EXCITABILITY

作品数:69被引量:120H指数:6
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相关作者:陈长勋金若敏张季叶谷瑞民张云红更多>>
相关机构:上海市中医药研究院哈尔滨医科大学附属第二医院哈尔滨医科大学香港大学更多>>
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Neuronomodulation of Excitable Neurons
《Neuroscience Bulletin》2024年第1期103-112,共10页Yizhang Chen Lin Xiao Jian Qiu 
supported by grants from the National Natural Science Foundation of China(31970913 and 32170957);the Natural Science Foundation of Guangdong Province(2021A1515012156);National Key Research and Development Program of China(2021ZD0201703);the Key-Area Research and Development Program of Guangdong Province(2019B030335001).
Neuronomodulation refers to the modulation of neural conduction and synaptic transmission(i.e.,the conduction process involved in synaptic transmission)of excitable neurons via changes in the membrane potential in res...
关键词:NEURON Membrane potential EXCITABILITY Chemoactivation Neuronomodulation 
Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal
《Neuroscience Bulletin》2023年第5期731-744,共14页Xiao-Wei Li Yi Ren Dong-Qing Shi Lei Qi Fang Xu Yanyang Xiao Pak-Ming Lau Guo-Qiang Bi 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32030200);the National Natural Science Foundation of China(31070935 and 62173326);the National Basic Research Program of China(2013CB835100);the Youth Innovation Promotion Association,CAS(2022367)。
Acetylcholine(ACh)is an important neuromod-ulator in various cognitive functions.However,it is unclear how ACh influences neural circuit dynamics by altering cellular properties.Here,we investigated how ACh influ-ence...
关键词:ACETYLCHOLINE Neuronal network REVERBERATION Synaptic current EXCITABILITY 
Protein Kinase C Controls the Excitability of Cortical Pyramidal Neurons by Regulating Kv2.2 Channel Activity被引量:1
《Neuroscience Bulletin》2022年第2期135-148,共14页Zhaoyang Li Wenhao Dong Xinyuan Zhang Jun-Mei Lu Yan-Ai Mei Changlong Hu 
supported by the National Natural Science Foundation of China(31771282);the China Postdoctoral Science Foundation(BX20200093 and 2021M690038).
The family of voltage-gated potassium Kv2 channels consists of the Kv2.1 and Kv2.2 subtypes.Kv2.1 is constitutively highly phosphorylated in neurons and its function relies on its phosphorylation state.Whether the fun...
关键词:Kv2.2 PKC PHOSPHORYLATION Pyramidal neurons EXCITABILITY 
Tweety-Homolog 1 Facilitates Pain via Enhancement of Nociceptor Excitability and Spinal Synaptic Transmission被引量:1
《Neuroscience Bulletin》2021年第4期478-496,共19页Wen-Juan Han Sui-Bin Ma Wen-Bin Wu Fu-Dong Wang Xiu-Li Cao Dong-Hao Wang Hai-Ning Wu Rou-Gang Xie Zhen-Zhen Li Fei Wang Sheng-Xi Wu Min-Hua Zheng Ceng Luo Hua Han 
the National Natural Science Foundation of China(31671088 and 31730041);the Natural Science Foundation of Shaanxi Province,China(2017ZDJC-01)。
Tweety-homolog 1(Ttyh1)is expressed in neural tissue and has been implicated in the generation of several brain diseases.However,its functional significance in pain processing is not understood.By disrupting the gene ...
关键词:Ttyh1 Inflammatory pain Peripheral sensitization Long-term potentiation 
Mutation inε-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice被引量:1
《Neuroscience Bulletin》2021年第3期311-322,共12页Jiao Li Yiqiong Liu Qin Li Xiaolin Huang Dingxi Zhou Hanjian Xu Feng Zhao Xiaoxiao Mi Ruoxu Wang Fan Jia Fuqiang Xu Jing Yang Dong Liu Xuliang Deng Yan Zhang 
supported by National Natural Science Foundation of China(31630028,91632305,and 91632303);the Fund for Distinguished Young Scholars of National Natural Science Foundation of China(81425009 and 81425007);the National Basic Science Research Program of China(2012CB933900 and 2015CB755600);the Strategic Priority Research Program(B)of China(XDB02050500)。
Myoclonus dystonia syndrome(MDS)is an inherited movement disorder,and most MDS-related mutations have so far been found in theε-sarcoglycan(SGCE)coding gene.By generating SGCE-knockout(KO)and human 237 C>T mutation k...
