236-1254,共19页Rosalind Lucier Mohamed O.Kamileen Yoko Nakamura Sofiia Serediuk Ranjit Barbole Jens Wurlitzer Maritta Kunert Sarah Heinicke Sarah E.O'Connor Prashant D.Sonawane; the Fulbright Us Student Program,which is sponsored by The US Department of State and the German-American Fulbright Commission.We thank Prof.M.Court for UGT nomenclature assignment.N.benthamiana and green unripe and purple ripe S.nigrum berries used in the main and supplementary figures were generated in BioRender.We kindly acknowledge the Max Planck Society and the European Research Council(788301)for funding.; Steroidal glycoalkaloids(SGAs)are specialized metabolites produced by hundreds of Solanum species,including important vegetable crops such as tomato,potato,and eggplant.Although it has been known that SGAs play import...; 关键词：steroidal glycoalkaloids SOLANUM biosynthetic pathway α-solamargine malonyl-solamargine specialized metabolites

The Value of Excipients and the Required Understanding of the Biological System in Product Development: An Impactful Example of Curaderm, a Topical Skin Cancer Treatment: 《International Journal of Clinical Medicine》2024年第2期68-87,共20页Tania Robyn Chase Kai Elliot Cham Bill Elliot Cham; The incidences of nonmelanoma skin cancer are increasing worldwide, and the ongoing war on its treatment necessitates the development of effective and non-invasive methods. Through basic and clinical research, non-inv...; 关键词：Curaderm BEC Solasodine Glycosides SOLAMARGINE Apoptosis Skin Cancer Actinic Keratosis KERATOACANTHOMA Basal Cell Carcinoma Squamous Cell Carcinoma

First in Man Topical Treatment of Melanoma with Solasodine Glycosides in a Formulation Curaderm: A Case Report被引量：1: 《Journal of Cancer Therapy》2020年第10期617-630,共14页B. E. Cham; Background: There is ample evidence to support the safety and efficacy of the topical anticance...; 关键词：MELANOMA Curaderm BEC SOLAMARGINE Non-Melanoma Skin Cancer METASTASIS

Curaderm, the Long-Awaited Breakthrough for Basal Cell Carcinoma被引量：1: 《International Journal of Clinical Medicine》2020年第10期579-604,共26页T. Chase K. E. Cham B. E. Cham; Background: Basal cells form a continuous cell layer at the bottom of the epidermis, which is the outermost layer of the skin. Basal cell carcinoma occurs when a mutation occurs in the DNA of a basal ...; 关键词：Basal Cell Carcinoma Skin Cancer BEC SOLAMARGINE Curaderm TOPICAL PHARMACOTHERAPY

Evaluation of Dermal Irritation and Skin Sensitization by Curaderm: 《International Journal of Clinical Medicine》2020年第9期548-558,共11页T. Chase K. E. Cham B. E. Cham; Purpose: To establish whether Curaderm, a topical pharmacotherapy for skin cancer, irritates or sensitizes normal skin. Methods: The dermal irritation and skin sensitization toxicity ...; 关键词：Curaderm BEC SOLAMARGINE Skin Cancer Dermal Irritation Skin Sensitization PSORIASIS

Combination Treatment with BEC and Cisplatin Synergistically Augments Anticancer Activity and Results in Increased Absolute Survival被引量：3: 《Journal of Cancer Therapy》2020年第8期470-482,共13页B. E. Cham; Plant-derived BEC with its main component solamargine possesses anticancer activities via its effect on a variety of biological pathways in a wide range of human cancer cells. High cure rates with BEC therapy have bee...; 关键词：BEC SOLAMARGINE CISPLATIN Curaderm ANTI-CANCER

Solasodine, Solamargine and Mixtures of Solasodine Rhamnosides: Pathway to Expansive Clinical Anticancer Therapies: 《International Journal of Clinical Medicine》2017年第12期692-713,共22页Bill E. Cham; Cancer remains a major cause of mortality worldwide. Progresses have been made in the understanding of the molecular basis of cancer, cancer detection, and cancer treatment. Important strides by treating early-stage c...; 关键词：Cancer BEC SOLAMARGINE Apoptosis MDR METASTASIS Curaderm

Treatment of Skin Cancer with a Selective Apoptotic-Inducing Curaderm<sup>BEC5</sup>Topical Cream Containing Solasodine Rhamnosides: 《International Journal of Clinical Medicine》2015年第5期326-333,共8页Aruba Cham Bill Cham; Solasodine rhamnosides produced in plants as secondary metabolites, are safe and effective when treating a variety of cancers, including non-melanoma skin cancers. They are cytotoxic against multi-drug resistant tumor...; 关键词：Skin Cancer BEC SOLAMARGINE Curaderm Apoptosis SOLASODINE Rhamnosides

Drug therapy: Solamargine and other solasodine rhamnosyl glycosides as anticancer agents: 《Modern Chemotherapy》2013年第2期33-49,共17页Bill E. Cham; In the last century, the discovery of cytotoxic agents was revolutionary for anticancer therapy. These therapies have resulted in better understanding of cancer in general. However, the development of agents that comb...; 关键词：CANCER Skin CANCER SOLAMARGINE Solasonine BEC SOLASODINE Rhamnosyl GLYCOSIDES CuradermBEC5 Apoptosis ANTINEOPLASTIC Targeted Therapy

Topical Curaderm<sup>BEC5</sup>Therapy for Periocular Nonmela-noma Skin Cancers: A Review of Clinical Outcomes: 《International Journal of Clinical Medicine》2013年第5期233-238,共6页Bill E. Cham; Approximately 5 to 10 percent of all skin cancers occur in the periocular region. Basal cell carcinoma is the most frequent malignant periocular tumor, followed by squamous cell carcinoma, sebaceous gland carcinoma, a...; 关键词：Periocular Skin Cancers CuradermBEC5 Apoptosis SOLAMARGINE Basal CELL CARCINOMA Squamous CELL CARCINOMA COSMESIS SOLANUM

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