SPHINGOSINE

作品数：80被引量：236H指数：8
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相关领域：医药卫生更多>>
相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Sphingosine 1-phosphate induces epicardial progenitor cell differentiation into smooth muscle-like cells
《Acta Biochimica et Biophysica Sinica》2019年第4期402-410,共9页Yu Li Yingrui Li Xiaodong Jing Yajie Liu Bin Liu Qiang She 
National Natural Science Foundation of China (No. 81770251).
Epicardial progenitor cells (EpiCs) which are derived from the proepicardium have the potential to differentiate into coronary vascular smooth muscle cells during development. Whether sphingosine 1-phosphate (S1P), a ...
关键词：EPICARDIAL PROGENITOR CELLS SPHINGOSINE 1-phosphate DIFFERENTIATION smooth muscle-like CELLS SPHINGOSINE 1-phosphate receptors 
Regulatory role of sphingosine kinase and sphingosine-1-phosphate receptor signaling in progenitor/stem cells被引量：2
《World Journal of Stem Cells》2018年第9期119-133,共15页Mei Li Ng Nagendra S Yarla Mario Menschikowski Olga A Sukocheva 
Balanced sphingolipid signaling is important for the maintenance of homeostasis. Sphingolipids were demonstrated to function as structural components, second messengers, and regulators of cell growth and survival in n...
关键词：Sphingosine-1-phosphate SPHINGOLIPIDS Embryonic STEM CELLS Mesenchymal STEM CELLS Bone marrow hematopoietic STEM CELLS SPHINGOSINE kinase PROGENITOR 
p38 mitogen-activated protein kinase regulates type-Ⅰ vs type-Ⅱ phenotyping of human vascular endothelial cells被引量：1
《World Journal of Translational Medicine》2015年第3期101-112,共12页Masako Nakahara Miwako Nishio Koichi Saeki Akira Yuo Kumiko Saeki 
Supported by A Grant-in-Aid from the Ministry of Health;Labour and Welfare of Japan;No.KHD1017;by that from JST;PRESTO
AIM: To identify kinases involved in phenotype regulation of vascular endothelial cells(VECs): Proproliferative G-protein signaling 5(RGS5)^(high)(typeⅠ) vs anti-proliferative RGS5^(low)(typeⅡ) VECs.METHODS: Proteom...
关键词：VASCULAR endothelial CELLS VASCULAR smooth muscle CELLS proteomic KINASE assay p38αmitogenactivated protein KINASE regulator of G-PROTEIN signaling 5 sphingosine-1-phosphate N-cadherin 
Role of Sphingosine 1-Phosphate (S1P) Receptor 1 in Experimental Autoimmune Encephalomyelitis —I
《Pharmacology & Pharmacy》2013年第8期628-637,共10页Noriyasu Seki Yasuhiro Maeda Hirotoshi Kataoka Kunio Sugahara Kenji Chiba 
Infiltration of myelin-specific helper T (Th) cells into the central nervous system (CNS) plays a key role in pathogenesis of experimental autoimmune encephalomyelitis (EAE). In this study, we investigated the involve...
关键词：SPHINGOSINE 1-Phosphosphate RECEPTOR 1 FINGOLIMOD Hydrochloride (FTY720) Experimental Autoimmune ENCEPHALOMYELITIS Th1 CELLS Th17 CELLS 
Roles of sphingosine-1-phosphate signaling in angiogenesis被引量：5
《World Journal of Biological Chemistry》2010年第10期298-306,共9页Yoh Takuwa Yasuo Okamoto Noriko Takuwa Kazuaki Yoshioka 
Supported by Grants from the Ministry of Education, Science, Sports and Culture of Japan and the Japan Society for the Promotion of Science;the Practical Application Research program of Japan Science and Technology Agency Innovation plaza Ishi-kawa
Sphingosine-1-phosphate (S1P) is a blood-borne lipid mediator with pleiotropic biological activities. S1P acts via the specific cell surface G-protein-coupled receptors, S1P1-5. S1P1 and S1P2 were originally identifie...
关键词：Sphingosine-1-phosphate ANGIOGENESIS Angiogenic therapy Rac Akt Vascular MATURATION Endothelial CELLS Bone-marrow-derived CELLS 
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