关键词:SGCE MDS FILOPODIA SYNAPSE EXCITABILITY 
Dopamine D2 Receptor-Mediated Modulation of Rat Retinal Ganglion Cell Excitability被引量:2
《Neuroscience Bulletin》2020年第3期230-242,共13页Ning Yin Yu-Long Yang Shuo Cheng Hong-Ning Wang Xin Hu Yanying Miao Fang Li Zhongfeng Wang 
the National Natural Science Foundation of China(31671078,81790642,and 31872765);the Shanghai Municipal Science and Technology Major Project(No.2018SHZDZX01)and ZJ Lab.
Ganglion cells(RGCs) are the sole output neurons of the retinal circuity. Here, we investigated whether and how dopamine D2 receptors modulate the excitability of dissociated rat RGCs. Application of the selective D2 ...
关键词:Retinal GANGLION cell DOPAMINE D2 receptor Outward K^+current Nav1.6 VOLTAGE-GATED Na^+current EXCITABILITY 
Cyproheptadine Regulates Pyramidal Neuron Excitability in Mouse Medial Prefrontal Cortex
《Neuroscience Bulletin》2018年第5期759-768,共10页Yan-Lin He Kai Wang Qian-Ru Zhao Yan-Ai Mei 
supported by the National Natural Science Foundation of China(31370827);the Shanghai Leading Academic Discipline Project [B111]
Cyproheptadine (CPH), a first-generation anti- histamine, enhances the delayed rectifier outward K+ current (IK) in mouse cortical neurons through a sigma-1 receptor-mediated protein kinase A pathway. In this stu...
关键词:CYPROHEPTADINE Neuronal excitability Te-traethylammonium-sensitive Ik cortical neurons Sigma-1 receptor 
Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 Receptors被引量:7
《Neuroscience Bulletin》2017年第4期365-372,共8页He-Ren Gao Qian-Xing Zhuang Yong-Xiao Zhang Zhang-Peng Chen Bin Li Xiao-Yang Zhang Yi-Ting Zhong Jian-Jun Wang Jing-Ning Zhu 
supported by grants from the National Natural Science Foundation of China(NSFC;31330033,91332124,31471112,31500848,81671107,31600834,J1210026);the NSFC/Research Grants Council(RGC)Joint Research Scheme(31461163001);the Ministry of Education of China(Specialized Research Fund for the Doctoral Program of Higher Education/RGC Earmarked Research Grant 20130091140003,and Fundamental Research Funds for the Central Universities);the Natural Science Foundation of Jiangsu Province,China(BK2011014,BK20140599,and BK20151384);the Postdoctoral Sciences Foundation,China(2013T60520)
Orexin, released from the hypothalamus, has been implicated in various basic non-somatic functions including feeding, the sleep-wakefulness cycle, emotion,and cognition. However, the role of orexin in somatic motor co...
关键词:OREXIN OX1 receptor OX2 receptor Globus pallidus internus Basal ganglia 
Dorsal root ganglion compression as an animal model of sciatica and low back pain被引量:9
《Neuroscience Bulletin》2012年第5期618-630,共13页Xiao-Yu Lin Jing Yang Hui-Ming Li San-Jue Hu Jun-Ling Xing 
supported by the National Natural Science Foundation of China(30870829)
As sciatica and low back pain are among the most common medical complaints, many studies have duplicated these conditions in animals. Chronic compression of the dorsal root ganglion (CCD) is one of these models. The...
关键词:animal model SCIATICA low back pain dorsal root ganglion EXCITABILITY CYTOKINE ANALGESIA 
SK channels modulate the excitability and firing precision of projection neurons in the robust nucleus of the arcopallium in adult male zebra finches被引量:1
《Neuroscience Bulletin》2012年第3期271-281,共11页Guo-Qiang Hou Xuan Pan Cong-Shu Liao Song-Hua Wang Dong-Feng Li 
supported by grants from the National Natural Science Foundation of China (30970363 and 31172092)
Objective Motor control is encoded by neuronal activity. Small conductance Ca2+-activated K+ channels (SK channels) maintain the regularity and precision of firing by contributing to the afterhyperpolarization (...
关键词:SK channels excitability firing precision robust nucleus of the arcopallium zebra finches 
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