PROGRAMMED_CELL_DEATH

作品数:271被引量:1070H指数:14
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相关作者:崔克明宋运淳王雅清王玲宁顺斌更多>>
相关机构:北京大学武汉大学昆明医科大学浙江大学更多>>
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Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration
《Neural Regeneration Research》2026年第1期406-416,共11页Xiaoxu Huang Yumeng Zhang Yuxin Jiang Tong Li Shiqi Yang Yimin Wang Bo Yu Minwen Zhou Guanran Zhang Xiaohuan Zhao Junran Sun Xiaodong Sun 
supported by the National Natural Science Foundation of China,Nos. 82171076 (to XS) and U22A20311 (to XS), 82101168 (to TL);Shanghai Science and technology Innovation Action Plan,No. 23Y11901300 (to JS);Science and Technology Commission of Shanghai Municipality,No. 21ZR1451500 (to TL);Shanghai Pujiang Program,No. 22PJ1412200 (to BY)。
Progressive photoreceptor cell death is one of the main pathological features of age-related macular degeneration and eventually leads to vision loss. Ferroptosis has been demonstrated to be associated with retinal de...
关键词:age-related macular degeneration ferroptosis light exposure damage oxidative stress pathway PHOTORECEPTOR programmed cell death solute carrier family 7 member 11(SLC7A11) 
Exosomes in stroke management:A promising paradigm shift in stroke therapy
《Neural Regeneration Research》2026年第1期6-22,共17页Bo Wang Pinzhen Chen Wenyan Li Zhi Chen 
supported by the Natural Science Foundation of Chongqing,No.CSTB2023NSCQ-mSX0561(to WL).
Effective treatment methods for stroke,a common cerebrovascular disease with a high mortality rate,are still being sought.Exosome therapy,a form of acellular therapy,has demonstrated promising efficacy in various dise...
关键词:angiogenesis animal model cerebrovascular disorder extracellular vesicle mortality rates neural stem cell NEUROINFLAMMATION oxidative stress programmed cell death therapy 
Mitochondrial quality control in human health and disease
《Military Medical Research》2025年第3期393-458,共66页Bo‑Hao Liu Chen‑Zhen Xu Yi Liu Zi‑Long Lu Ting‑Lv Fu Guo‑Rui Li Yu Deng Guo‑Qing Luo Song Ding Ning Li Qing Geng 
supported by the National Natural Science Foundation of China(8210082163,81800343);the Fundamental Research Fund for the Central Universities(2042021kf0081);the Science Fund for Creative Research Groups of the Natural Science Foundation of Hubei Province(2020CFA027);the Doctor of Excellence Program of the First Hospital of Jilin University(JDYY-DEP-2023043).
Mitochondria,the most crucial energy-generating organelles in eukaryotic cells,play a pivotal role in regulating energy metabolism.However,their significance extends beyond this,as they are also indispensable in vital...
关键词:Mitochondrial quality control(MQC) METABOLISM Programmed cell death CANCER Cardiovascular disease Metabolic disease Nervous disease Pulmonary disease Kidney disease Digestive system disease 
Role of ubiquitin-specific proteases in programmed cell death of breast cancer cells
《Genes & Diseases》2025年第3期319-328,共10页Wen Yan Shasha Xiang Jianbo Feng Xuyu Zu 
supported by grants from University of South China Innovation Foundation For Postgraduate(233YXC001);Postgraduate Scientific Research Innovation Project of Hunan Province(CX20230955);the National Natural Science Foundation of China(No.82103171,Jianbo Feng);the Clinical Medical Research“4310”Program of the University of South China(20224310NHYCG07).
Breast cancer (BC) is the most common malignant tumor and the leading cause ofcancer-related deaths among women worldwide. Great progress has been recently achieved incontrolling breast cancer;however, mortality from ...
关键词:ANOIKIS Apoptosis AUTOPHAGY Breast cancer Ferroptosis PYROPTOSIS Ubiquitin-specific proteases 
Oncolytic adenovirus H101 enhances the anti-tumor effects of PD-1 blockade via CD47 downregulation in tumor cells
《Oncology Research》2025年第5期1161-1172,共12页CHENXIAO QIAO YIPENG XU YEDIE HE ZHIJIAN CAI HUA WANG 
supported by Techpool Bio-Pharma Co.,Ltd.(grant no.AKR-S005).
