supported by grants from the National Natural Science Foundation of China(31970913 and 32170957);the Natural Science Foundation of Guangdong Province(2021A1515012156);National Key Research and Development Program of China(2021ZD0201703);the Key-Area Research and Development Program of Guangdong Province(2019B030335001).
Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in res...
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31070935 and 62173326);the National Basic Research Program of China(2013CB835100);the Youth Innovation Promotion Association,CAS(2022367)。
Acetylcholine(ACh)is an important neuromod-ulator in various cognitive functions.However,it is unclear how ACh influences neural circuit dynamics by altering cellular properties.Here,we investigated how ACh influ-ence...
supported by the National Natural Science Foundation of China(31771282);the China Postdoctoral Science Foundation(BX20200093 and 2021M690038).
The family of voltage-gated potassium Kv2 channels consists of the Kv2.1 and Kv2.2 subtypes.Kv2.1 is constitutively highly phosphorylated in neurons and its function relies on its phosphorylation state.Whether the fun...
the National Natural Science Foundation of China(31671088 and 31730041);the Natural Science Foundation of Shaanxi Province,China(2017ZDJC-01)。
Tweety-homolog 1(Ttyh1)is expressed in neural tissue and has been implicated in the generation of several brain diseases.However,its functional significance in pain processing is not understood.By disrupting the gene ...
supported by National Natural Science Foundation of China(31630028,91632305,and 91632303);the Fund for Distinguished Young Scholars of National Natural Science Foundation of China(81425009 and 81425007);the National Basic Science Research Program of China(2012CB933900 and 2015CB755600);the Strategic Priority Research Program(B)of China(XDB02050500)。
Myoclonus dystonia syndrome(MDS)is an inherited movement disorder,and most MDS-related mutations have so far been found in theε-sarcoglycan(SGCE)coding gene.By generating SGCE-knockout(KO)and human 237 C>T mutation k...
the National Natural Science Foundation of China(31671078,81790642,and 31872765);the Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01)and ZJ Lab.
Ganglion cells(RGCs) are the sole output neurons of the retinal circuity. Here, we investigated whether and how dopamine D2 receptors modulate the excitability of dissociated rat RGCs. Application of the selective D2 ...
supported by the National Natural Science Foundation of China(31370827);the Shanghai Leading Academic Discipline Project [B111]
Cyproheptadine (CPH), a first-generation anti- histamine, enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway. In this stu...
supported by grants from the National Natural Science Foundation of China(NSFC;31330033,91332124,31471112,31500848,81671107,31600834,J1210026);the NSFC/Research Grants Council(RGC)Joint Research Scheme(31461163001);the Ministry of Education of China(Specialized Research Fund for the Doctoral Program of Higher Education/RGC Earmarked Research Grant 20130091140003,and Fundamental Research Funds for the Central Universities);the Natural Science Foundation of Jiangsu Province,China(BK2011014,BK20140599,and BK20151384);the Postdoctoral Sciences Foundation,China(2013T60520)
Orexin, released from the hypothalamus, has been implicated in various basic non-somatic functions including feeding, the sleep-wakefulness cycle, emotion,and cognition. However, the role of orexin in somatic motor co...
supported by the National Natural Science Foundation of China(30870829)
As sciatica and low back pain are among the most common medical complaints, many studies have duplicated these conditions in animals. Chronic compression of the dorsal root ganglion (CCD) is one of these models. The...
supported by grants from the National Natural Science Foundation of China (30970363 and 31172092)
Objective Motor control is encoded by neuronal activity. Small conductance Ca2+-activated K+ channels (SK channels) maintain the regularity and precision of firing by contributing to the afterhyperpolarization (...