CYTOPROTECTIVE

作品数：25被引量：100H指数：5
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相关领域：医药卫生更多>>
相关作者：欧展辉陈玉嫦牛晓华何文茵宋兵更多>>
相关机构：广州医科大学更多>>
相关期刊：《Asian Pacific Journal of Tropical Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Advances in Biological Chemistry》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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H-ferritin: A new cytoprotective antioxidant strategy via detoxification of hydrogen peroxide to oxygen
《Nano Research》2025年第2期641-649,共9页Feiyan Zhu Jiuyang He Lingfei Kong Zhanjun Guo Pengpeng Liang Jianlin Zhang Xiangming Wang Minmin Liang 
This work was supported by the National Key R&D Program of China(No.2022YFA1205801);National Natural Science Foundation of China(Nos.T2225026,82172087,82071308,and 82404099);Peking University Third Hospital Clinical Key Project(Nos.BYSYZD2023041 and BYSYRCYJ2023004);Beijing Institute of Technology Research Fund Program for Young Scholars,and Outstanding Young Talent Project of Capital Medical University.
It is well reported that cellular ferritin reduces the intracellular oxidative stress by sequestering excess ferrous ions,preventing them from participating in Fenton reactions that generate damaging harmful reactive ...
关键词：ANTIOXIDANT H-ferritin nanozymes oxidative damage treatment of Parkinson's disease 
Na^(+)/K^(+)-ATPase:ion pump,signal transducer,or cytoprotective protein,and novel biological functions被引量：2
《Neural Regeneration Research》2024年第12期2684-2697,共14页Songqiang Huang Wanting Dong Xiaoqian Lin Jinsong Bian 
supported by the National Natural Science Foundation of China,No.82173800 (to JB);Shenzhen Science and Technology Program,No.KQTD20200820113040070 (to JB)。
Na^(+)/K^(+)-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na^(+)out of and two K^(+)into cells.Additionally,Na^...
关键词：ANTIBODY biological functions cellular communication electrochemical gradient ion balance ion channels Na^(+)/K^(+)-ATPase neurological diseases neurotransmitter release signal transduction 
Beyond boundaries:Neuroprotective effects of steroids and ecdysteroids in SH-SY5Y cells-A systematic review
《Neuroprotection》2024年第2期151-166,共16页Bizhar Ahmed Tayeb Isaac Kinyua Njangiru Renata Minorics 
Stipendium Hungaricum Scholarship founded by the Hungarian Government。
Steroids and ecdysteroids have been shown to exhibit a range of biological effects,including anti-inflammatory,anticancer,and neuroprotective.This systematic review aims to highlight the evidence-based neuroprotective...
关键词：ANTIAPOPTOTIC CYTOPROTECTIVE NEUROBLASTOMA NEUROSTEROIDS oxidative stress SH-SY5Y cells 
BL-918,a small-molecule activator of ULK1,induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy
《Acta Pharmacologica Sinica》2023年第3期524-537,共14页Wei Liu Shi-ou Zhu Yu-lin Guo Long-fang Tu Yong-qi Zhen Rong-yan Zhao Liang Ou-Yang Hiroshi Kurihara Rong-Rong He Bo Liu 
National Natural Science Foundation of China(Grant No.81873209,82172649,21314120 and 81922064);Key R&D Program of Sichuan Province(Grant No.2021YFS0046);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(grant number 2017BT01Y036)and GDUPS;Research Foundation for Administration of traditional Chinese medicine of Sichuan Province(Grant No.2020HJZX002);CAMS Innovation Fund for Medical Science(Grant 2019-RC-HL-023);National Clinical Research Center for Geriatrics,West China Hospital,Sichuan University(Grant Z20201004);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(grant 2020-JKCS-014).
Amyotrophic lateral sclerosis(ALS)is one of the most common fatal neurodegenerative diseases in adults.ALS pathogenesis is associated with toxic SOD1 aggregates generated by mutant SOD1.Since autophagy is responsible ...
关键词：amyotrophic lateral sclerosis cytoprotective autophagy ULK1 BL-918 PHARMACOKINETIC 
Is autophagy induction by PARP inhibitors a target for therapeutic benefit?
《Oncology Research》2022年第1期1-12,共12页AHMED M.ELSHAZLY TUONG VI V.NGUYEN DAVID A.GEWIRTZ 
Research in Dr.Gewirtz’s laboratory is supported by Grants#CA268819 and CA239706 from the National Cancer Institute;National Institutes of Health and Grant#W81XWH 19-1-0490 from the Department of Defense Congressionally Directed Breast Cancer Research Program.
