POTENTIAL

作品数：3476被引量：6263H指数：27
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  • 期刊=Signal Transduction and Targeted Therapyx
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Advances in calcium-sensing receptor modulation: biased signaling and therapeutic potential
《Signal Transduction and Targeted Therapy》2025年第1期10-12,共3页Luisa Uhlmann Ulf Wagner 
support from the German Research Foundation(grant number WA 2765/9-2).
In a recent study published in Science,Liu and colleagues used computational ultra-large library docking to discover new chemotypes acting as positive allosteric modulators(PAM)of the Calcium-Sensing Receptor(CaSR),1 ...
关键词：HOMEOSTASIS THERAPEUTIC POTENTIAL 
Multiplexed RNAs in lipid nanoparticles:potential therapeutic vaccine for chronic hepatitis B
《Signal Transduction and Targeted Therapy》2024年第12期5351-5353,共3页Hari Krishnareddy Rachamala Srujan Marepally 
A recent study published in Signal Transduction and Targeted Therapy by Wenjing Z.and Min Y.et al.presents a potential gamechanger in the field of chronic hepatitis B infection.The research focuses on the delivery of ...
关键词：al. HEPATITIS THERAPEUTIC 
Harnessing naturally occurring mutations for T-cell therapy:a potential new avenue to enhance treatment efficacy
《Signal Transduction and Targeted Therapy》2024年第5期1799-1801,共3页Michael Hiltensperger Jürgen Ruland Kilian Schober 
K.S.is supported by grants from the German Federal Ministry of Education and Research(BMBF,project-IDs 01KI2013 and 031L0290B);the Else Kröner-Fresenius-Stiftung(project-ID 2020_EKEA.127);the German Research Foundation(DFG)through the research training group RTG 2504(project-ID 401821119);the Interdisciplinary Center for Clinical Research of the University Hospital of Erlangen(project-ID A98);the European Union(Yellow4FLAVI consortium,project-ID 101137459);J.R.is supported by grants from the German Research Foundation(DFG)(project-ID 210592381-SFB 1054,project-ID 395357507-SFB 1371,project-ID 369799452-TRR 237,project-ID 452881907-TRR 338,project-ID 435874434-RTG 2668,RU 695/12-1);The Leukemia&Lymphoma Society,and the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation programme(grant agreement No 834154).
In a recent study published in Nature,Garcia et al.use a sophisticated approach to identify fitness-enhancing mutations for T cells that was inspired by cancer evolution.1 The identified CARD11-PIK3R3 gene fusion enha...
关键词：cancer POTENTIAL 
Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential被引量：2
《Signal Transduction and Targeted Therapy》2024年第4期1389-1422,共34页Yu-Ling Xiao Yue Gong Ying-Jia Qi Zhi-Ming Shao Yi-Zhou Jiang 
supported by grants from the National Natural Science Foundation of China (82103369);the China Postdoctoral Science Foundation (2022M710757).
Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease progression.Recently,dietary interventions have emerged as promising adjunctive treatment strategies not only for can...
关键词：DISEASES METABOLISM POTENTIAL 
The role of inflammasomes in human diseases and their potential as therapeutic targets被引量：6
《Signal Transduction and Targeted Therapy》2024年第2期479-508,共30页Jing Yao Keenan Sterling Zhe Wang Yun Zhang Weihong Song 
supported by the Key Laboratory of Alzheimer’s Disease of Zhejiang Province(ZJAD-2021004);the National Natural Science Foundation of China(82201576);Beijing Hospitals Authority Youth Programme(QML20210804);Beijing Medical Research 2021-8(YZ);the National Natural Science Foundation of China(82150710557,82230043 and 82293642)to WS.
Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response.Each inflammasome complex has three major components:an upstream sensor molecu...
关键词：inflam THERAPEUTIC POTENTIAL 
SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread
《Signal Transduction and Targeted Therapy》2023年第12期5581-5583,共3页Xinling Wang Lu Lu Shibo Jiang 
supported by grants from the National Natural Science Foundation of China(92169112 and 82202491).
In recent studies published in Nature and Lancet Infectious Diseases,1,2 SARS-CoV-2 Omicron subvariant BA.2.86 exhibited a substantial antigenic drift,enhanced receptor affinity,and less immune evasion to sera of indi...
关键词：WASTEWATER POTENTIAL BREAKTHROUGH 
Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases被引量：3
《Signal Transduction and Targeted Therapy》2023年第12期5686-5726,共41页Priyanka Dey Talukdar Urmi Chatterji 
CSIR,GoI,for funding the fellowship of P.D.T.(File No.-09/028(1066)/2018-EMR-I).
Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the co-activators.Deregulation of these ...
关键词：THERAPEUTIC eventually POTENTIAL 
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets被引量：27
《Signal Transduction and Targeted Therapy》2023年第10期4746-4782,共37页Chao Gao Jingwen Jiang Yuyan Tan Shengdi Chen 
This research was funded by the National Natural Science Foundation of China(81971187,82171401,81971183,and 82101477);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);Innovation Program of Shanghai Municipal Education Commission(2017-01-07-00-01-E00046).
Microglia activation is observed in various neurodegenerative diseases.Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.Some ide...
关键词：DEGENERATIVE HETEROGENEITY FUNCTIONS 
Mitochondrial dynamics in health and disease: mechanisms and potential targets被引量：28
《Signal Transduction and Targeted Therapy》2023年第10期4452-4476,共25页Wen Chen Huakan Zhao Yongsheng Li 
This work was supported by the NSFC of China(No.82273212 to H.Z.);the Major International(Regional)Joint Research Program of the NSFC of China(No.81920108027 to Y.L.);Performance Incentive for Scientific Research Institutions of Chongqing Guide Special Projects(No.cstc2020jxjl130014 to H.Z.);Research and Breeding Project of Chongqing Medical Biotechnology Association(No.cmba2022kyym-zkxmQ0006 to H.Z.).
Mitochondria are organelles that are able to adjust and respond to different stressors and metabolic needs within a cell,showcasing their plasticity and dynamic nature.These abilities allow them to effectively coordin...
关键词：FUNCTION FUNCTIONS DYNAMICS 
A promising small molecule binding pocket in class B GPCRs: expanding potential for drug development被引量：1
《Signal Transduction and Targeted Therapy》2023年第9期3888-3889,共2页Huan Xiao Qian Sun Qiu Sun 
This work was supported by Natural Science Foundation of Sichuan Province(Grants 2023NSFSC1839,2023NSFSC1154).
Recently,Xu et al.1 have published in Nature,solved the high-resolution structure of a small molecule agonist PCO371 and Gs bound human parathyroid hormone receptor 1(PTH1R)by cryo-electron microscopy.This study revea...
关键词：EXPANDING INSIGHT CLASS 
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