SPHINGOSINE

作品数：80被引量：236H指数：8
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相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport
《Cell Research》2024年第2期173-176,共4页Bin Pang Leiye Yu Tong Li Haizhan Jiao Xiaomei Wu Jinxin Wang Ruiping He Yurou Zhang Juan Wang Hongli Hu Wei Dai Li Chen Ruobing Ren 
Dear Editor,As one of the critical sphingolipid metabolites in eukaryotes,sphingosine-1-phosphate(S1P)acts as a bioactive lipid mediator in the immune and vascular systems.S1P prompts its physiological roles through t...
关键词：NS2 PROMPT MAINTAIN 
Structural basis of Sphingosine-1-phosphate transport via human SPNS2
《Cell Research》2024年第2期177-180,共4页Yaning Duan Nancy C.P.Leong Jing Zhao Yu Zhang Dat T.Nguyen Hoa T.T.Ha Na Wang Ruixue Xia Zhenmei Xu Zhengxiong Ma Yu Qian Han Yin Xinyan Zhu Anqi Zhang Changyou Guo Yu Xia Long N.Nguyen Yuanzheng He 
supported by the Startup Funds of HIT Center for Life Sciences;the National Natural Science Foundation of China(32070048 to Y.H.);Tsinghua University Initiative Scientific Research Program to Y.X.;We thank Dr.Zhiwei Huang of the HIT Center for Life Sciences for suggestion and support of this project,and Singapore Ministry of Health’s National ResearchOFIRG/OFIRG/0066/20;Ministry of Education MOE2018-T2-1-126,NUHSRO/2022/067/T1,and T2EP30123-0014(to L.N.N.).
Dear Editor,Sphingosine 1-phosphate(S1P)plays crucial roles in various physiological processes,including immune response,vascular development,and neural system homeostasis1 through activating S1P receptors(S1PRs).Nota...
关键词：HOMEOSTASIS TRANSPORT SINE 
Sphingosine 1-phosphate induces epicardial progenitor cell differentiation into smooth muscle-like cells
《Acta Biochimica et Biophysica Sinica》2019年第4期402-410,共9页Yu Li Yingrui Li Xiaodong Jing Yajie Liu Bin Liu Qiang She 
National Natural Science Foundation of China (No. 81770251).
Epicardial progenitor cells (EpiCs) which are derived from the proepicardium have the potential to differentiate into coronary vascular smooth muscle cells during development. Whether sphingosine 1-phosphate (S1P), a ...
关键词：EPICARDIAL PROGENITOR CELLS SPHINGOSINE 1-phosphate DIFFERENTIATION smooth muscle-like CELLS SPHINGOSINE 1-phosphate receptors 
Sphingosine 1 phosphate receptor-1 （S1PR1） signaling protects cardiac function by inhibiting cardiomyocyte autophagy被引量：5
《Journal of Geriatric Cardiology》2018年第5期334-345,共12页Yong-Zeng CHEN Fan WANG Hai-Jun WANG Hong-Bin LIU 
Objective To investigate the role of sphingosine-l-phosphate （S1P） and its receptors in cardiomyocyte autophagy, cardiomyocyte hypertrophy and cardiac function. Methods Cardiomyocytes were isolated from neonatal Vis...
关键词：AUTOPHAGY CARDIOMYOCYTE HYPERTROPHY S1PR1 
Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate被引量：4
《Journal of Geriatric Cardiology》2017年第11期696-702,共7页Xi WANG Fan WANG 
Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipoprotein （HDL）. Findings from a growing number of studies further indicate that sphingosine-...
关键词：APOM HDL-associated S1P Vascular function 
Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent path- way in endothelial cells in vitro被引量：2
《Acta Pharmacologica Sinica》2013年第3期360-366,共7页Chi-hao CHANG Yuan-li HUANG Ming-kwang SHYU Shee-uan CHEN Chih-hsin LIN Tsai-kai Ju JenHer LU Hsinyu LEE 
Aim： To investigate whether sphingosine-l-phosphate （SIP）, a potent angiogenic factor, induced vascular endothelial growth factor-C （VEGF-C） expression in endothelial cells in vitro and to examine its underlying ...
关键词：sphingosine-l-phosphate VEGF-C matrix metalloproteinase-2 fibroblast growth factor-I fibroblast growth factor receptor-i GM6001 SU5402 transactivation human umbilical vein endothelial cells RNA interference 
Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (H_2O_2) levels in guard cells in Vicia faba被引量：4
《Science China(Life Sciences)》2012年第11期974-983,共10页MA YinLi SHE XiaoPing YANG ShuShen 
supported by the Graduate Education Innovation Program Projects of Ministry of Education, China (Grant No. F-0922)
The role and signaling of sphingosine-l-phosphate （SIP） during darkness-induced stomatal closure were examined in Vicia faba. Darkness substantially raised S 1P and hydrogen peroxide （H202） levels and closed stoma...
关键词：sphingosine-l-phosphate cytosol pH hydrogen peroxide DARKNESS stomatal closure 
Overexpression of Rice Sphingosine-1-Phoshpate Lyase Gene OsSPL1 in Transgenic Tobacco Reduces Salt and Oxidative Stress Tolerance被引量：5
《Journal of Integrative Plant Biology》2012年第9期652-662,共11页Huijuan Zhang Jing Zhai Jibo Mo Dayong Li Fengming Song 
supported by the National Key Project for Research on Transgenic Plants (2009ZX08001-017B and 2011ZX08009-003-001);the National Natural Science Foundation of China (No. 30971880);the National High-tech R&D Program of China (No. 2 012AA101504);the Program for Changjiang Scholars and Innovative Research Team in the University of the Ministry of Education of China (No. IRT0943)
Sphingolipids, including sphingosine-l-phosphate （SIP）, have been shown to function as signaling mediators to regulate diverse aspects of plant growth, development, and stress response. In this study, we performed f...
关键词：SPHINGOLIPIDS sphingosine-l-phosphate lyase （SPL） OsSPL1 salt stress oxidative stress. 
Advance in the Study of the Mechanisms Regulated by Sphingosine-1-Phosphate
《Science Foundation in China》2010年第1期57-60,共4页Fei Ye Xiangqian Kong Cheng Luo 
supported by Natural Science Foundation of China(Grant No.20972174)
Sphingosine-1-phosphate（S1P） is a bioactive lipid messenger in the cells that regulate gene expression and NF-κB signal pathway through unknown mechanisms.Recently,Cheng Luo,associate professor of DDDC in Shanghai ...
关键词：SIP SphK1 SphK2 HDAC TRAF2 NF-kB signaling pathway 
Molecular and Functional Characterization of Sphingosine-1-Phosphate Lyase Homolog from Higher Plants被引量：3
《Journal of Integrative Plant Biology》2007年第3期323-335,共13页Yan Niu Kunling Chen Jizhou Wang Xin Liu Huanju Qin Aimin Zhang Daowen Wang 
Supported by the National Natural Science Foundation of China （30521001） and the Chinese Academy of Sciences （KSCX2-SW-304）.Acknowledgments The authors are grateful to Drs Lu Liang and Yiping Tong for helpful discussion on this work and the writing of the manuscript.
Sphingosine-1-phosphate lyase （SPL） is involved in degrading the conserved sphingolipid signaling molecule sphingosine-1-phosphate. However, molecular studies on plant SPL have not been reported to date. Here, we pr...
关键词：Arabidopsis cell death leaf development and senescence rice SPHINGOLIPID sphingosine-l-phosphate lyase 
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