Objective:To investigate the anti-tumor effects of an E1B55KD-deleted oncolytic adenovirus,H101,in combination with a humanized anti-PD-1(Programmed cell death protein 1)monoclonal antibody,Camrelizumab.Methods:Anti-t...
关键词:Cancer Oncolytic adenovirus Macrophage CD47 Programmed cell death protein 1 blockade(PD-1 blockade) 
Granulomatosis with polyangiitis induced by the anti-programmed cell death-1 inhibitor tislelizumab:A case report
《World Journal of Clinical Cases》2025年第15期56-62,共7页Jian-Hui Zhao Jing-Jiao Wang Yi-Wen Li 
BACKGROUND Immune checkpoint inhibitors(ICIs)are a new class of antitumor agents.They enhance antitumor effects by blocking inhibitory receptors and related ligands expressed on T cells.ICIs also modulate regular immu...
关键词:Tislelizumab Programmed cell death-1 inhibitor Granulomatosis with polyangiitis Anti-neutrophil cytoplasmic antibody-associated vasculitis Case report 
Relationship between Helicobacter pylori infection and programmed death-ligand 1 in gastric cancer:A meta-analysis
《World Journal of Clinical Oncology》2025年第4期280-290,共11页Hong-Chang Yang Cheng-Feng Fu Li-Jun Qiao Gen-He Long Li-Fen Yang Biao Yao 
BACKGROUND Gastric cancer(GC)is one of the most common malignancies worldwide,and Helicobacter pylori(HP)infection is a well-established risk factor for its development.Programmed death-ligand 1(PD-L1)expression is a ...
关键词:Helicobacter pylori Gastric cancer Programmed cell death protein 1/programmed death-ligand 1 Immune checkpoint blockade therapy PATHOGENESIS 
Quadruple therapy with immunotherapy and chemotherapy as firstline conversion treatment for unresectable advanced gastric adenocarcinoma: A case report
《World Journal of Gastrointestinal Oncology》2025年第4期503-514,共12页Xiao-Yu Du Ren-Jie Xia Li-Wen Shen Jian-Guo Ma Wei-Qing Yao Wei Xu Zhi-Peng Lin Liang-Bin Ma Guo-Qiang Niu Rui-Fang Fan Shu-Mei Xu Long Yan 
Supported by the Health Industry Research Program of Gansu Province,No.GSWSKY2021-043;the Youth Science and Technology Foundation of Gansu Province,No.22JR11RA002;the Natural Science Foundation of Gansu Province,No.22JR5RA008.
BACKGROUND The treatment of gastric cancer remains highly challenging,particularly in cases of unresectable locally advanced or metastatic disease.Although chemotherapy and immunotherapy have shown some efficacy in su...
关键词:Unresectable locally advanced gastric adenocarcinoma Conversion therapy IMMUNOTHERAPY Programmed cell death protein 1 inhibitors Sintilimab Case report 
Irreversible electroporation combined with anti-programmed cell death protein 1 therapy promotes tumor antigen-specific CD8+T cell response
《World Journal of Gastrointestinal Oncology》2025年第3期237-245,共9页Yang-Yang Ma Xiao-Hua Wang Jian-Ying Zeng Ji-Bing Chen Li-Zhi Niu 
Science and Technology Program of Guangzhou,No.202102010077;International Science Foundation of Guangzhou Fuda Cancer Hospital,No.Y2020-ZD-03.
BACKGROUND Irreversible electroporation(IRE)is a novel local tumor ablation approach with the potential to activate the host’s immune system.However,this approach is insufficient to prevent cancer progression,and com...
关键词:Irreversible electroporation Pancreatic cancer Programmed cell death protein 1 blockade CD8+T cell Anticancer immunity 
New techniques and strategies in drug discovery(2020–2024 update)
《Chinese Chemical Letters》2025年第3期104-112,共9页Qijie Gong Jian Song Yihui Song Kai Tang Panpan Yang Xiao Wang Min Zhao Liang Ouyang Li Rao Bin Yu Peng Zhan Saiyang Zhang Xiaojin Zhang 
supported by grants from the National Natural Science Foundation of China(No.82273770);the Foundation for Innovative Research Groups of the National Natural Science Foundation of Sichuan Province(No.24NSFTD0051).
In the realm of drug discovery,recent advancements have paved the way for innovative approaches and methodologies.This comprehensive review encapsulates six distinct yet interrelated mini-reviews,each shedding light o...
关键词:Drug discovery Covalent inhibitors Computational drug design Protein scaffolding Pro-PROTACs Programmed cell death C-C cleavage 
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