SPINAL_CORD

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A single-cell landscape of the regenerating spinal cord of zebrafish
《Neural Regeneration Research》2026年第2期780-789,共10页Lei Yao Xinyi Cai Saishuai Yang Yixing Song Lingyan Xing Guicai Li Zhiming Cui Jiajia Chen 
supported by the Jiangsu Province Traditional Chinese Medicine Technology Development Plan Project,Nos.MS2023113(to JC),MS2022090;Young and Middle-aged Academic Leaders of Jiangsu Qing-Lan Project(to GL).
Unlike mammals,zebrafish possess a remarkable ability to regenerate their spinal cord after injury,making them an ideal vertebrate model for studying regeneration.While previous research has identified key cell types ...
关键词：dividing oligodendrocyte macrophage MICROGLIA neuron proliferating oligodendrocyte radial glia single cell sequencing spinal cord regeneration transcriptome ZEBRAFISH 
Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway
《Neural Regeneration Research》2025年第12期3564-3573,共10页Ya Zheng Lingyun Cao Dan Zhao Qi Yang Chunya Gu Yeran Mao Guangyue Zhu Yulian Zhu Jing Zhao Dongsheng Xu 
supported by the National Natural Science Foundation of China,Nos.81772453(to DX),81974358(to DX),81973157(to JZ),82173646(to JZ),82302866(to YZ)。
Promoting synaptic plasticity and inducing functional reorganization of residual nerve fibers hold clinical significance for restoring motor function following spinal cord injury.Neuromagnetic stimulation targeting th...
关键词：DENDRITE inflammation magnetic stimulation nerve root neurological function neuronal damage NEUROTRANSMITTER spinal cord injury synaptic plasticity synaptic transmission 
Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord
《Neural Regeneration Research》2025年第11期3302-3316,共15页Yali Chen Yiyong Wei Jin Liu Tao Zhu Cheng Zhou Donghang Zhang 
supported by the National Natural Science Foundation of China,No.82301403(to DZ)。
Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative disorders.Glial cells include astrocyt...
关键词：astrocyte glial cell HUMAN microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord 
Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord
《Neural Regeneration Research》2025年第8期2311-2312,共2页Krisztián Pajer Tamás Bellák Antal Nógrádi 
Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular factors.Although the spinal cord ...
关键词：INJURED capacity MODIFIED 
Passive activity enhances residual control ability in patients with complete spinal cord injury被引量：1
《Neural Regeneration Research》2025年第8期2337-2347,共11页Yanqing Xiao Mingming Gao Zejia He Jia Zheng Hongming Bai Jia-Sheng Rao Guiyun Song Wei Song Xiaoguang Li 
supported by the Fundamental Research Funds for Central Public Welfare Research Institute,No.2020CZ-5(to WS and GS);the National Natural Science Foundation of China,No.31970970(to JSR);Fundamental Research Funds for the Central Universities,No.YWF-23-YG-QB-010(to JSR)。
Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury level.However,because of prolonged inactivity,initial attempts to activate these...
关键词：complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task 
Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord被引量：1
《Neural Regeneration Research》2025年第7期2095-2107,共13页Emily A.Hibbard Liwen Zhou Cathy Z.Yang Karthik Venkudusamy Yessenia Montoya Alexa Olivarez George D.Bittner Dale R.Sengelaub 
supported by the Department of Defense AFIRMⅢW81XWH-20-2-0029 grant subcontract;Lone Star Paralysis gift,UT POC19-1774-13 grant;Neuraptive Therapeutics Inc.26-7724-56 grant;National Institutes of Health R01-NS128086(all to GDB)。
Peripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions;behavioral recovery is typically poor.We used a plasmalemmal fusogen,polyethylene g...
关键词：AXOTOMY dorsal horn peripheral nerve injury PLASTICITY polyethylene glycol(PEG) sciatic nerve sensory terminals wheat germ agglutinin horseradish peroxidase 
Combinatorial therapies for spinal cord injury repair
《Neural Regeneration Research》2025年第5期1293-1308,共16页Carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.Silva 
funded by National funds,through the Foundation for Science and Technology (FCT)-project UIDB/50026/2020 (DOI 10.54499/UIDB/50026/2020),UIDP/50026/2020 (DOI 10.54499/UIDP/50026/2020) and LA/P/0050/2020 (DOI 10.54499/LA/P/0050/2020)(to NAS);Financial support was also provided by Prémios Santa Casa Neurociências–Prize Melo e Castro for Spinal Cord Injury Research (MC-18-2021);Wings for Life Spinal Cord Research Foundation (WFL-PT-14/23)(to NAS)。
Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed t...
关键词：electric stimulation neural tissue regeneration NEUROPROTECTION POLYTHERAPY spinal cord injury 
Ischemia-reperfusion injury after spinal cord decompressive surgery-An in vivo rat model
《Animal Models and Experimental Medicine》2025年第3期405-420,共16页Boyu Zhang Zhefeng Jin Pengren Luo He Yin Xin Chen Bowen Yang Xiaokuan Qin LiGuo Zhu Bo Xu Guoliang Ma Dian Zhang 
Wangjing Hospital Affiliated to China Academy of Chinese Medical Sciences,Grant/Award Number:WJYY-YJKT-2022-13。
Background:Although decompression surgery is the optimal treatment for patients with severe degenerative cervical myelopathy(DCM),some individuals experience no improvement or even a decline in neurological function a...
关键词：8-oxoG DNA degenerative cervical myelopathy spinal cord ischemia-reperfusion injury surgical decompression 
From single to combinatorial therapies in spinal cord injuries for structural and functional restoration
《Neural Regeneration Research》2025年第3期660-670,共11页Ernesto Doncel-Pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero 
Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychoso...
关键词：neural regeneration NEUROPROTECTION spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury 
Mechanistic insights into“Three Methods and Three Acupoints”Tuina therapy for improving spinal microcirculation and motor function in sciatic nerve injury model rats
《Journal of Traditional Chinese Medical Sciences》2025年第1期125-134,共10页Hanyu Zhang Yingqi Zhang Hourong Wang Jiayue Liu Jiawei Sun Jinping Chen Zhifeng Liu Tianyuan Yu Jian Shu 
supported by the National Natural Science Foundation of China(82274675&82074573);the Beijing Natural Science Foundation(7232278).
Objective:To investigate the effects of“Three Methods and Three Acupoints”(TMTP)Tuina therapy on spinal microcirculation in sciatic nerve injury(SNI).Methods:Thirty-six SpragueeDawley rats were randomly assigned to ...
关键词：Three Methods and Three Acupoints TUINA Spinal cord MICROCIRCULATION PI3K/Akt 
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