supported by the National Natural Science Foundation of China,Nos. 82171076 (to XS) and U22A20311 (to XS), 82101168 (to TL);Shanghai Science and technology Innovation Action Plan,No. 23Y11901300 (to JS);Science and Technology Commission of Shanghai Municipality,No. 21ZR1451500 (to TL);Shanghai Pujiang Program,No. 22PJ1412200 (to BY)。
Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss. Ferroptosis has been demonstrated to be associated with retinal de...
supported by the Natural Science Foundation of Chongqing,No.CSTB2023NSCQ-mSX0561(to WL).
Effective treatment methods for stroke,a common cerebrovascular disease with a high mortality rate,are still being sought.Exosome therapy,a form of acellular therapy,has demonstrated promising efficacy in various dise...
supported by the National Natural Science Foundation of China(8210082163,81800343);the Fundamental Research Fund for the Central Universities(2042021kf0081);the Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2020CFA027);the Doctor of Excellence Program of the First Hospital of Jilin University(JDYY-DEP-2023043).
Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital...
supported by grants from University of South China Innovation Foundation For Postgraduate(233YXC001);Postgraduate Scientific Research Innovation Project of Hunan Province(CX20230955);the National Natural Science Foundation of China(No.82103171,Jianbo Feng);the Clinical Medical Research“4310”Program of the University of South China(20224310NHYCG07).
Breast cancer (BC) is the most common malignant tumor and the leading cause ofcancer-related deaths among women worldwide. Great progress has been recently achieved incontrolling breast cancer;however, mortality from ...
supported by Techpool Bio-Pharma Co.,Ltd.(grant no.AKR-S005).
Objective:To investigate the anti-tumor effects of an E1B55KD-deleted oncolytic adenovirus,H101,in combination with a humanized anti-PD-1(Programmed cell death protein 1)monoclonal antibody,Camrelizumab.Methods:Anti-t...
BACKGROUND Immune checkpoint inhibitors(ICIs)are a new class of antitumor agents.They enhance antitumor effects by blocking inhibitory receptors and related ligands expressed on T cells.ICIs also modulate regular immu...
BACKGROUND Gastric cancer(GC)is one of the most common malignancies worldwide,and Helicobacter pylori(HP)infection is a well-established risk factor for its development.Programmed death-ligand 1(PD-L1)expression is a ...
Supported by the Health Industry Research Program of Gansu Province,No.GSWSKY2021-043;the Youth Science and Technology Foundation of Gansu Province,No.22JR11RA002;the Natural Science Foundation of Gansu Province,No.22JR5RA008.
BACKGROUND The treatment of gastric cancer remains highly challenging,particularly in cases of unresectable locally advanced or metastatic disease.Although chemotherapy and immunotherapy have shown some efficacy in su...
Science and Technology Program of Guangzhou,No.202102010077;International Science Foundation of Guangzhou Fuda Cancer Hospital,No.Y2020-ZD-03.
BACKGROUND Irreversible electroporation(IRE)is a novel local tumor ablation approach with the potential to activate the host’s immune system.However,this approach is insufficient to prevent cancer progression,and com...
supported by grants from the National Natural Science Foundation of China(No.82273770);the Foundation for Innovative Research Groups of the National Natural Science Foundation of Sichuan Province(No.24NSFTD0051).
In the realm of drug discovery,recent advancements have paved the way for innovative approaches and methodologies.This comprehensive review encapsulates six distinct yet interrelated mini-reviews,each shedding light o...