Nitric oxide(NO)is a gaseous molecule produced by 3 different NO synthase(NOS)isoforms:Neural/brain NOS(nNOS/bNOS,type 1),endothelial NOS(eNOS,type 3)and inducible NOS(type 2).Type 1 and 3 NOS are constitutively expre...
supported by the National Natural Science Foundation of China(82072072,32261160372,52275199,32171326,and 32371377);Guang Dong Basic and Applied Basic Research Foundation(2022B1515130010 and 2021A1515111035);Wenzhou Science and Technology Major Project(Y2023138);Wenzhou Institute,University of Chinese Academy of Sciences startup fund(WIUCASQD2023013);Beijing-Tianjin-Hebei Fundamental Research Cooperation Project(J230001);Leading Talent Project of Guangzhou Development District(2020-L013);Dongguan Science and Technology of Social Development Program(20231800906311).
Thrombosis and infection are 2 major complications associated with central venous catheters(CVCs),resulting in substantial mortality and morbidity.The concurrent long-term administration of antibiotics and anticoagula...
the Program of Graduate Education and Teaching Reform of Shanxi(No.2022YJJG302);the Applied Basic Research Programs of Shanxi(Nos.201801D221106,202203021221228);the Key R&D Project of Lvliang(No.2023GXYF04);Scientific Instrument Center of Shanxi University(No.201512)。
The imbalance of nitric oxide(NO)homeostasis in the brain is closely related to the occurrence of Parkinson’s disease(PD).Therefore,revealing the fluctuation of NO in brain is crucial for understanding the pathophysi...
supported by the National Key R&D Program of China,No.2019YFE0121200(to LQZ);the National Natural Science Foundation of China,Nos.82325017(to LQZ),82030032(to LQZ),82261138555(to DL);the Natural Science Foundation of Hubei Province,No.2022CFA004(to LQZ);the Natural Science Foundation of Jiangxi Province,No.20224BAB206040(to XZ);Research Project of Cognitive Science and Transdisciplinary Studies Center of Jiangxi Province,No.RZYB202201(to XZ).
With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic...
supported by grants from the National Natural Science Foundation of China(Nos.82273780,82173681 and 82104004);the Natural Science Foundation of Xinjiang Uygur Autonomous Region(2022D01D38,China);the open projects of State Key Laboratory of Natural Medicines(No.SKLNMZZ202213,China);the State Key Laboratory of Pathogenesis,Prevention,and Treatment of High Incidence Diseases in Central Asia Fund(SKL-HIDCA-2021-1,China);the Fundamental Research Funds for the Central Universities of China Pharmaceutical University(No.2632023TD04).
Ischemic stroke(IS)is a globally life-threatening disease.Presently,few therapeutic medicines are available for treating IS,and rt-PA is the only drug approved by the US Food and Drug Administration(FDA)in the US.In f...
The endothelium modulates vascular homeostasis owing to a variety of vasoconstrictors and vasodilators.Endothelial dysfunction(ED),characterized by impaired vasodilation,inflammation,and thrombosis,triggers future car...
supported by the National Natural Science Foundation of China(22302100,22025203,22121005);the Fundamental Research Funds for the Central Universities(Nankai University).
As a prominent contributor to air pollution,nitric oxide(NO)has emerged as a critical agent causing detrimental environmental and health ramifications.To mitigate emissions and facilitate downstream utilization,adsorp...
supported by the Russian Science Foundation grant(No.22-15-00120);supported by the grant(No.21-2-10-59-1)from the Foundation for the Development of Theoretical Physics and Mathematics BASIS.
Red blood cell(RBC)aggregation as well as their deformation significantly affects blood microrheology.These processes depend on various factors,one of which is concentration of the nitric oxide,one of the main signali...
supported by the Russian Science Foundation Grant No.22-15-00120.
Red blood cells(RBCs)are the most abundant human blood cells.RBC aggregation and deformation strongly determine blood viscosity which impacts hemorheology and microcirculation.In turn,RBC properties depend on di®erent...
Background:Resveratrol is a non-flavonoid polyphenol that shows promise in reducing proinflammatory factors and maintaining endothelial function,which hints at its potential role in slowing atherosclerosis and prevent...