PARP inhibitors have proven to be effective in conjunction with conventional therapeutics in the treatment of various solid as well as hematologic malignancies,particularly when the tumors are deficient in DNA repair p...
关键词：OLAPARIB Niraparib Rucaparib Talazoparib AUTOPHAGY CYTOPROTECTIVE CYTOTOXIC Non-protective 
A cytoprotective graphene oxide-polyelectrolytes nanoshell for single-cell encapsulation
《Frontiers of Chemical Science and Engineering》2021年第2期410-420,共11页Luanying He Yulin Chang Junhao Zhu Ying Bi Wenlin An Yiyang Dong Jia-Hui Liu Shihui Wang 
This work is supported by the National Key Research and Development Project of China(Grant No.218YFA0903000);the National Natural Science Foundation of China(Grant Nos.21606013,21301015);National Mega-project for Innovative Drugs(Grant No.2019ZX09721001-007-002);Shenzhen Science and Technology Project(Grant No.JCYJ20180507183842516).
Graphene oxide(GO)has been increasingly utilized in the fields of food,biomedicine,environment and other fields because of its benign biocompatible.We encapsulated two kinds of GO with different sizes on yeast cells w...
关键词：GO YEAST POLYELECTROLYTE CYTOPROTECTION nanomaterials 
Priming of intestinal cytoprotective genes and antioxidant capacity by dietary phytogenic inclusion in broilers被引量：1
《Animal Nutrition》2020年第3期305-312,共8页Konstantinos C.Mountzouris Vasileios V.Paraskeuas Konstantinos Fegeros 
ANCO Animal Nutrition Competence GmbH for provision of the PP and research funding(AUA research agreement 06.0068)
The potential of a phytogenic premix(PP)based on ginger,lemon balm,oregano and thyme to stimulate the expression of cytoprotective genes at the broiler gut level was evaluated in this study.In particular,the effects o...
关键词：POULTRY Nuclear factor(erythroid-derived 2)-like 2 Antioxidant Phytogenic GUT 
Tubeimoside-1, a triterpenoid saponin, induces cytoprotective autophagy in human breast cancer cells in vitro via Akt-mediated pathway被引量：13
《Acta Pharmacologica Sinica》2019年第7期919-928,共10页Shi-long Jiang Yi-di Guan Xi-sha Chen Peng Ge Xin-luan Wang Yuan-zhi Lao Song-shu Xiao Yi Zhang Jin-ming Yang Xiao-jun Xu Dong-sheng Cao Yan Cheng 
grants from the National Natural Science Foundation of China (Nos. 81422051, 81472593, and 31401208);the Hunan Natural Science Foundation of China (No. 2016JJ1020).
Autophagy, a form of cellular self-digestion by lysosome, is associated with various disease processes including cancers, and modulating autophagy has shown promise in the treatment of various malignancies. A number o...
关键词：tubeimoside-1 AUTOPHAGY apoptosis AKT BREAST cancer cells 
Effect of an extraction solvent on the antioxidant quality of Pinus densiflora needle extract被引量：1
《Journal of Pharmaceutical Analysis》2019年第3期193-200,共8页Thamizhiniyan Venkatesan Young-Woong Choi Young-Kyoon Kim 
the Korea Forestry Promotion Institute (R&D program for Forest Science Technology, Grant No. 2013070B101819-AA03);Kookmin University, South Korea, (Grant No. 2017) for financial support
Pinus densiflora needle extract (PDNE) is widely reported to have many pharmacological activities including antioxidant potential. However, the solvent system used for extraction greatly affects its antioxidant qualit...
关键词：PINUS densiflora NEEDLE EXTRACT OXIDATIVE stress CYTOPROTECTIVE Natural ANTIOXIDANT 
Cytoprotective Mechanism of the Novel Gastric Peptide BPC157 in Gastrointestinal Tract and Cultured Enteric Neurons and Glial Cells被引量：7
《Neuroscience Bulletin》2019年第1期167-170,共4页Xi-Yu Wang Meihua Qu Rui Duan Dengping Shi Ling Jin Jinping Gao Jackie D.Wood Junhua Li Guo-Du Wang 
supported by a JMEY International collaboration Grant(020002015)
Dear Editor,Body protection compound (BPC) 157 is a stable gastric pentadecapeptide. Predrag Sikiric’s team has carried out many investigations of its cytoprotective effects in different organs and tissues (1, 2)Thei...
关键词：BPC HT GI CYTOPROTECTIVE Mechanism of the NOVEL GASTRIC PEPTIDE BPC157 in Gastrointestinal Tract and CULTURED ENTERIC Neurons and Glial Cells 
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